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SGYP

Synergy Pharmaceuticals

$5.68

-0.11 (-1.90%)

16:44
03/01/17
03/01
16:44
03/01/17
16:44

Synergy Pharmaceuticals sees presenting more Phase 3 IBS-C data later in 2017

"In December 2016, we announced positive top-line results in the two Phase 3 clinical trials of TRULANCE for the treatment of adults with IBS-C," the company said. "In both trials, TRULANCE met the study's primary endpoint showing statistical significance in the percentage of patients who were overall responders compared to placebo during the 12-week treatment period. An Overall Responder, as defined by the FDA, is a patient who fulfills both greater than or equal to 30% reduction in worst abdominal pain and an increase of greater than or equal to 1 complete spontaneous bowel movement from baseline, in the same week, for at least 50% of the 12 treatment weeks. This is the current primary endpoint required for FDA approval in IBS-C. In both studies, the most common adverse event was diarrhea. We plan to file a new drug application supplement with clinical data in the first quarter of 2017 and expect a 10-month review period from submission. We plan to present additional Phase 3 data from the two IBS-C trials at an appropriate scientific meeting later this year."

  • 21

    Mar

SGYP Synergy Pharmaceuticals
$5.68

-0.11 (-1.90%)

01/23/17
ROTH
01/23/17
NO CHANGE
Target $10.5
ROTH
Buy
Synergy Pharmaceuticals price target raised to $10.50 from $6.50 at Roth Capital
Roth Capital analyst Michael Higgins raised his price target for Synergy Pharmaceuticals (SGYP) to $10.50 from $6.50 after the FDA approved Trulance for the treatment of adults with chronic idiopathic constipation, and due to Synergy Pharmaceuticals lowered risk profile and to better align with the valuation of its peer Ironwood Pharmaceuticals (IRWD). He reiterates a Buy rating on Synergy Pharmaceuticals' shares.
02/22/17
PIPR
02/22/17
NO CHANGE
Target $205
PIPR
Neutral
Piper physician survey a 'mixed bag' for Allergan's Linzess
Piper Jaffray analyst David Amsellem says his firm's survey of 39 physicians is a "mixed bag" for Allergan's (AGN) Linzess. The feedback from doctors suggest that the prospects for double-digit annual volume growth for Linzess over the long-term "are not nearly as strong as sentiment in the broader investor community would suggest," Amsellem tells investors in a research note. A bulk of the respondents have a favorable view of Linzess but also "misgivings regarding the incidence of diarrhea," the analyst adds. Further, Amsellem does not conclude that Synergy Pharmaceuticals' (SGYP) recently approved Trulance in chronic idiopathic constipation is the "poor man's Lizness." The lower incidence of diarrhea associated with Trulance does not necessarily mean that it is a less potent agent, the analyst contends. He keeps a Neutral rating on Allergan with a $205 price target.
02/22/17
WELS
02/22/17
NO CHANGE
WELS
Underperform
Wells thinks 50-plus salespeople just left Valeant for Synergy
Wells Fargo analyst David Maris says he asked Valeant Pharmaceuticals (VRX) whether industry speculation is true regarding the company losing 50-plus gastrointestinal salespeople to Synergy Pharmaceuticals (SGYP) following the latter's recent FDA approval. Valeant indicated that a number of salespeople have left but would not confirm how many, Maris tells investors in a research note. The analyst adds that Synergy would only comment that it has been very successful in hiring a large number of experienced salespeople. The loss of 50-plus salespeople would be another setback to the Salix/gastrointestinal salesforce at a time when prescription trends on Xifaxan are already weak, Maris contends. The analyst also learned that the son of Valeant CEO Joseph Papa joined Valeant in September 2016 as a product manager for Xifaxan, the company's largest product. Maris says Valeant acknowledged that several investors have already raised the matter. Maris has an Underperform rating on the shares, which closed the trading day down 4c to $16.35.
02/24/17
WELS
02/24/17
NO CHANGE
WELS
Wells says new Valeant is not new, calls shares overvalued
The market is underestimating Valeant Pharmaceuticals' "poor" prescription trends, reliance on price, employee turnover, execution risk on product launches, patent expiries including Xifaxan and numerous lawsuits, Wells Fargo analyst David Maris tells investors in a research note titled "Deja Valeant--We See History Repeating Itself." The stock is overvalued, and despite management wanting to talk about the "new Valeant," the company's business trends and pricing-driven model remain "old Valeant," Maris contends. He cut his Q4 earnings per share estimate for the company to $1.48 from $1.48, 2017 estimate to $5.03 from $5.14 and 2018 estimate to $5.45 from $5.91. His Q4 estimate remains well above the consensus of $1.22. Maris points out that since the new management team took over in 2016, Valeant set and then lowered guidance, raised prices on more than 50 products, missed key launch targets, had manufacturing issues and saw prescription declines continue. On the positive front, the company has sold $2.3B of assets, the analyst points out. Maris, who wrote this week that Valeant likely just lost 50-plus salespeople to Synergy Pharmaceuticals (SGYP), keeps an Underperform rating on Valeant with a $10-$13 price target range. The drugmaker closed yesterday at $16.58.

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Cisco

$35.90

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MKSI

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UQM

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