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2021-12-06 08:41:03 LEGN Legend Biotech $44.36 / -4.465 (-9.15%) , JNJ Johnson & Johnson $159.37 / +2.25 (+1.43%) 08:41 12/06/21 12/06 08:41 12/06/21 08:41	Legend submits NDA to Japan regulator for BCMA CAR-T therapy Cilta-cel for RRMM Legend Biotech (LEGN) announces submission of a New Drug Application, NDA, to the Japanese Ministry of Health, Labour and Welfare, MHLW, for ciltacabtagene autoleucel by its collaboration partner, Janssen Pharmaceutical (JNJ) . Cilta-cel is an investigational B-cell maturation antigen -directed chimeric antigen receptor CAR-T cell therapy for the treatment of adults with relapsed or refractory multiple myeloma who have received at least three prior therapies, including a proteasome inhibitor , an immunomodulatory agent , and an anti-CD38 antibody. The submission is based on results from the Phase 1b/2 CARTITUDE-1 study conducted in the US and Japan, which evaluated the efficacy and safety of cilta-cel for patients with relapsed or refractory multiple myeloma.1 Cilta-cel is currently under regulatory review by several health authorities around the world, including the United States and Europe. "Today's submission is an encouraging step in our mission to provide a potentially transformative cell therapy option to patients with multiple myeloma," said Ying Huang, PhD, CEO and CFO of Legend Biotech. "We look forward to closely collaborating with our partner Janssen and the MHLW in order to make cilta-cel available to patients living with relapsed or refractory multiple myeloma, who have exhausted several standard-of-care treatments and are facing poor prognoses." LEGN Legend Biotech $44.36 / -4.465 (-9.15%) JNJ Johnson & Johnson $159.37 / +2.25 (+1.43%)	07 Dec 25 Jan 28 Feb

2021-12-06 08:41:03

LEGN

Legend Biotech

$44.36 / -4.465 (-9.15%)

, JNJ

Johnson & Johnson

$159.37 / +2.25 (+1.43%)

08:41

12/06/21

12/06

08:41

12/06/21

08:41

Legend submits NDA to Japan regulator for BCMA CAR-T therapy Cilta-cel for RRMM

Legend Biotech (LEGN) announces submission of a New Drug Application, NDA, to the Japanese Ministry of Health, Labour and Welfare, MHLW, for ciltacabtagene autoleucel by its collaboration partner, Janssen Pharmaceutical (JNJ) . Cilta-cel is an investigational B-cell maturation antigen -directed chimeric antigen receptor CAR-T cell therapy for the treatment of adults with relapsed or refractory multiple myeloma who have received at least three prior therapies, including a proteasome inhibitor , an immunomodulatory agent , and an anti-CD38 antibody. The submission is based on results from the Phase 1b/2 CARTITUDE-1 study conducted in the US and Japan, which evaluated the efficacy and safety of cilta-cel for patients with relapsed or refractory multiple myeloma.1 Cilta-cel is currently under regulatory review by several health authorities around the world, including the United States and Europe. "Today's submission is an encouraging step in our mission to provide a potentially transformative cell therapy option to patients with multiple myeloma," said Ying Huang, PhD, CEO and CFO of Legend Biotech. "We look forward to closely collaborating with our partner Janssen and the MHLW in order to make cilta-cel available to patients living with relapsed or refractory multiple myeloma, who have exhausted several standard-of-care treatments and are facing poor prognoses."

LEGN

Legend Biotech

$44.36 / -4.465 (-9.15%)

JNJ

Johnson & Johnson

$159.37 / +2.25 (+1.43%)

07
Dec
25
Jan
28
Feb

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Recommendations	BASF price target lowered to EUR 62 from EUR 64 at Morgan Stanley » 14:51 05/25/22 05/25 14:51 05/25/22 14:51 BASFY BASF $13.15 / -0.09 (-0.68%) Morgan Stanley analyst… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return in 9 minutes Get Free Trial ShowHide Related Items >><< Company News Street Research Events BASFY BASF $13.15 / -0.09 (-0.68%) 03/29/22 BASF, Steelcase collaborate on Flex Perch Stool 01/25/22 Yield10 Bioscience hires Greenfield as Senior Director of Seed Operations 12/27/21 Aspen Aerogels, BASF terminate supply arrangement BASFY BASF $13.15 / -0.09 (-0.68%) 04/13/22 Stifel BASF downgraded to Hold from Buy at Stifel 04/08/22 Baader Helvea BASF downgraded to Add from Buy at Baader Helvea 03/31/22 Morgan Stanley BASF price target lowered to EUR 64 from EUR 76 at Morgan Stanley 03/31/22 Oddo BHF BASF downgraded to Neutral from Outperform at Oddo BHF 06/07/22 2022 European Materials Conference
Recommendations	Aurubis price target lowered to EUR 87 from EUR 95 at Morgan Stanley » 14:51 05/25/22 05/25 14:51 05/25/22 14:51 AIAGY Aurubis $48.15 / + (+0.00%) Morgan Stanley analyst… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Street Research AIAGY Aurubis $48.15 / + (+0.00%) 04/14/22 Deutsche Bank Aurubis price target raised to EUR 95 from EUR 90 at Deutsche Bank 03/24/22 Morgan Stanley Aurubis price target raised to EUR 91 from EUR 89 at Morgan Stanley 02/11/22 Morgan Stanley Aurubis price target raised to EUR 89 from EUR 88 at Morgan Stanley 02/08/22 Deutsche Bank Aurubis price target raised to EUR 90 from EUR 86 at Deutsche Bank
Recommendations	Prosus price target lowered to EUR 90 from EUR 110 at Citi » 14:50 05/25/22 05/25 14:50 05/25/22 14:50 PROSY Prosus $8.94 / -0.63 (-6.58%) Citi analyst Catherine… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return in 9 minutes Get Free Trial ShowHide Related Items >><< Street Research PROSY Prosus $8.94 / -0.63 (-6.58%) 05/24/22 Barclays Prosus downgraded to Equal Weight from Overweight at Barclays 05/20/22 JPMorgan Prosus price target lowered to EUR 69.40 from EUR 73.40 at JPMorgan 05/17/22 JPMorgan Prosus upgraded to Overweight from Neutral at JPMorgan 05/09/22 Jefferies Prosus assumed with a Hold at Jefferies
Recommendations	EOCL award watershed moment for BlackSky, GIS industry, says Benchmark » 14:50 05/25/22 05/25 14:50 05/25/22 14:50 BKSY BlackSky $2.85 / +1.66 (+139.50%) , PL Planet Labs $5.80 / +0.78 (+15.54%) , MAXR Maxar Technologies $28.94 / +4.425 (+18.05%) Benchmark analyst Josh… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return tomorrow Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings On The Fly Events Options BKSY PL MAXR BKSY BlackSky $2.85 / +1.66 (+139.50%) 13:46 Today BlackSky says EOCL contract with options valued up to $1.021B 10:40 Today BlackSky awarded 10-year EOCL contract with U.S. government 10:28 Today BlackSky, Maxar and Planet awarded commercial imagery contracts, NRO says 04/04/22 BlackSky's new satellites began revenue-generating commercial operations PL Planet Labs $5.80 / +0.78 (+15.54%) 10:31 Today Planet Labs unit awarded EOCL contract by U.S. government 05/03/22 Telesat Holdings announces $30.65M Funded Space Act Agreement from NASA 04/20/22 Planet Labs reports PlanetScope, SkySat join ESA Third Party Missions portfolio 04/18/22 Planet Labs enters Canadian Boreal Forest research partnership with universities MAXR Maxar Technologies $28.94 / +4.425 (+18.05%) 10:53 Today Maxar Technologies trading resumes 10:31 Today NRO awards Maxar ten-year contract under EOCL acquisition 10:28 Today BlackSky, Maxar and Planet awarded commercial imagery contracts, NRO says 09:49 Today Maxar Technologies trading halted, news pending BKSY PL MAXR BKSY BlackSky $2.85 / +1.66 (+139.50%) PL Planet Labs $5.80 / +0.78 (+15.54%) 12:07 Today Benchmark Planet's EOCL position increases long-term visibility, says Benchmark 01/27/22 Needham Planet Labs initiated with a Buy at Needham 01/27/22 Needham Planet Labs initiated with a Buy at Needham 01/12/22 Goldman Sachs Planet Labs initiated with a Buy at Goldman Sachs MAXR Maxar Technologies $28.94 / +4.425 (+18.05%) 14:10 Today Canaccord Canaccord keeps Buy on Maxar Technologies, raises price target to $40 05/17/22 BofA Maxar Technologies downgraded to Underperform from Neutral at BofA 05/10/22 Canaccord Maxar Technologies upgraded to Buy at Canaccord on valuation 05/10/22 JPMorgan Maxar Technologies price target raised to $49 from $47 at JPMorgan BKSY PL MAXR BKSY BlackSky $2.85 / +1.66 (+139.50%) 05/11/22 BlackSky maintains 2022 revenue view $58M-$62M, one est. $61.5M 05/11/22 BlackSky reports Q1 EPS (17c) vs. (70c) last year. PL Planet Labs $5.80 / +0.78 (+15.54%) 12/13/21 Planet Labs sees Q4 revenue $35M-$37M, one estimate $40.3M 12/13/21 Planet Labs reports Q3 EPS ($1.38) vs. ($1.06) last year MAXR Maxar Technologies $28.94 / +4.425 (+18.05%) 10:33 Today Maxar Technologies tightens 2022 revenue view $1.805B-$1.855B 05/09/22 Maxar Technologies reports Q1 EPS (10c), consensus (5c) 02/22/22 Maxar Technologies reports Q4 EPS 94c, consensus 7c PL MAXR PL Planet Labs $5.80 / +0.78 (+15.54%) 01/12/22 Wall Street in Fives - Must Read Lists for Wednesday 01/12/22 Wall Street in Fives - Must Read Lists at Midday 01/07/22 Kohl's, Visa downgrades among today's top calls on Wall Street 12/13/21 Fly Intel: After-Hours Movers MAXR Maxar Technologies $28.94 / +4.425 (+18.05%) 05/17/22 What You Missed On Wall Street On Tuesday 05/17/22 What You Missed On Wall Street This Morning 05/17/22 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 01/20/22 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 06/14/22 Planet Labs - PL BKSY PL MAXR BKSY BlackSky $2.85 / +1.66 (+139.50%) 01/11/22 Largest borrow rate increases among liquid names 12/09/21 Largest borrow rate increases among liquid names PL Planet Labs $5.80 / +0.78 (+15.54%) 01/12/22 Planet Labs PBC call volume above normal and directionally bullish 12/23/21 Planet Labs PBC call volume above normal and directionally bullish 12/08/21 Four new option listings and three option delistings on December 8th MAXR Maxar Technologies $28.94 / +4.425 (+18.05%) 02/22/22 Maxar Technologies options imply 11.5% move in share price post-earnings
Downgrade	Columbus McKinnon downgraded to Hold from Buy at Craig-Hallum » 14:49 05/25/22 05/25 14:49 05/25/22 14:49 CMCO Columbus McKinnon $32.49 / -0.32 (-0.98%) Craig-Hallum analyst Greg… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return in 9 minutes Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Events CMCO Columbus McKinnon $32.49 / -0.32 (-0.98%) 03/21/22 Columbus McKinnon raises quarterly dividend 17% to 7c from 6c per share CMCO Columbus McKinnon $32.49 / -0.32 (-0.98%) 01/03/22 Barrington Cars.com, Vizio among Barrington's 'Best Ideas' for 2002 12/07/21 Fly Intel: Top five analyst initiations 12/07/21 JPMorgan Columbus McKinnon initiated with an Overweight at JPMorgan 05/26/21 Barrington Columbus McKinnon price target raised to $78 from $67 at Barrington CMCO Columbus McKinnon $32.49 / -0.32 (-0.98%) 06:58 Today Columbus McKinnon sees Q1 revenue $220M-$230M, consensus $237.11M 06:57 Today Columbus McKinnon reports Q4 adjusted EPS 79c, consensus 79c 01/27/22 Columbus McKinnon sees Q4 revenue $235M, consensus $236.83M 01/27/22 Columbus McKinnon reports Q3 adjusted EPS 60c, consensus 54c 10:00 Today Columbus McKinnon - CMCO 05/26/22 Columbus McKinnon

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