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IONS

Ionis Pharmaceuticals

$34.30 /

+0.575 (+1.71%)

, BIIB

Biogen

$270.29 /

+0.66 (+0.24%)

08:49
03/29/23
03/29
08:49
03/29/23
08:49

Ionis Pharmaceuticals' IONIS-MAPTRx shows tau reduction efficacy in Alzheimer's

Ionis Pharmaceuticals (IONS) reported that its partner Biogen (BIIB) presented new Phase 1b clinical data showing that IONIS-MAPTRx reduced soluble tau protein in cerebrospinal fluid in a dose-dependent and sustained manner in patients with early-stage Alzheimer's disease. IONIS-MAPTRx also reduced aggregated tau pathology in all brain composites assessed. The primary endpoint of the Phase 1b study and long-term extension study was safety and tolerability, with biomarker data as an exploratory endpoint. The accumulation of pathological tau tangles has been shown to promote neuronal damage and death. IONIS-MAPTRx is an investigational antisense medicine discovered by Ionis that is being developed by Biogen. It is designed to target microtubule-associated protein tau mRNA and prevent production of tau protein. In this study, the majority of adverse events were mild or moderate in severity, of which the most common were headache, back pain, and post-lumbar puncture syndrome. The results showed that IONIS-MAPTRx reduced biomarkers of soluble tau in CSF in a dose-dependent and sustained manner, with all dose groups showing approximately a 60% reduction from baseline CSF tau levels by the end of the LTE. The Phase 2 study of IONIS-MAPTRx is in progress and currently recruiting participants in the U.S.

IONS

Ionis Pharmaceuticals

$34.30 /

+0.575 (+1.71%)

BIIB

Biogen

$270.29 /

+0.66 (+0.24%)

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OTHER BREAKING NEWS FROM THE FLY

Recommendations
Hims & Hers price target lowered to $11 from $12 at Piper Sandler » 07:15
05/30/23
05/30
07:15
05/30/23
07:15
HIMS

Hims & Hers

$9.07 /

+0.03 (+0.33%)

Piper Sandler lowered the…

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HIMS Hims & Hers
$9.07 /

+0.03 (+0.33%)

HIMS Hims & Hers
$9.07 /

+0.03 (+0.33%)

05/09/23 SVB Securities
SVB Securities keeps Market Perform on Hims & Hers, raises price target to $11
05/09/23 BofA
Hims & Hers price target raised to $15 from $13.50 at BofA
05/09/23 Piper Sandler
Hims & Hers price target raised to $12 from $11 at Piper Sandler
05/09/23 Citi
Citi 'unbothered' by issues driving volatility in Hims & Hers shares
HIMS Hims & Hers
$9.07 /

+0.03 (+0.33%)

HIMS Hims & Hers
$9.07 /

+0.03 (+0.33%)

HIMS Hims & Hers
$9.07 /

+0.03 (+0.33%)

Hot Stocks
Clover Leaf Capital announces option agreement between North Shore, Skyharbour » 07:15
05/30/23
05/30
07:15
05/30/23
07:15
CLOE

Clover Leaf Capital

$11.26 /

+0.06 (+0.54%)

Clover Leaf Capital…

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CLOE Clover Leaf Capital
$11.26 /

+0.06 (+0.54%)

Hot Stocks
Protalix CEO issues letter to shareholders » 07:15
05/30/23
05/30
07:15
05/30/23
07:15
PLX

Protalix

$2.06 /

-0.035 (-1.67%)

Protalix announced the…

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PLX Protalix
$2.06 /

-0.035 (-1.67%)

PLX Protalix
$2.06 /

-0.035 (-1.67%)

PLX Protalix
$2.06 /

-0.035 (-1.67%)

General news
FX Action: » 07:15
05/30/23
05/30
07:15
05/30/23
07:15
$ECON

Economic Data

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Recommendations
Natera price target lowered to $70 from $80 at Piper Sandler » 07:14
05/30/23
05/30
07:14
05/30/23
07:14
NTRA

Natera

$48.66 /

+0.42 (+0.87%)

Piper Sandler analyst…

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NTRA Natera
$48.66 /

+0.42 (+0.87%)

NTRA Natera
$48.66 /

+0.42 (+0.87%)

05/10/23 Baird
Natera price target raised to $66 from $65 at Baird
05/10/23 Credit Suisse
Natera price target raised to $70 from $65 at Credit Suisse
05/05/23 UBS
Natera initiated with a Buy at UBS
03/30/23 Piper Sandler
Piper says inclusion of Natera's Signatera in NCCN guidelines 'matter of time'
NTRA Natera
$48.66 /

+0.42 (+0.87%)

  • 16
    Nov
NTRA Natera
$48.66 /

+0.42 (+0.87%)

Hot Stocks
NeoGenomics to showcase RaDaR Assay at ASCO meeting » 07:12
05/30/23
05/30
07:12
05/30/23
07:12
NEO

NeoGenomics

$17.27 /

-0.12 (-0.69%)

NeoGenomics announced new…

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NEO NeoGenomics
$17.27 /

-0.12 (-0.69%)

NEO NeoGenomics
$17.27 /

-0.12 (-0.69%)

05/16/23 Raymond James
NeoGenomics downgraded to Market Perform from Outperform at Raymond James
05/16/23 Raymond James
NeoGenomics downgraded to Market Perform from Outperform at Raymond James
05/15/23 Piper Sandler
NeoGenomics price target raised to $23 from $20 at Piper Sandler
05/09/23 TD Cowen
NeoGenomics price target raised to $22 from $20 at TD Cowen
NEO NeoGenomics
$17.27 /

-0.12 (-0.69%)

NEO NeoGenomics
$17.27 /

-0.12 (-0.69%)

Hot Stocks
Contango Ore to join Russell 3000 index » 07:12
05/30/23
05/30
07:12
05/30/23
07:12
CTGO

Contango Ore

$25.31 /

-0.79 (-3.03%)

Contango Ore announced…

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CTGO Contango Ore
$25.31 /

-0.79 (-3.03%)

10/31/22 Roth Capital
Contango Ore initiated with a Buy at Roth Capital
Hot Stocks
BeiGene: BRUKINSA approved by Health Canada for CLL treatment in adults » 07:11
05/30/23
05/30
07:11
05/30/23
07:11
BGNE

BeiGene

$236.64 /

+8.45 (+3.70%)

BeiGene announced that…

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BGNE BeiGene
$236.64 /

+8.45 (+3.70%)

BGNE BeiGene
$236.64 /

+8.45 (+3.70%)

04/12/23 BofA
BeiGene price target raised to $263.30 from $230.10 at BofA
03/17/23 Piper Sandler
Leap Therapeutics news 'disappointing at first glance,' says Piper Sandler
03/17/23 Mizuho
Leap Therapeutics price target lowered to $2 from $3 at Mizuho
02/28/23 Cowen
BeiGene price target raised to $262 from $213 at Cowen
BGNE BeiGene
$236.64 /

+8.45 (+3.70%)

BGNE BeiGene
$236.64 /

+8.45 (+3.70%)

BGNE BeiGene
$236.64 /

+8.45 (+3.70%)

Hot Stocks
PyroGenesis signs contract for five metric tons of titanium metal powder » 07:11
05/30/23
05/30
07:11
05/30/23
07:11
PYR

PyroGenesis

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PyroGenesis Canada…

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PYR PyroGenesis
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Hot Stocks
Asante Gold provides update on management cease trade order » 07:11
05/30/23
05/30
07:11
05/30/23
07:11
ASGOF

Asante Gold

$1.49 /

+ (+0.00%)

Asante Gold provided its…

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ASGOF Asante Gold
$1.49 /

+ (+0.00%)

ASGOF Asante Gold
$1.49 /

+ (+0.00%)

05/09/23 Canaccord
Asante Gold downgraded to Hold from Speculative Buy at Canaccord
04/21/23 Canaccord
Asante Gold price target lowered to C$2.20 from C$3 at Canaccord
Initiation
William Blair starts Vertex with Outperform, $382 fair value estimate » 07:10
05/30/23
05/30
07:10
05/30/23
07:10
VRTX

Vertex Pharmaceuticals

$329.89 /

-2.63 (-0.79%)

William Blair analyst…

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VRTX Vertex Pharmaceuticals
$329.89 /

-2.63 (-0.79%)

VRTX Vertex Pharmaceuticals
$329.89 /

-2.63 (-0.79%)

05:51 Today William Blair
Vertex Pharmaceuticals initiated with an Outperform at William Blair
05/25/23 WestPark Capital
Vertex Pharmaceuticals initiated with a Hold at WestPark Capital
05/04/23 Piper Sandler
Vertex Pharmaceuticals assumed with an Overweight at Piper Sandler
05/03/23 Maxim
Vertex Pharmaceuticals price target raised to $400 from $325 at Maxim
VRTX Vertex Pharmaceuticals
$329.89 /

-2.63 (-0.79%)

VRTX Vertex Pharmaceuticals
$329.89 /

-2.63 (-0.79%)

VRTX Vertex Pharmaceuticals
$329.89 /

-2.63 (-0.79%)

VRTX Vertex Pharmaceuticals
$329.89 /

-2.63 (-0.79%)

Hot Stocks
C4 Therapeutics, Betta enter exclusive licensing agreement for CFT8919 » 07:10
05/30/23
05/30
07:10
05/30/23
07:10
CCCC

C4 Therapeutics

$3.08 /

-0.015 (-0.48%)

C4 Therapeutics and Betta…

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CCCC C4 Therapeutics
$3.08 /

-0.015 (-0.48%)

CCCC C4 Therapeutics
$3.08 /

-0.015 (-0.48%)

06:35 Today Evercore ISI
C4 Therapeutics price target lowered to $10, transferred at Evercore ISI
05/08/23 H.C. Wainwright
C4 Therapeutics price target lowered to $25 from $35 at H.C. Wainwright
03/28/23 BofA
C4 Therapeutics price target lowered to $5 from $11 at BofA
02/24/23 Credit Suisse
Credit Suisse ups C4 Therapeutics to Neutral on 'dramatically' improved outlook
CCCC C4 Therapeutics
$3.08 /

-0.015 (-0.48%)

CCCC C4 Therapeutics
$3.08 /

-0.015 (-0.48%)

Hot Stocks
JBT Corporation to sell its AeroTech business to Oshkosh for $800M » 07:10
05/30/23
05/30
07:10
05/30/23
07:10
JBT

JBT Corporation

$105.75 /

+3.07 (+2.99%)

, OSK

Oshkosh

$73.89 /

-0.205 (-0.28%)

JBT Corporation (JBT)…

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OSK Oshkosh
$73.89 /

-0.205 (-0.28%)

JBT JBT Corporation
$105.75 /

+3.07 (+2.99%)

04/26/23 Baird
Baird bumps JBT Corporation price target to $128 after Q1 beat
11/02/22 BMO Capital
JBT Corporation price target lowered to $120 from $135 at BMO Capital
10/28/22 Baird
JBT Corporation price target lowered to $110 from $117 at Baird
10/27/22 Baird
JBT Corporation price target lowered to $110 from $117 at Baird
OSK Oshkosh
$73.89 /

-0.205 (-0.28%)

05/09/23 Evercore ISI
Oshkosh price target lowered to $82 from $89 at Evercore ISI
05/01/23 DA Davidson
Oshkosh price target lowered to $86 from $95 at DA Davidson
04/28/23 Stifel
Oshkosh price target lowered to $101 from $109 at Stifel
04/28/23 Credit Suisse
Oshkosh price target lowered to $96 from $113 at Credit Suisse
JBT JBT Corporation
$105.75 /

+3.07 (+2.99%)

OSK Oshkosh
$73.89 /

-0.205 (-0.28%)

OSK Oshkosh
$73.89 /

-0.205 (-0.28%)

General news
Oil Action: » 07:10
05/30/23
05/30
07:10
05/30/23
07:10
$ECON

Economic Data

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Oil Action: oil prices…

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$ECON Economic Data
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$ECON Economic Data
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$ECON Economic Data
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Hot Stocks
Tilray's SweetWater Brewing launches SweetWater Spirits » 07:09
05/30/23
05/30
07:09
05/30/23
07:09
TLRY

Tilray

$1.86 /

-0.495 (-21.02%)

SweetWater Brewing…

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TLRY Tilray
$1.86 /

-0.495 (-21.02%)

TLRY Tilray
$1.86 /

-0.495 (-21.02%)

04/12/23 Roth MKM
Tilray price target lowered to $2.50 from $3.00 at Roth MKM
04/11/23 TD Cowen
Tilray price target lowered to $5 from $9 at TD Cowen
01/10/23 MKM Partners
Tilray price target lowered to $3 from $4 at MKM Partners
01/10/23 Canaccord
Tilray price target lowered to $5 from $7 at Canaccord
TLRY Tilray
$1.86 /

-0.495 (-21.02%)

TLRY Tilray
$1.86 /

-0.495 (-21.02%)

TLRY Tilray
$1.86 /

-0.495 (-21.02%)

TLRY Tilray
$1.86 /

-0.495 (-21.02%)

Hot Stocks
Plug Power makes major strategic move into Finland's green hydrogen economy » 07:08
05/30/23
05/30
07:08
05/30/23
07:08
PLUG

Plug Power

$8.27 /

-0.115 (-1.37%)

Plug Power plans to…

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PLUG Plug Power
$8.27 /

-0.115 (-1.37%)

PLUG Plug Power
$8.27 /

-0.115 (-1.37%)

05/22/23 Piper Sandler
Plug Power price target lowered to $8 from $10 at Piper Sandler
05/11/23 Truist
Plug Power price target lowered to $9 from $11 at Truist
05/11/23 Northland
Plug Power price target lowered to $13 from $25 at Northland
05/10/23 RBC Capital
Plug Power price target lowered to $12 from $17 at RBC Capital
PLUG Plug Power
$8.27 /

-0.115 (-1.37%)

PLUG Plug Power
$8.27 /

-0.115 (-1.37%)

PLUG Plug Power
$8.27 /

-0.115 (-1.37%)

Hot Stocks
Resolute Forest selling Thunder Bay pulp and paper mill » 07:08
05/30/23
05/30
07:08
05/30/23
07:08
RFP

Resolute Forest

$21.91 /

+ (+0.00%)

Resolute Forest has…

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RFP Resolute Forest
$21.91 /

+ (+0.00%)

RFP Resolute Forest
$21.91 /

+ (+0.00%)

02/27/23 Scotiabank
Resolute Forest downgraded to Underperform from Sector Perform at Scotiabank
10/18/22 RBC Capital
Resolute Forest downgraded to Sector Perform from Outperform at RBC Capital
10/18/22 RBC Capital
Resolute Forest downgraded to Sector Perform from Outperform at RBC Capital
08/09/22 TD Securities
Resolute Forest downgraded to Tender from Hold at TD Securities
RFP Resolute Forest
$21.91 /

+ (+0.00%)

Initiation
Crispr Therapeutics resumed with an Outperform at William Blair » 07:07
05/30/23
05/30
07:07
05/30/23
07:07
CRSP

Crispr Therapeutics

$64.66 /

+0.8 (+1.25%)

William Blair resumed…

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CRSP Crispr Therapeutics
$64.66 /

+0.8 (+1.25%)

CRSP Crispr Therapeutics
$64.66 /

+0.8 (+1.25%)

05/23/23 Citi
Crispr Therapeutics price target raised to $70 from $55 at Citi
05/09/23 Stifel
Crispr Therapeutics price target lowered to $64 from $69 at Stifel
04/13/23 Cantor Fitzgerald
Cantor starts Crispr Therapeutics at Overweight on commercialization chances
04/13/23 Cantor Fitzgerald
Crispr Therapeutics initiated with an Overweight at Cantor Fitzgerald
CRSP Crispr Therapeutics
$64.66 /

+0.8 (+1.25%)

CRSP Crispr Therapeutics
$64.66 /

+0.8 (+1.25%)

CRSP Crispr Therapeutics
$64.66 /

+0.8 (+1.25%)

Hot Stocks
Aurora Europe, Ethypharm chosen to supply dried medical cannabis flower » 07:07
05/30/23
05/30
07:07
05/30/23
07:07
ACB

Aurora Cannabis

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Aurora Europe GmbH, a…

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ACB Aurora Cannabis
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ACB Aurora Cannabis
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02/13/23 CIBC
Aurora Cannabis price target lowered to C$1.75 from C$2.25 at CIBC
02/10/23 Canaccord
Aurora Cannabis price target lowered to C$1.50 from C$2 at Canaccord
02/10/23 Canaccord
Aurora Cannabis price target lowered to C$1.50 from C$2.00 at Canaccord
01/27/23 Stifel
Aurora Cannabis price target lowered to C$1.45 from C$1.75 at Stifel
ACB Aurora Cannabis
/

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ACB Aurora Cannabis
/

+

ACB Aurora Cannabis
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ACB Aurora Cannabis
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Syndicate
Oculis offers to sell 5M shares of common stock » 07:07
05/30/23
05/30
07:07
05/30/23
07:07
OCS

Oculis

$11.62 /

-0.48 (-3.97%)

BofA Securities and SVB…

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OCS Oculis
$11.62 /

-0.48 (-3.97%)

OCS Oculis
$11.62 /

-0.48 (-3.97%)

05/10/23 Pareto
Oculis initiated with a Buy at Pareto
04/28/23 Wedbush
Oculis initiated with an Outperform at Wedbush
OCS Oculis
$11.62 /

-0.48 (-3.97%)

Hot Stocks
Atea Pharmaceuticals board rejects unsolicited proposal from Tang Capital » 07:06
05/30/23
05/30
07:06
05/30/23
07:06
AVIR

Atea Pharmaceuticals

$4.70 /

+0.065 (+1.40%)

Atea Pharmaceuticals…

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AVIR Atea Pharmaceuticals
$4.70 /

+0.065 (+1.40%)

AVIR Atea Pharmaceuticals
$4.70 /

+0.065 (+1.40%)

Hot Stocks
Arcimoto announces availability of new Arcimoto MUV » 07:06
05/30/23
05/30
07:06
05/30/23
07:06
FUV

Arcimoto

$1.54 /

+0.09 (+6.21%)

Arcimoto announced the…

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FUV Arcimoto
$1.54 /

+0.09 (+6.21%)

FUV Arcimoto
$1.54 /

+0.09 (+6.21%)

02/15/23 Dawson James
Arcimoto upgraded to Neutral from Sell at Dawson James
12/01/22 Alliance Global Partners
Arcimoto price target raised to $11 from $7 at Alliance Global Partners
09/06/22 Dawson James
Arcimoto downgraded to Sell from Neutral at Dawson James
06/21/22 Dawson James
Arcimoto producing more cars but still needs cash, says Dawson James
  • 18
    Jan
FUV Arcimoto
$1.54 /

+0.09 (+6.21%)

Upgrade
Knot Offshore Partners upgraded to Buy from Neutral at Alliance Global Partners » 07:06
05/30/23
05/30
07:06
05/30/23
07:06
KNOP

Knot Offshore Partners

$4.81 /

-0.035 (-0.72%)

Alliance Global Partners…

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KNOP Knot Offshore Partners
$4.81 /

-0.035 (-0.72%)

KNOP Knot Offshore Partners
$4.81 /

-0.035 (-0.72%)

02/01/23 Alliance Global Partners
Knot Offshore Partners upgraded to Neutral from Sell at Alliance Global Partners
01/12/23 Alliance Global Partners
Knot Offshore Partners downgraded to Sell from Buy at Alliance Global Partners
01/06/23 B. Riley
Knot Offshore Partners price target lowered to $15 from $22 at B. Riley
12/13/22 Alliance Global Partners
Knot Offshore Partners initiated with a Buy at Alliance Global Partners
KNOP Knot Offshore Partners
$4.81 /

-0.035 (-0.72%)

KNOP Knot Offshore Partners
$4.81 /

-0.035 (-0.72%)

Hot Stocks
Diebold signs debt restructuring agreement with key stakeholders » 07:05
05/30/23
05/30
07:05
05/30/23
07:05
DBD

Diebold

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Diebold has entered into…

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DBD Diebold
/

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DBD Diebold
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05/04/23 Wedbush
Wedbush downgrades Diebold to Neutral, lowers price target to $1
05/04/23 Wedbush
Diebold downgraded to Neutral from Outperform at Wedbush
03/17/23 Wedbush
Wedbush keeps Outperform rating on Diebold after mid-quarter update
10/24/22 DA Davidson
Diebold downgraded to Neutral from Buy at DA Davidson
DBD Diebold
/

+

DBD Diebold
/

+

Hot Stocks
Telesat Holdings selects SFL to manufacture LEO 3 demonstration satellite » 07:05
05/30/23
05/30
07:05
05/30/23
07:05
TSAT

Telesat Holdings

$6.91 /

-0.34 (-4.69%)

Telesat announced a…

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TSAT Telesat Holdings
$6.91 /

-0.34 (-4.69%)

TSAT Telesat Holdings
$6.91 /

-0.34 (-4.69%)

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