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ALXN

Alexion

$118.78

0.54 (0.46%)

06:32
12/26/17
12/26
06:32
12/26/17
06:32

Alexion receives marketing authorization for Soliris in Japan

Alexion Pharmaceuticals announced that the Ministry of Health, Labour and Welfare in Japan has approved Soliris as a treatment for patients with generalized myasthenia gravis who are anti-acetylcholine receptor antibody-positive and whose symptoms are difficult to control with high-dose intravenous immunoglobulin therapy or plasmapheresis. Soliris is the first and only complement inhibitor approved in Japan as a treatment for these patients. In the Phase 3 REGAIN study and its ongoing open-label extension study, Soliris demonstrated treatment benefits for patients with anti-AChR antibody-positive gMG who had previously failed immunosuppressive treatment and continued to suffer from significant unresolved disease symptoms, which can include difficulties seeing, walking, talking, swallowing and breathing. These patients are at an increased risk of disease exacerbations and crises that may require hospitalization and intensive care and may be life-threatening. Japan's MHLW based its approval of this new indication of Soliris on comprehensive clinical data from the Phase 3, randomized, double-blind, placebo-controlled, multicenter REGAIN study. Soliris is also approved in the EU for the treatment of refractory gMG in adults who are anti-AChR antibody-positive, and in the U.S. for the treatment of adult patients with gMG who are anti-AchR antibody-positive.

  • 03

    Jan

ALXN Alexion
$118.78

0.54 (0.46%)

12/18/17
SBSH
12/18/17
NO CHANGE
SBSH
Citi downgrades stance on large-cap Biotechnology to Neutral
Citi analyst Robyn Karnauskas downgraded her view on the large-cap Biotechnology sector to Neutral heading into 2018. The negative sentiment on the space may not change in the near term as valuations are not cheap and there are few catalysts in 2018, Karnauskas tells investors in a research note. Valuations in the group do not appear cheap when you look at the growth profile of large-cap biotech versus the broader market, the analyst contends. She believes the "only way out for the sector is innovation," and prefers to move to the sidelines "until we see something there." Where Karnauskas does see upside in 2018 is in shares of Alexion (ALXN), BioMarin (BMRN), Vertex (VRTX) and Tesaro (TSRO).
12/18/17
BARD
12/18/17
UPGRADE
Target $150
BARD
Outperform
Alexion upgraded to Outperform on Soliris strength, ALXN1210 potential at Baird
As reported previously, Baird analyst Michael Ulz upgraded Alexion to Outperform from Neutral. The analyst cited the company's management changes, major restructuring efforts, and a refocused strategy. He also noted the progress of strong underlying Soliris demand trends and its successful label expansion and potential for positive Phase 3 readouts for ALXN1210 in 2018. Ulz has a $150 price target on Alexion shares.
12/18/17
MSCO
12/18/17
NO CHANGE
MSCO
Morgan Stanley sees opportunities in biotech amid 'limited' investor conviction
With clinical catalysts in large-cap Biotechnology limited to only five key Phase III readouts - three of which are from Alexion (ALXN) - investors are describing their 2018 picks in the space as the "least worst" of the group, according to Morgan Stanley analyst Matthew Harrison. However, he believes this lack of conviction creates real opportunity for outsized moves in 2018, with Amgen (AMGN) identified by Harrison as the biggest potential beneficiary of M&A given "its likely newfound access" to about $39B in offshore cash. Other biotech names the analyst highlights on the up side include Biogen (BIIB), BioMarin (BMRN), Biohaven (BHVN) and Sarepta (SRPT). Meanwhile, Harrison highlights his concerns about potential downside for BioVerativ (BIVV) and Innoviva (INVA), on both of which he keeps Underweight ratings.
12/19/17
JEFF
12/19/17
NO CHANGE
Target $114
JEFF
Hold
Jefferies cuts Alexion target to $114 after polling neurologists
Jefferies analyst Eun Yang cut her price target for Alexion Pharmaceuticals to $114 from $122 after conducting a poll of 25 U.S. neurologists to assess potential use of Soliris in the newly approved indication of generalized myasthenia gravis. The stock closed yesterday up 33c to $116.09. The neurologist poll indicates "quite limited" Soliris use in gMG due to other available therapies and the drug's cost, Yang tells investors in a research note. As such, the analyst views consensus estimates for the gMG indication as aggressive. She notes her estimates are 40% below the 2024 consensus of greater than $1B in sales. Yang sees potential weakness in Alexion shares as estimates come down and keeps a Hold rating on the shares.

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