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2021-03-02 12:04:00 EPZM Epizyme $9.65 / -0.13 (-1.33%) 12:04 03/02/21 03/02 12:04 03/02/21 12:04	Epizyme reports preliminary data from Phase 1b/3 study of EZH-302 The combination of TAZVERIK + R2 is being evaluated in the Phase 1b safety run-in portion of the EZH-302 trial, which enrolled a total of 13 patients. Among the 13 patients evaluated in this standard dose escalation design, no Dose Limiting Toxicities were observed during the first cycle of treatment up to the highest dose of 800mg of TAZVERIK twice daily. As of mid-February, initial data from the trial also showed: All but one of the 13 patients enrolled remain on therapy, and, to date, seven of the patients were also considered evaluable for efficacy based on the availability of tumor scans from investigators. All seven evaluable patients demonstrated a response to treatment with TAZVERIK+R2 with three complete responses and four partial responses. The safety profile of TAZVERIK + R2 observed in these patients to date is consistent with that previously described with the respective drugs; no patients have discontinued due to an adverse event. Based on these early safety and activity findings, Epizyme is preparing to commence the Phase 3 randomization portion of the trial. The Company plans to present further data from the Phase 1b portion of the study at a medical meeting in 2021. Preliminary Data from Phase 1b/2 Study EZH-1101	02 Mar
EPZM Epizyme $9.65 / -0.13 (-1.33%) 02/25/21 Morgan Stanley Epizyme downgraded to Equal Weight on Tazverik challenges at Morgan Stanley 02/25/21 Morgan Stanley Epizyme downgraded to Equal Weight from Overweight at Morgan Stanley 02/24/21 Citi Epizyme price target lowered to $27 from $35 at Citi 12/21/20 Jefferies Epizyme downgraded to Hold at Jefferies on lower than consensus Tazverik view

2021-03-02 12:04:00

EPZM

Epizyme

$9.65 / -0.13 (-1.33%)

12:04

03/02/21

03/02

12:04

03/02/21

12:04

Epizyme reports preliminary data from Phase 1b/3 study of EZH-302

The combination of TAZVERIK + R2 is being evaluated in the Phase 1b safety run-in portion of the EZH-302 trial, which enrolled a total of 13 patients. Among the 13 patients evaluated in this standard dose escalation design, no Dose Limiting Toxicities were observed during the first cycle of treatment up to the highest dose of 800mg of TAZVERIK twice daily. As of mid-February, initial data from the trial also showed: All but one of the 13 patients enrolled remain on therapy, and, to date, seven of the patients were also considered evaluable for efficacy based on the availability of tumor scans from investigators. All seven evaluable patients demonstrated a response to treatment with TAZVERIK+R2 with three complete responses and four partial responses. The safety profile of TAZVERIK + R2 observed in these patients to date is consistent with that previously described with the respective drugs; no patients have discontinued due to an adverse event. Based on these early safety and activity findings, Epizyme is preparing to commence the Phase 3 randomization portion of the trial. The Company plans to present further data from the Phase 1b portion of the study at a medical meeting in 2021. Preliminary Data from Phase 1b/2 Study EZH-1101

02
Mar

EPZM Epizyme

$9.65 / -0.13 (-1.33%)

02/25/21 Morgan Stanley: Epizyme downgraded to Equal Weight on Tazverik challenges at Morgan Stanley

02/25/21 Morgan Stanley: Epizyme downgraded to Equal Weight from Overweight at Morgan Stanley

02/24/21 Citi: Epizyme price target lowered to $27 from $35 at Citi

12/21/20 Jefferies: Epizyme downgraded to Hold at Jefferies on lower than consensus Tazverik view

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General news	FX Action: The dollar » 10:50 04/23/21 04/23 10:50 04/23/21 10:50 $ECON Economic Data / + FX Action: The dollar… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return in 9 minutes Get Free Trial ShowHide Related Items >><<
Recommendations	Newmont price target lowered to C$101 from C$102 at National Bank » 10:48 04/23/21 04/23 10:48 04/23/21 10:48 NEM Newmont $65.75 / +0.04 (+0.06%) National Bank analyst… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals Events Options NEM Newmont $65.75 / +0.04 (+0.06%) 03/11/21 Infosys, Newmont extend collaboration to digitize mine delivery models 03/10/21 Newmont to acquire GT Gold for C$3.25 per share in cash 03/10/21 Newmont to acquire remaining 85.1% of GT Gold for approximately $311M 02/26/21 SSR Mining names Alison White as CFO NEM Newmont $65.75 / +0.04 (+0.06%) 02/19/21 Citi Newmont price target lowered to $66 from $70 at Citi 02/10/21 JPMorgan Newmont assumed with an Overweight at JPMorgan 02/02/21 National Bank Newmont price target lowered to C$109 from C$111 at National Bank 01/11/21 National Bank Newmont price target lowered to C$111 from C$122 at National Bank NEM Newmont $65.75 / +0.04 (+0.06%) 02/18/21 Newmont reports Q4 EPS $1.02, consensus 95c 10/29/20 Newmont reports Q3 EPS 86c, consensus 85c NEM Newmont $65.75 / +0.04 (+0.06%) 12/19/20 Alphabet, Apple among Barron's 10 Top stocks for 2021, Barron's says 04/29/21 Newmont - NEM 04/28/21 Newmont Corp NEM Newmont $65.75 / +0.04 (+0.06%) 04/15/21 Newmont Mining call volume above normal and directionally bullish 03/18/21 Newmont Mining put volume heavy and directionally bearish 03/09/21 Unusually active option classes on open March 9th 01/29/21 Newmont Mining call volume above normal and directionally bullish
Hot Stocks	Casey's General Stores appoints Paul Suarez as CISO » 10:48 04/23/21 04/23 10:48 04/23/21 10:48 CASY Casey's General Stores $221.47 / -0.15 (-0.07%) , WMT Walmart $139.59 / -0.08 (-0.06%) Casey's General… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return in 9 minutes Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly Events Options CASY WMT CASY Casey's General Stores $221.47 / -0.15 (-0.07%) 03/22/21 Casey's General Stores to acquire 49 Oklahoma stores for $39M in cash 03/22/21 Alimentation Couche-Tard plans to sell 355 sites following strategic review 03/08/21 Casey's General Stores CEO says 'our balance sheet remains strong' 03/08/21 Casey's General Stores reports Q3 fuel same-store gallons sold down 12.1% y/y WMT Walmart $139.59 / -0.08 (-0.06%) 04/20/21 Velodyne Lidar signs multi-year sales agreement with Gatik 04/20/21 U.K.'s CMA: Bellis' purchase of Asda raises some competition concerns 04/19/21 Walmart adds the BinaxNOW COVID-19 Antigen Self Test 04/19/21 Abbott begins shipping BinaxNOW COVID-19 Ag Self Test to retailers CASY WMT CASY Casey's General Stores $221.47 / -0.15 (-0.07%) 04/07/21 Fly Intel: Top five analyst downgrades 04/07/21 Raymond James Casey's General Stores downgraded to Market Perform at Raymond James 04/07/21 Raymond James Casey's General Stores downgraded to Market Perform from Outperform at Raymond James 03/10/21 Raymond James Casey's General Stores price target raised to $215 from $200 at Raymond James WMT Walmart $139.59 / -0.08 (-0.06%) 10:21 Today Cowen Walmart+ members may have declined to 11.1M in March, says Cowen 04/06/21 Morgan Stanley Walmart+ membership 'seems to have stagnated,' says Morgan Stanley 03/16/21 MKM Partners Walmart price target lowered to $141 from $154 at MKM Partners 02/23/21 Evercore ISI Walmart accelerating change with investments, says Evercore ISI CASY WMT CASY Casey's General Stores $221.47 / -0.15 (-0.07%) 03/08/21 Casey's General Stores reports Q3 EPS $1.04, consensus 97c 12/07/20 Casey's General Stores reports Q2 EPS $3.00, consensus $2.80 12/07/20 Notable companies reporting after market close WMT Walmart $139.59 / -0.08 (-0.06%) 02/18/21 Walmart reports Q4 adjusted EPS $1.39, consensus $1.51 02/17/21 Notable companies reporting before tomorrow's open 02/17/21 Notable companies reporting before tomorrow's open 11/17/20 Walmart reports Q3 adjusted EPS $1.34, consensus $1.18 CASY WMT CASY Casey's General Stores $221.47 / -0.15 (-0.07%) 02/06/21 Time to buy Casey's General Stores, Barron's says WMT Walmart $139.59 / -0.08 (-0.06%) 04/21/21 Walmart phasing out automated pickup towers, WSJ reports 04/13/21 Walmart compliance chief leaving company, WSJ reports 04/13/21 Walmart chief ethics and compliance officer leaving company, WSJ says 04/09/21 McDonald's closing 'hundreds' of restaurants inside Walmart, WSJ reports CASY WMT CASY Casey's General Stores $221.47 / -0.15 (-0.07%) 04/07/21 Fox Corp., L Brands upgrades among today's top calls on Wall Street 12/07/20 Fly Intel: After-Hours Movers WMT Walmart $139.59 / -0.08 (-0.06%) 04/19/21 Charged: Walmart invests in GM-backed self-driving company Cruise 04/19/21 Vizio rises as Wall Street analysts roll out bullish coverage 03/17/21 Street Fight: Analysts diverge on Plug following financial restatement news 03/10/21 Fly Intel: What to watch in Oracle's earnings report 06/02/21 Wal-Mart Stores, Inc. WMT WMT Walmart $139.59 / -0.08 (-0.06%) 04/20/21 Wal-Mart call volume above normal and directionally bullish 04/06/21 Wal-Mart call volume above normal and directionally bullish 04/05/21 Unusually active option classes on open April 5th 03/29/21 Unusually active option classes on open March 29th

Recommendations	Kirkland Lake Gold price target raised to C$52 from C$51 at National Bank » 10:47 04/23/21 04/23 10:47 04/23/21 10:47 KL Kirkland Lake Gold $38.32 / -0.255 (-0.66%) National Bank analyst… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Events Options KL Kirkland Lake Gold $38.32 / -0.255 (-0.66%) 04/09/21 Kirkland Lake Gold reports Q1 production of 302,847 ounces 03/01/21 Kirkland Lake Gold names Natasha Vaz as COO 01/12/21 Kirkland Lake Gold says Q4 production totalted 369,434 ounces, up 32% y/y 12/16/20 Kirkland Lake Gold raises quarterly dividend 50% to 18.75c per share KL Kirkland Lake Gold $38.32 / -0.255 (-0.66%) 04/16/21 TD Securities Kirkland Lake Gold upgraded to Action List Buy from Buy at TD Securities 04/06/21 Scotiabank Kirkland Lake Gold price target lowered to C$61 from C$68 at Scotiabank 04/01/21 TD Securities Kirkland Lake Gold price target raised to C$77 from C$75 at TD Securities 03/17/21 National Bank Kirkland Lake downgraded to Sector Perform from Outperform at National Bank KL Kirkland Lake Gold $38.32 / -0.255 (-0.66%) 11/05/20 Kirkland Lake Gold reports Q3 EPS 91c vs. 80c year-over-year 05/06/21 Kirkland Lake Gold - KL KL Kirkland Lake Gold $38.32 / -0.255 (-0.66%) 11/24/20 Kirkland Lake Gold call volume above normal and directionally bullish
Hot Stocks	Liberty TripAdvisor Holdings trading resumes 10:46 04/23/21 04/23 10:46 04/23/21 10:46
Recommendations	Kinross Gold price target raised to C$14 from C$13.75 at National Bank » 10:46 04/23/21 04/23 10:46 04/23/21 10:46 KGC Kinross Gold $7.44 / -0.1 (-1.33%) National Bank analyst… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Events Options KGC Kinross Gold $7.44 / -0.1 (-1.33%) 02/10/21 Kinross Gold sees FY21 CapEx $900M, plus or minus 5% 02/10/21 Kinross Gold sees FY21 gold equivalent production 2.4M ounces 01/05/21 Gold Standard Ventures announces senior leadership changes KGC Kinross Gold $7.44 / -0.1 (-1.33%) 02/11/21 Barclays Kinross Gold price target raised to $10 from $9 at Barclays 02/10/21 JPMorgan Kinross initiated with Overweight, added to Focus List at JPMorgan 02/08/21 Stifel Kinross Gold price target lowered to C$14.50 from C$14.75 at Stifel 01/11/21 National Bank Kinross Gold price target lowered to C$17.25 from C$18 at National Bank KGC Kinross Gold $7.44 / -0.1 (-1.33%) 02/10/21 Kinross Gold reports Q4 adjusted EPS 27c, consensus 22c 11/04/20 Kinross Gold reports Q3 EPS ,25c consensus 21c 05/12/21 Kinross Gold - KGC KGC Kinross Gold $7.44 / -0.1 (-1.33%) 04/15/21 Kinross Gold call volume above normal and directionally bullish 04/12/21 Kinross Gold call volume above normal and directionally bullish 04/09/21 Kinross Gold call volume above normal and directionally bullish 02/19/21 Kinross Gold put volume heavy and directionally bearish
Recommendations	Agnico Eagle price target lowered to C$97 from C$98 at National Bank » 10:45 04/23/21 04/23 10:45 04/23/21 10:45 AEM Agnico Eagle $65.86 / -0.27 (-0.41%) National Bank analyst… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return in 9 minutes Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Events Options AEM Agnico Eagle $65.86 / -0.27 (-0.41%) 02/16/21 Osisko Gold receives approval for Canadian Malartic Underground construction 02/11/21 Agnico Eagle sees 2021 gold production of 2.05M oz 01/20/21 TMAC receives final court approval for acquisition by Agnico Eagle 01/05/21 Agnico Eagle to acquire TMAC Resources for C$2.20 per share AEM Agnico Eagle $65.86 / -0.27 (-0.41%) 02/23/21 Canaccord Agnico Eagle price target lowered to C$110 from C$115 at Canaccord 02/23/21 Canaccord Agnico Eagle selloff overdone, says Canaccord 02/10/21 JPMorgan Agnico Eagle initiated with a Neutral at JPMorgan 02/02/21 National Bank Agnico Eagle price target lowered to C$109 from C$112 at National Bank AEM Agnico Eagle $65.86 / -0.27 (-0.41%) 02/11/21 Agnico Eagle reports Q4 adjusted EPS 67c, consensus 65c 10/28/20 Agnico Eagle reports Q3 adjusted EPS 78c, consensus 67c 04/30/21 Agnico Eagle - AEM AEM Agnico Eagle $65.86 / -0.27 (-0.41%) 12/16/20 Largest borrow rate increases among liquid names 11/23/20 Largest borrow rate increases among liquid names 11/13/20 Largest borrow rate increases among liquid names
Syndicate	Agiliti indicated to open at $15-$16, IPO priced at $14 » 10:45 04/23/21 04/23 10:45 04/23/21 10:45 AGTI Agiliti $10.51 / + (+0.00%) Agiliti (AGTI) priced… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Syndicate AGTI Agiliti $10.51 / + (+0.00%) 10:44 Today Agiliti indicated to open at $15-$16, IPO priced at $14 23 Apr

Events

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CSTR
Today at 12:00

CapStar Financial - CSTR Conference Calls
IONS
Today at 12:00

Ionis Pharmaceuticals - IONS Conference Calls
MOFG
Today at 12:00

MidWestOne - MOFG Conference Calls
MYFW
Today at 12:00

First Western Financial - MYFW Conference Calls
SBSI
Today at 12:00

Southside Bancshares - SBSI Conference Calls
BMY
Today at 12:00

Biotechnology Industry Meetings
WSFS
Today at 13:00

WSFS Financial - WSFS Conference Calls
FHB
Today at 13:00

First Hawaiian - FHB Conference Calls
CIVB
Today at 13:00

Civista Bancshares - CIVB Conference Calls
ACBI
Today at 13:00

Atlantic Capital - ACBI Conference Calls

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Syndicate

This week’s upcoming IPOs and secondary offerings

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Mon	CHWY X CHWY Chewy Block Trade Managers: Morgan Stanley Priced at: $82.50 6.1M Shares IFBD X IFBD Infobird IPO Managers: WestPark Capital Priced at: $4.00 6.25M Shares
Tues	DV X DV DoubleVerify IPO Managers: Goldman Sachs & JPMorgan, Barclays, RBC Capital, Truist, William Blair, KeyBanc, Canaccord, JMP Securities, Needham, Loop Capital, Capital One Priced at: $27.00 13.3M Shares Special Comments Ratings Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial PATH X PATH UiPath IPO Managers: Morgan Stanley & JPMorgan, BofA, Credit Suisse, Barclays, Wells Fargo, SMBC Nikko, BMO Capital, MIZU, KeyBanc, TD Securities, Truist, Cowen, Evercore ISI, Macquarie, Nomura, RBC Capital, Canaccord, DA Davidson, Oppenheimer, Needham Priced at: $56.00 23.89M Shares Special Comments Ratings Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial SKYT X SKYT SkyWater Technology IPO Managers: Jefferies & Cowen, Piper Sandler Priced at: $14.00 6.96M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial TRKA X TRKA Troika Media IPO Managers: Kingswood Priced at: $4.15 5.78M Shares FUTU X FUTU Futu Holdings Secondary Managers: BofA & Haitong Priced at: $130.00 9.5M Shares ZLAB X ZLAB Zai Lab Secondary Managers: JPMorgan, Goldman Sachs, Jefferies, Citi, SVB Leerink & Guggenheim Priced at: $150.00 4.78M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial NOTV X NOTV Inotiv Spot Secondary Managers: Colliers Priced at: $17.00 2.647M Shares
Wed	KNBE X KNBE KnowBe4 IPO Managers: Morgan Stanley, Goldman Sachs, BofA & KKR Priced at: $16.00 9.5M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial NPCE X NPCE NeuroPace IPO Managers: JPMorgan & Morgan Stanley, Wells Fargo, SVB Leerink Priced at: $17.00 6M Shares Special Comments Ratings Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial ZY X ZY Zymergen IPO Managers: JPMorgan & Goldman Sachs, BofA, UBS, LAZA Priced at: $31.00 16.13M Shares Special Comments Ratings Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial EOLS X EOLS Evolus Spot Secondary Managers: SVB Leerink, Stifel & Cantor Fitzgerald Priced at: $9.50 9M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial NBSE X NBSE NeuBase Therapeutics Spot Secondary Managers: RBC Capital, Oppenheimer & Chardan, National Securities Priced at: $5.00 8M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial
Thurs	AGTI X AGTI Agiliti IPO Managers: BofA, Goldman Sachs, Morgan Stanley & BMO Capital, Citi, JEFF< UBSW, KeyBanc, Raymond James, MUFG, SMBC Nikko, MISC, SIEB Priced at: $14.00 26.316M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial IMPL X IMPL Impel NeuroPharma IPO Managers: Cowen & Guggenheim, Wedbush Priced at: $15.00 5.33M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial RAIN X RAIN Rain Therapeutics IPO Managers: Goldman Sachs, Citi, Piper Sandler & Guggenheim Priced at: $17.00 7.353M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial SWIM X SWIM Latham Group IPO Managers: Barclays, BofA, Morgan Stanley & Goldman Sachs, Nomura, William Blair, Baird, KeyBanc, Truist Priced at: $19.00 20M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial TMCI X TMCI Treace Medical IPO Managers: JPMorgan & Morgan Stanley, SVB Leerink, Stifel Priced at: $17.00 11.25M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial EDAP X EDAP EDAP TMS Spot Secondary Managers: Piper Sandler Priced at: $6.75 4.15M Shares Special Comments Some content is locked. Log in above or sign up for a free trial to see this information. Get Free Trial
Fri	No deals

Mon	No deals
Tues	No deals
Wed	No deals
Thurs	No deals
Fri	No deals

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Epizyme reports preliminary data from Phase 1b/3 study of EZH-302

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