Sangamo,Case Western Reserve University announce $11M NIH grant
Case Western Reserve University and Sangamo Therapeutics announced the award of an $11M grant from the National Institutes of Health for a planned study of gene-edited T cells designed to eradicate persistent HIV infection in patients receiving anti-retroviral therapy, a combination of medicines that slows the rate at which HIV replicates. The grant will fund a clinical trial to test the hypothesis that treating patients with their own gene-edited T cells may lead to a sustained increase in T cell counts and eradication of latent HIV reservoirs. T cells (so-called because they develop in the thymus gland) are responsible for a variety of immune responses. Currently available treatments do not completely cure infected individuals due to the persistence of a latent HIV virus population. As a result, if treatment is stopped, the dormant virus rapidly emerges and reestablishes the infection.