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ALNA

Allena Pharmaceuticals

$1.22 /

+0.04 (+3.39%)

08:20
07/12/21
07/12
08:20
07/12/21
08:20

Allena on track to start two Phase 2a studies of ALLN-346 in Q3

Allena Pharmaceuticals provided progress updates on its clinical programs: ALLN-346, a first-in-class, oral urate degrading enzyme in development for the treatment of patients with hyperuricemia and gout in the setting of chronic kidney disease and reloxaliase, a first-in-class, oral oxalate degrading enzyme in development for the treatment of patients with enteric hyperoxaluria. ALLN-346 is an investigational first-in-class, non-absorbed, orally administered enzyme for the treatment of hyperuricemia and gout, a metabolic disorder characterized by high systemic levels of uric acid that can lead to several complications, including arthritis, kidney stones, and chronic kidney disease. The Company recently completed a Phase 1b multiple ascending dose study of ALLN-346. The study included 18 healthy volunteers, who received either ALLN-346 or placebo for seven days. There were two cohorts consisting of nine subjects each, with the first receiving three capsules of ALLN-346 three times daily, and the second receiving five capsules of ALLN-346 three times daily. ALLN-346 was well tolerated with no evidence of systemic absorption, as confirmed by an enzyme-linked immunosorbent assay. Evaluation of clinical and laboratory parameters revealed no significant safety signals and no serious adverse events were reported. As previously reported, the Company is preparing to initiate two randomized, double-blind, placebo-controlled Phase 2a studies to obtain initial bioactivity data and additional safety data for ALLN-346 in patients with hyperuricemia and gout during the third quarter of 2021. Initial results from the Phase 2a program are expected during the fourth quarter of 2021. An inpatient study is planned to initially enroll 12 patients with hyperuricemia randomized to receive either five capsules of ALLN-346 or matching placebo three times daily during a one-week treatment period. Key bioactivity endpoints will include serum uric acid level, 24-hour urine uric acid level, and renal clearance of uric acid. Following evaluation of the data from the initial 12 patients, the Company will make a determination regarding potentially extending the study to include up to an additional 12 patients, either to obtain additional data at the five-capsule, three-times-daily dose, or to evaluate a different dose. An outpatient study is planned to enroll 24 hyperuricemic patients with gout and mild-to-moderate chronic kidney disease randomized to receive either five capsules of ALLN-346 or matching placebo, three times daily, during a two-week treatment period. Two cohorts of 12 patients each are planned, with the first cohort consisting of patients with an eGFR (estimated glomerular filtration rate, a measure of renal function) of 60-89 mls/minute, and the second consisting of patients with an eGFR of 30-59 mls/minute. Key bioactivity endpoints will include serum uric acid level, 24-hour urine uric acid level, and renal clearance of uric acid. The limitations of existing gout treatments were highlighted in the Company's recent KOL Webinar. Specifically, managing gout in the setting of advanced chronic kidney disease remains a significant challenge for clinicians because currently available agents are either dose-limited or contraindicated in these patients. There are approximately 500,000 patients with gout and advanced chronic kidney disease in the United States.

  • 02

    Dec

ALNA Allena Pharmaceuticals
$1.22 /

+0.04 (+3.39%)

10/01/20 B. Riley
Allena Pharmaceuticals price target raised to $5 from $4 at B. Riley Securities

TODAY'S FREE FLY STORIES

Conference/Events
Intra-Cellular to hold a virtual investor event » 12:25
10/20/21
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12:25
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12:25
ITCI

Intra-Cellular

$41.83 /

-0.02 (-0.05%)

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ITCI Intra-Cellular
$41.83 /

-0.02 (-0.05%)

ITCI Intra-Cellular
$41.83 /

-0.02 (-0.05%)

10/19/21 RBC Capital
Intra-Cellular price target raised to $48 from $44 at RBC Capital
09/22/21 Needham
Intra-Cellular initiated with a Buy at Needham
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Intra-Cellular price target raised to $70 from $55 at Jefferies
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ITCI Intra-Cellular
$41.83 /

-0.02 (-0.05%)

Options
Million dollar call buyer in FarFetch November upside » 12:20
10/20/21
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FTCH

Farfetch

$39.84 /

-0.19 (-0.47%)

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FTCH Farfetch
$39.84 /

-0.19 (-0.47%)

FTCH Farfetch
$39.84 /

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FTCH Farfetch
$39.84 /

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Technical Analysis
NASDAQ market internals summary » 12:17
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Einhorn declines comment when asked if still short Tesla » 12:14
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Hot Stocks
Green Brick jumps 9% to $23.60 as Chairman Einhorn discusses on CNBC  12:09
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Hot Stocks
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+3.07 (+1.00%)

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MLAB Mesa Labs
$311.55 /

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Hot Stocks
Einhorn says Green Brick Partners has 'huge' backlog level » 12:08
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$22.32 /

+0.71 (+3.29%)

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$22.32 /

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Hot Stocks
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Evoqua Water

$39.30 /

+0.055 (+0.14%)

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AQUA Evoqua Water
$39.30 /

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  • 09
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AQUA Evoqua Water
$39.30 /

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Hot Stocks
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GRBK

Green Brick

$22.27 /

+0.66 (+3.05%)

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$22.27 /

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  • 26
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Hot Stocks
Waters, University of Delaware announce bioprocessing innovation partnership » 12:06
10/20/21
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12:06
WAT

Waters

$354.33 /

+5.34 (+1.53%)

Waters Corporation and…

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WAT Waters
$354.33 /

+5.34 (+1.53%)

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$354.33 /

+5.34 (+1.53%)

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$354.33 /

+5.34 (+1.53%)

Options
Intel call volume above normal and directionally bullish » 12:05
10/20/21
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INTC

Intel

$55.25 /

+0.04 (+0.07%)

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INTC Intel
$55.25 /

+0.04 (+0.07%)

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$55.25 /

+0.04 (+0.07%)

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Hot Stocks
MSG Entertainment, MSG Entertainment renew marketing partnership with JPMorgan » 12:04
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, JPM

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Madison Square Garden…

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Hot Stocks
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GWH

ESS Inc.

$15.86 /

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$15.86 /

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Hot Stocks
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DNA

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$13.36 /

-1.44 (-9.73%)

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$13.36 /

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Hot Stocks
Peabody Energy falls -10.1% » 12:01
10/20/21
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12:01
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BTU

Peabody Energy

$14.29 /

-1.605 (-10.10%)

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$14.29 /

-1.605 (-10.10%)

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$14.29 /

-1.605 (-10.10%)

10/19/21 B. Riley
Peabody Energy price target raised to $23 from $22 at B. Riley
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$14.29 /

-1.605 (-10.10%)

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$14.29 /

-1.605 (-10.10%)

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$14.29 /

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Hot Stocks
Pinterest rises 12.0% » 12:00
10/20/21
10/20
12:00
10/20/21
12:00
PINS

Pinterest

$62.73 /

+7.135 (+12.83%)

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$62.73 /

+7.135 (+12.83%)

PINS Pinterest
$62.73 /

+7.135 (+12.83%)

10/18/21 Wedbush
Wedbush continues to favor Google, Snap headed into quarterly results
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Pinterest outlook remains positive, says OTR Global
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PINS Pinterest
$62.73 /

+7.135 (+12.83%)

PINS Pinterest
$62.73 /

+7.135 (+12.83%)

PINS Pinterest
$62.73 /

+7.135 (+12.83%)

PINS Pinterest
$62.73 /

+7.135 (+12.83%)

Hot Stocks
Clearwater Paper rises 12.6% » 12:00
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12:00
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CLW

Clearwater Paper

$40.92 /

+4.42 (+12.11%)

Clearwater Paper is up…

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CLW Clearwater Paper
$40.92 /

+4.42 (+12.11%)

CLW Clearwater Paper
$40.92 /

+4.42 (+12.11%)

05:51 Today RBC Capital
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Clearwater Paper price target lowered to $33 from $41 at RBC Capital
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$40.92 /

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Hot Stocks
Permian Basin Royalty Trust rises 19.7% » 12:00
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10/20
12:00
10/20/21
12:00
PBT

Permian Basin Royalty Trust

$8.57 /

+1.41 (+19.69%)

Permian Basin Royalty…

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Hot Stocks
Sony says 'God of War' coming to PC in January » 11:57
10/20/21
10/20
11:57
10/20/21
11:57
SONY

Sony

$112.95 /

+0.45 (+0.40%)

, TCEHY

Tencent

$65.57 /

+1.5 (+2.34%)

, KKR

KKR

$69.71 /

+1.32 (+1.93%)

, DIS

Disney

$170.21 /

-0.97 (-0.57%)

Sony (SONY) announced…

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SONY Sony
$112.95 /

+0.45 (+0.40%)

TCEHY Tencent
$65.57 /

+1.5 (+2.34%)

KKR KKR
$69.71 /

+1.32 (+1.93%)

DIS Disney
$170.21 /

-0.97 (-0.57%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

09/27/21 Cowen
Sony initiated with an Outperform at Cowen
09/10/21 Truist
Apple will likely appeal ruling in Epic case, says Truist
07/27/21 Morgan Stanley
Sony upgraded to Overweight at Morgan Stanley on animation business growth
07/27/21 Morgan Stanley
Sony upgraded to Overweight from Equal Weight at Morgan Stanley
TCEHY Tencent
$65.57 /

+1.5 (+2.34%)

10/11/21 Mizuho
Tencent price target lowered to HK$510 from HK$530 at Mizuho
09/24/21 Morgan Stanley
Sohu completion of Sogou deal positive in unlocking value, says Morgan Stanley
09/13/21 Loop Capital
Tencent downgraded to Hold from Buy at Loop Capital
09/10/21 Truist
Apple will likely appeal ruling in Epic case, says Truist
KKR KKR
$69.71 /

+1.32 (+1.93%)

10/14/21 BMO Capital
JPMorgan price target raised to $140 from $139 at BMO Capital
10/07/21 Jefferies
KKR resumed with a Buy at Jefferies
09/13/21 Citi
Citi ups KKR target to Street-high, opens 'Positive Catalyst Watch"
09/10/21 Truist
Apple will likely appeal ruling in Epic case, says Truist
DIS Disney
$170.21 /

-0.97 (-0.57%)

10/18/21
Fly Intel: Top five analyst downgrades
10/18/21 MoffettNathanson
Disney price target lowered to $180 from $185 at MoffettNathanson
10/18/21 Barclays
Barclays downgrades Disney on slowing of streaming growth
10/18/21 Barclays
Disney downgraded to Equal Weight from Overweight at Barclays
SONY Sony
$112.95 /

+0.45 (+0.40%)

KKR KKR
$69.71 /

+1.32 (+1.93%)

DIS Disney
$170.21 /

-0.97 (-0.57%)

  • 11
    Nov
SONY Sony
$112.95 /

+0.45 (+0.40%)

TCEHY Tencent
$65.57 /

+1.5 (+2.34%)

KKR KKR
$69.71 /

+1.32 (+1.93%)

DIS Disney
$170.21 /

-0.97 (-0.57%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

TCEHY Tencent
$65.57 /

+1.5 (+2.34%)

KKR KKR
$69.71 /

+1.32 (+1.93%)

DIS Disney
$170.21 /

-0.97 (-0.57%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

KKR KKR
$69.71 /

+1.32 (+1.93%)

DIS Disney
$170.21 /

-0.97 (-0.57%)

Hot Stocks
CD Projekt delays next-gen 'Cyberpunk,' 'Witcher 3' updates to 2022 » 11:55
10/20/21
10/20
11:55
10/20/21
11:55
OTGLY

CD Projekt

$12.49 /

+0.392 (+3.24%)

, MSFT

Microsoft

$307.23 /

-1.095 (-0.36%)

, SONY

Sony

$112.95 /

+0.45 (+0.40%)

CD Projekt Red (OTGLY)…

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ShowHide Related Items >><<
OTGLY CD Projekt
$12.49 /

+0.392 (+3.24%)

MSFT Microsoft
$307.23 /

-1.095 (-0.36%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

OTGLY CD Projekt
$12.49 /

+0.392 (+3.24%)

09/21/21 Berenberg
CD Projekt price target lowered to PLN 138 from PLN 140 at Berenberg
09/02/21 Barclays
CD Projekt price target lowered to PLN 145 from PLN 150 at Barclays
08/02/21 Goldman Sachs
CD Projekt downgraded to Sell from Neutral at Goldman Sachs
07/14/21 VTB Capital
CD Projekt downgraded to Hold from Buy at VTB Capital
MSFT Microsoft
$307.23 /

-1.095 (-0.36%)

08:17 Today Wedbush
Microsoft price target raised to $375 from $350 at Wedbush
05:01 Today Jefferies
Microsoft price target raised to $375 from $345 at Jefferies
10/18/21 Morgan Stanley
Morgan Stanley says Cloud, Hybrid solutions should power 'strong' Microsoft Q1
10/06/21 Morgan Stanley
CIO survey shows Microsoft 'further solidifying leadership,' says Morgan Stanley
SONY Sony
$112.95 /

+0.45 (+0.40%)

09/27/21 Cowen
Sony initiated with an Outperform at Cowen
09/10/21 Truist
Apple will likely appeal ruling in Epic case, says Truist
07/27/21 Morgan Stanley
Sony upgraded to Overweight at Morgan Stanley on animation business growth
07/27/21 Morgan Stanley
Sony upgraded to Overweight from Equal Weight at Morgan Stanley
MSFT Microsoft
$307.23 /

-1.095 (-0.36%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

MSFT Microsoft
$307.23 /

-1.095 (-0.36%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

OTGLY CD Projekt
$12.49 /

+0.392 (+3.24%)

MSFT Microsoft
$307.23 /

-1.095 (-0.36%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

MSFT Microsoft
$307.23 /

-1.095 (-0.36%)

SONY Sony
$112.95 /

+0.45 (+0.40%)

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