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CARA

Cara Therapeutics

$12.89

0.29 (2.30%)

04:55
11/10/17
11/10
04:55
11/10/17
04:55

Cara Therapeutics management to meet with JPMorgan

Meeting to be held in Boston on November 10 hosted by JPMorgan.

  • 10

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    Nov

CARA Cara Therapeutics
$12.89

0.29 (2.30%)

06/30/17
PIPR
06/30/17
NO CHANGE
Target $27
PIPR
Overweight
Cara Therapeutics selloff a buying opportunity, says Piper Jaffray
Piper Jaffray analyst Charles Duncan believes last night's Phase II trial results from Cara Therapeutics with oral CR845 in osteoarthritis hip and knee pain are "encouraging" at the highest 5mg dose. These results suggest oral CR845 has analgesic efficacy, with a differentiated safety/tolerability profile for a chronic agent, Duncan tells investors in a research note. He recommends using any stock weakness as a buying opportunity and keeps an Overweight rating on Cara with a $27 price target.
06/30/17
HCWC
06/30/17
NO CHANGE
Target $30
HCWC
Buy
Cara study results 'could have been far worse,' says H.C. Wainwright
H.C. Wainwright analyst Corey Davis says that even though Cara Therapeutics missed the primary endpoint in its Phase 2 study with oral CR845 in osteoarthritis pain, the company "unequivocally showed" a positive signal in the pre-specified subset of patients with hip osteoarthritis, but not knee. Most importantly, CR845 showed an "incredibly benign side effect profile," Davis tells investors in a research note. The analyst calls CR845 the first ever successful proof of concept study for an oral kappa opioid with virtually no side effects. The study "could have been far worse," and while not an obvious win that allows progression to Phase 3, the next step will be to conduct another Phase 2 with changes that can optimize the chances of CR845 showing clear efficacy. Davis keeps a Buy rating on Cara shares with a $30 price target. The stock in premarket trading is down 29%, or $7.52, to $17.99.
06/30/17
JANY
06/30/17
DOWNGRADE
Target $21
JANY
Neutral
Cara Therapeutics downgraded to Neutral from Buy at Janney Capital
Janney Capital analyst Ken Trbovich said the results of Cara Therapeutics' first placebo-controlled study of oral CR845 do not mean the end to development of the agent for chronic pain, but they also do not allow Cara to advance to a pivotal study next year, as he believes investors were expecting. Given that the pivotal study for this program has been pushed out to 2019/2020 from 2018 and that these results, combined with the decision a week ago to increase enrollment in the ongoing adaptive Phase 3 study of I.V. CR845 in postsurgical pain, gives him less confidence in a positive outcome for the Phase 3 than he'd previously had, Trbovich downgraded Cara to Neutral from Buy and lowered his fair value estimate to $21 from $22.
06/30/17
06/30/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Celgene (CELG) downgraded to Neutral from Buy at BTIG with analyst Dane Leone citing a reduction in Mongersen and Ozanimod estimates. 2. Cara Therapeutics (CARA) downgraded to Neutral from Buy at Janney Capital with analyst Ken Trbovich saying the results of Cara Therapeutics' first placebo-controlled study of oral CR845 do not mean the end to development of the agent for chronic pain, but they also do not allow Cara to advance to a pivotal study next year, as he believes investors were expecting. 3. AmerisourceBergen (ABC) downgraded to Neutral from Buy at BofA/Merrill with analyst Steven Valiquette saying AmerisourceBergen is up 20% year-to-date but believes further upside will be difficult as data indicates generic pricing deflation accelerated in May. 4. RE/MAX Holdings (RMAX) downgraded to Underperform from Neutral at BofA/Merrill. 5. Vipshop (VIPS) downgraded to Hold from Buy at Deutsche Bank with analyst Alan Hellawell saying he has "competitive pressure and growth concerns" with June seeing industry-wide discounting. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

TSLA

Tesla

$315.05

2.55 (0.82%)

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GT

Goodyear Tire

$29.94

0.63 (2.15%)

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HMC

Honda

$32.62

0.02 (0.06%)

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Honda recalls 900,000 minivans on tip forward seats, Reuters says »

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PG

Procter & Gamble

$88.43

-0.82 (-0.92%)

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Activist investors Nelson Peltz still in P&G picture, Barron's says »

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BHGE

Baker Hughes

$30.91

0.76 (2.52%)

, GE

General Electric

$18.21

-0.04 (-0.22%)

09:39
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Buy Baker Hughes, Barron's says »

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BHGE

Baker Hughes

$30.91

0.76 (2.52%)

GE

General Electric

$18.21

-0.04 (-0.22%)

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CSCO

Cisco

$35.90

0.02 (0.06%)

09:19
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More needed for Cisco to have 'groove back,' Barron's says »

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IBM

IBM

$148.97

-0.15 (-0.10%)

09:10
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IBM could be next to fetch higher valuation, Barron's says »

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GE

General Electric

$18.21

-0.04 (-0.22%)

09:05
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11/18
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Option play offer some help given GE dividend, depressed stock, Barron's says »

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GE

General Electric

$18.21

-0.04 (-0.22%)

09:00
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Periodicals
Risk remains after GE dividend cut, Barron's says »

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TWX

Time Warner

$88.72

0.71 (0.81%)

, T

AT&T

$34.51

-0.01 (-0.03%)

08:21
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11/18
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Week in review: How Trump's policies moved stocks »

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TWX

Time Warner

$88.72

0.71 (0.81%)

T

AT&T

$34.51

-0.01 (-0.03%)

NYT

New York Times

$17.65

0.05 (0.28%)

TEX

Terex

$44.82

0.8 (1.82%)

03/08/13
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TPIC

TPI Composites

$19.06

-0.97 (-4.84%)

07:25
11/18/17
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07:25
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07:25
Conference/Events
TPI Composites to host investor day »

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SYNA

Synaptics

$38.21

0.57 (1.51%)

04:55
11/18/17
11/18
04:55
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04:55
Conference/Events
Synaptics management to meet with KeyBanc »

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MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

, BRCD

Brocade

18:01
11/17/17
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18:01
Hot Stocks
S&P announces changes to S&P MidCap 400, S&P SmallCap 600 indices »

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MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

BRCD

Brocade

IVR

Invesco Mortgage

$17.36

0.07 (0.40%)

AVGO

Broadcom

$271.86

-0.25 (-0.09%)

TCMD

Tactile Systems

$25.98

-0.23 (-0.88%)

LMOS

Lumos Networks

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WGL

WGL Holdings

$84.32

-0.14 (-0.17%)

18:01
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Earnings
WGL Holdings reports Q4 adjusted EPS (17c), consensus (19c) »

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TCMD

Tactile Systems

$25.98

-0.23 (-0.88%)

, LMOS

Lumos Networks

17:58
11/17/17
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Tactile Systems to replace Lumos Networks in S&P 600 at open on 11/22 »

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TCMD

Tactile Systems

$25.98

-0.23 (-0.88%)

LMOS

Lumos Networks

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IVR

Invesco Mortgage

$17.36

0.07 (0.40%)

, MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

17:56
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Breaking Hot Stocks news story on Invesco Mortgage, MKS Instruments »

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IVR

Invesco Mortgage

$17.36

0.07 (0.40%)

MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

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MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

, BRCD

Brocade

17:55
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Hot Stocks
MKS Instruments to replace Brocade in S&P 400 at open on 11/22 »

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MKSI

MKS Instruments

$103.50

-0.35 (-0.34%)

BRCD

Brocade

AVGO

Broadcom

$271.86

-0.25 (-0.09%)

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  • 06

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UQM

UQM Technologies

$1.18

0.015 (1.29%)

17:24
11/17/17
11/17
17:24
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17:24
Syndicate
Breaking Syndicate news story on UQM Technologies »

UQM Technologies files to…

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GS

Goldman Sachs

$238.02

-1.35 (-0.56%)

17:23
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Goldman Sachs has $510M lawsuit dismissed, Reuters reports »

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VICL

Vical

$1.94

-0.02 (-1.02%)

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LGND

Ligand

$140.31

-1.4 (-0.99%)

17:18
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Ligand director sells 5,000 common shares »

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LGND

Ligand

$140.31

-1.4 (-0.99%)

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Ligand CFO sells 6,559 common shares »

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LGND

Ligand

$140.31

-1.4 (-0.99%)

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Ligand CEO sells 5,269 common shares »

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MBI

MBIA

$9.01

0.13 (1.46%)

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Breaking Hot Stocks news story on MBIA »

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RBCN

Rubicon

$8.07

0.1218 (1.53%)

17:03
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Breaking Hot Stocks news story on Rubicon »

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