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2022-06-09 07:37:19 OLMA Olema Oncology $4.01 / +0.255 (+6.80%) 07:37 06/09/22 06/09 07:37 06/09/22 07:37	Olema updates clinical progress in OP-1250 development program Olema Pharmaceuticals announced clinical development progress for OP-1250, a complete estrogen receptor antagonis and a selective ER degrader n development for the treatment of metastatic breast cancer. "We are extremely pleased with the emerging clinical profile of OP-1250 and the encouraging progress achieved over the last six months. High investigator enthusiasm has led to rapid enrollment across the development program. In our Phase 1b monotherapy dose expansion, we have seen favorable tolerability and encouraging early anti-tumor activity. In the Phase 1b combination trial with palbociclib, two initial cohorts have completed the dose limiting toxicity evaluation period and we have demonstrated combinability for OP-1250 with no induced metabolism of palbociclib," said Sean P. Bohen, M.D., Ph.D., President and Chief Executive Officer of Olema Oncology. "We are entering an exciting period with the selection of our Recommended Phase 2 Dose later this month, followed by enrollment in our Phase 2 cohorts and plans to initiate an additional Phase 1b combination trial with each of ribociclib and alpelisib. We expect these datasets will further validate OP-1250's clinical profile and lay the foundation for our planned pivotal monotherapy study to begin next year." Olema continues to be well capitalized with sufficient cash to fund our planned research and development operations into the second half of 2024.	16 Jun

2022-06-09 07:37:19

OLMA

Olema Oncology

$4.01 / +0.255 (+6.80%)

07:37

06/09/22

06/09

07:37

06/09/22

07:37

Olema updates clinical progress in OP-1250 development program

Olema Pharmaceuticals announced clinical development progress for OP-1250, a complete estrogen receptor antagonis and a selective ER degrader n development for the treatment of metastatic breast cancer. "We are extremely pleased with the emerging clinical profile of OP-1250 and the encouraging progress achieved over the last six months. High investigator enthusiasm has led to rapid enrollment across the development program. In our Phase 1b monotherapy dose expansion, we have seen favorable tolerability and encouraging early anti-tumor activity. In the Phase 1b combination trial with palbociclib, two initial cohorts have completed the dose limiting toxicity evaluation period and we have demonstrated combinability for OP-1250 with no induced metabolism of palbociclib," said Sean P. Bohen, M.D., Ph.D., President and Chief Executive Officer of Olema Oncology. "We are entering an exciting period with the selection of our Recommended Phase 2 Dose later this month, followed by enrollment in our Phase 2 cohorts and plans to initiate an additional Phase 1b combination trial with each of ribociclib and alpelisib. We expect these datasets will further validate OP-1250's clinical profile and lay the foundation for our planned pivotal monotherapy study to begin next year." Olema continues to be well capitalized with sufficient cash to fund our planned research and development operations into the second half of 2024.

16
Jun

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