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SNY

Sanofi

$48.43

-0.29 (-0.60%)

, REGN

Regeneron

$433.45

-7.81 (-1.77%)

12:53
09/16/17
09/16
12:53
09/16/17
12:53

Sanofi Regeneron announce positive results for Duxipent in Atopic Dermatitis

Sanofi (SNY) and Regeneron (REGN) have announced positive results from the Phase 3 CAFE study of Dupixent, or dupilumab, in adults with moderate-to-severe atopic dermatitis who are inadequately controlled with or intolerant to the broad immunosuppressant drug cyclosporine A, or CSA, or when this treatment is medically inadvisable. In the study, Dupixent with topical corticosteroids, or TCS, significantly improved measures of overall disease severity, skin clearing, itching, and patient reported quality of life measures. CSA is approved for the treatment of atopic dermatitis in most European countries and Japan; it is not approved in the U.S. for this use. The results of this study are being presented at the European Academy of Dermatology and Venerology Congress in Geneva, Switzerland. The primary endpoint of the study was the proportion of patients that achieved a 75% or greater improvement in the Eczema Area and Severity Index, or EASI-75, score at 16 weeks from baseline. 59% of patients who received Dupixent weekly with TCS, and 63% of patients who received Dupixent every two weeks with TCS achieved EASI-75, compared to 30% of those patients who received placebo with TCS. The mean percent change improvement in EASI from baseline at 16 weeks was 78% and 80% for patients who received Dupixent weekly or every two weeks with TCS, respectively, compared to 47% for those who received placebo plus TCS. Other secondary endpoints of the study included measures of the impact of Dupixent on the persistent itch caused by the disease, quality of life measures, and symptoms of anxiety and depression. No new adverse events were reported in the study.

SNY

Sanofi

$48.43

-0.29 (-0.60%)

REGN

Regeneron

$433.45

-7.81 (-1.77%)

  • 18

    Oct

SNY Sanofi
$48.43

-0.29 (-0.60%)

07/31/17
ADAM
07/31/17
NO CHANGE
Target $522
ADAM
Buy
Dupixent authorization approval rate outweighs Q2 miss, says Canaccord
Regeneron (REGN) partner Sanofi (SNY) reported a "very high" 73%-83% prior authorization approval rate for Dupixent in Q2, which Canaccord analyst John Newman said outweighs the fact that sales for the drug at $30.6M were slightly below the $33M consensus forecast. The analyst, who sees rapid payor acceptance of Dupixent as "much more crucial" than the initial quarterly revenue, keeps a Buy rating and $522 price target on Regeneron shares.
08/30/17
HSBC
08/30/17
UPGRADE
Target $81
HSBC
Hold
Sanofi upgraded to Hold from Reduce at HSBC
HSBC analyst Steve McGarry upgraded Sanofi to Hold and increased its price target to $81 from $79 citing valuation and said he sees few catalysts to own the shares either.
08/30/17
08/30/17
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Sanofi (SNY) upgraded to Hold from Reduce at HSBC, with analyst Steve McGarry citing valuation. 2. M.D.C. Holdings (MDC) upgraded to Market Perform from Underperform at Wells Fargo with analyst Stephen East saying he sees "little reason the equity would move meaningfully lower" from current levels. 3. Ciena (CIEN) upgraded to Buy from Neutral at Citi with analyst Stanley Kovler saying the risk/reward is positive into third quarter results. 4. Six Flags (SIX) upgraded to Buy from Neutral at Hilliard Lyons with analyst Jeff Thomison citing improved valuation based on its 13% year-to-date pullback. 5. Prospect Capital (PSEC) upgraded to Market Perform from Underperform at Raymond James with analyst Robert Dodd saying he expects near-term earnings will cover the lower dividend run-rate but notes downside risk remains. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/11/17
FBCO
09/11/17
NO CHANGE
Target $485
FBCO
Outperform
Regeneron, Sanofi asthma trial 'statistically significant,' says Credit Suisse
Credit Suisse analyst Alethia Young notes that Regeneron (REGN)/Sanofi (SNY) released top-line asthma results, and the overall trial was "statistically significant." Specifically, the trial hit in the overall population, but it is unclear if the trial was statistically significant in the low eosinophil level patients alone, she notes. The analyst reiterates an Outperform rating and $485 price target on Regeneron's shares.
REGN Regeneron
$433.45

-7.81 (-1.77%)

09/07/17
PIPR
09/07/17
NO CHANGE
Target $557
PIPR
Overweight
Regeneron selloff today a buying opportunity, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff notes shares of Regeneron Pharmaceuticals (REGN) are trading lower after Phase IIb readouts from competitors Amgen (AMGN) and AstraZeneca (AZN) in asthma and AbbVie (ABBV) in atopic dermatitis met their primary endpoints. The analyst does not see an "immediate competitive threat" to Regeneron's Dupixent, which he says has successfully launched in atopic dermatitis following FDA approval in March. He recommends buying the shares on today's selloff ahead of expected "positive" Phase III Dupixent asthma data. Dupixent maintains at least a two-year lead ahead of these competitive agents, Tenthoff tells investors in an intraday research note. The analyst reiterates an Overweight rating on Regeneron with a $557 price target.
09/11/17
PIPR
09/11/17
NO CHANGE
Target $557
PIPR
Overweight
Regeneron pullback today a buying opportunity, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff recommends using today's weakness in shares of Regeneron Pharmaceuticals as a buying opportunity. The analyst calls the Phase III Quest data in severe asthma patients positive and projects peak U.S. asthma sales of $2.2B by 2025. He reiterates an Overweight rating on Regeneron with a $557 price target. The stock in early trading is down 6% to $443.39.
09/14/17
RBCM
09/14/17
INITIATION
Target $475
RBCM
Sector Perform
Regeneron initiated with a Sector Perform at RBC Capital
RBC Capital analyst Kennen MacKay initiated Regeneron with a Sector Perform and a $475 price target.

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IBM

IBM

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ATR

AptarGroup

$87.24

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FULT

Fulton Financial

$18.30

-0.25 (-1.35%)

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SNAP

Snap

$14.01

0.49 (3.62%)

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PAVmed

$2.54

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PODD

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, DXCM

Dexcom

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Recommendations
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IBM

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$169.12

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$48.36

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TWTR

Twitter

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, FB

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IBM

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$169.12

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IBM

IBM

$169.12

0.47 (0.28%)

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Downgrade
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APRN

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