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VNDA

Vanda

$17.00

-0.25 (-1.45%)

16:08
09/13/17
09/13
16:08
09/13/17
16:08

Vanda reports results from Phase II clinical study of tradipitant

Vanda Pharmaceuticals announced results from an 8-week randomized Phase II clinical study of tradipitant as a monotherapy in the treatment of chronic pruritus in patients with atopic dermatitis. Tradipitant was shown to improve the intensity of the worst itch patients experienced, as well as atopic dermatitis disease severity. Tradipitant demonstrated significant and clinically meaningful improvement in a number of measures of itch. Specifically, significant improvements were observed in the measurement of Worst Itch Visual Analog Scale (p=0.019). Tradipitant also showed significant effects in a responder analysis for Worst Itch in patients who achieved improvements of greater than or equal to 40 points improvement from baseline in Worst Itch VAS scores (p=0.037) or greater than or equal to 30 points (p=0.049). On the pre-specified primary endpoint of Average Itch VAS, tradipitant showed improvement over placebo, but this improvement was not significant due to high placebo effect and the lack of sensitivity of this measure. Consistent with the observed improvements in Worst Itch, which is associated with scratching behavior, tradipitant also demonstrated disease modifying properties by showing significant improvement in the Total SCORAD scale (p=0.008) and Objective SCORAD scale (p=0.005). Specifically, tradipitant showed significant improvements in several clinical features of severity of atopic dermatitis, including excoriation, erythema, oozing and dryness.

  • 13

    Sep

VNDA Vanda
$17.00

-0.25 (-1.45%)

09/01/17
JMPS
09/01/17
NO CHANGE
JMPS
Vanda risk/reward ratio positive into trial results, says JMP Securities
JMP Securities analyst Jason Butler says that the risk/reward ratio of Vanda stock is attractive ahead of the expected results of a Phase 2 trial evaluating tradipitant to treat pruritus in atopic dermatitis. The analyst says that the risk/reward ratio is positive due to the stock's attractive valuation and the chances of the drug's success. He raised his price target on the shares to $24 from $22 and keeps an Outperform rating on the stock.
08/29/17
JEFF
08/29/17
NO CHANGE
Target $21
JEFF
Buy
Vanda could rally 25% on positive September data, says Jefferies
Jefferies analyst Matthew Andrews notes that Vanda Pharmaceuticals in September will report Phase II data in atopic dermatitis with chronic pruritus. Tradipitant in chronic pruritus represents a key clinical event for Vanda shares, Andrews tells investors in a research note. The analyst sees share upside of 15%-25% on positive data and a floor of $13-$14 per share if results are negative. Vanda closed yesterday up 20c to $16.50. Chronic pruritus "conservatively" represents a $530M-plus market for tradipitant, which could add $10-$15 per share, Andrews estimates. He has a Buy rating on Vanda with a $21 price target.
06/27/17
PIPR
06/27/17
INITIATION
Target $23
PIPR
Overweight
Vanda assumed with an Overweight at Piper Jaffray
Piper Jaffray analyst Charles Duncan assumed coverage of Vanda Pharmaceuticals with an Overweight rating and $23 price target. The analyst sees the company's growth at a potential inflection point with Hetlioz's non-24 revenue stream gaining momentum towards the $100M mark.
05/26/17
HCWC
05/26/17
INITIATION
Target $18
HCWC
Buy
Vanda initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Corey Davis started Vanda Pharmaceuticals with a Buy rating and $18 price target. With both Fanapt and Hetlioz having long exclusivity periods, the company now has a "solid base business," the analyst contends. Davis believes Vanda's pipeline is not priced into the shares and could provide "substantial upside."

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RNVA

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EKSO

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UNH

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DLR

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$NSD

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TSS

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$NYE

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FB

Facebook

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IDA

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VLRX

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FB

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DCIX

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SEP

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SEV

Sevcon

$22.04

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BorgWarner

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ATOS

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CB

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AAPL

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MRK

Merck

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