2022-01-04 16:06:59 INBX Inhibrx
01/04/22 01/0416:06 01/04/2216:06 | Inhibrx announces results from Part 3 of the 4-part Phase 1 trial of INBRX-106Inhibrx announced initial results from Part 3 of the 4-part Phase 1 trial of INBRX-106, a novel hexavalent OX40 agonist, in combination with Keytruda, in development for the treatment of patients with solid tumors. Additionally, an update on single agent data from Part 1 and Part 2 of the trial was provided. In the all-comer Part 3 of this Phase 1 trial, the dose of INBRX-106 was escalated in combination with Keytruda(R) in 21 patients with locally advanced or metastatic solid tumors. INBRX-106 in combination with Keytruda was observed to be well tolerated, with predominantly mild or moderate immune-related toxicities noted. The maximum administered dose of INBRX-106 was 0.3 mg/kg, at which dose-limiting, immune-related toxicities such as dermatitis were observed. Accordingly, 0.1 mg/kg dosed every three weeks was determined to be the maximum tolerated dose of INBRX-106 in combination with Keytruda. |
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