2022-07-06 11:05:02 ATHE Alterity Therapeutics
07/06/22 07/0611:05 07/06/2211:05 | Alterity Therapeutics doses first patient in ATH434 Phase 2 trialAlterity Therapeutics announced the first patient has been dosed in the Company's Phase 2 clinical trial of ATH434 in Multiple System Atrophy, a rare and highly debilitating Parkinsonian disorder .The Phase 2 clinical trial is a randomized, double-blind, placebo-controlled investigation of ATH434 in patients with early-stage MSA. The study will explore the effect of ATH434 treatment on imaging and protein biomarkers, such as aggregating alpha-synuclein and excess iron, which are important contributors to MSA pathology. Clinical and biomarker endpoints will permit comprehensive assessment of ATH434 efficacy along with characterization of safety and pharmacokinetics. The study is expected to enroll approximately 60 adult patients to receive one of two doses of ATH434 or placebo. Patients will receive treatment for 12 months which will provide an opportunity to detect changes in efficacy endpoints to optimize design of a definitive Phase 3 study. |
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