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AGEN

Agenus

$4.33

-0.14 (-3.13%)

, GSK

GlaxoSmithKline

$40.84

-0.26 (-0.63%)

10:15
10/21/17
10/21
10:15
10/21/17
10:15

FDA approves GlaxoSmithKline shingles vaccine with Agenus QS-21 Stimulon

Agenus (AGEN) has announced that the Food and Drug Administration granted marketing authorization to GlaxoSmithKline's (GSK) herpes zoster vaccine, SHINGRIX, containing Agenus' proprietary immune adjuvant QS-21 Stimulon. SHINGRIX is indicated for prevention of herpes zoster - also known as shingles - in adults aged 50 years and older. The addition of QS-21 Stimulon helps improve the vaccine's effectiveness by boosting immune response in older adults who often experience age-related decline in immunity. The FDA approval of SHINGRIX was based on data pooled from two pivotal Phase III clinical trials in more than 37,000 people, which demonstrated an efficacy rate against shingles greater than 90% independent of age, as well as a sustained efficacy over the four-year follow-up period. SHINGRIX also reduced the overall incidence of postherpetic neuralgia, the most common and oftentimes debilitating chronic nerve pain associated with shingles. The most common side effects reported in clinical trials of SHINGRIX were pain, redness and swelling at the injection site, the majority of which were transient and mild to moderate in intensity, lasting less than three days. The addition of QS-21 Stimulon is being studied to determine its potential to help a diverse range of vaccines work more effectively to treat or cure difficult-to-treat diseases, like cancer. QS-21 Stimulon is currently being used in combination with Agenus' neoantigen vaccine, AutoSynVax, now in a Phase 1 clinical trial in cancer. QS-21 Stimulon is also currently being evaluated in numerous GlaxoSmithKline vaccine development candidates for both therapeutic and prophylactic applications.

AGEN

Agenus

$4.33

-0.14 (-3.13%)

GSK

GlaxoSmithKline

$40.84

-0.26 (-0.63%)

  • 23

    Oct

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    Oct

  • 25

    Oct

  • 06

    Nov

AGEN Agenus
$4.33

-0.14 (-3.13%)

10/28/16
HCWC
10/28/16
DOWNGRADE
Target $5
HCWC
Neutral
Agenus downgraded to Neutral from Buy at H.C. Wainwright
H.C. Wainwright analyst Swayampakula Ramakanth downgraded Agenus to Neutral saying any significant clinical results are at least 12-18 months away. The analyst expects the stock to be range bound given a lack of catalysts. He cut his price target for the shares to $5 from $10.
GSK GlaxoSmithKline
$40.84

-0.26 (-0.63%)

07/10/17
PIPR
07/10/17
NO CHANGE
Target $5
PIPR
Neutral
OncoMed termination from GSK not surprising, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff believes GlaxoSmithKline (GSK) terminating its agreement with OncoMed Pharmaceuticals (OMED) is not surprising since tarextumab, the only remaining asset under the collaboration, failed previously to meet the primary endpoint in a Phase II study for first-line small cell lung cancer. The analyst says he remains focused on OncoMed's early stage pipeline including navicixizumab, rosmantuzumab and I/O assets anti-TIGIT and GITR trimer. Tenthoff keeps a Neutral rating on OncoMed with a $5 price target.
08/30/17
ARGS
08/30/17
NO CHANGE
ARGS
GlaxoSmithKline weakness creates buying opportunity, says Argus
Argus analyst John Eade says that the 8% decline in GlaxoSmithKline's stock over the past quarter has created a buying opportunity. The analyst expects the company's profits to rise by low single percentage digits in 2017 and 2018, and he calls its 5% dividend yield attractive.
09/08/17
MSCO
09/08/17
DOWNGRADE
MSCO
Underweight
GlaxoSmithKline downgraded to Underweight from Equal Weight at Morgan Stanley
Morgan Stanley analyst Vincent Meunier downgraded GlaxoSmithKline to Underweight saying its 2020 roadmap appears "challenging" given capital allocation constraints and low R&D optionality.
10/16/17
JEFF
10/16/17
NO CHANGE
Target $115
JEFF
Buy
Jefferies ups price target on top global pick AbbVie to $115
Jefferies analyst Jeffrey Holford keeps AbbVie (ABBV) as his top global Pharmaceuticals pick for October, followed by Roche (RHHBY), Novartis (NVS), Bayer (BAYRY), Johnson & Johnson (JNJ), Eli Lilly (LLY) and GlaxoSmithKline (GSK). The analyst raised his price target for AbbVie shares to $115 from $107 and keeps a Buy rating on the name. Among his other target changes include bumping Eli Lilly's to $100 from $96.

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MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

, BRCD

Brocade

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MKSI

MKS Instruments

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BRCD

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IVR

Invesco Mortgage

$17.36

0.07 (0.40%)

AVGO

Broadcom

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TCMD

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LMOS

Lumos Networks

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WGL

WGL Holdings

$84.32

-0.14 (-0.17%)

18:01
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WGL Holdings reports Q4 adjusted EPS (17c), consensus (19c) »

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TCMD

Tactile Systems

$25.98

-0.23 (-0.88%)

, LMOS

Lumos Networks

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TCMD

Tactile Systems

$25.98

-0.23 (-0.88%)

LMOS

Lumos Networks

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IVR

Invesco Mortgage

$17.36

0.07 (0.40%)

, MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

17:56
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Breaking Hot Stocks news story on Invesco Mortgage, MKS Instruments »

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IVR

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$17.36

0.07 (0.40%)

MKSI

MKS Instruments

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-0.35 (-0.34%)

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MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

, BRCD

Brocade

17:55
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Hot Stocks
MKS Instruments to replace Brocade in S&P 400 at open on 11/22 »

S&P 500 constituent…

MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

BRCD

Brocade

AVGO

Broadcom

$271.86

-0.25 (-0.09%)

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UQM

UQM Technologies

$1.18

0.015 (1.29%)

17:24
11/17/17
11/17
17:24
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17:24
Syndicate
Breaking Syndicate news story on UQM Technologies »

UQM Technologies files to…

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GS

Goldman Sachs

$238.02

-1.35 (-0.56%)

17:23
11/17/17
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17:23
Periodicals
Goldman Sachs has $510M lawsuit dismissed, Reuters reports »

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VICL

Vical

$1.94

-0.02 (-1.02%)

17:18
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Breaking Hot Stocks news story on Vical »

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LGND

Ligand

$140.31

-1.4 (-0.99%)

17:18
11/17/17
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Hot Stocks
Ligand director sells 5,000 common shares »

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LGND

Ligand

$140.31

-1.4 (-0.99%)

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Ligand CFO sells 6,559 common shares »

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LGND

Ligand

$140.31

-1.4 (-0.99%)

17:17
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Ligand CEO sells 5,269 common shares »

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MBI

MBIA

$9.01

0.13 (1.46%)

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Breaking Hot Stocks news story on MBIA »

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RBCN

Rubicon

$8.07

0.1218 (1.53%)

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ANCB

Anchor Bancorp

$24.75

-0.1 (-0.40%)

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Anchor Bancorp announces stock repurchase program, 10b5-1 trading plan »

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GIFI

Gulf Island Fabrication

$12.30

-0.1 (-0.81%)

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Breaking Syndicate news story on Gulf Island Fabrication »

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MPB

Mid Penn Bancorp

$31.09

0.59 (1.93%)

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Mid Penn Bancorp, Scottdale shareholders approve merger »

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CALD

Callidus Software

$28.95

0.3 (1.05%)

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Callidus Software initiated at First Analysis »

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GIFI

Gulf Island Fabrication

$12.30

-0.1 (-0.81%)

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GE

General Electric

$18.21

-0.04 (-0.22%)

16:42
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General Electric CEO acquires 60,000 common shares »

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NRE

Northstar Realty Europe

$14.20

0.05 (0.35%)

16:33
11/17/17
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Syndicate
Breaking Syndicate news story on Northstar Realty Europe »

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FHN

First Horizon

$18.40

0.1 (0.55%)

, CBF

Capital Bank

$39.95

0.25 (0.63%)

16:33
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16:33
Hot Stocks
First Horizon, Capital Bank agree to sell two branches to Apex Bank »

First Horizon (FHN) and…

FHN

First Horizon

$18.40

0.1 (0.55%)

CBF

Capital Bank

$39.95

0.25 (0.63%)

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LII

Lennox

$194.25

-0.75 (-0.38%)

16:32
11/17/17
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Lennox executive sells 2,500 common shares »

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TBNK

Territorial Bancorp

$30.99

0.21 (0.68%)

16:31
11/17/17
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16:31
Hot Stocks
Territorial Bancorp declares special cash dividend of 30c per share »

Payable on December 20.…

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TRTN

Triton International

$40.07

-0.77 (-1.89%)

16:30
11/17/17
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Hot Stocks
Triton International's Hanau sells 10,000 common shares »

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16:30
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Options
Preliminary option volume of 21.1M today »

Preliminary option volume…

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