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ALNY

Alnylam

$34.27

-1.94 (-5.36%)

07:02
10/10/16
10/10
07:02
10/10/16
07:02

Alnylam: DMC recommends continuation of APOLLO Phase 3 trial

Alnylam Pharmaceuticals announced that the Data Monitoring Committee, or DMC, for the Phase 3 APOLLO study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy met on October 7, 2016 and recommended continuation of the trial without modification. The APOLLO DMC met at the request of the company following the decision - announced on October 5, 2016 - to discontinue development of revusiran for the treatment of hereditary ATTR amyloidosis with cardiomyopathy. The DMC will continue to meet periodically per their remit to monitor the overall safety of patisiran in the APOLLO study through its completion. The APOLLO study has completed enrollment of 225 patients at 44 sites in 19 countries, between December 2013 and January 2016.

  • 14

    Oct

  • 06

    Nov

ALNY Alnylam
$34.27

-1.94 (-5.36%)

10/06/16
COWN
10/06/16
NO CHANGE
Target $100
COWN
Outperform
Alnylam price target lowered to $100 from $150 at Cowen
Cowen analyst Ritu Baral noted Alnylam announced the discontinuation of revusiran for the treatment of hereditary ATTR amyloidosis with cardiomyopathy due to risk/benefit and safety signals. The analyst does not believe it signals any risk to the platform, as other programs have shown solid safety. Baral said revusiran was a minor driver so she maintained her Outperform rating and lowered her price target to $100 from $150 on Alnylam shares.
10/06/16
BMOC
10/06/16
UPGRADE
BMOC
Outperform
Ionis Pharmaceuticals upgraded on reduced competition, valuation at BMO Capital
As noted earlier, BMO Capital upgraded Ionis (IONS) to Outperform from Market Perform. After Alnylam (ALNY) announced that it was discontinuing one of its Phase III RNAi drugs due to poor clinical outcomes, BMO Capital analyst Do Kim expects Ionis to benefit from the reduced competition. Kim recommends buying Ionis' stock on weakness today. Target to $48 from $42.
10/07/16
MSCO
10/07/16
DOWNGRADE
MSCO
Equal Weight
Alnylam downgraded to Equal Weight from Overweight at Morgan Stanley
10/07/16
MSCO
10/07/16
DOWNGRADE
Target $36
MSCO
Equal Weight
Alnylam downgraded to Equal Weight from Overweight at Morgan Stanley
Morgan Stanley analyst David Lebowitz downgraded Alnylam Pharmaceuticals after the company discontinued development of revusiran. The analyst removed Alnylam from its model and cut its price target to $36 from $93 on shares.

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