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DCPH

Deciphera

$16.73

-0.27 (-1.59%)

07:03
11/10/17
11/10
07:03
11/10/17
07:03

Deciphera reports data analysis from Phase 1 clinical trial of DCC-2618

Deciphera Pharmaceuticals announced the presentation of data analysis from its ongoing Phase 1 clinical trial of DCC-2618, the Company's pan-KIT and PDGFRalpha inhibitor. The analysis and update was presented at the Annual Meeting of The Connective Tissue Oncology Society, or CTOS, on November 10, 2017, in Maui, HI, USA. The presentation reviews data from the same trial presented at the European Society for Medical Oncology, or ESMO, 2017 Congress in September 2017, and provides pharmacodynamic support for the recommended dose of 150 mg once daily. As reported at ESMO, the data showed that in heavily pretreated patients with gastrointestinal stromal tumorsm or GIST, treatment with DCC-2618 at greater than 100 mg daily resulted in disease control rates of 76% at 12 weeks and 57% at 24 weeks. Deciphera also provided an update on enrollment of the ongoing Phase 1 clinical trial announcing that as of October 31, 2017, a total of 125 patients had been dosed with DCC-2618 of which 109 were GIST patients, including 54 GIST patients in three expansion cohorts of the Phase 1 trial, which are enrolling 2nd-line, 3rd-line, and fourth-to-fifth line GIST patients, respectively. "The analysis presented at CTOS supports the selection of 150 mg once daily as the recommend dose and supports the planned evaluation of DCC-2618 in a placebo-controlled, randomized, pivotal Phase 3 trial in patients with GIST, who have previously failed all three approved therapies," said Michael Taylor, Ph.D., President and CEO of Deciphera Pharmaceuticals. "There are no approved therapies for these fourth-line GIST patients and new treatment options are desperately needed."

  • 28

    Nov

DCPH Deciphera
$16.73

-0.27 (-1.59%)

10/23/17
10/23/17
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Ball Corp. (BLL) initiated with a Buy at UBS. 2. Deciphera (DCPH) was initiated with a Buy at Nomura Instinet, an Outperform at JMP Securities, and an Overweight at JPMorgan. 3. Nightstar Therapeutics (NITE) was initiated with an Outperform at Leerink, BMO Capital, and Wedbush, and a Buy at Jefferies. 4. Roku (ROKU) initiated with an Outperform at William Blair, a Perform at Oppenheimer, a Sector Perform at RBC Capital, an Equal Weight at Morgan Stanley, and a Neutral at Citi. 5. Tableau (DATA) initiated with a Buy at Needham. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
10/23/17
NOMU
10/23/17
INITIATION
Target $57
NOMU
Buy
Deciphera initiated with a Buy at Nomura Instinet
Nomura Instinet analyst Christopher Mara started Deciphera Pharmaceuticals with a Buy rating and $57 price target. The analyst believes catalysts over the next 12 months will confirm Deciphera's lead compound DCC-2618 as a best-in-class agent for second-line gastrointestinal stromal tumors. He recommends owning the shares over the next 12 months.
10/23/17
JMPS
10/23/17
INITIATION
Target $38
JMPS
Outperform
Deciphera initiated with an Outperform at JMP Securities
JMP Securities analyst Michael King started Deciphera with an Outperform rating and $38 price target, estimating the U.S. market potential for DCC-2618 in gastrointestinal stromal tumors to be $1.05B at peak in FY2025 and the potential in systemic mastocytosis to be $208M at peak, also in FY2025.
10/23/17
JPMS
10/23/17
INITIATION
Target $30
JPMS
Overweight
Deciphera initiated with an Overweight at JPMorgan
JPMorgan analyst Jessica Fye started Deciphera with an Overweight rating and $30 price target. The analyst sees a "very high probability" of success in gastrointestinal stromal tumors, which she pegs at a greater than $500M peak opportunity.

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