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RHHBY

Roche

$28.05

-0.27 (-0.95%)

, EXEL

Exelixis

$21.09

-1.01 (-4.57%)

14:32
04/09/18
04/09
14:32
04/09/18
14:32

Roche study of biomarker-driven therapy in mCRC suspended

A study of biomarker-driven therapy in metastatic colorectal cancer, or mCRC, sponsored by Hoffmann-La Roche (RHHBY) has been suspended "following iDMC review of cohort 4 data a temporary recruitment halt to the whole study and a temporary halt to randomisation into cohort 4 has been undertaken," according to a post to ClinicalTrials.gov. The post is being attributed as the reason for a late day move lower in shares of Exelixis (EXEL), which has dropped over 2%. In January of this year, Exelixis announced the presentation of updated results from the Genentech-sponsored phase 1b clinical trial of cobimetinib, an Exelixis-discovered MEK inhibitor, in combination with atezolizumab, an anti-PDL1 antibody discovered and developed by Genentech, a member of the Roche Group, in patients with metastatic colorectal cancer. Reference Link

RHHBY

Roche

$28.05

-0.27 (-0.95%)

EXEL

Exelixis

$21.09

-1.01 (-4.57%)

  • 08

    May

  • 30

    May

  • 12

    Jun

RHHBY Roche
$28.05

-0.27 (-0.95%)

02/27/18
02/27/18
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Stryker (SYK) upgraded to Neutral from Sell at Citi by analyst Amit Hazan, who believes supply issues at Zimmer Biomet (ZBH) could drive share gains for Stryker. 2. Chipotle (CMG) upgraded to Outperform from Neutral at Baird by analyst David Tarantino, who cited its new CEO and the potential for the company to demonstrate better sales/traffic momentum over the next 12-24 months. He believes it will support investor sentiment given the opportunity for the company to deliver strong earnings power if unit volumes begin to recover. 3. Itron (ITRI) upgraded to Buy from Hold at Cannacord Genuity by analyst Chip Moore, who said he has increased conviction in the company's forward earnings power and finds current share levels a "very compelling" entry point. He notes the stock is down 10% since the SilverSpring Networks deal announcement back in September. Moore's views the combination as compelling and has increased confidence in cost saving potential post close. 4. Winnebago (WGO) upgraded to Outperform from Market Perform at BMO Capital by analyst Gerrick Johnson, who said that the RV market growth -- currently in its 9th year -- will continue at a 10% pace, adding that the company's growth can outgain the competition because of its "operating improvement, enhanced product offering, and emerging trade-up cycle from first time buyers." The analyst also noted that Winnebago will benefit from lower corporate taxes while its stock trades at "significant" valuation discount. 5. Exelixis (EXEL) upgraded to Outperform from Perform at Oppenheimer by analyst Leah Rush Cann. The analyst is now applying a valuation methodology for profitable companies to Exelixis, since the company turned profitable for the full-year 2017. She expects Exelixis will continue to develop its commercial drugs, Cabometyx and Cometriq, while its partner Genentech (RHHBY) will continue to develop Cotellic. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
03/09/18
PIPR
03/09/18
NO CHANGE
Target $170
PIPR
Overweight
Piper confident in Alexion positioning after Roche trial halt
Piper Jaffray analyst Christopher Raymond keeps an Overweight on Alexion Pharmaceuticals (ALXN) following news of a temporary trial halt for Roche's (RHHBY) Soliris/AXLN1210 challenger RO7112689 in Europe. While a bit early to write off RO7112689 as a competitive threat, the halt highlights the strength of the clinical profile for ALXN1210 and Soliris, Raymond tells investors in a research note. He remains remains confident in Alexion's positioning and bullish on the shares with a $170 price target.
03/27/18
MSCO
03/27/18
DOWNGRADE
MSCO
Underweight
Roche downgraded to Underweight from Equal Weight at Morgan Stanley
Morgan Stanley analyst Vincent Meunier downgraded Roche to Underweight from Equal Weight, citing the expected impact of biosimilars on margins and increasing competition in lung cancer. The analyst lowered his 2020 sales and earnings estimates and said Roche offers slower growth in terms of both the top and bottom line over 2018-2021 than large pharma peers. He cut his price target on Roche shares to CHF230 from CHF260.
04/09/18
JEFF
04/09/18
NO CHANGE
JEFF
Buy
Jefferies ponders other potential suitors for AveXis after Novartis deal
Jefferies analyst Biren Amin asks who else can jump into the mix after AveXis (AVXS) agreed to be acquired by Novartis (NVS) for $218 per share in an all-cash deal. The analyst, who does not expect anti-trust issues to arise with the deal on the table, notes the speculation that Biogen (BIIB) may need to evaluate AveXis at some point. The Novartis deal could be the "trigger that forces it to do so," Amin writes in a research note. Further, the analyst has always felt Roche (RHHBY) could have an interest in AveXis given its development program with RG7916. He points out that AveXis Chairman Dan Welch was the CEO of Intermune when Roche purchased the company in 2014 for $8.3B. AveXis in premarket trading is up 81%, or $94.14, to $210.05.
EXEL Exelixis
$21.09

-1.01 (-4.57%)

01/04/18
PIPR
01/04/18
NO CHANGE
Target $37
PIPR
Overweight
Piper ups Exelixis target to $37, names a top pick for 2018
Piper Jaffray analyst Edward Tenthoff names Exelixis a top pick for 2018 and raised his price target for the shares to $37 from $33. The analyst expects Cabometyx growth from driven label expansion and is positive into the Phase III Cotexo data in the first half of 2018.
02/27/18
OPCO
02/27/18
UPGRADE
OPCO
Outperform
Exelixis upgraded to Outperform from Perform at Oppenheimer
02/27/18
OPCO
02/27/18
UPGRADE
Target $40
OPCO
Outperform
Exelixis upgraded to Outperform with $40 target at Oppenheimer
Oppenheimer analyst Leah Rush Cann upgraded Exelixis to Outperform from Perform with a $40 price target. The analyst is now applying a valuation methodology for profitable companies to Exelixis, since the company turned profitable for the full-year 2017. She expects Exelixis will continue to develop its commercial drugs, Cabometyx and Cometriq, while its partner Genentech will continue to develop Cotellic. Cann views the company's Q4 results as "strong."

TODAY'S FREE FLY STORIES

TSG

The Stars Group

$29.35

0.4 (1.38%)

, SKYAY

Sky

18:31
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The Stars Group to acquire Sky Betting & Gaming for $4.7B »

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The Stars Group

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SKYAY

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LUV

Southwest

$54.76

-0.02 (-0.04%)

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TPR

Tapestry

$53.03

-0.255 (-0.48%)

16:17
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DAL

Delta Air Lines

$55.40

0.34 (0.62%)

, GM

General Motors

$37.61

-0.16 (-0.42%)

16:05
04/21/18
04/21
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04/21/18
16:05
Periodicals
Delta, GM look cheap, with growth potential, Barron's says »

While a solid start to…

DAL

Delta Air Lines

$55.40

0.34 (0.62%)

GM

General Motors

$37.61

-0.16 (-0.42%)

GT

Goodyear Tire

$27.00

0.06 (0.22%)

LNC

Lincoln National

$71.59

-0.04 (-0.06%)

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GIS

General Mills

$43.41

-0.61 (-1.39%)

15:57
04/21/18
04/21
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General Mills shares fall to 'bargain territory,' Barron's says »

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CCL

Carnival

$65.88

0.82 (1.26%)

, RCL

Royal Caribbean

$119.11

1.18 (1.00%)

15:51
04/21/18
04/21
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15:51
Periodicals
Cruise operators can offer 'nice' yields, solid dividend growth, Barron's says »

Cruise operators, like…

CCL

Carnival

$65.88

0.82 (1.26%)

RCL

Royal Caribbean

$119.11

1.18 (1.00%)

NCLH

Norwegian Cruise Line

$55.65

0.71 (1.29%)

DIS

Disney

$100.24

-0.64 (-0.63%)

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GOOG

Alphabet

$1,072.73

-15.18 (-1.40%)

, GOOGL

Alphabet Class A

$1,076.64

-12.83 (-1.18%)

15:42
04/21/18
04/21
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15:42
Periodicals
Tech giants may make own custom chips to get edge on one another, Barron's says »

There has been a tension…

GOOG

Alphabet

$1,072.73

-15.18 (-1.40%)

GOOGL

Alphabet Class A

$1,076.64

-12.83 (-1.18%)

AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

FB

Facebook

$166.29

-1.82 (-1.08%)

AAPL

Apple

$165.71

-7.08 (-4.10%)

MSFT

Microsoft

$95.01

-1.1 (-1.14%)

BIDU

Baidu

$232.38

-4.73 (-1.99%)

BABA

Alibaba

$179.07

-2.14 (-1.18%)

INTC

Intel

$51.53

-0.68 (-1.30%)

NVDA

Nvidia

$228.74

-0.21 (-0.09%)

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EPD

Enterprise Products

$26.60

-0.03 (-0.11%)

, MMP

Magellan Midstream

$65.16

-0.755 (-1.15%)

15:32
04/21/18
04/21
15:32
04/21/18
15:32
Periodicals
MPL valuations look cheap, Barron's says »

Master limited…

EPD

Enterprise Products

$26.60

-0.03 (-0.11%)

MMP

Magellan Midstream

$65.16

-0.755 (-1.15%)

MPLX

MPLX

PAA

Plains All American

$24.68

0.42 (1.73%)

03/08/13
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AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

, TWX

Time Warner

$96.23

-0.34 (-0.35%)

08:34
04/21/18
04/21
08:34
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08:34
Periodicals
Trump's tweets politicize U.S. markets, Barron's says »

With President Donald…

AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

TWX

Time Warner

$96.23

-0.34 (-0.35%)

T

AT&T

$34.67

-0.15 (-0.43%)

MYL

Mylan

$40.73

-0.08 (-0.20%)

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03/06/13
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FB

Facebook

$166.29

-1.82 (-1.08%)

, AAPL

Apple

$165.71

-7.08 (-4.10%)

08:15
04/21/18
04/21
08:15
04/21/18
08:15
Periodicals
Facebook, Apple embody new tech divide, Barron's says »

For several years now,…

FB

Facebook

$166.29

-1.82 (-1.08%)

AAPL

Apple

$165.71

-7.08 (-4.10%)

AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

NFLX

Netflix

$327.57

-5.12 (-1.54%)

GOOG

Alphabet

$1,072.73

-15.18 (-1.40%)

GOOGL

Alphabet Class A

$1,076.64

-12.83 (-1.18%)

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AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

, ACIA

Acacia Communications

$27.54

1.04 (3.92%)

08:00
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04/21
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08:00
Hot Stocks
Week in review: How Trump's policies moved stocks »

Catch up on the top…

AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

ACIA

Acacia Communications

$27.54

1.04 (3.92%)

OCLR

Oclaro

$8.27

0.08 (0.98%)

NOK

Nokia

$5.96

0.125 (2.14%)

NPTN

NeoPhotonics

$6.05

-0.01 (-0.17%)

LITE

Lumentum

$58.90

-1.05 (-1.75%)

FNSR

Finisar

$15.43

0.045 (0.29%)

MSFT

Microsoft

$95.01

-1.1 (-1.14%)

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04:55
04/21/18
04/21
04:55
04/21/18
04:55
Conference/Events
International Monetary Fund & World Bank Group to co-host an annual meeting »

2018 Spring Meeting will…

SPX

S&P 500

, SPY

SPDR S&P 500 ETF Trust

$266.66

-2.18 (-0.81%)

18:08
04/20/18
04/20
18:08
04/20/18
18:08
Periodicals
North Korea to suspend nuclear and ICBM tests, Bloomberg reports »

North Korea also plans to…

SPX

S&P 500

SPY

SPDR S&P 500 ETF Trust

$266.66

-2.18 (-0.81%)

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ADM

Archer Daniels

$45.50

-0.295 (-0.64%)

, BG

Bunge

$73.72

-1.935 (-2.56%)

18:03
04/20/18
04/20
18:03
04/20/18
18:03
Periodicals
Archer Daniels, Bunge talks end without merger deal, Bloomberg reports »

Advanced merger…

ADM

Archer Daniels

$45.50

-0.295 (-0.64%)

BG

Bunge

$73.72

-1.935 (-2.56%)

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  • 02

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CE

Celanese

$111.69

0.56 (0.50%)

18:02
04/20/18
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18:02
Hot Stocks
Celanese announces price increases in Asia »

Celanese will increase…

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IOTS

Adesto Technologies

$8.65

-0.2 (-2.26%)

17:33
04/20/18
04/20
17:33
04/20/18
17:33
Hot Stocks
Breaking Hot Stocks news story on Adesto Technologies »

180 Degree Capital lowers…

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  • 23

    May

SIGM

Sigma Designs

$6.30

0.1 (1.61%)

17:22
04/20/18
04/20
17:22
04/20/18
17:22
Hot Stocks
Sigma Designs to delay filing Annual Report on Form 10-K »

Sigma Designs is unable…

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BRK.A

Berkshire Hathaway

$300,140.00

-260 (-0.09%)

, BRK.B

Berkshire Hathaway

$200.09

-0.32 (-0.16%)

17:22
04/20/18
04/20
17:22
04/20/18
17:22
Hot Stocks
Breaking Hot Stocks news story on Berkshire Hathaway, Berkshire Hathaway, Torchmark »

Berkshire Hathaway…

BRK.A

Berkshire Hathaway

$300,140.00

-260 (-0.09%)

BRK.B

Berkshire Hathaway

$200.09

-0.32 (-0.16%)

TMK

Torchmark

$87.22

0.02 (0.02%)

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SMHI

SEACOR Marine Holdings

$22.90

-0.86 (-3.62%)

, CG

Carlyle Group

$20.85

0.15 (0.72%)

17:17
04/20/18
04/20
17:17
04/20/18
17:17
Syndicate
SEACOR Marine Holdings announces $56.9M private placement of common stock »

SEACOR Marine Holdings…

SMHI

SEACOR Marine Holdings

$22.90

-0.86 (-3.62%)

CG

Carlyle Group

$20.85

0.15 (0.72%)

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  • 12

    Jun

AVAV

AeroVironment

$56.66

-0.15 (-0.26%)

17:12
04/20/18
04/20
17:12
04/20/18
17:12
Hot Stocks
AeroVironment awarded $44.7M U.S. Army contract modification »

AeroVironment was awarded…

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  • 09

    May

XLE

Energy Select Sector SPDR

$73.30

-0.36 (-0.49%)

, XLU

Utilities SPDR

$50.29

-0.45 (-0.89%)

17:10
04/20/18
04/20
17:10
04/20/18
17:10
General news
Week ending ETF Scorecard: Energy outperforms again, Staples lag »

S&P500 SECTORS:…

XLE

Energy Select Sector SPDR

$73.30

-0.36 (-0.49%)

XLU

Utilities SPDR

$50.29

-0.45 (-0.89%)

IYR

DJ US Real Estate Index Fund

$73.94

-0.62 (-0.83%)

XLP

Consumer Staples Sector SPDR

$50.49

-0.85 (-1.66%)

XLY

Consumer Discretionary Sector SPDR

$102.97

-1.06 (-1.02%)

XLB

S&P Select Materials SPDR

$59.00

-0.36 (-0.61%)

XLF

Financial Select Sector

$27.89

0.015 (0.05%)

XLV

Health Care Select Sector SPDR

$82.10

-0.45 (-0.55%)

XLK

Technology Select Sector SPDR

$66.18

-0.97 (-1.44%)

XLI

Industrial Select Sector SPDR

$75.59

-0.32 (-0.42%)

GLD

SPDR Gold Trust

$126.61

-1.01 (-0.79%)

SLV

iShares Silver Trust

$16.14

-0.11 (-0.68%)

USO

United States Oil Fund

$13.76

-0.01 (-0.07%)

UNG

United States Natural Gas Fund

$22.56

0.475 (2.15%)

HYG

iShares iBoxx $ High Yield Corporate Bond

$85.91

-0.19 (-0.22%)

LQD

iShares iBoxx $ Investment Grade Corporate Bond

$115.47

-0.49 (-0.42%)

TLT

iShares 20+ Year Treasury Bond Fund

$118.47

-0.88 (-0.74%)

IEF

iShares 7-10 Year Treasury Bond ETF

$101.57

-0.355 (-0.35%)

SHY

iShares 1-3 Year Treasury Bond

$83.26

-0.03 (-0.04%)

IWD

iShares Russell 1000 Value

$121.38

-0.61 (-0.50%)

IWF

iShares Russell 1000 Growth

$137.65

-1.53 (-1.10%)

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JAGX

Jaguar Health

$0.16

-0.0051 (-3.02%)

17:07
04/20/18
04/20
17:07
04/20/18
17:07
Syndicate
Breaking Syndicate news story on Jaguar Health »

Jaguar Health files to…

03/08/13
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WMT

Walmart

$86.98

-0.9 (-1.02%)

, FB

Facebook

$166.29

-1.82 (-1.08%)

17:05
04/20/18
04/20
17:05
04/20/18
17:05
Hot Stocks
Walmart says Kevin Systrom will not stand for re-election to board »

Walmart and Systrom, the…

WMT

Walmart

$86.98

-0.9 (-1.02%)

FB

Facebook

$166.29

-1.82 (-1.08%)

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WMT

Walmart

$86.98

-0.9 (-1.02%)

, MCD

McDonald's

$158.77

-0.76 (-0.48%)

17:03
04/20/18
04/20
17:03
04/20/18
17:03
Hot Stocks
Walmart announces McDonald's Steve Easterbrook as independent nominee to board »

"This year's…

WMT

Walmart

$86.98

-0.9 (-1.02%)

MCD

McDonald's

$158.77

-0.76 (-0.48%)

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Barclays

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  • 20

    Apr

  • 30

    Apr

  • 17

    May

  • 24

    May

  • 30

    May

  • 30

    May

  • 01

    Jun

SPY

SPDR S&P 500 ETF Trust

$266.66

-2.18 (-0.81%)

, USO

United States Oil Fund

$13.76

-0.01 (-0.07%)

17:00
04/20/18
04/20
17:00
04/20/18
17:00
General news
Weekly CFTC Commitment of Traders highlights »

S&P500 net long 2.5K…

SPY

SPDR S&P 500 ETF Trust

$266.66

-2.18 (-0.81%)

USO

United States Oil Fund

$13.76

-0.01 (-0.07%)

GLD

SPDR Gold Trust

$126.61

-1.01 (-0.79%)

FXE

Euro Currency Trust

$118.04

-0.65 (-0.55%)

FXC

CurrencyShares Canadian Dollar Trust

$77.37

-0.54 (-0.69%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

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