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GNBT

Generex

$3.78

0.04 (1.07%)

, MRK

Merck

09:31
07/31/17
07/31
09:31
07/31/17
09:31

Generex reports collaboration with Merck to evaluate Keytruda, AE37 combination

Generex Biotechnology (GNBT) announced that its wholly-owned subsidiary, Antigen Express, has entered into a clinical trial collaboration agreement with Merck (MRK), through a wholly-owned subsidiary, to evaluate Antigen's AE37 cancer vaccine in combination with Merck's anti-PD-1 therapy, KEYTRUDA, in patients with metastatic triple-negative breast cancer. The study will evaluate preliminary safety and efficacy of the combination in a Phase II trial. The combination of AE37 plus KEYTRUDA follows previous studies, in which both therapies have individually shown encouraging results in patients with triple-negative breast cancer. In a controlled, randomized trial of AE37 in 300 breast cancer patients, the most encouraging results were observed in those with triple-negative breast cancer. Similarly, KEYTRUDA has shown encouraging activity in patients with metastatic triple-negative breast cancer. The attractiveness of the combination lies in the different mechanisms of action of the two immunotherapeutic drugs: AE37 specifically activates T cells to attack cancer cells while KEYTRUDA increases the ability of the body's immune system to help detect and fight tumor cells. The collaboration agreement is between Antigen Express and Merck. Under the terms of the agreement, the trial will be sponsored by Antigen Express. Additional details were not disclosed.

GNBT

Generex

$3.78

0.04 (1.07%)

MRK

Merck

  • 28

    Aug

  • 22

    Sep

GNBT Generex
$3.78

0.04 (1.07%)

MRK Merck

07/27/17
GSCO
07/27/17
NO CHANGE
GSCO
Merck could trade up $5 following AstraZeneca MYSTIC failure, says Goldman Sachs
Goldman analyst Jami Rubin expects Merck (MRK) to trade up approximately $5 based on sentiment following AstraZeneca's MYSTIC failure as it partially de-risks longer-term estimates for Keytruda. As a result, the analyst raised Merck's Keytruda sales estimates by $600M in 2018 and $1B in 2019 and beyond, increasing earnings estimates by 14c-20c, and raising his price target on shares to $74 from $70. Rubin cautions that long-term estimates could be at risk if other competitor trials are successful. The analyst rates Merck a Neutral.
07/27/17
FBCO
07/27/17
NO CHANGE
FBCO
Merck unlikely to buy PARP company after Astra deal, says Credit Suisse
Credit Suisse analyst Alethia Young believes Merck (MRK) is unlikely to acquire a PARP inhibitor company like Tesaro (TSRO) or Clovis (CLVS) after inking an immuno-oncology deal with AstraZeneca (AZN).
07/27/17
JANY
07/27/17
NO CHANGE
Target $107
JANY
Buy
PARP deals may make Clovis more attractive buyout candidate, says Janney
The partnerships announced today between AstraZeneca (AZN) and Merck (MRK) as well as Tesaro (TSRO) and Takeda highlight pharma's willingness to expand on PARP's, Janney analyst Debjit Chattopadhyay tells investors in a research note. Clovis' (CLVS) Rubraca is now the only unencumbered PARP and is "far cheaper" on a relative valuation basis than peer Tesaro, the analyst adds. He believes Clovis could now become a more compelling takeover candidate. Chattopadhyay has a Buy rating on the shares with a $107 price target. The stock in midday trading is up 7%, or $5.90, to $93.33.
07/28/17
RHCO
07/28/17
NO CHANGE
RHCO
Merck, AstraZeneca deal positive, says SunTrust
After Merck (MRK) paid $1.6B upfront for access to Astrazeneca's (AZN) PARP inhibitor, Lynparza and another drug, SunTrust analyst John Boris says that the deal "makes strategic/financial sense and validates the PARP inhibitor class." He adds that the companies are "ideally positioned" to leverage a combination of IO and PARP therapies. The analyst reiterates a $73 price target and a Buy rating on Merck.

TODAY'S FREE FLY STORIES

KSU

Kansas City Southern

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-0.07 (-0.07%)

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RXII

RXi Pharmaceuticals

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WIN

Windstream

$1.98

0.06 (3.13%)

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Windstream CEO acquires 25,381 common shares »

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CVM

CEL-SCI

$2.44

-0.22 (-8.27%)

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Breaking Syndicate news story on CEL-SCI »

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TRN

Trinity Industries

$28.20

-0.03 (-0.11%)

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ValueAct raises stake inTrinity Industries to 11% from 9.8% »

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LPTN

Lpath

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Breaking Hot Stocks news story on Lpath »

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PGR

Progressive

$48.63

0.12 (0.25%)

17:08
08/18/17
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Progressive CFO sells 50,000 common shares »

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TMO

Thermo Fisher

$172.57

-0.32 (-0.19%)

17:06
08/18/17
08/18
17:06
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17:06
Hot Stocks
Thermo Fisher director sells 11,318 shares »

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  • 06

    Sep

SMBC

Southern Missouri Bancorp

$31.18

-0.05 (-0.16%)

17:06
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17:06
Hot Stocks
Southern Missouri Bancorp and Southern Missouri Bancshares to merge »

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IEP

Icahn Enterprises

$50.00

-0.2 (-0.40%)

16:58
08/18/17
08/18
16:58
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16:58
Hot Stocks
Breaking Hot Stocks news story on Icahn Enterprises »

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IEP

Icahn Enterprises

$50.00

-0.2 (-0.40%)

16:57
08/18/17
08/18
16:57
08/18/17
16:57
Hot Stocks
Breaking Hot Stocks news story on Icahn Enterprises »

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IEP

Icahn Enterprises

$50.00

-0.2 (-0.40%)

16:57
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Breaking Hot Stocks news story on Icahn Enterprises »

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IEP

Icahn Enterprises

$50.00

-0.2 (-0.40%)

16:56
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Icahn no longer special advisor to President Trump on regulatory reform issues »

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NVTA

Invitae

$9.60

0.05 (0.52%)

16:55
08/18/17
08/18
16:55
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Breaking Syndicate news story on Invitae »

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NVTA

Invitae

$9.60

0.05 (0.52%)

16:49
08/18/17
08/18
16:49
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Syndicate
Breaking Syndicate news story on Invitae »

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MU

Micron

$30.38

0.76 (2.57%)

16:48
08/18/17
08/18
16:48
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Hot Stocks
Micron director sells 25,000 common shares »

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  • 29

    Aug

  • 06

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INSY

Insys Therapeutics

$9.17

-0.11 (-1.19%)

16:42
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Insys agrees to pay $4.45M to settle opioid marketing suit »

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AKTX

Akari Therapeutics

16:34
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16:34
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Breaking Syndicate news story on Akari Therapeutics »

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JMBA

Jamba

$9.11

-0.04 (-0.44%)

16:32
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Jamba receives expected letter from Nasdaq »

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HIL

Hill International

$4.50

0.2 (4.65%)

16:31
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Hill International receives NYSE notice regarding late Form 10-Q filing »

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TGT

Target

$55.65

-0.47 (-0.84%)

16:30
08/18/17
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Periodicals
Target ends relationship with food startup Hampton Creek, Bloomberg says »

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16:30
08/18/17
08/18
16:30
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16:30
Options
Preliminary option volume of 23.2M today »

Preliminary option volume…

NBEV

New Age Beverages

$3.51

-0.49 (-12.25%)

16:29
08/18/17
08/18
16:29
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16:29
Hot Stocks
New Age Beverages director sells nearly 42,000 common shares »

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  • 28

    Sep

ATW

Atwood Oceanics

$6.26

0.22 (3.64%)

, ESV

Ensco

$4.28

0.12 (2.88%)

16:24
08/18/17
08/18
16:24
08/18/17
16:24
Hot Stocks
Atwood Oceanics, Ensco file proxy materials in connection with pending merger »

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ATW

Atwood Oceanics

$6.26

0.22 (3.64%)

ESV

Ensco

$4.28

0.12 (2.88%)

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NSRGY

Nestle

$83.76

-0.1 (-0.12%)

16:23
08/18/17
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Nestle faces potential fraud suit over Poland Spring marketing, WSJ says »

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