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ARRY

Array BioPharma

$13.14

0.26 (2.02%)

15:17
01/20/18
01/20
15:17
01/20/18
15:17

Array BioPharma updates results from BEACON Phase 3 trial

Array BioPharma and Pierre Fabre announced updated results from the 30 patient safety lead-in of the Phase 3 BEACON CRC trial evaluating the triplet combination of encorafenib, a BRAF inhibitor, binimetinib, a MEK inhibitor and cetuximab, an anti-EGFR antibody, in patients with BRAF-mutant metastatic colorectal cancer whose disease has progressed after one or two prior regimens. The data were presented at the ASCO 2018 Gastrointestinal Cancers Symposium in San Francisco, California. In patients with the BRAFV600E mutation, the estimated median progression-free survival at the time of analysis was 8 months. The confirmed overall response rate in patients with the BRAFV600E mutation was 48%, and 3 patients achieved complete responses. Further, the ORR was 62% in the 16 patients who received only one prior line of therapy. These data represent substantial improvements compared to several separate historical published standard of care benchmarks for this population. In the safety lead-in, the triplet combination was generally well-tolerated. Two patients discontinued treatment due to adverse events with only one of these considered related to treatment. The most common grade 3 or 4 AEs seen in at least 10% of patients were fatigue, urinary tract infection, increased aspartate aminotransferase and increased blood creatine kinase. All patients with elevated baseline levels of the tumor markers CEA and CA19-9 had a reduction from baseline, with similar and substantial reductions across both markers in patients with objective responses and those with stable disease. The enrollment in the randomized portion of the BEACON CRC trial is ongoing.

  • 30

    Jun

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ARRY Array BioPharma
$13.14

0.26 (2.02%)

09/20/17
PIPR
09/20/17
NO CHANGE
Target $18
PIPR
Overweight
Array BioPharma price target raised to $18 from $14 at Piper Jaffray
Piper Jaffray analyst Edward Tenthoff raised his price target for Array BioPharma to $18 and reiterates an Overweight rating on the shares. The company recently strengthened its balance sheet ahead of next summer's approvals, Tenthoff tells investors in a research note. The FDA accepted new drug applications for binimetinib and encorafenib for BRAF-mutant melanoma and the analyst anticipates approval by the June 30 action date.
11/29/17
PIPR
11/29/17
NO CHANGE
PIPR
Array BioPharma pipeline has upside, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff reiterated an Overweight rating and $18 price target on Array BioPharma shares, noting the company is expected to transition into a commercial biotech company in 2018. Tenthoff sees upside in Array's wholly-owned pipeline, including oral CSF-1R inhibitor ARRY-382.
12/13/17
COWN
12/13/17
NO CHANGE
Target $15
COWN
Outperform
Array BioPharma named a best idea for 2018 at Cowen
Cowen analyst Chris Shibutani calls Array BioPharma a best idea for 2018. Key readouts in 2017 substantially de-risked the company's commercialization prospects in BRAF-mutant melanoma, which is on track for approval in 2018, Shibutani tells investors in a research note. He believes several of the company's opportunities remain underappreciated and keeps an Outperform rating on the shares with a $15 price target.
12/22/17
JEFF
12/22/17
NO CHANGE
Target $13
JEFF
Buy
Array BioPharma price target raised to $13 from $9 at Jefferies
Jefferies analyst Eun Yang raised her price target for Array BioPharma to $13 citing the potential for the Binimetinib/anti-PD-1 colorectal cancer. This could be the biggest value driver for Array, Yang tells investors in a research note. The analyst now assumes 30% probability-adjusted peak sales of $1.2B for binimetinib. She keeps a Buy rating on Array.

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ORCL

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ORCL

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ORCL

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