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ALNY

Alnylam

$78.15

-2.42 (-3.00%)

05:37
09/15/17
09/15
05:37
09/15/17
05:37

Nomura says reduce Alnylam exposure, starts with Reduce rating

Nomura Instinet analyst Christopher Marai last night initiated Alnylam Pharmaceuticals with a Reduce rating and $56 price target. The analyst recommends reducing exposure to the shares ahead of the patisiran Phase 3 Apollo readout. He sees a good chance of a successful readout, but notes that a "possible, unlikely disappointment" could send shares "substantially" lower. A patisiran launch will likely be "slow and disappointing," based on competition and the relatively poor product profile, Marai told investors in a research note.

ALNY Alnylam
$78.15

-2.42 (-3.00%)

09/07/17
LEER
09/07/17
NO CHANGE
LEER
Market Perform
Fear of skeptics comes true as Alnylam Fitusiran halted, says Leerink
Leerink analyst Paul Matteis notes that Alnylam has announced that it has suspended Fitusiran dosing due to a fatal thrombotic event in a patient with hemophilia A without inhibitors. The analyst notes that blood clot risk was always highlighted as a theoretical concern in discussions with investors who were more skeptical on the program. The company aims to resume dosing as soon as possible upon agreement with global regulatory authorities and with appropriate protocol amendments in place for enhanced safety monitoring, he adds. However, Matteis believes that the commercial opportunity may now be limited given the risk-averse nature of the hemophilia patient population. He reiterates a Market Perform on the shares.
09/07/17
PIPR
09/07/17
NO CHANGE
Target $110
PIPR
Overweight
Piper says buy Alnylam selloff today for late September data release
Piper Jaffray analyst Edward Tenthoff lowered his price target for Alnylam Pharmaceuticals to $110 from $126 after the company said it discontinued dosing of fitusiran in all ongoing studies following a fatal thrombotic event in a Hemophilia A patient. The stock in premarket trading is down 12%, or $10.52, to $75.50. The analyst believes the death is related to fitusiran mechanism and not more broadly the RNAi platform. As such, he's a buyer of Alnylam shares on today's weakness ahead of the Phase III Apollo data on patisiran in 225 hereditary ATTR Amyloidosis with Polyneuropathy patients in late September. While Tenthoff expects Alnylam will be able to re-initiate dosing of fitusiran and the Atlas studies with protocol adjustments, he "conservatively" removed all value for fitusiran, which dropped his price target.
09/08/17
LEER
09/08/17
NO CHANGE
Target $72
LEER
Market Perform
Alnylam price target lowered to $72 from $83 at Leerink
Leerink analyst Paul Matteis lowered his price target for Alnylam Pharmaceuticals to $72 after removing sales from non-inhibitor patients from his valuation and reducing his odds-of-success for fitusiran in the inhibitor population to 35%. The changes follow Alnylam's announcement that dosing in the Phase 3 Atlas programs has been halted due to a fatal thrombotic event in a patient with hemophilia A without inhibitors. The analyst keeps a Market Perform rating on Alnylam.
09/14/17
NOMU
09/14/17
INITIATION
Target $56
NOMU
Reduce
Alnylam initiated with a Reduce at Nomura Instinet
Nomura initiated Alnylam with a Reduce and a $56 price target.

TODAY'S FREE FLY STORIES

HPE

HP Enterprise

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0.16 (1.17%)

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HPE

HP Enterprise

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YUM

Yum! Brands

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MAR

Marriott

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ESPGY

Esprit Holdings

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BA

Boeing

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M

Macy's

$21.16

-0.32 (-1.49%)

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TAHO

Tahoe Resources

$5.60

0.02 (0.36%)

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ATKR

Atkore

$18.42

0.02 (0.11%)

18:11
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Conference/Events
Atkore management to meet with JPMorgan »

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  • 26

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YOGA

YogaWorks

$4.00

-0.04 (-0.99%)

, TXN

Texas Instruments

$86.05

0.22 (0.26%)

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TXN

Texas Instruments

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PSDO

Presidio

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VSAR

Versartis

$21.60

-0.25 (-1.14%)

ASND

Ascendis Pharma

$27.74

-1.55 (-5.29%)

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  • 21

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FTR

Frontier Communications

$11.69

-0.31 (-2.58%)

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Frontier Communications operations in Florida return to near-normal levels »

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PLYA

Playa Hotels & Resorts

$10.66

-0.06 (-0.56%)

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Playa Hotels & Resorts reports no significant damage from Maria »

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ASND

Ascendis Pharma

$27.74

-1.55 (-5.29%)

, VSAR

Versartis

$21.60

-0.25 (-1.14%)

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CE

Celanese

$103.90

-0.04 (-0.04%)

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DNOW

NOW Inc.

$12.98

0.1 (0.78%)

18:03
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NOW Inc. management to meet with JPMorgan »

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JOBS

51job

$58.50

0.01 (0.02%)

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HES

Hess Corp.

$43.63

0.17 (0.39%)

17:53
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APC

Anadarko

$48.49

3.68 (8.21%)

17:43
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Anadarko analyst commentary  »

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  • 27

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HCC

Warrior Met Coal

$23.28

-1.05 (-4.32%)

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MAA

MAA

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-0.03 (-0.03%)

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NOC

Northrop Grumman

$280.42

0.38 (0.14%)

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GD

General Dynamics

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1.45 (0.71%)

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AAN

Aaron's

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MDC

M.D.C. Holdings

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