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KRON

Kronos Bio

$7.31 /

+0.15 (+2.09%)

13:15
04/08/22
04/08
13:15
04/08/22
13:15

Kronos Bio data show potential of KB-0742 in breast, lung, ovarian cancers

Kronos Bio shared preclinical data on its internally discovered, highly selective, oral cyclin dependent kinase 9 inhibitor, KB-0742, adding to evidence that the compound has the potential to treat certain MYC-amplified and transcriptionally addicted solid tumors. The data will be presented in three posters at the American Association for Cancer Research Annual Meeting 2022, which begins today in New Orleans. The company will also present findings on a liquid biopsy assay platform that it has developed to potentially assess patient responses in the next stage of the ongoing Phase 1/2 clinical trial of KB-0742. In the first poster, researchers evaluated 11 tumor types using immortalized cell lines, including patient-derived cell line, patient-derived organoid and patient-derived xenograft models. Of the 11 cancer types, triple-negative breast cancer, ovarian cancer and lymphoma showed good responses to KB-0742. Tumor regressions were observed in the three models of ovarian cancer. For triple-negative breast cancer and ovarian cancer, immortalized cell lines and patient-derived cell lines indicated lower half maximal inhibitory concentration values with increased MYC amplification or expression, and in vivo assessments using PDX models showed good correlation of tumor growth inhibition and MYC amplification/expression. The data also showed antitumor activity of greater than 50% tumor growth inhibition in several xenograft models of lymphoma, including one double-hit model. Based on the analysis, the researchers concluded that triple-negative breast and ovarian cancer showed the strongest correlation between sensitivity to KB-0742 and MYC expression. In a second poster, KB-0742 was evaluated in certain tumors that rely on dysregulated activity of a particular transcription factor to drive their malignant phenotype. These include the fusion gene EWS-FLI1 in Ewing sarcoma, PAX3/7-FOXO1 fusions in rhabdomyosarcoma, and brachyury (T) in chordoma. The activity of KB-0742 was assessed in vivo using two PDX models of chordoma. These findings provide additional rationale for the use of KB-0742 as a potential treatment for chordoma, sarcoma and other transcriptionally addicted tumors. In a third poster at AACR, the company evaluated KB-0742 in small-cell lung cancer. In a panel of six PDO small-cell lung cancer models with different treatment histories, KB-0742 was active in the models, regardless of treatment history. In a separate study of four treatment-naive PDO models, KB-0742 was active in three transcription factor-driven subtypes of small-cell lung cancer, and the response correlated significantly with c-MYC and MYCL expression. Together, these data support the evaluation of KB-0742 as a potential treatment for small-cell lung cancer.

OTHER BREAKING NEWS FROM THE FLY

Technical Analysis
Consumer Staples Sector SPDR: Pivot points » 09:28
05/26/22
05/26
09:28
05/26/22
09:28
XLP

Consumer Staples Sector SPDR

$73.34 /

+ (+0.00%)

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XLP Consumer Staples Sector SPDR
$73.34 /

+ (+0.00%)

07/19/21 Morgan Stanley
Morgan Stanley equity strategist upgrades Consumer Staples, downgrades Materials
XLP Consumer Staples Sector SPDR
$73.34 /

+ (+0.00%)

XLP Consumer Staples Sector SPDR
$73.34 /

+ (+0.00%)

Recommendations
Columbus McKinnon price target lowered to $57 from $66 at Barrington » 09:25
05/26/22
05/26
09:25
05/26/22
09:25
CMCO

Columbus McKinnon

$31.62 /

-1.19 (-3.63%)

Barrington analyst…

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CMCO Columbus McKinnon
$31.62 /

-1.19 (-3.63%)

CMCO Columbus McKinnon
$31.62 /

-1.19 (-3.63%)

08:37 Today Craig-Hallum
Craig-Hallum downgrades Columbus McKinnon to Hold, lowers price target to $35
07:20 Today JPMorgan
Columbus McKinnon downgraded on inflation, cost pressures at JPMorgan
05:44 Today JPMorgan
Columbus McKinnon downgraded to Neutral from Overweight at JPMorgan
05/25/22 Craig-Hallum
Columbus McKinnon downgraded to Hold at Craig-Hallum on lack of catalysts
CMCO Columbus McKinnon
$31.62 /

-1.19 (-3.63%)

General news
Treasury Action: shorter dated coupons continue to outperform » 09:25
05/26/22
05/26
09:25
05/26/22
09:25
$ECON

Economic Data

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Treasury Action: shorter…

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$ECON Economic Data
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$ECON Economic Data
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$ECON Economic Data
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Conference/Events
Jefferies UK industrials analyst to hold an analyst/industry conference call » 09:25
05/26/22
05/26
09:25
05/26/22
09:25

UK Industrials Analyst…

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Conference/Events
JPMorgan large cap banks analyst holds analyst/industry conference call » 09:25
05/26/22
05/26
09:25
05/26/22
09:25

Large Cap Banks Analyst…

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Hot Stocks
Liquidity Services selected to auction assets of major oil pipeline project » 09:24
05/26/22
05/26
09:24
05/26/22
09:24
LQDT

Liquidity Services

$13.59 /

+0.49 (+3.74%)

Liquidity Services has…

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LQDT Liquidity Services
$13.59 /

+0.49 (+3.74%)

LQDT Liquidity Services
$13.59 /

+0.49 (+3.74%)

05/09/22 Barrington
Liquidity Services target lowered to $26 at Barrington on adjusted EBITDA view
LQDT Liquidity Services
$13.59 /

+0.49 (+3.74%)

LQDT Liquidity Services
$13.59 /

+0.49 (+3.74%)

Recommendations
Vapotherm price target lowered to $2.50 from $5 at Piper Sandler » 09:24
05/26/22
05/26
09:24
05/26/22
09:24
VAPO

Vapotherm

$3.03 /

+0.075 (+2.54%)

Piper Sandler analyst…

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VAPO Vapotherm
$3.03 /

+0.075 (+2.54%)

VAPO Vapotherm
$3.03 /

+0.075 (+2.54%)

05/06/22 Canaccord
Canaccord downgrades Vapotherm on risk of covenant breach
05/05/22 Canaccord
Vapotherm downgraded to Hold from Buy at Canaccord
05/05/22 Piper Sandler
Vapotherm price target lowered to $5 from $8 at Piper Sandler
04/18/22 BTIG
Vapotherm price target lowered to $10 from $37 at BTIG
VAPO Vapotherm
$3.03 /

+0.075 (+2.54%)

VAPO Vapotherm
$3.03 /

+0.075 (+2.54%)

Earnings
StealthGas reports Q1 adjusted EPS 23c vs. 2c last year » 09:23
05/26/22
05/26
09:23
05/26/22
09:23
GASS

StealthGas

$2.49 /

+0.075 (+3.11%)

Reports Q1 revenue $35.9M…

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GASS StealthGas
$2.49 /

+0.075 (+3.11%)

GASS StealthGas
$2.49 /

+0.075 (+3.11%)

04/27/22 Jefferies
StealthGas reinstated with a Buy at Jefferies
GASS StealthGas
$2.49 /

+0.075 (+3.11%)

GASS StealthGas
$2.49 /

+0.075 (+3.11%)

Technical Analysis
Health Care Select Sector SPDR: Pivot points » 09:21
05/26/22
05/26
09:21
05/26/22
09:21
XLV

Health Care Select Sector SPDR

$131.28 /

-0.09 (-0.07%)

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XLV Health Care Select Sector SPDR
$131.28 /

-0.09 (-0.07%)

XLV Health Care Select Sector SPDR
$131.28 /

-0.09 (-0.07%)

Hot Stocks
Hudson Capital to change name to Freight Technologies » 09:20
05/26/22
05/26
09:20
05/26/22
09:20
HUSN

Hudson Capital

$1.58 /

+ (+0.00%)

, FRGT

Freight Technologies

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Hudson Capital will…

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HUSN Hudson Capital
$1.58 /

+ (+0.00%)

HUSN Hudson Capital
$1.58 /

+ (+0.00%)

HUSN Hudson Capital
$1.58 /

+ (+0.00%)

Recommendations
Northland ups Photronics estimates 'significantly,' bumps price target to $26 » 09:20
05/26/22
05/26
09:20
05/26/22
09:20
PLAB

Photronics

$17.85 /

+2.805 (+18.64%)

Northland analyst Gus…

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PLAB Photronics
$17.85 /

+2.805 (+18.64%)

PLAB Photronics
$17.85 /

+2.805 (+18.64%)

08:37 Today DA Davidson
Photronics price target raised to $30 from $26 at DA Davidson
05/25/22 Stifel
Photronics price target raised to $23 from $21 at Stifel
04/11/22 Stifel
Photronics upgraded to Buy from Hold at Stifel
03/15/22 DA Davidson
DA Davidson 'bullish' on Photronics after CEO departure
PLAB Photronics
$17.85 /

+2.805 (+18.64%)

PLAB Photronics
$17.85 /

+2.805 (+18.64%)

Hot Stocks
Perrigo's omeprazole mini capsules for heartburn approved by FDA » 09:20
05/26/22
05/26
09:20
05/26/22
09:20
PRGO

Perrigo

$39.28 /

+0.775 (+2.01%)

Perrigo has received…

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PRGO Perrigo
$39.28 /

+0.775 (+2.01%)

PRGO Perrigo
$39.28 /

+0.775 (+2.01%)

11/11/21 Raymond James
Perrigo price target lowered to $55 from $59 at Raymond James
10/14/21
Fly Intel: Top five analyst upgrades
10/14/21 Raymond James
Raymond James upgrades Perrigo to buy on HRA deal, tax settlement
10/14/21 Raymond James
Perrigo upgraded to Outperform from Market Perform at Raymond James
PRGO Perrigo
$39.28 /

+0.775 (+2.01%)

PRGO Perrigo
$39.28 /

+0.775 (+2.01%)

PRGO Perrigo
$39.28 /

+0.775 (+2.01%)

Hot Stocks
Goldenbridge Acquisition Ltd (Units) trading halted, news pending  09:20
05/26/22
05/26
09:20
05/26/22
09:20
 
Hot Stocks
Goldenbridge Acquisition Ltd trading halted, news pending  09:20
05/26/22
05/26
09:20
05/26/22
09:20
GBRG

Goldenbridge Acquisition

$10.11 /

-0.39 (-3.71%)

 
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GBRG Goldenbridge Acquisition
$10.11 /

-0.39 (-3.71%)

Hot Stocks
Victoria's Secret launches VS&Co-Lab digital platform » 09:18
05/26/22
05/26
09:18
05/26/22
09:18
VSCO

Victoria's Secret

$41.48 /

+1.135 (+2.81%)

Victoria's Secret…

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VSCO Victoria's Secret
$41.48 /

+1.135 (+2.81%)

VSCO Victoria's Secret
$41.48 /

+1.135 (+2.81%)

05/16/22 JPMorgan
Victoria's Secret price target lowered to $71 from $86 at JPMorgan
04/05/22 Wells Fargo
Victoria's Secret price target lowered to $70 from $75 at Wells Fargo
04/01/22 Barclays
Victoria's Secret price target lowered to $61 from $76 at Barclays
03/03/22 BMO Capital
Victoria's Secret price target lowered to $72 from $80 at BMO Capital
VSCO Victoria's Secret
$41.48 /

+1.135 (+2.81%)

VSCO Victoria's Secret
$41.48 /

+1.135 (+2.81%)

Hot Stocks
Qualigen Therapeutics announces two abstracts on RAS Inhibitor program » 09:17
05/26/22
05/26
09:17
05/26/22
09:17
QLGN

Qualigen Therapeutics

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+

Qualigen Therapeutics…

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QLGN Qualigen Therapeutics
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QLGN Qualigen Therapeutics
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09/03/21 Alliance Global Partners
Qualigen price target lowered to $6.50 from $9.50 at Alliance Global Partners
QLGN Qualigen Therapeutics
/

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QLGN Qualigen Therapeutics
/

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Recommendations
Alibaba earnings beat on cost optimization initiatives, says JPMorgan » 09:17
05/26/22
05/26
09:17
05/26/22
09:17
BABA

Alibaba

$82.32 /

-0.1 (-0.12%)

JPMorgan analyst Alex Yao…

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BABA Alibaba
$82.32 /

-0.1 (-0.12%)

BABA Alibaba
$82.32 /

-0.1 (-0.12%)

05/23/22 Baird
Alibaba price target lowered to $144 from $160 at Baird
05/18/22 Truist
Alibaba price target lowered to $132 from $180 at Truist
05/16/22 JPMorgan
Alibaba upgraded to Overweight from Underweight at JPMorgan
05/02/22 Mizuho
Alibaba price target lowered to $160 from $180 at Mizuho
BABA Alibaba
$82.32 /

-0.1 (-0.12%)

BABA Alibaba
$82.32 /

-0.1 (-0.12%)

BABA Alibaba
$82.32 /

-0.1 (-0.12%)

BABA Alibaba
$82.32 /

-0.1 (-0.12%)

Hot Stocks
Terreno Realty acquires two industrial properties in California for $27.2M » 09:17
05/26/22
05/26
09:17
05/26/22
09:17
TRNO

Terreno Realty

$60.31 /

+0.46 (+0.77%)

Terreno Realty acquired…

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TRNO Terreno Realty
$60.31 /

+0.46 (+0.77%)

TRNO Terreno Realty
$60.31 /

+0.46 (+0.77%)

05/18/22 JMP Securities
Terreno Realty initiated with an Outperform at JMP Securities
05/17/22 Mizuho
Terreno Realty price target lowered to $64 from $76 at Mizuho
01/13/22 Mizuho
Terreno Realty price target raised to $76 from $65 at Mizuho
01/11/22 Baird
Terreno Realty downgraded to Neutral at Baird amid Industrial REIT rebalance
TRNO Terreno Realty
$60.31 /

+0.46 (+0.77%)

  • 05
    Nov
General news
The U.S. GDP report » 09:15
05/26/22
05/26
09:15
05/26/22
09:15
$ECON

Economic Data

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+

The U.S. GDP report…

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$ECON Economic Data
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$ECON Economic Data
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$ECON Economic Data
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$ECON Economic Data
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Technical Analysis
iShares Trust Russell 2000 Index Fund: Pivot points » 09:14
05/26/22
05/26
09:14
05/26/22
09:14
IWM

iShares Trust Russell 2000 Index Fund

$178.80 /

+3.25 (+1.85%)

The following are the…

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IWM iShares Trust Russell 2000 Index Fund
$178.80 /

+3.25 (+1.85%)

IWM iShares Trust Russell 2000 Index Fund
$178.80 /

+3.25 (+1.85%)

IWM iShares Trust Russell 2000 Index Fund
$178.80 /

+3.25 (+1.85%)

Recommendations
Transcat price target lowered to $80 from $97 at Roth Capital » 09:13
05/26/22
05/26
09:13
05/26/22
09:13
TRNS

Transcat

$63.29 /

+0.21 (+0.33%)

Roth Capital analyst…

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TRNS Transcat
$63.29 /

+0.21 (+0.33%)

TRNS Transcat
$63.29 /

+0.21 (+0.33%)

05/25/22 Craig-Hallum
Transcat price target lowered to $81 from $94 at Craig-Hallum
02/03/22 Craig-Hallum
Pullback in Transcat shares creates buying opportunity, says Craig-Hallum
12/20/21 H.C. Wainwright
Transcat price target raised to $105 from $95 at H.C. Wainwright
11/04/21 Craig-Hallum
Transcat price target raised to $94 from $72 at Craig-Hallum
TRNS Transcat
$63.29 /

+0.21 (+0.33%)

TRNS Transcat
$63.29 /

+0.21 (+0.33%)

Hot Stocks
BioSig Technologies rolls out national commercial launch campaign » 09:13
05/26/22
05/26
09:13
05/26/22
09:13
BSGM

BioSig Technologies

$1.16 /

+0.06 (+5.45%)

BioSig Technologies…

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BSGM BioSig Technologies
$1.16 /

+0.06 (+5.45%)

  • 02
    Jul
BSGM BioSig Technologies
$1.16 /

+0.06 (+5.45%)

Initiation
Lightning eMotors assumed with an Outperform at Northland » 09:12
05/26/22
05/26
09:12
05/26/22
09:12
ZEV

Lightning eMotors

$3.45 /

-0.025 (-0.72%)

Northland analyst…

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ZEV Lightning eMotors
$3.45 /

-0.025 (-0.72%)

ZEV Lightning eMotors
$3.45 /

-0.025 (-0.72%)

03/29/22 DA Davidson
Lightning eMotors price target lowered to $13 from $17 at DA Davidson
03/14/22 Benchmark
Lightning eMotors price target lowered to $9 from $14 at Benchmark
10/05/21 DA Davidson
DA Davidson sees 'positive takeaways' from meeting with Lightning eMotors
08/19/21 Benchmark
Lightning eMotors price target lowered to $14 from $17 at Benchmark
ZEV Lightning eMotors
$3.45 /

-0.025 (-0.72%)

ZEV Lightning eMotors
$3.45 /

-0.025 (-0.72%)

ZEV Lightning eMotors
$3.45 /

-0.025 (-0.72%)

Hot Stocks
Sidus picks L3Harris software for LizzieSat Constellation » 09:11
05/26/22
05/26
09:11
05/26/22
09:11
SIDU

Sidus Space

$1.47 /

+0.0598 (+4.24%)

, LHX

L3Harris Technologies

$236.61 /

-0.995 (-0.42%)

Sidus Space (SIDU), a…

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SIDU Sidus Space
$1.47 /

+0.0598 (+4.24%)

LHX L3Harris Technologies
$236.61 /

-0.995 (-0.42%)

SIDU Sidus Space
$1.47 /

+0.0598 (+4.24%)

LHX L3Harris Technologies
$236.61 /

-0.995 (-0.42%)

05/02/22 Jefferies
L3Harris Technologies price target lowered to $300 from $320 at Jefferies
05/02/22 Susquehanna
L3Harris Technologies price target lowered to $298 from $302 at Susquehanna
03/31/22 Jefferies
L3Harris Technologies still Jefferies' top pick in Defense
03/07/22 Wells Fargo
L3Harris Technologies price target raised to $291 from $240 at Wells Fargo
SIDU Sidus Space
$1.47 /

+0.0598 (+4.24%)

LHX L3Harris Technologies
$236.61 /

-0.995 (-0.42%)

  • 15
    Dec
LHX L3Harris Technologies
$236.61 /

-0.995 (-0.42%)

SIDU Sidus Space
$1.47 /

+0.0598 (+4.24%)

LHX L3Harris Technologies
$236.61 /

-0.995 (-0.42%)

LHX L3Harris Technologies
$236.61 /

-0.995 (-0.42%)

Recommendations
First Wave BioPharma price target lowered to $9 from $20 at Roth Capital » 09:11
05/26/22
05/26
09:11
05/26/22
09:11
FWBI

First Wave BioPharma

/

+

Roth Capital analyst…

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FWBI First Wave BioPharma
/

+

FWBI First Wave BioPharma
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12/07/21 Maxim
First Wave BioPharma downgraded to Hold from Buy at Maxim
12/07/21 Maxim
First Wave BioPharma downgraded to Hold from Buy at Maxim

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