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2023-03-22 08:43:50 PBLA Panbela Therapeutics / + 08:43 03/22/23 03/22 08:43 03/22/23 08:43	Panbela announces new patent in Japan for production of SBP-101 process Panbela Therapeutics announced an Issue Notification for patent JP 7232845 titled "METHODS FOR PRODUCING -3,8,13,18- TETRAAZAICOSANE-6,15-DIOL". This patent, developed in collaboration with Syngene International , an integrated research, development, and manufacturing services company, claims a novel process with a reduced number of synthetic steps from seventeen to six to produce SBP-101, a lead investigational product. The patent is valid till 2039. Jennifer K. Simpson, PhD, MSN, CRNP, President & Chief Executive Officer of Panbela Therapeutics, commented, "We're excited to have this patent in Japan. Expansion of our patent portfolio further supports our global clinical programs. This patent is the outcome of the dedicated efforts of our valued long-term partner Syngene International Ltd. in helping us achieve this important goal." First issued in the United States in 2021, this patent covers a shorter synthesis of SBP-101, which provides many benefits including: the ability to manufacture product with a reduced lead time quicker access to drug supply facilitating expansion into additional indications and 3 enables a scalable, efficient and cost-effective manufacturing process for future commercialization. Jonathan Hunt, Managing Director and Chief Executive Officer, Syngene International Ltd., said, "We have been partnering with Panbela for the last decade, and I am proud of the work achieved through the successful collaboration. In this case, reducing the number of steps in production and simplifying the manufacturing process means that the drug will reach patients faster. The protection of SBP-101 production through patents in the U.S. and now in Japan are significant milestones." Dr. Simpson added, "The Company expects to continue innovation and patent portfolio building to support our clinical programs. This process in this patent utilizes a pharmaceutical starting material that is widely available, increasing the availability of drug supply moving forward. "	26 Jan

2023-03-22 08:43:50

PBLA

Panbela Therapeutics

/ +

08:43

03/22/23

03/22

08:43

03/22/23

08:43

Panbela announces new patent in Japan for production of SBP-101 process

Panbela Therapeutics announced an Issue Notification for patent JP 7232845 titled "METHODS FOR PRODUCING -3,8,13,18- TETRAAZAICOSANE-6,15-DIOL". This patent, developed in collaboration with Syngene International , an integrated research, development, and manufacturing services company, claims a novel process with a reduced number of synthetic steps from seventeen to six to produce SBP-101, a lead investigational product. The patent is valid till 2039. Jennifer K. Simpson, PhD, MSN, CRNP, President & Chief Executive Officer of Panbela Therapeutics, commented, "We're excited to have this patent in Japan. Expansion of our patent portfolio further supports our global clinical programs. This patent is the outcome of the dedicated efforts of our valued long-term partner Syngene International Ltd. in helping us achieve this important goal." First issued in the United States in 2021, this patent covers a shorter synthesis of SBP-101, which provides many benefits including: the ability to manufacture product with a reduced lead time quicker access to drug supply facilitating expansion into additional indications and 3 enables a scalable, efficient and cost-effective manufacturing process for future commercialization. Jonathan Hunt, Managing Director and Chief Executive Officer, Syngene International Ltd., said, "We have been partnering with Panbela for the last decade, and I am proud of the work achieved through the successful collaboration. In this case, reducing the number of steps in production and simplifying the manufacturing process means that the drug will reach patients faster. The protection of SBP-101 production through patents in the U.S. and now in Japan are significant milestones." Dr. Simpson added, "The Company expects to continue innovation and patent portfolio building to support our clinical programs. This process in this patent utilizes a pharmaceutical starting material that is widely available, increasing the availability of drug supply moving forward. "

26
Jan

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Hot Stocks	Tilray's SweetWater Brewing launches SweetWater Spirits » 07:09 05/30/23 05/30 07:09 05/30/23 07:09 TLRY Tilray $1.86 / -0.495 (-21.02%) SweetWater Brewing… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:09 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly Options TLRY Tilray $1.86 / -0.495 (-21.02%) 05/26/23 Hexo announces ISS recommendation for arrangement with Tilray 05/25/23 Tilray's SweetWater Brewing announces summer release of American Lager 05/25/23 Tilray announces European market expansion in Italy 05/18/23 SweetWater Brewing introduces Colorado Orange Citrus Ale TLRY Tilray $1.86 / -0.495 (-21.02%) 04/12/23 Roth MKM Tilray price target lowered to $2.50 from $3.00 at Roth MKM 04/11/23 TD Cowen Tilray price target lowered to $5 from $9 at TD Cowen 01/10/23 MKM Partners Tilray price target lowered to $3 from $4 at MKM Partners 01/10/23 Canaccord Tilray price target lowered to $5 from $7 at Canaccord TLRY Tilray $1.86 / -0.495 (-21.02%) 04/10/23 Tilray reports Q3 EPS ($1.90) vs. 9c last year 01/09/23 Tilray reports Q2 adjusted EPS (6c) vs. (8c) last year TLRY Tilray $1.86 / -0.495 (-21.02%) 04/21/23 Booker says lawmakers to revive cannabis banking bill, Marijuana Moment says 04/10/23 Tilray to buy Hexo in deal worth about $250M, Bloomberg says 12/27/22 FDA explores regulating CBD in foods, supplements, WSJ reports 12/05/22 Defense bill with marijuana reform attached is delayed, Marijuana Moment says TLRY Tilray $1.86 / -0.495 (-21.02%) 05/26/23 What You Missed On Wall Street On Friday 05/26/23 What You Missed On Wall Street This Morning 05/11/23 Here's What You Missed in Cannabis, Psychedelics This Week 05/04/23 Here's What You Missed in Cannabis This Week TLRY Tilray $1.86 / -0.495 (-21.02%) 05/08/23 Largest borrow rate increases among liquid names 05/05/23 Unusually active option classes on open May 5th 04/28/23 Unusual call flow in option market yesterday 04/27/23 Cannabis stock implied volatilities move higher as sector climbs
Hot Stocks	Plug Power makes major strategic move into Finland's green hydrogen economy » 07:08 05/30/23 05/30 07:08 05/30/23 07:08 PLUG Plug Power $8.27 / -0.115 (-1.37%) Plug Power plans to… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:08 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings On The Fly Events Options PLUG Plug Power $8.27 / -0.115 (-1.37%) 05/22/23 Plug Power lands three five megawatt electrolyzer projects 05/09/23 Plug Power down 12% at $8.20 after Q1 earnings miss, below-consensus guidance 05/01/23 Plug Power unveils new high-power stationary fuel cell system 04/04/23 Plug Power manufactured 122MW of its 1MW electrolyzer stack platform in Q1 PLUG Plug Power $8.27 / -0.115 (-1.37%) 05/22/23 Piper Sandler Plug Power price target lowered to $8 from $10 at Piper Sandler 05/11/23 Truist Plug Power price target lowered to $9 from $11 at Truist 05/11/23 Northland Plug Power price target lowered to $13 from $25 at Northland 05/10/23 RBC Capital Plug Power price target lowered to $12 from $17 at RBC Capital PLUG Plug Power $8.27 / -0.115 (-1.37%) 05/09/23 Plug Power sees FY23 revenue $1.2B-$1.4B, consensus $1.34B 05/09/23 Plug Power sees FY24 revenue $1.2B-$1.4B, consensus $2.07B 05/09/23 Plug Power reports Q1 EPS (35c), consensus (26c) 03/01/23 Plug Power sees FY23 revenue $1.4B, consensus $1.37B PLUG Plug Power $8.27 / -0.115 (-1.37%) 05/27/23 Short Report: Bears reload on Mobileye after sharp gains in stock price 05/09/23 What You Missed On Wall Street This Morning 04/24/23 What You Missed This Week in EVs and Clean Energy 04/18/23 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 06/27/23 Plug Power Inc PLUG Plug Power $8.27 / -0.115 (-1.37%) 05/22/23 Unusually active option classes on open May 22nd 05/19/23 Plug Power call volume above normal and directionally bullish 05/18/23 Plug Power call volume above normal and directionally bullish 05/17/23 Plug Power call volume above normal and directionally bullish
Hot Stocks	Resolute Forest selling Thunder Bay pulp and paper mill » 07:08 05/30/23 05/30 07:08 05/30/23 07:08 RFP Resolute Forest $21.91 / + (+0.00%) Resolute Forest has… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:08 Get Free Trial ShowHide Related Items >><< Company News Street Research Options RFP Resolute Forest $21.91 / + (+0.00%) 12/28/22 Resolute, Paper Excellence merger gets Canadian Competition Bureau approval 12/19/22 Resolute Forest exec Minguez sells 47,594 common shares RFP Resolute Forest $21.91 / + (+0.00%) 02/27/23 Scotiabank Resolute Forest downgraded to Underperform from Sector Perform at Scotiabank 10/18/22 RBC Capital Resolute Forest downgraded to Sector Perform from Outperform at RBC Capital 10/18/22 RBC Capital Resolute Forest downgraded to Sector Perform from Outperform at RBC Capital 08/09/22 TD Securities Resolute Forest downgraded to Tender from Hold at TD Securities RFP Resolute Forest $21.91 / + (+0.00%) 03/21/23 Three new option listings and option delistings on March 21st
Initiation	Crispr Therapeutics resumed with an Outperform at William Blair » 07:07 05/30/23 05/30 07:07 05/30/23 07:07 CRSP Crispr Therapeutics $64.66 / +0.8 (+1.25%) William Blair resumed… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:07 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings On The Fly Events Options CRSP Crispr Therapeutics $64.66 / +0.8 (+1.25%) 04/27/23 Crispr Therapeutics CEO Kulkarni sells $1.3M in company shares 04/03/23 Vertex Pharmaceuticals, Crispr Therapeutics complete rolling BLAs to FDA 03/29/23 Crispr Therapeutics announces departure of board member 03/27/23 Vertex Pharmaceuticals, Crispr Therapeutics enter CRISPR/Cas9 licensing pact CRSP Crispr Therapeutics $64.66 / +0.8 (+1.25%) 05/23/23 Citi Crispr Therapeutics price target raised to $70 from $55 at Citi 05/09/23 Stifel Crispr Therapeutics price target lowered to $64 from $69 at Stifel 04/13/23 Cantor Fitzgerald Cantor starts Crispr Therapeutics at Overweight on commercialization chances 04/13/23 Cantor Fitzgerald Crispr Therapeutics initiated with an Overweight at Cantor Fitzgerald CRSP Crispr Therapeutics $64.66 / +0.8 (+1.25%) 05/08/23 Crispr Therapeutics reports Q1 EPS (67c), consensus ($1.70) 02/22/23 Crispr Therapeutics reports Q4 EPS ($1.41) vs. ($1.84) y/y CRSP Crispr Therapeutics $64.66 / +0.8 (+1.25%) 04/13/23 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 04/13/23 Fly Intel: Pre-market Movers 06/02/23 2023 ASCO Annual Meeting CRSP Crispr Therapeutics $64.66 / +0.8 (+1.25%) 05/26/23 Crispr Therapeutics put volume heavy and directionally bearish 05/11/23 Crispr Therapeutics put volume heavy and directionally bearish 05/09/23 Crispr Therapeutics call volume above normal and directionally bullish 05/08/23 Crispr Therapeutics options imply 4.2% move in share price post-earnings
Hot Stocks	Aurora Europe, Ethypharm chosen to supply dried medical cannabis flower » 07:07 05/30/23 05/30 07:07 05/30/23 07:07 ACB Aurora Cannabis / + Aurora Europe GmbH, a… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:07 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Periodicals On The Fly Options ACB Aurora Cannabis / + 04/27/23 Bipartisan lawmakers reintroduce Safe Banking Act for cannabis businesses 04/26/23 Aurora Cannabis partners with Strainprint for tracking program 04/17/23 Curaleaf spikes over 7% after NJ CRC Board reverses, okays adult use renewals 03/24/23 Aurora Cannabis announces Nasdaq notice of non-compliance ACB Aurora Cannabis / + 02/13/23 CIBC Aurora Cannabis price target lowered to C$1.75 from C$2.25 at CIBC 02/10/23 Canaccord Aurora Cannabis price target lowered to C$1.50 from C$2 at Canaccord 02/10/23 Canaccord Aurora Cannabis price target lowered to C$1.50 from C$2.00 at Canaccord 01/27/23 Stifel Aurora Cannabis price target lowered to C$1.45 from C$1.75 at Stifel ACB Aurora Cannabis / + 02/09/23 Aurora Cannabis reports Q2 adjusted EBITDA C$1.4M vs. (C$7.1M) a year ago 02/09/23 Aurora Cannabis reports Q2 revenue C$61.7M vs. C$60.6M a year ago ACB Aurora Cannabis / + 04/21/23 Booker says lawmakers to revive cannabis banking bill, Marijuana Moment says 12/27/22 FDA explores regulating CBD in foods, supplements, WSJ reports 12/05/22 Defense bill with marijuana reform attached is delayed, Marijuana Moment says ACB Aurora Cannabis / + 05/11/23 Here's What You Missed in Cannabis, Psychedelics This Week 05/04/23 Here's What You Missed in Cannabis This Week 04/20/23 Here's What You Missed in Cannabis This Week 04/13/23 Here's What You Missed in Cannabis This Week ACB Aurora Cannabis / + 05/24/23 Largest borrow rate increases among liquid names 05/23/23 Largest borrow rate increases among liquid names 05/22/23 Aurora Cannabis options imply 17.4% move in share price post-earnings 05/18/23 Aurora Cannabis options imply 11.0% move in share price post-earnings
Syndicate	Oculis offers to sell 5M shares of common stock » 07:07 05/30/23 05/30 07:07 05/30/23 07:07 OCS Oculis $11.62 / -0.48 (-3.97%) BofA Securities and SVB… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:07 Get Free Trial ShowHide Related Items >><< Company News Street Research On The Fly Events OCS Oculis $11.62 / -0.48 (-3.97%) 05/22/23 Oculis' OCS-01 eye drops meet efficacy endpoint in Phase 3 macular edema trial 04/26/23 Oculis opens new office in Boston, appoints Fang Li as SVP, regulatory affairs 04/04/23 Oculis to host call to discuss late-stage pipeline, near-term milestones 03/16/23 Oculis completes enrollment in Phase 3 OCS-01 OPTIMIZE trial OCS Oculis $11.62 / -0.48 (-3.97%) 05/10/23 Pareto Oculis initiated with a Buy at Pareto 04/28/23 Wedbush Oculis initiated with an Outperform at Wedbush OCS Oculis $11.62 / -0.48 (-3.97%) 04/28/23 Street Wrap: Today's Top 15 Upgrades, Downgrades, Initiations 08/02/23 Biotech/Biopharma

Hot Stocks	Atea Pharmaceuticals board rejects unsolicited proposal from Tang Capital » 07:06 05/30/23 05/30 07:06 05/30/23 07:06 AVIR Atea Pharmaceuticals $4.70 / +0.065 (+1.40%) Atea Pharmaceuticals… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:06 Get Free Trial ShowHide Related Items >><< Company News Earnings Events AVIR Atea Pharmaceuticals $4.70 / +0.065 (+1.40%) 05/23/23 Atea Pharmaceuticals confirms receipt of Concentra Biosciences proposal 05/22/23 Atea Pharmaceuticals up 37% after buyout offer from Tang Capital 05/22/23 Tang Capital reports 3.6% stake in Atea Pharmaceuticals 04/25/23 Atea Pharmaceuticals announces U.S. FDA FTD granted to bemnifosbuvir AVIR Atea Pharmaceuticals $4.70 / +0.065 (+1.40%) 05/08/23 Atea Pharmaceuticals reports Q1 EPS (43c), consensus (48c) 02/28/23 Atea Pharmaceuticals reports Q4 EPS (41c), consensus (45c) 06/16/23 Atea Pharmaceuticals, Inc.
Hot Stocks	Arcimoto announces availability of new Arcimoto MUV » 07:06 05/30/23 05/30 07:06 05/30/23 07:06 FUV Arcimoto $1.54 / +0.09 (+6.21%) Arcimoto announced the… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:06 Get Free Trial ShowHide Related Items >><< Company News Street Research Syndicate On The Fly Events FUV Arcimoto $1.54 / +0.09 (+6.21%) 05/09/23 Arcimoto announces strategic agreement with Faction Technology 04/20/23 Arcimoto appoints Chris Dawson as CEO 03/01/23 Arcimoto opens vehicles sales in 4 new states 02/21/23 Arcimoto to begin 2023 vehicle production for spring deliveries FUV Arcimoto $1.54 / +0.09 (+6.21%) 02/15/23 Dawson James Arcimoto upgraded to Neutral from Sell at Dawson James 12/01/22 Alliance Global Partners Arcimoto price target raised to $11 from $7 at Alliance Global Partners 09/06/22 Dawson James Arcimoto downgraded to Sell from Neutral at Dawson James 06/21/22 Dawson James Arcimoto producing more cars but still needs cash, says Dawson James 18 Jan FUV Arcimoto $1.54 / +0.09 (+6.21%) 01/17/23 Fly Intel: After-Hours Movers 06/16/23 Arcimoto, Inc.
Upgrade	Knot Offshore Partners upgraded to Buy from Neutral at Alliance Global Partners » 07:06 05/30/23 05/30 07:06 05/30/23 07:06 KNOP Knot Offshore Partners $4.81 / -0.035 (-0.72%) Alliance Global Partners… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:06 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings On The Fly KNOP Knot Offshore Partners $4.81 / -0.035 (-0.72%) 04/10/23 Knot Offshore Partners CEO, CFO Gary Chapman steps down 01/12/23 Knot Offshore Partners falls -37.9% 01/12/23 Knot Offshore Partners falls -43.3% 01/12/23 Knot Offshore Partners falls -40.5% KNOP Knot Offshore Partners $4.81 / -0.035 (-0.72%) 02/01/23 Alliance Global Partners Knot Offshore Partners upgraded to Neutral from Sell at Alliance Global Partners 01/12/23 Alliance Global Partners Knot Offshore Partners downgraded to Sell from Buy at Alliance Global Partners 01/06/23 B. Riley Knot Offshore Partners price target lowered to $15 from $22 at B. Riley 12/13/22 Alliance Global Partners Knot Offshore Partners initiated with a Buy at Alliance Global Partners KNOP Knot Offshore Partners $4.81 / -0.035 (-0.72%) 05/25/23 Knot Offshore Partners reports Q1 operating income $17.7M vs. $19.6M in Q4 KNOP Knot Offshore Partners $4.81 / -0.035 (-0.72%) 01/12/23 What You Missed On Wall Street On Thursday 01/12/23 What You Missed On Wall Street This Morning
Hot Stocks	Diebold signs debt restructuring agreement with key stakeholders » 07:05 05/30/23 05/30 07:05 05/30/23 07:05 DBD Diebold / + Diebold has entered into… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:05 Get Free Trial ShowHide Related Items >><< Company News Street Research Earnings Options DBD Diebold / + 05/05/23 Diebold receives continued listing standard notice from NYSE 03/21/23 Diebold confirms closing on $55M of additional liquidity 03/16/23 Diebold down 9%, sees risk to generating cash to sustain operating needs 02/06/23 Diebold announces Octavio Marquez was elected Chairman DBD Diebold / + 05/04/23 Wedbush Wedbush downgrades Diebold to Neutral, lowers price target to $1 05/04/23 Wedbush Diebold downgraded to Neutral from Outperform at Wedbush 03/17/23 Wedbush Wedbush keeps Outperform rating on Diebold after mid-quarter update 10/24/22 DA Davidson Diebold downgraded to Neutral from Buy at DA Davidson DBD Diebold / + 05/03/23 Diebold sees FY23 revenue $3.7B-$3.9B, consensus $3.82B 05/03/23 Diebold reports Q1 non-GAAP EPS (85c), consensus 7c 02/09/23 Diebold reports Q4 adjusted EPS 79c, consensus 38c DBD Diebold / + 04/11/23 Largest borrow rate increases among liquid names 04/10/23 Largest borrow rate increases among liquid names
Hot Stocks	Telesat Holdings selects SFL to manufacture LEO 3 demonstration satellite » 07:05 05/30/23 05/30 07:05 05/30/23 07:05 TSAT Telesat Holdings $6.91 / -0.34 (-4.69%) Telesat announced a… Story temporarily locked. To read stories as they happen please subscribe, Login above, or return on Jun 2nd, 07:05 Get Free Trial ShowHide Related Items >><< Company News Earnings TSAT Telesat Holdings $6.91 / -0.34 (-4.69%) 02/08/23 Mynaric delivers CONDOR Mk2terminals to Telesat Government Solutions 02/07/23 Telesat selected by Anuvu to provide antennas, ground-station infrastructure 12/19/22 Telesat Holdings appoints Harlow as President of Telesat Government Solutions 12/15/22 Spacecom completes testing campaign of Telesat's LEO demonstration satellite TSAT Telesat Holdings $6.91 / -0.34 (-4.69%) 05/11/23 Telesat Holdings sees 2023 revenue C$690M-C$710M 05/11/23 Telesat Holdings reports Q1 EPS C$0.60 vs. C$1.13 last year 03/29/23 Telesat Holdings sees FY23 revenue $690M-$710M 03/29/23 Telesat Holdings reports Q4 EPS C$1.76 vs C$1.28 last year

Events

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GLNG
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Golar LNG - GLNG Conference Calls
BNR
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Burning Rock Biotech - BNR Conference Calls
TIGR
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UP Fintech - TIGR Conference Calls
GOTU
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Gaotu Techedu - GOTU Conference Calls
TCRR
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TCR2 Therapeutics Inc. Firm Sponsored Meetings
YTRA
Today at 08:30

Yatra - YTRA Conference Calls
MDWD
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MediWound - MDWD Conference Calls
Today at 09:00

Case-Shiller Home Price Index: 20-City Unadjusted Y/Y: March 2023 Government Event
Today at 09:00

FHFA House Price Index M/M: March 2023 Government Event
Today at 09:00

FHFA House Price Index Y/Y: March 2023 Government Event

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Syndicate

This week’s upcoming IPOs and secondary offerings

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Not Priced

Mon	No deals
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Mon	No deals
Tues	No deals
Wed	AZTR X AZTR Azitra IPO Managers: ThinkEquity $4.50-5.50 2.4M Shares SXTP X SXTP 60 Degrees Pharmaceuticals IPO Managers: WallachBeth $4.30-6.30 1.415M Shares
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Panbela announces new patent in Japan for production of SBP-101 process

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