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ALNY

Alnylam

$190.59 /

-7.19 (-3.64%)

16:05
10/27/21
10/27
16:05
10/27/21
16:05

Alnylam says vutrisiran met all secondary endpoints in HELIOS-A Phase 3 study

Alnylam Pharmaceuticals announced that the HELIOS-A Phase 3 study of vutrisiran, an investigational RNAi therapeutic in development for the treatment of the polyneuropathy associated with hereditary transthyretin-mediated (hATTR) amyloidosis, met all secondary endpoints measured at 18 months, including statistically significant improvements in neuropathy as measured by the modified Neuropathy Impairment Score (mNIS+7), quality of life (QOL), gait speed, nutritional status and overall disability, relative to external placebo data from the APOLLO Phase 3 study of patisiran. The final secondary endpoint, reduction in serum TTR levels with vutrisiran, demonstrated non-inferiority relative to the within-study patisiran arm, as expected. In addition, patients treated with vutrisiran showed improvements in exploratory endpoints, including the biomarker NT-proBNP and certain echocardiographic parameters, relative to placebo, and an improvement in technetium uptake relative to baseline in a majority of patients in a planned cohort, providing potential evidence for reduced cardiac amyloid burden. Vutrisiran continued to demonstrate an encouraging safety and tolerability profile. Alnylam previously announced that HELIOS-A met its primary and secondary endpoints at nine months and study results were presented at the 2021 American Academy of Neurology (AAN) Virtual Annual Meeting. "These results build on the positive vutrisiran data shared earlier this year and suggest that the reduction of neurologic impairment and improvement in quality of life in patients with hATTR amyloidosis with polyneuropathy observed as early as nine months are maintained at 18 months. We are also encouraged by the hypothesis-supporting, exploratory endpoints and cardiac amyloid imaging results," said Rena N. Denoncourt, Vice President, TTR Franchise Lead. "Vutrisiran is currently under review by multiple regulatory authorities around the world, bringing this low-dose, once-quarterly, subcutaneously administered investigational therapy with a highly-attractive profile one step closer to being a potentially available therapeutic option for patients living with this progressive, life-threatening, multi-system disease. We look forward to presenting full 18-month results of the HELIOS-A study at a medical conference in early 2022, and progressing our efforts to build an industry-leading franchise of medicines for the treatment of the polyneuropathy of hATTR amyloidosis and potentially additional indications for the future."

  • 28

    Oct

  • 14

    Apr

ALNY Alnylam
$190.59 /

-7.19 (-3.64%)

10/04/21 UBS
Alnylam upgraded to Buy from Neutral at UBS
09/29/21 Piper Sandler
Pipeline captured in Alnylam's valuation, says Piper Sandler
08/27/21 BMO Capital
Alnylam price target raised to $196 from $174 at BMO Capital
08/04/21 Barclays
Alnylam price target raised to $216 from $196 at Barclays

TODAY'S FREE FLY STORIES

Recommendations
Synthomer price target lowered to 435 GBp from 480 GBp at UBS » 13:04
12/08/21
12/08
13:04
12/08/21
13:04
SYYYF

Synthomer

$6.24 /

+ (+0.00%)

UBS analyst Geoff Haire…

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SYYYF Synthomer
$6.24 /

+ (+0.00%)

12/06/21 Morgan Stanley
Synthomer downgraded to Underweight from Overweight at Morgan Stanley
Options
GameStop options imply 11.4% move in share price post-earnings » 13:04
12/08/21
12/08
13:04
12/08/21
13:04
GME

GameStop

$177.44 /

-0.24 (-0.14%)

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GME GameStop
$177.44 /

-0.24 (-0.14%)

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$177.44 /

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GME GameStop
$177.44 /

-0.24 (-0.14%)

GME GameStop
$177.44 /

-0.24 (-0.14%)

GME GameStop
$177.44 /

-0.24 (-0.14%)

GME GameStop
$177.44 /

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Recommendations
Fuchs Petrolub price target lowered to EUR 41 from EUR 42 at UBS » 13:02
12/08/21
12/08
13:02
12/08/21
13:02
FUPBY

Fuchs Petrolub

$11.52 /

+0.235 (+2.08%)

UBS analyst Eleanor…

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FUPBY Fuchs Petrolub
$11.52 /

+0.235 (+2.08%)

10/13/21 UBS
Fuchs Petrolub upgraded to Neutral from Sell at UBS
08/18/21 Stifel
Fuchs Petrolub upgraded to Buy from Hold at Stifel
07/14/21 UBS
Fuchs Petrolub price target lowered to EUR 39 from EUR 41 at UBS
06/30/21 Kepler Cheuvreux
Fuchs Petrolub downgraded to Hold from Buy at Kepler Cheuvreux
Recommendations
Covestro price target lowered to EUR 53 from EUR 61 at UBS » 13:02
12/08/21
12/08
13:02
12/08/21
13:02
COVTY

Covestro

$29.45 /

+0.56 (+1.94%)

UBS analyst Geoff Haire…

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COVTY Covestro
$29.45 /

+0.56 (+1.94%)

12/07/21 JPMorgan
Covestro upgraded to Neutral from Underweight at JPMorgan
11/18/21 HSBC
Covestro upgraded to Buy from Hold at HSBC
10/19/21 Societe Generale
Covestro price target lowered to EUR 56 from EUR 74 at Societe Generale
10/18/21 Societe Generale
Covestro downgraded to Hold from Buy at Societe Generale
Recommendations
Arkema price target lowered to EUR 120 from EUR 123 at UBS » 13:01
12/08/21
12/08
13:01
12/08/21
13:01
ARKAY

Arkema

$138.32 /

-0.976 (-0.70%)

UBS analyst Geoff Haire…

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ARKAY Arkema
$138.32 /

-0.976 (-0.70%)

ARKAY Arkema
$138.32 /

-0.976 (-0.70%)

12/07/21 JPMorgan
Arkema downgraded to Neutral from Overweight at JPMorgan
11/11/21 JPMorgan
Arkema price target raised to EUR 134 from EUR 130 at JPMorgan
11/11/21 Deutsche Bank
Arkema price target raised to EUR 145 from EUR 140 at Deutsche Bank
10/14/21 Morgan Stanley
Arkema price target raised to EUR 122 from EUR 120 at Morgan Stanley
Hot Stocks
Comtech awarded $2M satellite ground station equipment order from Intellian » 13:00
12/08/21
12/08
13:00
12/08/21
13:00
CMTL

Comtech

$25.57 /

+0.43 (+1.71%)

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CMTL Comtech
$25.57 /

+0.43 (+1.71%)

CMTL Comtech
$25.57 /

+0.43 (+1.71%)

10/05/21 Noble Capital
Comtech downgraded to Market Perform from Outperform at Noble Capital
10/05/21 Citi
Comtech price target raised to $26 from $24 at Citi
06/09/21 Northland
Comtech price target lowered to $28 from $31 at Northland
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Comtech price target lowered to $26 from $29 at Citi
CMTL Comtech
$25.57 /

+0.43 (+1.71%)

CMTL Comtech
$25.57 /

+0.43 (+1.71%)

CMTL Comtech
$25.57 /

+0.43 (+1.71%)

Recommendations
Yara price target raised to NOK 440 from NOK 420 at UBS » 13:00
12/08/21
12/08
13:00
12/08/21
13:00
YARIY

Yara

$25.30 /

+1.03 (+4.24%)

UBS analyst Andrew Stott…

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YARIY Yara
$25.30 /

+1.03 (+4.24%)

12/07/21 JPMorgan
Yara price target raised to NOK 500 from NOK 400 at JPMorgan
12/06/21 Morgan Stanley
Yara price target raised to NOK 470 from NOK 455 at Morgan Stanley
11/05/21 Deutsche Bank
Yara price target raised to NOK 500 from NOK 480 at Deutsche Bank
10/22/21 Berenberg
Yara price target raised to NOK 495 from NOK 480 at Berenberg
Recommendations
Valeo price target raised to EUR 38 from EUR 36 at UBS » 12:59
12/08/21
12/08
12:59
12/08/21
12:59
VLEEY

Valeo

$15.49 /

+0.21 (+1.37%)

UBS analyst David Lesne…

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VLEEY Valeo
$15.49 /

+0.21 (+1.37%)

12/02/21 Barclays
Valeo upgraded to Overweight from Equal Weight at Barclays
10/21/21 Barclays
Valeo price target lowered to EUR 25 from EUR 28 at Barclays
10/08/21 UBS
Valeo price target lowered to EUR 36 from EUR 40 at UBS
10/07/21 Citi
Valeo upgraded to Neutral from Sell at Citi
Conference/Events
American Public Education management to meet virtually with B. Riley » 12:58
12/08/21
12/08
12:58
12/08/21
12:58
APEI

American Public Education

$22.34 /

+0.34 (+1.55%)

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APEI American Public Education
$22.34 /

+0.34 (+1.55%)

APEI American Public Education
$22.34 /

+0.34 (+1.55%)

06/14/21 Truist
American Public Education price target lowered to $38 from $43 at Truist
04/06/21 Truist
American Public Education initiated with a Buy at Truist
04/06/21 Truist
American Public Education initiated with a Buy at Truist
03/17/21 William Blair
American Public Education initiated with an Outperform at William Blair
APEI American Public Education
$22.34 /

+0.34 (+1.55%)

  • 25
    Feb
Recommendations
STMicroelectronics price target raised to EUR 45 from EUR 41.50 at UBS » 12:57
12/08/21
12/08
12:57
12/08/21
12:57
STM

STMicroelectronics

$49.03 /

-1.07 (-2.14%)

UBS analyst David…

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STM STMicroelectronics
$49.03 /

-1.07 (-2.14%)

STM STMicroelectronics
$49.03 /

-1.07 (-2.14%)

06:45 Today Morgan Stanley
STMicroelectronics downgraded to Equal Weight from Overweight at Morgan Stanley
11/02/21 Societe Generale
STMicroelectronics price target raised to EUR 55 from EUR 54 at Societe Generale
11/01/21 Credit Suisse
STMicroelectronics price target raised to EUR 49.50 at Credit Suisse
10/29/21 Barclays
STMicroelectronics price target raised to EUR 50 from EUR 45 at Barclays
STM STMicroelectronics
$49.03 /

-1.07 (-2.14%)

STM STMicroelectronics
$49.03 /

-1.07 (-2.14%)

Recommendations
Plastic Omnium price target raised to EUR 24 from EUR 23 at UBS » 12:54
12/08/21
12/08
12:54
12/08/21
12:54
PASTF

Plastic Omnium

$36.50 /

+ (+0.00%)

UBS analyst Patrick…

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PASTF Plastic Omnium
$36.50 /

+ (+0.00%)

10/08/21 UBS
Plastic Omnium price target lowered to EUR 23 from EUR 32 at UBS
10/01/21 Deutsche Bank
Plastic Omnium price target lowered to EUR 25 from EUR 30 at Deutsche Bank
12/09/20 Kepler Cheuvreux
Plastic Omnium downgraded to Hold from Buy at Kepler Cheuvreux
Recommendations
K+S AG price target raised to EUR 15.25 from EUR 13.95 at UBS » 12:54
12/08/21
12/08
12:54
12/08/21
12:54
KPLUY

K+S AG

$8.83 /

+0.0068 (+0.08%)

UBS analyst Patrick…

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KPLUY K+S AG
$8.83 /

+0.0068 (+0.08%)

12/07/21 JPMorgan
K+S AG price target raised to EUR 10.50 from EUR 8.60 at JPMorgan
11/15/21 Deutsche Bank
K+S AG price target raised to EUR 16 from EUR 15 at Deutsche Bank
11/15/21 AlphaValue/Baader
K+S AG upgraded to Buy from Reduce at AlphaValue/Baader
11/12/21 Scotiabank
K+S AG price target raised to EUR 17 from EUR 16 at Scotiabank
Recommendations
Infineon price target raised to EUR 49 from EUR 45 at UBS » 12:52
12/08/21
12/08
12:52
12/08/21
12:52
IFNNY

Infineon

$48.39 /

+2.36 (+5.13%)

UBS analyst David…

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IFNNY Infineon
$48.39 /

+2.36 (+5.13%)

IFNNY Infineon
$48.39 /

+2.36 (+5.13%)

04:50 Today Morgan Stanley
Infineon downgraded to Equal Weight from Overweight at Morgan Stanley
04:49 Today JPMorgan
Infineon downgraded to Neutral from Overweight at JPMorgan
11/12/21 Credit Suisse
Infineon price target raised to EUR 47.40 from EUR 43 at Credit Suisse
11/11/21 JPMorgan
Infineon price target raised to EUR 47 from EUR 42 at JPMorgan
IFNNY Infineon
$48.39 /

+2.36 (+5.13%)

Recommendations
Freenet price target raised to EUR 21.30 from EUR 20.80 at UBS » 12:52
12/08/21
12/08
12:52
12/08/21
12:52
FRTAF

Freenet

$24.60 /

+ (+0.00%)

UBS analyst Polo Tang…

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FRTAF Freenet
$24.60 /

+ (+0.00%)

11/10/21 Barclays
Freenet price target raised to EUR 27 from EUR 25 at Barclays
11/10/21 Deutsche Bank
Freenet price target raised to EUR 22 from EUR 20 at Deutsche Bank
07/20/21 Citi
Citi opens 'positive catalyst watch' on Freenet
05/10/21 Barclays
Freenet price target raised to EUR 25 from EUR 24 at Barclays
Conference/Events
Cowen life science/diagnostic analyst holds analyst/industry conference call » 12:50
12/08/21
12/08
12:50
12/08/21
12:50

Life Science &…

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Hot Stocks
Empire State Realty OP trading resumes  12:49
12/08/21
12/08
12:49
12/08/21
12:49
 
Recommendations
EMS-Chemie price target raised to CHF 930 from CHF 920 at UBS » 12:48
12/08/21
12/08
12:48
12/08/21
12:48
EMSHF

EMS-Chemie

$946.00 /

+ (+0.00%)

UBS analyst Patrick…

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EMSHF EMS-Chemie
$946.00 /

+ (+0.00%)

04/21/21 UBS
EMS-Chemie upgraded on electric vehicle 'reinvention' at UBS
04/21/21 UBS
EMS-Chemie upgraded to Neutral from Sell at UBS
03/15/21 Stifel
EMS-Chemie upgraded to Hold from Sell at Stifel
02/09/21 Kepler Cheuvreux
EMS-Chemie upgraded to Hold from Reduce at Kepler Cheuvreux
Recommendations
British American Tobacco price target raised to 3,700 GBp from 3,500 GBp at UBS » 12:46
12/08/21
12/08
12:46
12/08/21
12:46
BTI

British American Tobacco

$35.44 /

+0.28 (+0.80%)

UBS analyst Nik Oliver…

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BTI British American Tobacco
$35.44 /

+0.28 (+0.80%)

BTI British American Tobacco
$35.44 /

+0.28 (+0.80%)

11/30/21 JPMorgan
British American Tobacco price target lowered to 3,100 GBp at JPMorgan
09/30/21 Stifel
Stifel surprised and 'disappointed' by ITC banning IQOS importation
09/30/21 BofA
Altria, Philip Morris still well positioned despite IQOS 'setback,' says BofA
09/28/21 UBS
British American Tobacco price target lowered to 3,500 GBp at UBS
BTI British American Tobacco
$35.44 /

+0.28 (+0.80%)

BTI British American Tobacco
$35.44 /

+0.28 (+0.80%)

General news
Treasury Action: TIPS breakevens have continued higher » 12:45
12/08/21
12/08
12:45
12/08/21
12:45
$ECON

Economic Data

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$ECON Economic Data
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$ECON Economic Data
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Hot Stocks
Empire State Realty OP trading halted, volatility trading pause  12:44
12/08/21
12/08
12:44
12/08/21
12:44
 
Periodicals
Apollo aims to raise $25B for next flagship buyout fund, Bloomberg says » 12:44
12/08/21
12/08
12:44
12/08/21
12:44
APO

Apollo Global

$71.02 /

+0.085 (+0.12%)

Apollo Global is seeking…

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APO Apollo Global
$71.02 /

+0.085 (+0.12%)

APO Apollo Global
$71.02 /

+0.085 (+0.12%)

11/09/21 Truist
Athene Holding price target raised to $88 from $68 at Truist
11/09/21 Argus
Apollo Global price target raised to $90 from $76 at Argus
11/05/21
Fly Intel: Top five analyst upgrades
11/05/21 Deutsche Bank
Deutsche Bank upgrades Apollo to Buy says Athene deal 'stands out'
APO Apollo Global
$71.02 /

+0.085 (+0.12%)

APO Apollo Global
$71.02 /

+0.085 (+0.12%)

APO Apollo Global
$71.02 /

+0.085 (+0.12%)

APO Apollo Global
$71.02 /

+0.085 (+0.12%)

Conference/Events
GTY Technology management to meet virtually with DA Davidson » 12:32
12/08/21
12/08
12:32
12/08/21
12:32
GTYH

GTY Technology

$7.56 /

-0.13 (-1.69%)

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GTYH GTY Technology
$7.56 /

-0.13 (-1.69%)

GTYH GTY Technology
$7.56 /

-0.13 (-1.69%)

08/12/21 DA Davidson
GTY Technology initiated with a Buy at DA Davidson
12/18/20 Craig-Hallum
GTY Technology Holdings initiated with a Buy at Craig-Hallum
GTYH GTY Technology
$7.56 /

-0.13 (-1.69%)

Conference/Events
Cornerstone Building Brands management to meet virtually with DA Davidson » 12:29
12/08/21
12/08
12:29
12/08/21
12:29
CNR

Cornerstone Building Brands

$17.05 /

+0.22 (+1.31%)

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CNR Cornerstone Building Brands
$17.05 /

+0.22 (+1.31%)

CNR Cornerstone Building Brands
$17.05 /

+0.22 (+1.31%)

06/09/21 Barclays
Cornerstone Building Brands price target raised to $21 from $15 at Barclays
05/13/21 DA Davidson
Cornerstone Building Brands upgraded to Buy from Neutral at DA Davidson
05/13/21 DA Davidson
Cornerstone Building Brands upgraded to Buy from Neutral at DA Davidson
03/05/21 Barclays
Cornerstone Building Brands price target raised to $13 from $10 at Barclays
CNR Cornerstone Building Brands
$17.05 /

+0.22 (+1.31%)

  • 09
    Mar
  • 04
    Feb
Hot Stocks
NICE issues guidance for Dupixent as add-on for severe asthma » 12:29
12/08/21
12/08
12:29
12/08/21
12:29
REGN

Regeneron

$639.52 /

+5.59 (+0.88%)

The U.K.'s National…

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REGN Regeneron
$639.52 /

+5.59 (+0.88%)

REGN Regeneron
$639.52 /

+5.59 (+0.88%)

12/06/21 Cowen
Regeneron assumed with a Market Perform at Cowen
12/06/21 Cowen
Regeneron assumed with a Market Perform at Cowen
12/06/21 Goldman Sachs
Regeneron initiated with a Buy at Goldman Sachs
12/02/21 JonesTrading
Decibel Therapeutics initiated with a Buy at JonesTrading
REGN Regeneron
$639.52 /

+5.59 (+0.88%)

REGN Regeneron
$639.52 /

+5.59 (+0.88%)

REGN Regeneron
$639.52 /

+5.59 (+0.88%)

REGN Regeneron
$639.52 /

+5.59 (+0.88%)

Options
Faraday Future Intelligent Electric call volume above normal and directionally bullish » 12:25
12/08/21
12/08
12:25
12/08/21
12:25
FFIE

Faraday Future

$5.54 /

-0.03 (-0.54%)

Bullish option flow…

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FFIE Faraday Future
$5.54 /

-0.03 (-0.54%)

FFIE Faraday Future
$5.54 /

-0.03 (-0.54%)

11/16/21 Wedbush
Wedbush downgrades Faraday Future to Neutral, sees shares in 'penalty box'
11/16/21 Wedbush
Faraday Future downgraded to Neutral from Outperform at Wedbush
10/25/21 Wedbush
Hertz mega deal another 'feather in the cap' for Tesla, says Wedbush
08/17/21 Wedbush
Wedbush bullish on Faraday Future, initiates with an Outperform
FFIE Faraday Future
$5.54 /

-0.03 (-0.54%)

FFIE Faraday Future
$5.54 /

-0.03 (-0.54%)

FFIE Faraday Future
$5.54 /

-0.03 (-0.54%)

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