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XENE

Xenon Pharmaceuticals

$6.03

0.175 (2.99%)

06:11
05/15/18
05/15
06:11
05/15/18
06:11

Xenon Pharmaceuticals presents 'positive' XEN1101 Phase 1 data

Xenon Pharmaceuticals presented positive interim data from its ongoing XEN1101 Phase 1 clinical trial in a podium presentation at the 14th Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain. XEN1101 is a Kv7 potassium channel opener being developed by Xenon for the treatment of epilepsy including: treatment-resistant adult and pediatric focal seizures as well as rare, pediatric forms of epilepsy, such as EIEE7, an early infantile epileptic encephalopathy associated with mutations in the KCNQ2 gene encoding the Kv7.2 potassium channel; and potentially other neurological disorders. Xenon presented interim data from its ongoing XEN1101 Phase 1 clinical trial, which is evaluating the safety, tolerability and pharmacokinetics of both single ascending doses and multiple ascending doses of XEN1101 in healthy subjects, along with results from the completed Phase 1a pilot transcranial magnetic stimulation study in 8 healthy subjects. The pilot TMS study was designed to assess XEN1101's ability to inhibit cortical excitability, an important CNS effect observed with anti-epileptic drugs. Based on this pilot Phase 1a TMS study, Xenon has initiated a double-blind, placebo-controlled, randomized cross-over Phase 1b TMS study, which is expected to include approximately 15 to 20 healthy subjects and be completed by mid-year, with data expected in the second half of 2018.

XENE Xenon Pharmaceuticals
$6.03

0.175 (2.99%)

06/27/17
WELS
06/27/17
NO CHANGE
WELS
Market Perform
Teva TV-45070 trial miss a 'modest disappointment,' says Wells Fargo
Wells Fargo analyst David Maris said TV-45070 has not been a focus for Teva (TEVA) investors, but he still views the news that the company and partner Xenon Pharmaceuticals' (XENE) Phase 2 trial in post-herpetic neuralgia missed its primary endpoint as a "modest disappointment" given the need for Teva's pipeline to offset the tough generic market and the eventual competition for Copaxone. Maris keeps a Market Perform rating on Teva.
06/28/17
JEFF
06/28/17
NO CHANGE
Target $5
JEFF
Buy
Xenon Pharmaceuticals price target lowered to $5 from $8 at Jefferies
Jefferies analyst Maury Raycroft lowered his price target for Xenon Pharmaceuticals to $5 citing the "disappointing" Phase II results for TV-45070 in postherpetic neuralgia. The analyst, noting the company's other programs continue to advance, keeps a Buy rating on Xenon.
03/22/18
JEFF
03/22/18
NO CHANGE
Target $6
JEFF
Buy
Xenon Pharmaceuticals price target raised to $6 from $5 at Jefferies
Jefferies analyst Maury Raycroft raised his price target for Xenon Pharmaceuticals to $6 and keeps a Buy rating on the shares after traveling with management. The analyst sees 2018 as a key year for the company with data readouts in epilepsy. Initial data in May will likely move the stock, Raycroft tells investors in a research note.

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