Exelixis announes Daiichi Sankyo submitted application for esaxerenone
Exelixis announced that its partner Daiichi Sankyo Company has submitted its regulatory application for esaxerenone as a treatment for patients with hypertension to the Japanese Pharmaceutical and Medical Devices Agency. Esaxerenone is a compound identified during the prior research collaboration between Exelixis and Daiichi Sankyo, and has been subsequently developed by Daiichi Sankyo. As a result of the submission, Exelixis will receive a $20M milestone payment per the two companies' collaboration agreement. Daiichi Sankyo's application is based on the results of phase 3 studies including ESAX-HTN, a randomized, double-blind, three-arm parallel group comparison study evaluating the efficacy and safety of esaxerenone versus eplerenone in patients with essential hypertension in Japan.