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IMGN

ImmunoGen

$3.37

-0.03 (-0.88%)

16:47
03/01/17
03/01
16:47
03/01/17
16:47

ImmunoGen announces presentations for AACR conference

ImmunoGen announced that nine abstracts will be presented at the upcoming American Association of Cancer Research Annual Meeting April 1-5. The title of the presentations include: "Bystander activity and in vivo efficacy of a folate receptor alpha-targeting antibody-drug conjugate with a novel peptide linker," for which the company commented that "M9346A-NL-DM is a novel ADC, employing a new linker, with enhanced bystander activity and anti-tumor activity"; "Peptide-cleavable maytansinoid induce high bystander killing leading to improved anti-tumor activity in vivo," for which the company commented that "a new promising type of maytansinoid ADC provides a high degree of bystander killing, improved activity in tumor models in vivo"; "Antibody-drug conjugates of peptide-linked Indolino-Benzodiazepine DNA-alkylator provides improved anti-tumor activity over that of a crosslinker," for which the company commented that "preclinical research shows that DNA-alkylating IGNs provide improved anti-tumor activity over that of a DNA-crosslinking ADC"; "Target validation, antibody discovery and preclinical data supporting ADAM9 as an antibody-drug conjugate therapeutic target for solid tumors," for which the company commented that "these data demonstrate that anti-ADAM9 ADCs exhibit antitumor activity against a broad panel of ADAM9-positive malignancies and cause durable remissions in preclinical models at doses expected to be clinically achievable"; "In vitro and in vivo activity of a novel c-Met-targeting antibody-drug conjugate," for which the company commented that "an anti-cMet antibody conjugated with the payload DGN549 exhibits compelling, c-Met targeted anti-cancer activity in vitro and in vivo"; "A novel CD19-targeting antibody-drug conjugate, huB4-DGN462, shows promising in vitro and in vivo activity in CD19-positive lymphoma models ," for which the company commented that "a novel CD19-targeting ADC presents strong preclinical anti-lymphoma activity"; and "Increased internalization and processing of the CD37-targeting antibody-drug conjugate, naratuximab emtansine IMGN529, in the presence of rituximab leads to enhanced potency in diffuse large B-cell lymphoma models," for which the company commented that "data show enhanced activity of rituximab plus IMGN529 combination in DLBCL models, supporting the clinical development of this combination."

  • 06

    Mar

IMGN ImmunoGen
$3.37

-0.03 (-0.88%)

04/29/16
RBCM
04/29/16
DOWNGRADE
RBCM
Sector Perform
ImmunoGen downgraded to Sector Perform from Outperform at RBC Capital
05/02/16
RBCM
05/02/16
DOWNGRADE
RBCM
Sector Perform
ImmunoGen downgraded on data shortfall at RBC Capital
As noted earlier, RBC Capital downgraded ImmunoGen to Sector Perform from Outperform. The firm notes that the company's "lead asset mirvetuximab soravtansine produced lower than previously reported response rates in ovarian cancer." RBC adds that the company, without consulting with the FDA, decided not to seek accelerated approval for the drug. The firm thinks that the risk facing the drug has increased significantly. Target to $7 from $18.
05/02/16
05/02/16
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Seagate (STX) downgraded to Underweight at JPMorgan by analyst Rod Hall, who said the company's fundamentals continue to deteriorate following its "weak" Q3 results. The analyst believes the current dividend is unsustainable. Hall sees structural weakness in end-market demand amid weak PC sales. The company was also downgraded to Sector Perform at RBC Capital after the firm called the company's results and guidance disappointing, and says that its 2017 EPS guidance is aggressive. 2. Arrow Electronics (ARW), Avnet (AVT) and Tech Data (TECD) were double downgraded to Sell while SYNNEX (SNX) was double downgraded to Neutral at Citi with analyst Jim Suva citing early evidence that the cloud is increasingly starting to disrupt traditional IT distributors. The analyst adds that Information Technology spending has increasingly shifted to the cloud, which makes consensus estimates for IT distributors too high. 3. Groupon (GRPN) downgraded to Underperform at RBC Capital by analyst Mark Mahaney, who said the company's Q1 results highlighted "deteriorating fundamentals" and "substantial challenges" going forward. Mahaney said growth in North America revenue, gross profit, local billings and units all decelerated in Q1. 4. ImmunoGen (IMGN) downgraded to Sector Perform at RBC Capital because the firm notes that the company's "lead asset mirvetuximab soravtansine produced lower than previously reported response rates in ovarian cancer." RBC adds that the company, without consulting with the FDA, decided not to seek accelerated approval for the drug. 5. Eastman Chemical (EMN) downgraded to Underperform from Buy at CLSA by analyst Nils-Bertil Wallin recommending taking profits in shares given weaker guidance, an anemic global economy, potential ethylene oversupply, and difficult market to sell ethylene assets. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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