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MCRB

Seres Therapeutics

$19.06 /

+1.05 (+5.83%)

07:06
03/08/21
03/08
07:06
03/08/21
07:06

Seres discontinues enrollment in SER-401 study in metastatic melanoma

Seres Therapeutics announced that the Company, in collaboration with study partners, The Parker Institute for Cancer Immunotherapy, PICI, and The University of Texas MD Anderson Cancer Center, has voluntarily discontinued further enrollment in the Melanoma Checkpoint and Gut Microbiome Alteration With Microbiome Intervention study evaluating the safety and drug activity of SER-401 or fecal microbiota transplant in combination with nivolumab in patients with metastatic melanoma. "While we are disappointed to discontinue enrollment, we are encouraged by the opportunity to apply the learnings from this study towards future development programs at Seres that can directly benefit the oncology community in search of new treatment options," said Matthew Henn, Ph.D., Chief Scientific Officer at Seres. "We want to thank the patients, their care partners, our collaborators and the medical professionals who participated in this study, despite the COVID-19 pandemic, and helped further advance our understanding of the role microbiome therapeutics play in the treatment of cancer." A preliminary analysis of results from 10 subjects who received either SER-401 or placebo in combination with nivolumab indicated that SER-401 was safe and well-tolerated. There were no patients enrolled in the FMT portion of the study. Subjects currently enrolled in the study will complete the study protocol. Given challenges in enrollment due to the COVID-19 pandemic, subsequent anticipated time to study completion, and progress in its preclinical oncology pipeline, Seres has decided to deprioritize further development of SER-401. The Company will continue to advance its research and development efforts in cancer, applying learnings from the SER-401 trial. Evidence continues to emerge that suggests gut microbiome modulation may augment responses to cancer immunotherapy, including improving responses in PD-1 refractory patients1. Seres and its collaborators continue to be excited about the opportunity to develop next-generation therapeutics targeting gut microbes for the treatment of individuals living with cancer. Seres will continue to engage with MD Anderson and PICI to advance the development of medicines in this field, and maintains a robust preclinical program in oncology as well as a collaboration with Memorial Sloan Kettering Cancer Center centered on advancing microbiome therapeutics in various settings of oncology. Seres' immuno-oncology patent portfolio includes the option to exclusively license foundational intellectual property from MD Anderson, based upon the work of Jennifer Wargo, M.D., professor of Surgical Oncology and Genomic Medicine.

  • 16

    Mar

  • 13

    Aug

MCRB Seres Therapeutics
$19.06 /

+1.05 (+5.83%)

03/05/21 Chardan
Seres Therapeutics upgraded to Buy from Neutral at Chardan
01/12/21 Piper Sandler
Additional Seres '109 analysis strengthens BLA filing, says Piper Sandler
12/23/20 JMP Securities
Seres Therapeutics initiated with a Market Perform at JMP Securities
11/09/20 Oppenheimer
Seres Therapeutics price target raised to $38 from $34 at Oppenheimer

TODAY'S FREE FLY STORIES

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GreenBox announced the…

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GBOX GreenBox
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Earnings
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GATX

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-0.08 (-0.08%)

CEO Brian Kenney…

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GATX GATX
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GATX upgraded to Overweight as overcapacity looks set to end at Stephens
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CACI awarded $376M contract by National Geospatial-Intelligence Agency » 08:33
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+1.84 (+0.71%)

CACI International…

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CACI CACI
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Hot Stocks
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Comments taken from Q3…

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Earnings
GATX reports Q1 EPS $1.02, consensus 85c » 08:33
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08:33
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08:33
GATX

GATX

$95.92 /

-0.08 (-0.08%)

Reports Q1 revenue…

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GATX GATX
$95.92 /

-0.08 (-0.08%)

GATX GATX
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-0.08 (-0.08%)

03/29/21 Wells Fargo
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$95.92 /

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Earnings
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BMI

Badger Meter

$96.37 /

+0.64 (+0.67%)

Reports Q1 revenue…

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BMI Badger Meter
$96.37 /

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BMI Badger Meter
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Hot Stocks
Kandi Technologies completes Jinhua manufacturing exit inspection » 08:33
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KNDI

Kandi Technologies

$5.52 /

-0.09 (-1.60%)

Kandi Technologies…

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KNDI Kandi Technologies
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Recommendations
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SAM

Boston Beer

$1,288.37 /

-7.385 (-0.57%)

Evercore ISI analyst Eric…

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SAM Boston Beer
$1,288.37 /

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04/14/21 Deutsche Bank
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SAM Boston Beer
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Earnings
Better Choice Company reports Q1 preliminary gross sales $13.4M » 08:30
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08:30
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BTTR

Better Choice Company

$1.25 /

-0.05 (-3.85%)

Relative to Gross Sales…

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BTTR Better Choice Company
$1.25 /

-0.05 (-3.85%)

BTTR Better Choice Company
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Downgrade
PPD downgraded to Hold from Buy at Jefferies » 08:30
04/20/21
04/20
08:30
04/20/21
08:30
PPD

PPD

$46.20 /

-0.1 (-0.22%)

Jefferies analyst David…

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PPD PPD
$46.20 /

-0.1 (-0.22%)

PPD PPD
$46.20 /

-0.1 (-0.22%)

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PPD PPD
$46.20 /

-0.1 (-0.22%)

  • 17
    Sep
PPD PPD
$46.20 /

-0.1 (-0.22%)

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$46.20 /

-0.1 (-0.22%)

General news
FX Action: USD-CAD » 08:30
04/20/21
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08:30
04/20/21
08:30
$ECON

Economic Data

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+

FX Action: USD-CAD…

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    Options
    Four new option listings and one option delisting on April 20th » 08:30
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    , WBAI

    500.com

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    ACAC Acies Acquisition
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    WBAI 500.com
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    • 14
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    GBOX GreenBox
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    WBAI 500.com
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    WBAI 500.com
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    Hot Stocks
    Microchip announces maXTouch MXT2912TD-UW touchscreen controller » 08:29
    04/20/21
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    MCHP

    Microchip

    $153.93 /

    -4.44 (-2.80%)

    Microchip Technology…

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    MCHP Microchip
    $153.93 /

    -4.44 (-2.80%)

    MCHP Microchip
    $153.93 /

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    04/08/21 Morgan Stanley
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    Microchip price target raised to $180 from $135 at JPMorgan
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    MCHP Microchip
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    MCHP Microchip
    $153.93 /

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    Conference/Events
    Apple to hold a special event » 08:28
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    08:28
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    AAPL

    Apple

    $134.86 /

    +0.74 (+0.55%)

    Management is holding an…

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    AAPL Apple
    $134.86 /

    +0.74 (+0.55%)

    AAPL Apple
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    04/19/21 Needham
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    Wedbush expecting new Apple iPad launches 'with a few surprises' this week
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    Facebook assumed with Neutral at Wedbush, cites privacy risk
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    +0.74 (+0.55%)

    AAPL Apple
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    AAPL Apple
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    AAPL Apple
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    Hot Stocks
    Super League Gaming, Mobcrush to share new offering at Esports Newfront » 08:27
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    SLGG

    Super League Gaming

    $5.50 /

    -0.1 (-1.79%)

    Super League is thrilled…

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    SLGG Super League Gaming
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    SLGG Super League Gaming
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    • 27
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    Recommendations
    Leslie's price target raised to $28 from $26 at Loop Capital » 08:27
    04/20/21
    04/20
    08:27
    04/20/21
    08:27
    LESL

    Leslie's

    /

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    Loop Capital analyst…

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    LESL Leslie's
    /

    +

    LESL Leslie's
    /

    +

    02/10/21 Berenberg
    Leslie's initiated with a Hold at Berenberg
    02/05/21 Jefferies
    Leslie's price target raised to $37 from $33 at Jefferies
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    Fly Intel: Top five analyst downgrades
    LESL Leslie's
    /

    +

    • 11
      Feb
    • 29
      Oct
    LESL Leslie's
    /

    +

    LESL Leslie's
    /

    +

    Recommendations
    Barrington cuts Haemonetics target to $91 after customer loss 'shocker' » 08:27
    04/20/21
    04/20
    08:27
    04/20/21
    08:27
    HAE

    Haemonetics

    $74.78 /

    -42.27 (-36.11%)

    Barrington analyst…

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    HAE Haemonetics
    $74.78 /

    -42.27 (-36.11%)

    HAE Haemonetics
    $74.78 /

    -42.27 (-36.11%)

    04/19/21 CJS Securities
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    Haemonetics price target raised to $140 from $110 at JMP Securities
    HAE Haemonetics
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    -42.27 (-36.11%)

    HAE Haemonetics
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    -42.27 (-36.11%)

    Hot Stocks
    evTS announces agreement with Blink Charging to distribute portable EV charger » 08:27
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    BLNK

    Blink Charging

    $33.75 /

    -2.715 (-7.45%)

    ev Transportation…

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    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    03/08/21 Cowen
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    BLNK Blink Charging
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    -2.715 (-7.45%)

    • 08
      Jan
    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    BLNK Blink Charging
    $33.75 /

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    BLNK Blink Charging
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    -2.715 (-7.45%)

    Recommendations
    Pool Corp. price target raised to $405 from $390 at Loop Capital » 08:26
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    04/20
    08:26
    04/20/21
    08:26
    POOL

    Pool Corp.

    $382.80 /

    +0.38 (+0.10%)

    Loop Capital analyst…

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    POOL Pool Corp.
    $382.80 /

    +0.38 (+0.10%)

    POOL Pool Corp.
    $382.80 /

    +0.38 (+0.10%)

    02/10/21 Berenberg
    Leslie's initiated with a Hold at Berenberg
    01/15/21 Jefferies
    Pool Corp. price target raised to $400 from $350 at Jefferies
    12/31/20 William Blair
    Azek, Trex among Blair's top Specialty Distribution ideas for 2021
    11/11/20 Stephens
    Pool Corp. resumed with an Equal Weight at Stephens
    POOL Pool Corp.
    $382.80 /

    +0.38 (+0.10%)

    POOL Pool Corp.
    $382.80 /

    +0.38 (+0.10%)

    POOL Pool Corp.
    $382.80 /

    +0.38 (+0.10%)

    Hot Stocks
    Zscaler announces enhancements for Zscaler Zero Trust Exchange » 08:26
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    04/20
    08:26
    04/20/21
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    ZS

    Zscaler

    $190.86 /

    -1.62 (-0.84%)

    Zscaler announced…

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    ZS Zscaler
    $190.86 /

    -1.62 (-0.84%)

    ZS Zscaler
    $190.86 /

    -1.62 (-0.84%)

    04/16/21 Canaccord
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    Zscaler initiated with a Buy at Mizuho
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    Truist upgrades Zscaler to Buy, sees 'large deals' driving upside
    ZS Zscaler
    $190.86 /

    -1.62 (-0.84%)

    ZS Zscaler
    $190.86 /

    -1.62 (-0.84%)

    ZS Zscaler
    $190.86 /

    -1.62 (-0.84%)

    Hot Stocks
    Blink Charging announces distribution agreement with EV Transportation Services » 08:25
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    04/20
    08:25
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    08:25
    BLNK

    Blink Charging

    $33.75 /

    -2.715 (-7.45%)

    Blink Charging announced…

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    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    03/08/21 Cowen
    Blink Charging initiated with an Outperform at Cowen
    02/05/21 Roth Capital
    Blink Charging initiated with a Buy at Roth Capital
    08/14/20
    Fly Intel: Top five analyst downgrades
    08/14/20 H.C. Wainwright
    Blink Charging downgraded to Neutral from Buy at H.C. Wainwright
    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    • 08
      Jan
    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    BLNK Blink Charging
    $33.75 /

    -2.715 (-7.45%)

    Upgrade
    Seek Limited upgraded to Hold from Underperform at Jefferies » 08:25
    04/20/21
    04/20
    08:25
    04/20/21
    08:25
    SKLTY

    Seek Limited

    $48.41 /

    + (+0.00%)

    Jefferies analyst Roger…

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    SKLTY Seek Limited
    $48.41 /

    + (+0.00%)

    02/23/21 Jefferies
    Seek Limited downgraded to Underperform from Hold at Jefferies
    Technical Analysis
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