Boston Scientific has announced the first results from the ACURATE neo2 Post Market Clinical Follow-up, or PMCF, study evaluating the performance of the ACURATE neo2TM Aortic Valve System. The findings, which included a high procedural success rate of 98.4% and low rates of mortality and paravalvular leak, were presented during a late-breaking clinical trial session at PCR London Valves 2022 and published simultaneously in EuroIntervention. In this European study, the primary safety endpoint of all-cause mortality was 0.8% at 30 days. The data also demonstrated that no patients experienced greater than moderate PVL, 1.9% experienced moderate PVL and 18.9% experienced mild PVL. Other notable findings from the study included a low 6.5% rate of new pacemaker implantation 30 days post procedure, with no incidence of disabling stroke or acute kidney injury. The single-arm, prospective ACURATE neo2 PMCF study includes 250 patients with severe aortic stenosis from 18 European centers and will evaluate outcomes for five years following the procedure. It also includes a primary imaging endpoint to assess the visually apparent thickening of the prosthetic valve leaflets, a phenomenon with theoretical potential effects on valve durability or thrombotic complications. The reported HALT rate of 24.5% at 30 days post procedure falls within the range presented in previous TAVR trials with competitive devices. The ACURATE neo2 Aortic Valve System received CE Mark in 2020 and is being evaluated in the currently enrolling ACURATE IDE trial in the U.S. and Canada.

Melco Resorts & Entertainment announced that the Macau government has provisionally awarded a ten-year concession to operate games of fortune and chance in casinos in Macau to Melco Resorts Limited, a subsidiary of the company. The final award of such concession, and the terms and conditions of the concession contract, remain subject to the determination of the Macau government. Lawrence Ho, Chairman and Chief Executive Officer of Melco commented, "We are honored to have been selected and granted a provisional award for the concession to operate gaming in Macau and would like to thank the Macau government for running a smooth and transparent process. We are committed to Macau and its development as Asia's premier tourist destination."

As a global provider of essential internet infrastructure for commerce, Shopify announced a record-setting Black Friday with sales of $3.36 billion from the start of Black Friday in New Zealand through the end of Black Friday in California. This marks a 17% increase in sales over Black Friday in 2021 --19% on a constant currency basis. At its peak, merchants on Shopify saw sales of $3.5 million per minute at 12:01 PM EST on Black Friday, collectively. The company also noted top selling countries and cities where shoppers made purchases from: United States, United Kingdom and Canada, with the top-selling cities on Black Friday including London, New York, and Los Angeles; Top product categories: Apparel & accessories, followed by health & beauty, and home & garden; Average cart price: $102.31 USD or $105.10 USD on a constant currency basis; 15%: Cross-border orders worldwide on Black Friday as a percentage of total orders; 27%: Growth in POS sales made by Shopify merchants globally over last year's Black Friday.Reference Link

MGM Grand Paradise announced it "would like to express our sincere gratitude to the Government of Macao Special Administrative Region for granting us the provisional award of new gaming concession, allowing us to contribute to the future development of Macau's integrated tourism and leisure industries." The company added: "We fully devote to the Macao SAR. We will continue to develop the city with our strengths and contribute to the non-gaming industry, meanwhile making vigorous efforts in expanding the tourist markets from foreign countries. With confidence in the future of the Macao SAR, we firmly believe in Macau's full recovery and continue to grow, becoming even stronger as a holistic tourism destination. MGM Grand Paradise will continue to work with all sectors of the society to a new chapter in the development of tourism, leisure, and entertainment and create a milestone of 'Integrated Tourism in Asia'." MGM China Holdings Limited, the holding company of MGM Grand Paradise, is majority owned by MGM Resorts International. Reference Link

The Sands China group has been awarded a new 10-year gaming concession in Macao, as announced by the Macao government Saturday, the company stated. The concession is awarded on a provisional basis, subject to finalizing and entering into a new gaming concession contract with the Macao SAR. Robert Goldstein, the chairman and chief executive officer of Sands China Ltd. and its parent company Las Vegas Sands, said: "Our commitment to Macao has never wavered and we are honoured to continue the partnership we began with the government and people of Macao 20 years ago. In the coming decade and beyond, we will remain steadfast in our strategy of continuous investment in Macao - in its economy, its people and its community. Macao's future as an international tourism destination remains bright and we look forward to furthering our leadership role in helping it reach its full potential."

Wynn Resorts announced that Wynn Resorts Macau received a provisional award of a gaming concession from the Macau government. "The ultimate award of the gaming concession contract remains subject to the final documentation of its exact terms and conditions with the Macau government," the company stated.