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2023-02-01 08:04:07 MRSN Mersana Therapeutics $6.57 / +0.05 (+0.77%) 08:04 02/01/23 02/01 08:04 02/01/23 08:04	Mersana Therapeutics initiates expansion portion of UPGRADE-A trial Mersana Therapeutics announced that patient dosing is underway in the expansion portion of its UPGRADE-A clinical trial of UpRi in combination with carboplatin in platinum-sensitive ovarian cancer. UpRi is Mersana's first-in-class NaPi2b-targeting ADC with a novel scaffold-linker-payload designed to enable a high drug-to-antibody ratio and controlled bystander effect. "While the combination of carboplatin and paclitaxel has historically served as the standard of care in early lines of therapy for platinum-sensitive ovarian cancer, it is limited by distinct tolerability and side effect challenges that can include severe neutropenia, peripheral neuropathy and alopecia," said Dr. Arvin Yang, Senior Vice President and Chief Medical Officer of Mersana Therapeutics. "With UPGRADE-A, we are investigating the potential benefits of replacing paclitaxel with UpRi in the induction phase of treatment and then continuing UpRi as maintenance monotherapy. We are pleased to enter this exciting new phase of the trial." Mersana expects to report interim data from UPGRADE-A in the second half of 2023.

2023-02-01 08:04:07

MRSN

Mersana Therapeutics

$6.57 / +0.05 (+0.77%)

08:04

02/01/23

02/01

08:04

02/01/23

08:04

Mersana Therapeutics initiates expansion portion of UPGRADE-A trial

Mersana Therapeutics announced that patient dosing is underway in the expansion portion of its UPGRADE-A clinical trial of UpRi in combination with carboplatin in platinum-sensitive ovarian cancer. UpRi is Mersana's first-in-class NaPi2b-targeting ADC with a novel scaffold-linker-payload designed to enable a high drug-to-antibody ratio and controlled bystander effect. "While the combination of carboplatin and paclitaxel has historically served as the standard of care in early lines of therapy for platinum-sensitive ovarian cancer, it is limited by distinct tolerability and side effect challenges that can include severe neutropenia, peripheral neuropathy and alopecia," said Dr. Arvin Yang, Senior Vice President and Chief Medical Officer of Mersana Therapeutics. "With UPGRADE-A, we are investigating the potential benefits of replacing paclitaxel with UpRi in the induction phase of treatment and then continuing UpRi as maintenance monotherapy. We are pleased to enter this exciting new phase of the trial." Mersana expects to report interim data from UPGRADE-A in the second half of 2023.

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Options	Toast Inc call volume above normal and directionally bullish » 14:45 05/31/23 05/31 14:45 05/31/23 14:45 TOST Toast $20.93 / -0.805 (-3.70%) Bullish option flow… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:45 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly Events Options TOST Toast $20.93 / -0.805 (-3.70%) 05/22/23 Toast CEO sells $3.36M in common stock 05/16/23 Toast director buys $12.5M in common stock 05/15/23 Cathie Wood's ARK Investment bought 100K shares of Toast today 05/15/23 Toast director sells $1.1M in common stock TOST Toast $20.93 / -0.805 (-3.70%) 06:43 Today Mizuho Block point-of-sale business concerns may be overdone, says Mizuho 05/24/23 DA Davidson Toast assumed with a Buy at DA Davidson 05/16/23 Mizuho Toast price target raised to $25 from $23 at Mizuho 04/19/23 Baird Toast price target lowered to $21 from $24 at Baird TOST Toast $20.93 / -0.805 (-3.70%) 05/09/23 Toast raises FY23 revenue view to $3.71B-$3.80B consensus $3.65B 05/09/23 Toast sees Q2 revenue $920M-$950M, consensus $906.1M 05/09/23 Toast reports Q1 EPS (16c), consensus (17c) 05/09/23 Notable companies reporting after market close TOST Toast $20.93 / -0.805 (-3.70%) 02/11/23 Toast more than just restaurant payments, stock looks like a buy, Barron's says TOST Toast $20.93 / -0.805 (-3.70%) 05/09/23 Fly Intel: After-Hours Movers 05/04/23 Here's what Wall Street experts are saying about Block ahead of earnings 04/06/23 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 04/02/23 Sell these stocks now, proven algorithm says 06/08/23 Toast, Inc. TOST Toast $20.93 / -0.805 (-3.70%) 05/17/23 Toast Inc call volume above normal and directionally bullish 05/09/23 Toast Inc options imply 12.1% move in share price post-earnings 05/08/23 Toast Inc call volume above normal and directionally bullish 04/26/23 Toast Inc call volume above normal and directionally bullish
Recommendations	Bluebird Bio short report brings up 'well appreciated' risks, says Baird » 14:44 05/31/23 05/31 14:44 05/31/23 14:44 BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) Baird expects… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:44 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Syndicate On The Fly Events Options BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 14:43 Today Grizzly Research says Bluebird Bio 'has entered death spiral' 04/24/23 Bluebird Bio submits BLA for lovo-cel gene therapy for SCD treatments 01/18/23 Bluebird Bio falls 14% to $6.28 after 20M share offering of common stock 01/06/23 Bluebird Bio to sell second Zynteglo PRV for $95M BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 04/28/23 JPMorgan Bluebird Bio initiated with an Overweight at JPMorgan 03/30/23 BofA Bluebird Bio price target lowered to $6 from $8 at BofA 03/29/23 Raymond James Bluebird Bio reaction to lovo-cel BLA delay 'overdone,' says Raymond James 03/06/23 Baird Baird starts Bluebird at Outperform, sees lovo-cel beating estimates BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 05/09/23 Bluebird Bio reports Q1 EPS 21c,vs ($1.66) last year 03/29/23 Bluebird Bio reports Q4 EPS (38c), consensus (44c) 19 Jan BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 04/28/23 What You Missed On Wall Street On Friday 04/28/23 What You Missed On Wall Street This Morning 03/29/23 What You Missed On Wall Street On Wednesday 03/29/23 What You Missed On Wall Street This Morning 06/16/23 bluebird bio, Inc. BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 03/10/23 Bluebird Bio options imply 10.1% move in share price post-earnings 03/07/23 Bluebird Bio options imply 4.8% move in share price post-earnings
Hot Stocks	Grizzly Research says Bluebird Bio 'has entered death spiral' » 14:43 05/31/23 05/31 14:43 05/31/23 14:43 BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) In a recently published… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:43 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Syndicate On The Fly Events Options BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 04/24/23 Bluebird Bio submits BLA for lovo-cel gene therapy for SCD treatments 01/18/23 Bluebird Bio falls 14% to $6.28 after 20M share offering of common stock 01/06/23 Bluebird Bio to sell second Zynteglo PRV for $95M 01/03/23 Bluebird Bio appoints Joseph Vittiglio, JD, chief business and legal officer BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 04/28/23 JPMorgan Bluebird Bio initiated with an Overweight at JPMorgan 03/30/23 BofA Bluebird Bio price target lowered to $6 from $8 at BofA 03/29/23 Raymond James Bluebird Bio reaction to lovo-cel BLA delay 'overdone,' says Raymond James 03/06/23 Baird Baird starts Bluebird at Outperform, sees lovo-cel beating estimates BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 05/09/23 Bluebird Bio reports Q1 EPS 21c,vs ($1.66) last year 03/29/23 Bluebird Bio reports Q4 EPS (38c), consensus (44c) 19 Jan BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 04/28/23 What You Missed On Wall Street On Friday 04/28/23 What You Missed On Wall Street This Morning 03/29/23 What You Missed On Wall Street On Wednesday 03/29/23 What You Missed On Wall Street This Morning 06/16/23 bluebird bio, Inc. BLUE Bluebird Bio $3.33 / +0.01 (+0.30%) 03/10/23 Bluebird Bio options imply 10.1% move in share price post-earnings 03/07/23 Bluebird Bio options imply 4.8% move in share price post-earnings
Recommendations	Cofinimmo price target lowered to EUR 96 from EUR 110 at Berenberg » 14:43 05/31/23 05/31 14:43 05/31/23 14:43 CFMOF Cofinimmo $79.45 / -1.12 (-1.39%) Berenberg analyst Kai… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:43 Get Free Trial ShowHide Related Items >><< Street Research CFMOF Cofinimmo $79.45 / -1.12 (-1.39%) 03/13/23 Barclays Cofinimmo price target lowered to EUR 76 from EUR 80 at Barclays 02/21/23 JPMorgan Cofinimmo price target lowered to EUR 95 from EUR 100 at JPMorgan 02/07/23 Berenberg Cofinimmo price target lowered to EUR 110 from EUR 155 at Berenberg 01/23/23 UBS Cofinimmo price target lowered to EUR 105 from EUR 110 at UBS

Recommendations	Aedifica price target lowered to EUR 95 from EUR 105 at Berenberg » 14:42 05/31/23 05/31 14:42 05/31/23 14:42 AEDFF Aedifica $80.47 / + (+0.00%) Berenberg analyst Kai… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:42 Get Free Trial ShowHide Related Items >><< Street Research AEDFF Aedifica $80.47 / + (+0.00%) 03/13/23 Barclays Aedifica price target lowered to EUR 57 from EUR 60 at Barclays 02/08/23 Berenberg Aedifica price target lowered to EUR 110 from EUR 130 at Berenberg 01/23/23 UBS Aedifica price target lowered to EUR 105 from EUR 115 at UBS 11/24/22 Morgan Stanley Aedifica downgraded to Equal Weight from Overweight at Morgan Stanley
Periodicals	Google no longer supports original Chromecast, Verge reports » 14:41 05/31/23 05/31 14:41 05/31/23 14:41 GOOG Alphabet $123.74 / -0.93 (-0.75%) , GOOGL Alphabet $123.00 / -0.685 (-0.55%) Alphabet's Google is… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:41 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly Events Options GOOG GOOGL GOOG Alphabet $123.74 / -0.93 (-0.75%) 05/29/23 Fly Intel: Top five weekend stock stories 05/29/23 Nvidia announces DGX GH200 AI supercomputer 05/25/23 Google starts access to new generative AI capacity in Search 05/24/23 Pershing Square: In very early days of AI development GOOGL Alphabet $123.00 / -0.685 (-0.55%) 05/29/23 Fly Intel: Top five weekend stock stories 05/29/23 Nvidia announces DGX GH200 AI supercomputer 05/25/23 Google starts access to new generative AI capacity in Search 05/24/23 Pershing Square: In very early days of AI development GOOG GOOGL GOOG Alphabet $123.74 / -0.93 (-0.75%) 05/30/23 JPMorgan Google AI chip orders accelerating at Broadcom, says JPMorgan 05/30/23 KeyBanc Broadcom price target raised to $820 from $720 at KeyBanc 05/24/23 BofA Google's three pillars 'still upright' despite Bing in ChatGPT, says BofA 05/24/23 BofA Partnership with Waymo 'positive for Uber on several fronts,' says BofA GOOGL Alphabet $123.00 / -0.685 (-0.55%) 05/30/23 JPMorgan Google AI chip orders accelerating at Broadcom, says JPMorgan 05/30/23 KeyBanc Broadcom price target raised to $820 from $720 at KeyBanc 05/24/23 BofA Google's three pillars 'still upright' despite Bing in ChatGPT, says BofA 05/24/23 BofA Partnership with Waymo 'positive for Uber on several fronts,' says BofA GOOG GOOGL GOOG Alphabet $123.74 / -0.93 (-0.75%) 04/25/23 Alphabet reports Q1 EPS $1.17, consensus $1.07 04/25/23 Alphabet reports Q1 Google Cloud revenue $7.45B vs. $5.82B last year 04/25/23 Alphabet reports Q1 EPS $1.17, consensus $1.07 04/25/23 Notable companies reporting after market close GOOGL Alphabet $123.00 / -0.685 (-0.55%) 04/25/23 Alphabet reports Q1 EPS $1.17, consensus $1.07 04/25/23 Alphabet reports Q1 Google Cloud revenue $7.45B vs. $5.82B last year 04/25/23 Alphabet reports Q1 EPS $1.17, consensus $1.07 04/25/23 Notable companies reporting after market close GOOG GOOGL GOOG Alphabet $123.74 / -0.93 (-0.75%) 05:47 Today Google's Pixel Watch 2 to have Snapdragon W5 chip, 9to5Google reports 05/26/23 Google ordered to pay Sonos $32.5M in patent infringement case, Verge says 05/25/23 YouTube to shut down Stories on June 26 amid focus on Shorts, TechCrunch says 05/24/23 DoorDash sued in $1B lawsuit for charging iPhone users more, NY Post reports GOOGL Alphabet $123.00 / -0.685 (-0.55%) 05:47 Today Google's Pixel Watch 2 to have Snapdragon W5 chip, 9to5Google reports 05/26/23 Google ordered to pay Sonos $32.5M in patent infringement case, Verge says 05/25/23 YouTube to shut down Stories on June 26 amid focus on Shorts, TechCrunch says 05/24/23 DoorDash sued in $1B lawsuit for charging iPhone users more, NY Post reports GOOG GOOGL GOOG Alphabet $123.74 / -0.93 (-0.75%) 05/30/23 What You Missed On Wall Street This Morning 05/24/23 #SocialStocks: Meta fined EUR 1.2B in Ireland for infringing on data laws 05/17/23 #SocialStocks: Tech companies seek employees abroad after hiring freeze 05/15/23 What You Missed On Wall Street On Monday GOOGL Alphabet $123.00 / -0.685 (-0.55%) 05/30/23 What You Missed On Wall Street This Morning 05/24/23 #SocialStocks: Meta fined EUR 1.2B in Ireland for infringing on data laws 05/17/23 #SocialStocks: Tech companies seek employees abroad after hiring freeze 05/15/23 What You Missed On Wall Street On Monday 06/02/23 Alphabet Inc. CL A 06/02/23 Alphabet Inc. CL C GOOG GOOGL GOOG Alphabet $123.74 / -0.93 (-0.75%) 05/11/23 Unusually active option classes on open May 11th 04/25/23 Alphabet options imply 4.8% move in share price post-earnings 03/16/23 Alphabet call buyer realizes 17% same-day gains 02/28/23 Notable open interest changes for February 28th GOOGL Alphabet $123.00 / -0.685 (-0.55%) 05/22/23 Notable open interest changes for May 22nd 05/16/23 Early notable gainers among liquid option names on May 16th 05/15/23 Unusually active option classes on open May 15th 05/15/23 Notable open interest changes for May 15th
Options	Pure Storage options imply 8.3% move in share price post-earnings » 14:34 05/31/23 05/31 14:34 05/31/23 14:34 PSTG Pure Storage $28.85 / -0.565 (-1.92%) Pre-earnings options… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:34 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings On The Fly Events Options PSTG Pure Storage $28.85 / -0.565 (-1.92%) 03/02/23 Pure Storage falls -16.2% 03/02/23 Pure Storage falls -14.8% PSTG Pure Storage $28.85 / -0.565 (-1.92%) 04/06/23 Wedbush Wedbush upgrades Pure Storage to Outperform with $34 price target 04/06/23 Wedbush Pure Storage upgraded to Outperform from Neutral at Wedbush 03/02/23 Deutsche Bank Pure Storage price target lowered to $32 from $38 at Deutsche Bank 03/02/23 Lake Street Pure Storage price target lowered to $32 from $38 at Lake Street PSTG Pure Storage $28.85 / -0.565 (-1.92%) 12:57 Today Notable companies reporting after market close 03/01/23 Pure Storage sees FY24 revenue growth in mid- to high-single digits 03/01/23 Pure Storage reports Q4 non-GAAP EPS 53c, consensus 39c 03/01/23 Notable companies reporting after market close PSTG Pure Storage $28.85 / -0.565 (-1.92%) 04/06/23 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 03/02/23 What You Missed On Wall Street On Thursday 03/02/23 What You Missed On Wall Street This Morning 03/01/23 Fly Intel: After-Hours Movers 17:00 Today Pure Storage - PSTG 06/14/23 Pure Storage PSTG Pure Storage $28.85 / -0.565 (-1.92%) 05/26/23 Pure Storage call volume above normal and directionally bullish 05/25/23 Unusually active option classes on open May 25th 05/22/23 Pure Storage put volume heavy and directionally bearish 05/12/23 Pure Storage call volume above normal and directionally bullish
Hot Stocks	PG&E says criminal charges arising from 2020 Zogg Fire to be dismissed » 14:32 05/31/23 05/31 14:32 05/31/23 14:32 PCG PG&E $16.91 / +0.245 (+1.47%) Pacific Gas and Electric… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:32 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Syndicate Options PCG PG&E $16.91 / +0.245 (+1.47%) 05/15/23 Third Point buys Alibaba, cuts AIG in Q1 03/15/23 PG&E names Carolyn Burke as CFO, effective May 4 03/02/23 PG&E says NRC approves request related to continued operations at DCPP 02/14/23 Third Point buys AIG, exits T-Mobile in Q4 PCG PG&E $16.91 / +0.245 (+1.47%) 05/30/23 RBC Capital PG&E price target raised to $21 from $20 at RBC Capital 04/03/23 Ladenburg PG&E initiated with a Buy at Ladenburg 02/02/23 BofA Interactive Brokers, Knight-Swift, PG&E added to 'US 1' list at BofA 02/01/23 Wells Fargo Wells downgrades Edison International, recommends swap into PG&E PCG PG&E $16.91 / +0.245 (+1.47%) 05/04/23 PG&E backs FY23 EPS view $1.19-$1.23, consensus $1.21 05/04/23 PG&E reports Q1 EPS 29c, consensus 29c 02/23/23 PG&E backs FY23 EPS view $1.19-$1.23, consensus $1.22 02/23/23 PG&E reports Q4 core EPS 26c, consensus 28c 12 Apr 10 Jan 13 Dec 28 Oct 05 Oct PCG PG&E $16.91 / +0.245 (+1.47%) 05/17/23 PG&E call volume above normal and directionally bullish 02/24/23 Early notable gainers among liquid option names on February 24th 02/07/23 PG&E call volume above normal and directionally bullish 02/06/23 PG&E call volume above normal and directionally bullish
Earnings	Dow Inc. sees Q2 net sales $11.0B-$11.5B, consensus $12.12B » 14:29 05/31/23 05/31 14:29 05/31/23 14:29 DOW Dow Inc. $48.93 / -0.585 (-1.18%) Says in slides for… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 3rd, 14:29 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly Events Options DOW Dow Inc. $48.93 / -0.585 (-1.18%) 05/25/23 Dow Inc. and New Energy Blue collaborate to develop plastic materials from corn 04/25/23 Dow Inc. selects Linde as industrial gas partner for clean hydrogen, nitrogen 04/25/23 Dow Inc. expects benefit of operational, cost actions to continue through 2023 04/25/23 Dow Inc. reports Q1 operating EPS 71c, consensus 36c DOW Dow Inc. $48.93 / -0.585 (-1.18%) 04/27/23 BMO Capital Dow Inc. price target lowered to $58 from $65 at BMO Capital 04/26/23 Mizuho Dow Inc. price target raised to $53 from $45 at Mizuho 04/11/23 Piper Sandler Piper upgrades six chemical stocks on feedstock cost shifts 04/11/23 Piper Sandler Piper upgrades six chemical stocks on feedstock cost shifts DOW Dow Inc. $48.93 / -0.585 (-1.18%) 01/26/23 Dow Inc. reports Q4 operating EPS 46c, consensus 58c DOW Dow Inc. $48.93 / -0.585 (-1.18%) 02/18/23 Dow, Celanese among stocks to play future of plastic, Barron's says DOW Dow Inc. $48.93 / -0.585 (-1.18%) 04/12/23 What You Missed On Wall Street On Wednesday 04/12/23 What You Missed On Wall Street This Morning 04/12/23 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 03/20/23 What You Missed On Wall Street On Monday 07/25/23 Dow Inc. - DOW DOW Dow Inc. $48.93 / -0.585 (-1.18%) 05/02/23 Dow Chemical call volume above normal and directionally bullish 03/10/23 Dow Chemical call volume above normal and directionally bullish 01/30/23 Dow Chemical put volume heavy and directionally bearish 01/10/23 Dow Chemical put volume heavy and directionally bearish

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