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PTI

Proteostasis

$4.30

0.04 (0.94%)

07:17
06/23/17
06/23
07:17
06/23/17
07:17

Proteostasis files IND application for PTI-808 with FDA

Proteostasis Therapeutics announced that the company has filed an Investigational New Drug, or IND, application with the FDA for PTI-808, its cystic fibrosis transmembrane conductance regulator, or CFTR, potentiator. Proteostasis plans to initiate a Phase 1 study of PTI-808 in healthy volunteers in July.

PTI Proteostasis
$4.30

0.04 (0.94%)

11/01/16
WBLR
11/01/16
DOWNGRADE
Target $81
WBLR
Market Perform
William Blair downgrades Vertex with competition looming
William Blair analyst Y. Katherine Xu downgraded Vertex Pharmaceuticals (VRTX) to Market Perform from Outperform after attending the North American Cystic Fibrosis Conference. Looming competition "has become more and more real," Xu tells investors in a research note. The triple combo in vitro data from Vertex, AbbVie (ABBV)/Galapagos (GLPG) and Proteostasis (PTI) appear comparable, Xu contends. The analyst expects "deteriorating pricing" for the Vertex's Cystic Fibrosis franchise starting in 2022 due to competition. She lowered her price target for the shares to $81 from $105. Vertex closed yesterday at $78.86.
08/12/16
LEER
08/12/16
NO CHANGE
Target $20
LEER
Outperform
Proteostasis price target raised to $20 from $15 at Leerink
Leerink analyst Joseph Schwartz raised his price target for Proteostasis to $20 from $15 after the company reported promising data from a Phase 1 study of its PTI-248, which is being developed as an add-on to amplify the effect of currently approved therapies for cystic fibrosis. Leerink has an Outperform rating on the shares.

TODAY'S FREE FLY STORIES

INFY

Infosys

$14.79

-1.14 (-7.16%)

04:04
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04:04
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CPN

Calpine

$14.92

1.42 (10.52%)

04:02
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EL

Estee Lauder

$105.92

7.6 (7.73%)

04:02
08/21/17
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04:02
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DOC

Physicians Realty Trust

$17.94

-0.24 (-1.32%)

04:01
08/21/17
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04:01
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HBMD

Howard Bancorp

$18.05

0.65 (3.74%)

03:58
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03:58
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  • 18

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SNA

Snap-On

$147.96

-0.86 (-0.58%)

03:56
08/21/17
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03:56
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Snap-On rating change  »

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E

Eni SpA

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STO

Statoil

$18.41

0.31 (1.71%)

03:55
08/21/17
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03:55
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REPYY

Repsol

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03:55
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TOT

Total

$50.49

0.61 (1.22%)

03:55
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03:55
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CSIQ

Canadian Solar

$16.63

0.23 (1.40%)

03:55
08/21/17
08/21
03:55
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03:55
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Canadian Solar rating change  »

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AAP

Advance Auto Parts

$93.26

0.41 (0.44%)

03:43
08/21/17
08/21
03:43
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03:43
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Advance Auto Parts rating change  »

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HOME

At Home Group

$22.53

-0.22 (-0.97%)

03:40
08/21/17
08/21
03:40
08/21/17
03:40
Initiation
At Home Group initiated  »

At Home Group initiated…

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GWW

Grainger

$161.39

-3.21 (-1.95%)

03:40
08/21/17
08/21
03:40
08/21/17
03:40
Initiation
Grainger initiated  »

Grainger reinstated with…

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  • 17

    Oct

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    Jan

NKE

Nike

$54.95

-2.51 (-4.37%)

03:40
08/21/17
08/21
03:40
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03:40
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Nike rating change  »

Nike downgraded to Hold…

03/08/13
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  • 03

    Oct

  • 04

    Oct

03:40
08/21/17
08/21
03:40
08/21/17
03:40
General news
FX Action: USD-CAD has settled near 1.2600 »

FX Action: USD-CAD has…

03:05
08/21/17
08/21
03:05
08/21/17
03:05
General news
FX Update: The dollar majors traded without drama »

FX Update: The dollar…

WUBA

58.com

$53.26

-0.23 (-0.43%)

20:25
08/20/17
08/20
20:25
08/20/17
20:25
Earnings
Notable company reporting before Monday's open »

The notable company…

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  • 21

    Aug

WUBA

58.com

$53.26

-0.23 (-0.43%)

20:16
08/20/17
08/20
20:16
08/20/17
20:16
Earnings
Breaking Earnings news story on 58.com »

58.com sees Q3 revenue up…

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  • 21

    Aug

WUBA

58.com

$53.26

-0.23 (-0.43%)

20:11
08/20/17
08/20
20:11
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20:11
Earnings
58.com reports Q2 EPS 55c, consensus 20c »

Reports Q2 revenue…

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  • 21

    Aug

SBUX

Starbucks

$52.70

-0.34 (-0.64%)

, LMT

Lockheed Martin

$299.20

-2.22 (-0.74%)

20:02
08/20/17
08/20
20:02
08/20/17
20:02
Hot Stocks
On The Fly: Top five weekend stock stories »

Catch up on the…

SBUX

Starbucks

$52.70

-0.34 (-0.64%)

LMT

Lockheed Martin

$299.20

-2.22 (-0.74%)

GDI

Gardner Denver

$21.97

-0.03 (-0.14%)

CAH

Cardinal Health

$64.38

-0.78 (-1.20%)

PDCO

Patterson Companies

$36.45

-0.31 (-0.84%)

RMD

ResMed

$73.07

0.28 (0.38%)

ABC

AmerisourceBergen

$78.60

-1.34 (-1.68%)

UNH

UnitedHealth

$190.82

-1.88 (-0.98%)

AAP

Advance Auto Parts

$93.26

0.41 (0.44%)

MSI

Motorola Solutions

$87.37

0.24 (0.28%)

LGF.A

Lionsgate

$28.41

0.37 (1.32%)

BGS

B&G Foods

$31.40

-0.3 (-0.95%)

MDLZ

Mondelez

$42.94

-0.47 (-1.08%)

SRE

Sempra Energy

$116.55

0.76 (0.66%)

BRK.A

Berkshire Hathaway

$267,377.00

302 (0.11%)

03/08/13
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  • 22

    Aug

  • 23

    Aug

  • 23

    Aug

  • 24

    Aug

  • 29

    Aug

  • 06

    Sep

  • 11

    Sep

  • 14

    Sep

  • 18

    Sep

  • 20

    Sep

  • 21

    Sep

  • 25

    Sep

  • 27

    Sep

  • 29

    Sep

  • 02

    Nov

  • 25

    Jan

SRE

Sempra Energy

$116.55

0.76 (0.66%)

, BRK.A

Berkshire Hathaway

$267,377.00

302 (0.11%)

18:47
08/20/17
08/20
18:47
08/20/17
18:47
Periodicals
Sempra Energy near deal to acquire Oncor Electric, Bloomberg reports »

Sempra Energy (SRE) is…

SRE

Sempra Energy

$116.55

0.76 (0.66%)

BRK.A

Berkshire Hathaway

$267,377.00

302 (0.11%)

03/08/13
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03/06/13
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  • 14

    Sep

TWX

Time Warner

$101.19

-0.42 (-0.41%)

, CMCSA

Comcast

$40.52

0.25 (0.62%)

18:34
08/20/17
08/20
18:34
08/20/17
18:34
Hot Stocks
Box Office Battle: 'Hitman's Bodyguard' wins weekend with $21.6M »

Lionsgate' (LGF.A)…

TWX

Time Warner

$101.19

-0.42 (-0.41%)

CMCSA

Comcast

$40.52

0.25 (0.62%)

CMCSK

Comcast

SNE

Sony

$38.77

-0.23 (-0.59%)

FOX

21st Century Fox

$26.79

-0.1 (-0.37%)

FOXA

21st Century Fox

$27.26

-0.09 (-0.33%)

LGF.A

Lionsgate

$28.41

0.37 (1.32%)

DIS

Disney

$100.70

-0.68 (-0.67%)

VIAB

Viacom

$28.59

-0.62 (-2.12%)

VIA

Viacom

$38.80

-3.6 (-8.49%)

03/08/13
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03/06/13
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  • 11

    Sep

  • 27

    Sep

  • 29

    Sep

GME

GameStop

$21.22

0.12 (0.57%)

, MSFT

Microsoft

$72.49

0.09 (0.12%)

17:08
08/20/17
08/20
17:08
08/20/17
17:08
Hot Stocks
GameStop kicks off nationwide pre-orders for Microsoft Xbox One X »

GameStop (GME) is…

GME

GameStop

$21.22

0.12 (0.57%)

MSFT

Microsoft

$72.49

0.09 (0.12%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 24

    Aug

  • 05

    Sep

GS

Goldman Sachs

$222.15

0.73 (0.33%)

16:48
08/20/17
08/20
16:48
08/20/17
16:48
Periodicals
Goldman Sachs receives approval to trade equities in Saudi Arabia, Reuters says »

Goldman Sachs has…

03/08/13
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03/06/13
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  • 17

    Oct

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