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MRK

Merck

16:16
06/12/17
06/12
16:16
06/12/17
16:16

Merck issues update on two Keytruda studies, says pauses enrollment

Merck provided an update on two combination studies of KEYTRUDA, the company's anti-PD-1 therapy, in the blood cancer multiple myeloma. Merck has accepted the external Data Monitoring Committee recommendation to pause new enrollment on KEYNOTE-183 and KEYNOTE-185, two studies exploring KEYTRUDA treatment in combination with other therapies in multiple myeloma. "The pause is to allow for additional information to be collected to better understand more reports of death in the KEYTRUDA groups," the company said. Patients currently enrolled in these two studies will continue to receive treatment. Other studies of KEYTRUDA continue unchanged. KEYNOTE-183 is a Phase 3 study comparing pomalidomide and low-dose dexamethasone with KEYTRUDA to pomalidomide and low-dose dexamethasone alone in patients with refractory or relapsed and refractory multiple myeloma who have undergone at least 2 lines of prior treatment. KEYNOTE-185 is a Phase 3 study comparing lenalidomide and low-dose dexamethasone with KEYTRUDA to lenalidomide and low-dose dexamethasone alone in patients with newly diagnosed and treatment-naive multiple myeloma who are ineligible for autologous stem cell transplant.

  • 14

    Jun

  • 22

    Sep

MRK Merck

05/22/17
ADAM
05/22/17
NO CHANGE
Target $85
ADAM
Buy
CV events 'may kill' Amgen's romosozumab development, says Canaccord
Canaccord analyst John Newman said Amgen (AMGN) and partner UCB's report of a higher rate of cardiovascular Serious Adverse Events for romosozumab in the Phase 3 ARCH study in osteoporosis suggests a much lower chance of FDA approval for the drug and may "kill" romosozumab's development. He notes that Merck's (MRK) cathepsin-K inhibitor was previously discontinued due to increased risk of atrial fibrillation and stroke. In addition to the safety signals, Newman points out that romosozumab was worse than Radius' (RDUS) Tymlos for non-vertebral fracture and for vertebral fracture, suggesting Radius' drug also has much better efficacy, said the analyst, who keeps a Buy rating and $85 price target on Radius Health shares, which are up $4.47, or 12.8%, to $39.40 in pre-market trading.
06/05/17
PIPR
06/05/17
NO CHANGE
PIPR
Piper views AstraZeneca, J&J as ASCO standouts
The standouts at ASCO over the weekend were the "compelling results" presented on Johnson & Johnson's (JNJ) Zytiga from the Latitude study in prostate cancer and AstraZeneca's (AZN) Lynparza in the OlympiAD trial in BRCA mutant breast cancer, Piper Jaffray analyst Richard Purkiss tells investors in a research note. In lung cancer, Merck's (MRK) updated data in KN021G "appears more promising" than Bristol-Myers' (BMY) updated data in CM012, the analyst adds. Purkiss believes, however, that relative to recent ASCOs, the data "so far in totality is underwhelming."
06/06/17
WELS
06/06/17
NO CHANGE
WELS
Amazon may be the next threat to drug pricing, says Wells Fargo
After CNBC recently reported that Amazon (AMZN) is considering going into the prescription pharmacy business in the U.S., Wells Fargo surveyed nearly 2,900 U.S. adults and found that 54% of those polled said they would use or would probably use "Amazon Pharmacy." While the e-commerce giant has not confirmed its U.S. pharmacy interest, if it did enter the market analyst David Maris believes it could see fast adoption and "usher in a new age of price transparency." Maris also wonders if pharmacy "may be just the beginning" and if Amazon eyes the "even larger prize" of fully integrated digital healthcare. Publicly traded large-cap pharmaceuticals companies include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY). Publicly traded retail pharmacy operators include CVS Health (CVS), Walgreens (WBA), Fred's (FRED) and Rite Aid (RAD).
06/06/17
BMOC
06/06/17
NO CHANGE
BMOC
Incyte should be bought on recent weakness, says BMO Capital
BMO Capital analyst M. Ian Somaiya says that data on the combination of Bristol-Myers' (BMY) Opdivo and Incyte's (INCY) epacadostat "confirmed the benefit" seen in a previous study. The analyst says that the safety of Merck's (MRK) Keytruda in combination with epacadostat is better than the standard of care. He keeps a $166 price target and Outperform rating on Incyte.

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MRDN

Meridian Waste Solutions

$1.69

0.0101 (0.60%)

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Breaking Syndicate news story on Meridian Waste Solutions »

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APD

Air Products

$161.62

-0.67 (-0.41%)

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Breaking Syndicate news story on Air Products »

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BOOT

Boot Barn

$13.49

-0.23 (-1.68%)

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SD

SandRidge Energy

$17.50

0.88 (5.29%)

, BCEI

Bonanza Creek

$32.14

0.46 (1.45%)

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SandRidge Energy

$17.50

0.88 (5.29%)

BCEI

Bonanza Creek

$32.14

0.46 (1.45%)

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SD

SandRidge Energy

$17.50

0.88 (5.29%)

16:35
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Icahn reports 13.51% stake in SandRidge Energy, intends to vote against Bonanza »

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SYMC

Symantec

$28.43

0.32 (1.14%)

, AMZN

Amazon.com

$1,156.16

16.67 (1.46%)

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Symantec

$28.43

0.32 (1.14%)

AMZN

Amazon.com

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16.67 (1.46%)

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16:30
11/22/17
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16:30
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16:30
Options
Preliminary option volume of 13.6M today »

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AMZN

Amazon.com

$1,156.16

16.67 (1.46%)

16:26
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16:26
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Amazon Web Services announces Amazon ML Solutions Lab program »

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  • 18

    Mar

NRIM

Northrim BanCorp

$34.75

-0.25 (-0.71%)

16:22
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Northrim BanCorp announces CFO transition »

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AMZN

Amazon.com

$1,156.16

16.67 (1.46%)

, CERN

Cerner

$70.03

3.35 (5.02%)

16:21
11/22/17
11/22
16:21
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16:21
General news
On The Fly: Top stock stories for Wednesday »

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AMZN

Amazon.com

$1,156.16

16.67 (1.46%)

CERN

Cerner

$70.03

3.35 (5.02%)

HPE

HP Enterprise

$13.10

-1.02 (-7.22%)

HPQ

HP Inc.

$21.34

-1.12 (-4.99%)

DE

Deere

$145.25

6.02 (4.32%)

ROK

Rockwell Automation

$191.02

-2 (-1.04%)

EMR

Emerson

$61.88

1.53 (2.54%)

AKZOY

AkzoNobel

$31.04

0.475 (1.55%)

AXTA

Axalta Coating

$35.50

1.63 (4.81%)

GME

GameStop

$17.37

0.64 (3.83%)

GES

Guess

$15.62

-2.33 (-12.98%)

IRBT

iRobot

$68.50

-4.57 (-6.25%)

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  • 22

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  • 18

    Mar

CHMI

Cherry Hill Mortgage

$18.51

0.06 (0.33%)

16:21
11/22/17
11/22
16:21
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16:21
Syndicate
Breaking Syndicate news story on Cherry Hill Mortgage »

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NKTR

Nektar

$49.75

-0.23 (-0.46%)

16:20
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Nektar names new CRDO, CMO and CSO »

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VIX

Volatility Index S&P 500 Options

16:20
11/22/17
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Options
Closing CBOE SPX and VIX Index summary for November 22nd »

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VGZ

Vista Gold

$0.68

0.0069 (1.03%)

16:18
11/22/17
11/22
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16:18
Syndicate
Vista Gold enters $10M ATM agreement with H.C. Wainwright & Co. »

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GPX

GP Strategies

$23.50

-0.2 (-0.84%)

16:17
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GP Strategies announces $10M share repurchase increase »

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  • 29

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$NSD

NASDAQ Market Internals

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16:17
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NASDAQ market internals summary »

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GPX

GP Strategies

$23.50

-0.2 (-0.84%)

16:16
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GP Strategies names Michael Dugan as new CFO »

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  • 29

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$NYE

NYSE Market Internals

16:16
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16:16
Technical Analysis
NYSE market internals summary »

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FPP

FieldPoint Petroleum

$0.25

-0.015 (-5.77%)

16:13
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FieldPoint Petroleum to be suspended, pending delisting from NYSE American »

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AVA

Avista

$51.70

0.145 (0.28%)

16:12
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Avista names Kevin Christie CCO, Dennis Vermillion President »

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CWBR

CohBar, Inc.

16:11
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11/22
16:11
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16:11
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Breaking Syndicate news story on CohBar, Inc. »

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HTBX

Heat Biologics

$0.44

-0.0045 (-1.01%)

16:08
11/22/17
11/22
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16:08
Syndicate
Heat Biologics requests withdrawal of registration statement »

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TMST

TimkenSteel

$14.65

0.16 (1.10%)

16:06
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TimkenSteel and United Steelworkers reach tentative four-year agreement »

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AMNB

American National Bankshares

$39.00

-0.5 (-1.27%)

16:06
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11/22
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16:06
Hot Stocks
American National Bankshares raises quarterly dividend to 25c from 24c »

The dividend is payable…

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BMWYY

BMW

$34.10

0.09 (0.26%)

16:04
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11/22
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16:04
Periodicals
BMW to recall all i3 electric vehicles, Automotive News reports »

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