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SNDX

Syndax

$11.11

-0.27 (-2.37%)

, MRK

Merck

$59.76

0.58 (0.98%)

07:02
05/17/18
05/17
07:02
05/17/18
07:02

Syndax reports updated results from Phase 2 ENCORE 601 trial

Syndax Pharmaceuticals (SNDX) announced updated results from multiple cohorts of the ongoing Phase 2 ENCORE 601 trial of entinostat in combination with KEYTRUDA, Merck's (MRK) anti-PD-1 therapy. This data will be presented at the American Society of Clinical Oncology (ASCO) Annual Meeting being held June 1-5, 2018 in Chicago, Illinois. ENCORE 601 is a Phase 1b/2 trial evaluating the efficacy and safety of entinostat in combination with pembrolizumab across multiple cohorts of PD-(L)1 treatment-naive and pre-treated cancers, including non-small cell lung cancer, melanoma and microsatellite stable colorectal cancer. Confirmed objective responses with the combination regimen have been observed across all cohorts. Updated data continue to demonstrate a manageable toxicity profile for the entinostat-pembrolizumab combination, with treatment emergent adverse events observed consistent with those previously reported. The ENCORE 601 study also incorporates an extensive biomarker assessment of pre- and on-treatment blood and tumor samples from all patient cohorts with the goal of identifying a patient enrichment strategy that may predict enhanced clinical benefit across various cohorts and, therefore, potentially inform the design of future registration-directed studies.

SNDX

Syndax

$11.11

-0.27 (-2.37%)

MRK

Merck

$59.76

0.58 (0.98%)

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SNDX Syndax
$11.11

-0.27 (-2.37%)

08/11/17
OPCO
08/11/17
NO CHANGE
Target $29
OPCO
Outperform
Syndax price target raised to $29 from $25 at Oppenheimer
Oppenheimer analyst Hartaj Singh raised his price target for Syndax Pharmaceuticals to $29 saying he remains bullish following the Q2 results and business update. The Encore 601 trial melanoma stage two cohort continues to build on its "impressive" ASCO 2016 data, with full enrollment in Q3, a full quarter ahead of schedule, the analyst tells investors in a research note. He keeps an Outperform rating on Syndax.
01/05/18
RILY
01/05/18
INITIATION
Target $40
RILY
Buy
Syndax initiated with a Buy at B. Riley FBR
B. Riley FBR analyst Madhu Kumar started Syndax Pharmaceuticals with a Buy rating and $40 price target. The analyst sees "highly favorable risk/reward dynamics" for the company's lead asset, entinostat, in breast cancer.
01/05/18
01/05/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Becton Dickinson (BDX) initiated with an Overweight at KeyBanc. 2. Syndax (SNDX) initiated with a Buy at B. Riley FBR. 3. Sutherland Asset Management (SLD) initiated with an Outperform at JMP Securities. 4. Nike (NKE) was assumed with a Buy at Buckingham while Under Armour (UA, UAA) was assumed with a Neutral. 5. Regulus (RGLS) initiated with an Outperform at Leerink. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
05/09/18
NOMU
05/09/18
NO CHANGE
Target $22
NOMU
Buy
Syndax risk/reward positive into data, says Nomura Instinet
Nomura Instinet analyst Christopher Marai sees a positive risk/reward on Syndax Pharmaceuticals into the entinostat readout, expected in Q3. The analyst believes downside is limited on this readout, given expectations and the potential for success on the overall survival endpoint. He calls the stock "significantly undervalued" and keeps a Buy rating on Syndax with a $22 price target.
MRK Merck
$59.76

0.58 (0.98%)

04/25/18
DBAB
04/25/18
NO CHANGE
DBAB
Hold
Merck may need to reassess animal health unit, says Deutsche Bank
While Merck (MRK) describes its animal health unit as a key growth driver and an important part of the company, it remains to be seen whether investors will continue to accept this as a reason for the business to remain within the company, Deutsche Bank analyst Gregg Gilbert tells investors in a research note. He believes the unit is potentially undervalued. Given Zoetis' (ZTS) success as a company and a stock, and Eli Lilly's (LLY) ongoing review of strategic options for its Elanco Animal Health business, Gilbert conducted a preliminary separation analysis of Merck's animal health unit. The analysis suggests that a separation could be meaningfully accretive to earnings. The analyst keeps a Hold rating on Merck.
04/26/18
BMOC
04/26/18
NO CHANGE
Target $70
BMOC
Outperform
Merck price target raised to $70 from $65 at BMO Capital
BMO Capital analyst Alex Arfaei raised his price target on Merck to $70 and kept his Outperform rating, forecasting a "mixed to net-positive" Q1 earnings report. The analyst notes the focus will likely fall on the core Keytruda and Januvia franchises as he raises his peak sales estimate for the former to $13B from $12B after KN-189 data, which he expects to be further supported by discussions at ASCO.
05/10/18
STFL
05/10/18
NO CHANGE
STFL
Hold
Exelixis pullback may create interesting entry point, says Stifel
After Exelixis (EXEL) and partner Roche (RHHBY) announced the Phase 3 IMblaze370 trial did not achieve statistical-significance on the primary efficacy endpoint evaluating the ability of a combination of a MEK inhibitor and anti-PD-L1 to improve overall survival in patients with microsatellite stable metastatic colorectal cancer, Stifel analyst Stephen Willey said he believes attrition in Exelixis shares might create an interesting entry point. The failure of IMblaze370 removes some of Exelixis' longer-term optionality and he expects topics of RCC growth/competition, label expansion, and longer-term cabozantinib exclusivity to remain core to the story going forward, said Willey who has a Hold rating on the stock. Array BioPharma (ARRY) also has Phase 1/2 development collaborations in place with both Bristol-Myers (BMY) and Merck (MRK) evaluating the MEK/PD-1 hypothesis in earlier-lines of MSS mCRC, noted Willey, who said he would "be opportunistic" on any weakness in its shares. He maintains a Buy rating on Array, which is down 5% in pre-market trading.
05/16/18
SPHN
05/16/18
INITIATION
Target $16
SPHN
Overweight
Codexis initiated with an Overweight at Stephens
Stephens analyst Drew Jones started Codexis (CDXS) with an Overweight rating and $16 price target, stating that the company's CodeEvolver platform technology has been sought by pharma partners Merck (MRK), GlaxoSmithKline (GSK) and Nestle (NSRGY) and he expects continued deeper adoption from other major industry players.

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APTX

Aptinyx

$24.75

-0.76 (-2.98%)

21:40
11/14/18
11/14
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Initiation
Aptinyx initiated at Cantor Fitzgerald »

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OVID

Ovid Therapeutics

$4.75

-0.42 (-8.12%)

21:39
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Initiation
Ovid Therapeutics initiated at Cantor Fitzgerald »

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AXSM

Axsome Therapeutics

$2.82

-0.07 (-2.42%)

21:38
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Initiation
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DNLI

Denali Therapeutics

$17.53

0.24 (1.39%)

21:37
11/14/18
11/14
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Initiation
Denali Therapeutics initiated at Cantor Fitzgerald »

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OTIC

Otonomy

$2.34

-0.07 (-2.90%)

21:35
11/14/18
11/14
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21:35
Initiation
Otonomy initiated at Cantor Fitzgerald »

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  • 27

    Nov

AAPL

Apple

$186.81

-5.42 (-2.82%)

20:46
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Hot Stocks
Apple supplier AMS AG discontinues FY18 targets »

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  • 14

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WEI

Weidai

$0.00

(0.00%)

20:33
11/14/18
11/14
20:33
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20:33
Syndicate
Weidai 4.5M share IPO priced at $10.00 »

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  • 15

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CPB

Campbell Soup

$39.16

-0.1 (-0.25%)

20:31
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Campbell Soup responds to ISS regarding board elections »

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  • 20

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CRM

Salesforce

$129.25

-2.93 (-2.22%)

20:25
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20:25
Periodicals
Breaking Periodicals news story on Salesforce »

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WMT

Walmart

$101.58

-1.37 (-1.33%)

, JCP

J.C. Penney

$1.23

-0.05 (-3.91%)

20:25
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20:25
Earnings
Notable companies reporting before tomorrow's open »

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WMT

Walmart

$101.58

-1.37 (-1.33%)

JCP

J.C. Penney

$1.23

-0.05 (-3.91%)

BERY

Berry Global

$45.91

-0.49 (-1.06%)

03/08/13
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BHVN

Biohaven Pharmaceutical

$33.70

-3.18 (-8.62%)

19:53
11/14/18
11/14
19:53
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Recommendations
Biohaven Pharmaceutical analyst commentary at Piper Jaffray »

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LOXO

Loxo Oncology

$143.69

-15.62 (-9.80%)

19:51
11/14/18
11/14
19:51
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19:51
Initiation
Loxo Oncology initiated at Raymond James »

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OCUL

Ocular Therapeutix

$5.06

-0.25 (-4.71%)

19:50
11/14/18
11/14
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19:50
Initiation
Ocular Therapeutix initiated at Raymond James »

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VYGR

Voyager Therapeutics

$11.25

-0.54 (-4.58%)

19:49
11/14/18
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19:49
Upgrade
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  • 14

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GLPG

Galapagos NV

$103.79

1.03 (1.00%)

19:48
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Initiation
Galapagos NV initiated at Raymond James »

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COPY

CopyTele

$0.00

(0.00%)

19:47
11/14/18
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19:47
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19:47
Upgrade
CopyTele rating change at BMO Capital »

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VICI

VICI Properties

$21.43

-0.04 (-0.19%)

19:40
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Syndicate
VICI Properties 30M share Secondary priced at $21.00 »

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  • 15

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WHD

Cactus

$32.37

-0.7 (-2.12%)

19:37
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RVLT

Revolution Lighting

$1.42

(0.00%)

19:32
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Revolution Lighting receives revised $1.50 per share proposal from RVL LLC »

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GE

General Electric

$8.34

-0.265 (-3.08%)

19:20
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Periodicals
General Electric withdraws from Nigeria rail concession, Reuters says »

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BCSF

Bain Capital Specialty Finance

$0.00

(0.00%)

19:11
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Syndicate
Bain Capital Specialty Finance 7.5M share IPO price $20.25 »

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  • 15

    Nov

TSLA

Tesla

$344.07

5.36 (1.58%)

19:07
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