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APTO

Aptose Biosciences

$1.78

0.03 (1.71%)

07:35
12/26/17
12/26
07:35
12/26/17
07:35

Aptose Biosciences granted orphan drug designation for CG'806

Aptose Biosciences announced that the U.S. Food and Drug Administration has granted orphan drug designation to CG'806, a highly potent pan-FLT3/pan-BTK inhibitor, for the treatment of patients with acute myeloid leukemia. AML is a particularly devastating cancer of the blood and bone marrow and is the most common type of acute leukemia among adults, with an annual incidence of approximately 21,000 patients and causing more than 10,000 deaths each year in the U.S. AML cells utilize multiple forms of the FLT3 receptor tyrosine kinase and other pathways to promote rapid proliferation and to escape the inhibitory activities of many therapeutics. CG'806 is a highly potent inhibitor that simultaneously targets all known forms of FLT3 and other key oncogenic pathways that drive the proliferation of AML cancer cells, thereby providing CG'806 with a broad range of activity against AML and a strategy to delay mutational escape.

APTO Aptose Biosciences
$1.78

0.03 (1.71%)

06/08/17
RODM
06/08/17
INITIATION
Target $1
RODM
Neutral
Aptose Biosciences initiated with a Neutral at Rodman & Renshaw
Rodman & Renshaw analyst Joseph Pantginis started Aptose Biosciences with a Neutral rating and $1.00 price target. The analyst sees a lack of meaningful catalysts for the remainder of 2017.
09/07/17
HCWC
09/07/17
UPGRADE
Target $4
HCWC
Buy
Aptose Biosciences upgraded to Buy from Neutral at H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis upgraded Aptose Biosciences to Buy and raised his price target for the shares to $4 from $1. Having finalized manufacturing for CG'806 in a timely manner, Aptose can now further solidify its projected timeline for getting the drug into the clinic, Pantginis tells investors in a research note. The analyst increased his projected chance of success for CG'806 to 7% from 5%.
10/23/17
ROTH
10/23/17
INITIATION
Target $5
ROTH
Buy
Aptose Biosciences resumed with a Buy at Roth Capital
Roth Capital analyst Jotin Marango resumed Aptose Biosciences with a Buy rating and $5 price target as he sees fundamental value discounted due to formulation and manufacturing mishaps.
12/13/17
HCWC
12/13/17
NO CHANGE
Target $6
HCWC
Buy
Aptose Biosciences price target raised to $6 from $4 at H.C. Wainwright
H.C. Wainwright analyst Joseph Pantginis raised his price target for Aptose Biosciences to $6 saying the company's collaborators at the American Society of Hematology annual meeting presented a broad set of preclinical data, which provides a "nice boost" to the profile of CG'806. The analyst keeps a Buy rating on Aptose.

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