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MASI

Masimo

$91.11

0.26 (0.29%)

08:13
06/19/17
06/19
08:13
06/19/17
08:13

Masimo announces findings from Next Generation SedLine PSi study

Masimo announced the findings of an abstract presented at Euroanaesthesia 2017 in Geneva, Switzerland. In the study, researchers at University Medical Center Groningen, Netherlands, compared original and Next Generation versions of Masimo Patient State Index during Masimo SedLine brain function monitoring of patients under propofol and sevoflurane anesthesia. SedLine brain function monitoring features four simultaneous EEG leads to enable continuous assessment of both sides of the brain, four EEG waveforms, a Density Spectral Array, and PSi. Next Generation SedLine enhances PSi to make it less susceptible to electromyographic interference and to improve its performance in low-power EEG cases. In the study, Dr. Kuizenga and colleagues sought to compare the original and Next Generation PSi algorithms, referred to as PSi-1 and PSi-2, respectively, as they correlated with propofol and sevoflurane drug concentrations and with the Modified Observers Assessment of Alertness and Sedation scale. They also sought to assess the influence of 2 and 4 ng/mL effect-site concentrations of remifentanil on the performance of the two algorithms. The researchers enrolled 36 healthy volunteers, stratified by age, and assigned them randomly to a sequence of four sessions of anesthesia. In one session, propofol was administered in a series of graded steps; in the second, sevoflurane was similarly administered; in the third and fourth, the two concentrations of remifentanil were also administered. During each step of each session, after a twelve-minute delay for equilibration, MOAAS was tested and a blood sample was taken to measure drug concentrations. EEG was collected using Masimo Root with SedLine, from which time-synchronized PSi-1 and PSi-2 values were later extracted. The researchers then plotted MOAAS, drug concentration, PSi-1, and PSi-2 values over time. The researchers found that when charted against drug concentrations, PSi-2 showed "reduced population variability and improved baseline stability" compared to PSi-1. When charted against MOAAS, PSi-2 had "lower interindividual variability" than PSi-1. They also noted that "Both PSis distinguish MOAAS 5, 4, and 3 better during propofol anesthesia compared to sevoflurane. This difference disappears when adding remifentanil." The investigators concluded that "PSi-2 has enhanced signal stability and a better description of the dose-response relationship. PSi-2 has therefore improved capacity as a pharmacodynamic monitor of anesthesia compared to PSi-1." Next Generation SedLine has not received FDA 510(k) clearance and is not available for sale in the U.S.

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MASI Masimo
$91.11

0.26 (0.29%)

05/05/17
ROTH
05/05/17
NO CHANGE
Target $99
ROTH
Buy
Masimo price target lowered to $99 from $104 at Roth Capital
Roth Capital analyst Chris Lewis lowered his price target for Masimo to $99 from $104 noting that the stock was down despite "solid results," and saying he sees the reaction as possibly a "healthy reset" given the stock's run and heightened valuation. The analyst reiterates a Buy rating on the shares.
04/04/17
WEDB
04/04/17
NO CHANGE
WEDB
Masimo price target raised to $100 from $95 at Wedbush
Wedbush analyst Tao Levy raised the estimates on Masimo citing the significant increase in the intensity of this year's flu season versus last year's. The analyst raised the price target on the shares to $100 from $95 and keeps an Outperform rating on the stock.
03/21/17
ROTH
03/21/17
NO CHANGE
Target $104
ROTH
Buy
Masimo price target raised to $104 from $88 at Roth Capital
Roth Capital analyst Chris Lewis raised his price target for Masimo (MASI) to $104 from $88 after hosting a fireside discussion with the company's CEO and Chairman Joe Kiani, and EVP and CFO Mark de Raad. The analyst has a reaffirmed bullish outlook on Masimo, supported by the Philips (PHG) strategic partnership, elevated Core SET growth outlook, new parameter market opportunities, and his expectation for a continued focus on driving "strong earnings growth." He reiterates a Buy rating on Masimo's shares.
03/16/17
PIPR
03/16/17
DOWNGRADE
PIPR
Neutral
Masimo downgraded to Neutral from Overweight at Piper Jaffray
Piper Jaffray analyst William Quirk downgraded Masimo to Neutral citing valuation with the shares up 146% since the company announced a new CEO compensation package at the beginning of 2016 incentivizing a sale of the company. The analyst believes takeout expectations are justified, but his valuation models suggest limited upside from here. He keeps an $80 price target for the shares.

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