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WVE

Wave Life Sciences

$16.85

0.1 (0.60%)

07:04
07/17/17
07/17
07:04
07/17/17
07:04

Wave Life Sciences initiates two Phase 1b/2a clinical trials

Wave Life Sciences announced the initiation of the company's PRECISION-HD program, which includes PRECISION-HD1 and PRECISION-HD2, the company's two Phase 1b/2a clinical trials evaluating WVE-120101 and WVE-120102, respectively, for patients with Huntington's disease. PRECISION-HD1 and PRECISION-HD2 are Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled studies that will primarily evaluate the safety and tolerability of single and multiple doses of WVE-120101 and WVE-120102, respectively, administered intrathecally in HD patients. Additional exploratory objectives include assessing the impact that each compound has on the toxic mutant protein known to cause loss of brain cells in HD, as well as evaluating potential clinical effects and impact on brain atrophy as measured by magnetic resonance imaging. Both PRECISION-HD trials will follow the same protocol, and each will target a single nucleotide polymorphism, or "SNP," that marks a separate and distinct location on the mutant huntingtin gene transcript. Wave intends to enroll approximately 50 patients globally in each of the two studies through multiple sites, in Canada initially, with Europe and the United States to follow. The PRECISION-HD trials for WVE-120101 and WVE-120102 will include adult patients with early manifest HD who carry a SNP at the rs362307 or the rs362331 location, respectively. Potential HD patients for the PRECISION-HD program will be pre-screened for the presence of SNP1 or SNP2, and directed to the appropriate study upon qualifying for entry. Approximately two-thirds of all HD patients are expected to carry either SNP1, SNP2, or both, in association with the HD gene.

WVE Wave Life Sciences
$16.85

0.1 (0.60%)

08/16/16
LEER
08/16/16
NO CHANGE
Target $28
LEER
Outperform
Wave Life Sciences price target raised to $28 from $20 at Leerink
Leerink analyst Michael Schmidt raised his price target for Wave Life Sciences to $28 from $20 to reflect an incrementally higher probability-of-success for the company's programs in Huntington's disease and Duchenne Muscular Dystrophy. The analyst reiterates an Outperform rating on the shares.

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