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LOXO

Loxo Oncology

$73.29

0.94 (1.30%)

06:47
07/31/17
07/31
06:47
07/31/17
06:47

Loxo Oncology to acquire BTK inhibitor program from Redx Pharma

Loxo Oncology announced that the company has entered into a definitive agreement to purchase the Bruton's tyrosine kinase inhibitor program from Redx Pharma. The lead candidate from this program is expected to enter clinical development in 2018. Under the terms of the agreement, Loxo Oncology has made a $40M payment to Redx Pharma for the full acquisition of the BTK discovery program, including lead candidate LOXO-305. Loxo Oncology is not subject to milestone or royalty obligations. LOXO-305 was designed to reversibly bind BTK and preserve activity in the presence of the C481S acquired resistance mutation. Additionally, it was designed to avoid off-target kinases that have complicated the development of both covalent and reversible BTK inhibitors, such as EGFR, BMX, TEC, ITK, BLK, LCK and SRC. LOXO-305 will be entering studies in the coming months to enable submission of an Investigational New Drug application in 2018.

LOXO Loxo Oncology
$73.29

0.94 (1.30%)

06/05/17
STFL
06/05/17
NO CHANGE
STFL
Loxo Oncology price target raised to $71 from $52 at Stifel
Stifel analyst Stephen Willey says that the data on Loxo's larotrectinib "demonstrated a near-80%, impressively-durable response rate with an exceptional safety/tolerability profile." The analyst says that the data was better than expected and represents a paradigm shift in drug development," giving the stock "long-term optionality." Willey keeps a Buy rating on the shares.
06/05/17
JMPS
06/05/17
NO CHANGE
JMPS
Loxo Oncology data 'striking,' 'impressive,' says JMP Securities
JMP Securities analyst Michael King says that the data for Loxo's larotrectinib in patients with tumors harboring tropomyosin receptor kinase fusions was "striking." The analyst believes that the "depth of response" across many ages and disease types shown in the trial was "impressive." He raised his price target on the stock to $71 from $53 and keeps an Outperform rating.
06/05/17
SBSH
06/05/17
UPGRADE
Target $86
SBSH
Buy
Loxo Oncology upgraded to Buy from Neutral at Citi
Citi analyst Yigal Nochomovitz upgraded Loxo Oncology to Buy and raised his price target for the shares to $86 from $45. The analyst notes the 76% objective response rate for larotrectinib outperformed his bar for success of 70%-plus. FDA approval for larotrectinib is now as close to a "slam dunk" as it gets in Biotech, Nochomovitz tells investors in a research note.
05/15/17
PIPR
05/15/17
NO CHANGE
PIPR
Overweight
Ignyta breakthrough designation 'levels the field' with Loxo, says Piper Jaffray
Piper Jaffray analyst Joshua Schimmer said one of the key investor concerns regarding Ignyta's (RXDX) entrectinib has been a lack of breakthrough designation in patients with NTRK fusions, which was read as perhaps suggesting an "inferior" profile to Loxo Oncology's (LOXO) larotrectrinib. News that the FDA granted entrectinib the designation "levels the playing field" and should help ease investor concerns, said Schimmer, who keeps an Overweight rating on Ignyta shares.

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