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BPMC

Blueprint Medicines

$70.22

0.26 (0.37%)

09:04
11/10/17
11/10
09:04
11/10/17
09:04

Blueprint Medicines reports new Phase 1 data of BLU-285

Blueprint Medicines announced new Phase 1 clinical data for BLU-285, a highly selective KIT and PDGFRalpha inhibitor in development as a potential treatment for patients with advanced gastrointestinal stromal tumors, or GIST. The data confirm and build upon data previously presented for BLU-285 in patients with advanced GIST. The data showed 67% of patients with heavily pretreated KIT-driven GIST treated with 300 to 400 mg of BLU-285 once daily had radiographic tumor reductions. In this population, the data also showed an objective response rate of 17% and median progression free survival of 11.5 months. In patients with PDGFRalpha-D842 driven GIST, the data showed an ORR of 71% and an estimated 12-month PFS of 78 percent. BLU-285 was well-tolerated. Blueprint Medicines plans to pursue expedited development of BLU-285 in patients with PDGFRalpha D842V-driven GIST, and the company is on track to initiate a global, randomized Phase 3 clinical trial of BLU-285 in third-line GIST in 1H18, with the goal of supporting registration of BLU-285 in a broader GIST patient population.

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    Dec

BPMC Blueprint Medicines
$70.22

0.26 (0.37%)

11/06/17
WEDB
11/06/17
NO CHANGE
Target $82
WEDB
Outperform
Blueprint Medicines price target raised to $82 from $70 at Wedbush
Wedbush analyst David Nierengarten raised his price target for Blueprint Medicines to $82 from $70 after data in ASH abstract shows BLU-285 benefit in multiple mastocytosis burden measures that appear comparatively better than that achievable with midostaurin. The analyst expects ASH presentation to confirm high response rates that support an accelerated registration path. He reiterates an Outperform rating on the shares.
11/01/17
ADAM
11/01/17
NO CHANGE
Target $80
ADAM
Buy
Blueprint Medicines price target raised to $80 from $66 at Canaccord
Canaccord analyst Arlinda Lee raised her price target on Blueprint Medicines to $80 from $66 ahead of two meaningful clinical trial updates that are due out by year-end. She continues to view the company's pipeline of novel, rationally designed, targeted kinase inhibitors as attractive and reiterated her Buy rating on Blueprint Medicines shares.
09/29/17
BTIG
09/29/17
INITIATION
Target $90
BTIG
Buy
Blueprint Medicines initiated with a Buy at BTIG
BTIG analyst Dane Leone initiated Blueprint Medicines with a Buy and $90 price target based on expectations its lead compound, BLU-285, will be approved and sees minimal concerns about the competitive landscape, a longer-term opportunity in FGFR-driven HCC, and expectations the deeper pipeline will continue to emerge over the next 12-months, with optimism around BLU-667 data.
09/20/17
ADAM
09/20/17
NO CHANGE
Target $66
ADAM
Buy
Blueprint Medicines price target raised to $66 from $56 at Canaccord
After hosting a lunch with an associate professor of medicine at Harvard Medical School and Adult Leukemia Institute physician, Canaccord analyst Arlinda Lee noted the doctor said he was impressed with the early and deep response of normalization of bone marrow mast cell burden and tryptase seen in an early study of Blueprint Medicines' lead drug candidate BLU-285. The analyst, who has increase her view of the probability of success of BLU-285 to 50% from 40%, raised her target on Blueprint shares to $66 from $56 and keeps a Buy rating on the name.

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