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PFE

Pfizer

$35.79

-0.16 (-0.45%)

08:04
04/12/18
04/12
08:04
04/12/18
08:04

Pfizer initiates Phase 1b trial for DMD therapy candidate

Pfizer has initiated a Phase 1b clinical trial for its mini-dystrophin gene therapy candidate, PF-06939926, in boys with Duchenne muscular dystrophy, or DMD. The first boy received an infusion of the mini-dystrophin gene on March 22nd. Screening and enrollment of patients is expected to continue at up to four clinical research sites in the United States. Early data from this trial are expected in the first half of 2019, once all patients have been evaluated for one full year post-treatment. The multi-center, open-label, non-randomized, ascending dose study of a single intravenous infusion of PF-06939926 will enroll approximately 12 ambulatory boys aged 5 to 12 years with DMD. In addition to evaluating safety and tolerability, the study will evaluate measurements of dystrophin expression and distribution, as well as assessments of muscle strength, quality and function.

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PFE Pfizer
$35.79

-0.16 (-0.45%)

04/05/18
LEHM
04/05/18
NO CHANGE
LEHM
Barclays upgrades Merck, downgrades Biogen and Pfizer in sector reassessment
Barclays analyst Geoff Meacham made some rating changes while reassessing the Biopharmaceutical sector. Biopharma sentiment has been negative since the start of 2018, despite a modest pick-up in deals and diminished rhetoric on drug pricing, Meacham tells investors in a research note titled "U.S. Biopharmaceuticals: Where to from here?" The analyst believes "more transformative" acquisitions, "clean" Phase 3 wins, and even a relatively strong Q1 earnings season could help "re-rate the sector" and get investors more engaged in the group. Ahead of the Q1 earnings season, Meacham upgraded Merck (MRK) to Overweight from Equal Weight and downgraded to Equal Weight from Overweight shares of Biogen (BIIB), Pfizer (PFE), Biohaven Pharmaceutical (BHVN) and Myovant Sciences (MYOV). The analyst also lowered his price target for Equal Weight-rated AbbVie (ABBV) to $102 from $120, for Equal Weight-rated Amgen (AMGN) to $180 from $180, for Overweight-rated Prothena (PRTA) to $50 from $70 and for Overweight-rated Incyte (INCY) to $135 from $165.
04/05/18
04/05/18
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Intel (INTC) downgraded to Hold from Buy at Stifel with analyst Kevin Cassidy citing the peaking server central processing unit cycle and valuation for the downgrade. 2. Johnson Controls (JCI) downgraded to Underperform from Sector Perform at RBC Capital with analyst Deane Dray citing the company's exposure to additional cash flow pressures in fiscal 2018, reduction in fiscal 2020 targets, and a market rotation toward "more defensive names." 3. Ryder (R) downgraded to Underweight from Neutral at JPMorgan with analyst Brian Ossenbeck saying he is making a "longer term call on 2019 expectations," which he believes are too high and embed "significant gains on residual values and used truck sales." 4. Ollie's Bargain Outlet (OLLI) downgraded to Neutral from Buy at BofA/Merrill with analyst Elizabeth Suzuki saying valuation is getting "richer," quarterly comps have been decelerating since 2015, and are now expected to be 1%-2% in 2018. 5. Biogen (BIIB), Pfizer (PFE), Biohaven (BHVN), and Myovant Sciences (MYOV) were downgraded to Equal Weight from Overweight at Barclays. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
04/12/18
SBSH
04/12/18
NO CHANGE
SBSH
Sell
Pfizer has no interest in acquiring Bristol-Myers right now, says Citi
Citi analyst Andrew Baum says Pfizer's (PFE) CEO made it clear to him that the company has no interest in acquiring Bristol-Myers Squibb (BMY) in the absence of transformational data or a de-rating in the shares. Pfizer has high conviction in its current pipeline and believes that the return on investment is considerably higher than high risk transformational deals, particularly in the immuno-oncology space, Baum tells investors in a research note. The analyst expects Pfizer will meaningfully increase its current share repurchase program from the current $5B-$6B per annum to offset the earnings dilution from higher anticipated R&D investment to monetize its current pipeline. Baum keeps a Sell rating on Pfizer and continues to prefer shares of Merck (MRK), Bristol and Eli Lilly (LLY) in the U.S. The analyst lowered his price target for Bristol shares to $70 from $78 with Pfizer backing away from a potential takeover. He keeps a Buy rating on the shares, however.
04/12/18
SBSH
04/12/18
NO CHANGE
Target $70
SBSH
Buy
Bristol-Myers price target lowered to $70 from $78 at Citi
Citi analyst Andrew Baum lowered his price target for Bristol-Myers Squibb (BMY) to $70 after Pfizer (PFE) management made clear to him that they had no interest in acquiring Bristol without transformational data or a de-rating in the shares. The analyst removed the $8 per share risk adjusted M&A premium from his Bristol-Myers target price. He views his new price target as conservative, however, and keeps a Buy rating on the name.

TODAY'S FREE FLY STORIES

HBI

Hanesbrands

$17.22

-0.385 (-2.19%)

21:10
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CYOU

Changyou.com

$30.33

-0.16 (-0.52%)

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KSU

Kansas City Southern

$112.00

1.76 (1.60%)

21:07
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COUP

Coupa Software

$46.67

-0.61 (-1.29%)

21:07
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21:07
Initiation
Coupa Software initiated  »

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STT

State Street

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-4.57 (-4.39%)

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HAL

Halliburton

$51.95

-0.06 (-0.12%)

, HAS

Hasbro

$82.89

-1.1 (-1.31%)

20:25
04/22/18
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20:25
Earnings
Notable companies reporting before Monday's open »

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HAL

Halliburton

$51.95

-0.06 (-0.12%)

HAS

Hasbro

$82.89

-1.1 (-1.31%)

ALK

Alaska Air

$65.39

-0.165 (-0.25%)

KMB

Kimberly-Clark

$100.04

-3.3 (-3.19%)

LII

Lennox

$196.93

-5.755 (-2.84%)

LECO

Lincoln Electric

$92.68

-0.21 (-0.23%)

TCF

TCF Financial

$22.67

-0.11 (-0.48%)

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VIA

Viacom

$35.35

-0.25 (-0.70%)

, VIAB

Viacom

$30.65

-0.1 (-0.33%)

19:29
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VIA

Viacom

$35.35

-0.25 (-0.70%)

VIAB

Viacom

$30.65

-0.1 (-0.33%)

EPD

Enterprise Products

$26.60

-0.03 (-0.11%)

MMP

Magellan Midstream

$65.16

-0.755 (-1.15%)

MPLX

MPLX

PAA

Plains All American

$24.68

0.42 (1.73%)

GOOG

Alphabet

$1,072.73

-15.18 (-1.40%)

GOOGL

Alphabet Class A

$1,076.64

-12.83 (-1.18%)

AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

FB

Facebook

$166.29

-1.82 (-1.08%)

AAPL

Apple

$165.71

-7.08 (-4.10%)

MSFT

Microsoft

$95.01

-1.1 (-1.14%)

BIDU

Baidu

$232.38

-4.73 (-1.99%)

BABA

Alibaba

$179.07

-2.14 (-1.18%)

INTC

Intel

$51.53

-0.68 (-1.30%)

NVDA

Nvidia

$228.74

-0.21 (-0.09%)

CCL

Carnival

$65.88

0.82 (1.26%)

RCL

Royal Caribbean

$119.11

1.18 (1.00%)

NCLH

Norwegian Cruise Line

$55.65

0.71 (1.29%)

DIS

Disney

$100.24

-0.64 (-0.63%)

GIS

General Mills

$43.41

-0.61 (-1.39%)

DAL

Delta Air Lines

$55.40

0.34 (0.62%)

GM

General Motors

$37.61

-0.16 (-0.42%)

TPR

Tapestry

$53.03

-0.255 (-0.48%)

FSNUY

Fresenius SE

AKRX

Akorn

$19.68

0.31 (1.60%)

TCEHY

Tencent

03/08/13
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TCEHY

Tencent

18:45
04/22/18
04/22
18:45
04/22/18
18:45
Periodicals
Tencent Music Entertainment prepares IPO, WSJ reports »

Tencent Music…

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TAHO

Tahoe Resources

$5.39

-0.05 (-0.92%)

18:13
04/22/18
04/22
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18:13
Hot Stocks
Tahoe Resources labor strike at La Arena mine in Peru »

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LUV

Southwest

$54.76

-0.02 (-0.04%)

17:56
04/22/18
04/22
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17:56
Periodicals
Southwest cancels 40 flights for inspection, Reuters reports »

Southwest Airlines said…

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TWX

Time Warner

$96.23

-0.34 (-0.35%)

, CMCSA

Comcast

$33.21

-0.28 (-0.84%)

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TWX

Time Warner

$96.23

-0.34 (-0.35%)

CMCSA

Comcast

$33.21

-0.28 (-0.84%)

CMCSK

Comcast

SNE

Sony

$49.76

0.03 (0.06%)

FOX

21st Century Fox

$36.21

-0.46 (-1.25%)

FOXA

21st Century Fox

$36.69

-0.51 (-1.37%)

LGF.A

Lionsgate

$25.76

-0.44 (-1.68%)

DIS

Disney

$100.24

-0.64 (-0.63%)

VIAB

Viacom

$30.65

-0.1 (-0.33%)

VIA

Viacom

$35.35

-0.25 (-0.70%)

03/08/13
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BAC

Bank of America

$30.26

0.06 (0.20%)

, WFC

Wells Fargo

$52.57

1.02 (1.98%)

16:40
04/22/18
04/22
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16:40
Periodicals
Big banks push mortgage apps, websites as home lending slows, Reuters reports »

Big U.S. banks are racing…

BAC

Bank of America

$30.26

0.06 (0.20%)

WFC

Wells Fargo

$52.57

1.02 (1.98%)

JPM

JPMorgan

$111.47

-0.26 (-0.23%)

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AMZN

Amazon.com

$1,527.39

-29.57 (-1.90%)

16:34
04/22/18
04/22
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16:34
Periodicals
Amazon to broaden offering in groceries in India, Reuters says »

Amazon expects groceries…

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F

Ford

$10.82

-0.14 (-1.28%)

, WPP

WPP

$80.16

-1.21 (-1.49%)

16:27
04/22/18
04/22
16:27
04/22/18
16:27
Periodicals
Ford to take bids on some advertising managed by WPP, Reuters reports »

Ford (F) said it will…

F

Ford

$10.82

-0.14 (-1.28%)

WPP

WPP

$80.16

-1.21 (-1.49%)

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FB

Facebook

$166.29

-1.82 (-1.08%)

16:23
04/22/18
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16:23
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16:23
Periodicals
Facebook sets lobbying record, Axios reports »

Facebook spent $3.3M on…

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  • 25

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AKRX

Akorn

$19.68

0.31 (1.60%)

, FSNUY

Fresenius SE

16:19
04/22/18
04/22
16:19
04/22/18
16:19
Hot Stocks
Akorn responds to Fresenius decision to terminate merger agreement »

Akorn (AKRX) issued a…

AKRX

Akorn

$19.68

0.31 (1.60%)

FSNUY

Fresenius SE

03/08/13
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INFY

Infosys

$17.38

0.21 (1.22%)

15:34
04/22/18
04/22
15:34
04/22/18
15:34
Conference/Events
Infosys to host analyst meeting »

Analyst meeting to be…

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AKRX

Akorn

$19.68

0.31 (1.60%)

, FSNUY

Fresenius SE

14:08
04/22/18
04/22
14:08
04/22/18
14:08
Hot Stocks
Fresenius terminates merger agreement with Akorn over data breaches »

Fresenius (FSNUY) decided…

AKRX

Akorn

$19.68

0.31 (1.60%)

FSNUY

Fresenius SE

03/08/13
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LEVB

Level Brands

$5.15

0.25 (5.10%)

12:20
04/22/18
04/22
12:20
04/22/18
12:20
Conference/Events
Level Brands CEO Sumichrast interview to air on The RedChip Money Report »

Marty Sumichrast,…

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  • 22

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LEVB

Level Brands

$5.15

0.25 (5.10%)

04:55
04/22/18
04/22
04:55
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04:55
Conference/Events
Level Brands CEO Sumichrast interview to air on The RedChip Money Report »

Marty Sumichrast,…

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04:55
04/22/18
04/22
04:55
04/22/18
04:55
Conference/Events
International Monetary Fund & World Bank Group to co-host an annual meeting »

2018 Spring Meeting will…

CGNT

Cogentix Medical

$3.84

-0.005 (-0.13%)

19:21
04/21/18
04/21
19:21
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19:21
Hot Stocks
Laborie Medical announces completion of tender offer for Cogentix Medical »

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TSG

The Stars Group

$29.35

0.4 (1.38%)

, SKYAY

Sky

18:31
04/21/18
04/21
18:31
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18:31
Hot Stocks
The Stars Group to acquire Sky Betting & Gaming for $4.7B »

The Stars Group (TSG)…

TSG

The Stars Group

$29.35

0.4 (1.38%)

SKYAY

Sky

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LUV

Southwest

$54.76

-0.02 (-0.04%)

18:22
04/21/18
04/21
18:22
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18:22
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Southwest responds to Emergency Airworthiness Directive »

Southwest Airlines said…

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TPR

Tapestry

$53.03

-0.255 (-0.48%)

16:17
04/21/18
04/21
16:17
04/21/18
16:17
Periodicals
Tapestry could see more stock gains, Barron's says »

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03/08/13
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