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AGLE

Aeglea BioTherapeutics

07:09
06/14/18
06/14
07:09
06/14/18
07:09

Aeglea BioTherapeutics initiated with an Outperform at BMO Capital

BMO Capital analyst Matthew Luchini initiated Aeglea BioTherapeutics with an Outperform rating and a price target of $21. The analyst states that its lead drug, pegzilarginase, may "transform" the Arginase I Deficiency treatment, with the results from the Phase 1/2 trial for two patients showing improvement in clinically relevant endpoints. Luchini anticipates Q3 results to confirm the data, leading to the initiation of a phase 3 trial next year and a potential approval in 2021. The analyst adds that expansion into oncology and other preclinical studies for pegzilarginase offer further upside.

AGLE Aeglea BioTherapeutics

04/13/18
WELS
04/13/18
NO CHANGE
WELS
Outperform
Wells Fargo increasingly confident on Aeglea's pegzilarginase
Wells Fargo analyst Jim Birchenough reiterates an Outperform rating on shares of Aeglea BioTherapeutics following a call with senior management. The analyst has increased confidence on pegzilarginase's clinical results and the potential positive implications for a de-risked regulatory path. He continues to believe that Aeglea's orphan drug opportunity has been underestimated and sees further upside on additional updates expected in the second half of 2018. Birchenough keeps a $24 price target for the shares.
04/13/18
NEED
04/13/18
NO CHANGE
Target $20
NEED
Buy
Aeglea BioTherapeutics price target raised to $20 from $12 at Needham
Needham analyst Chad Messer raised his price target on Aeglea BioTherapeutics to $20 after the company's Phase 1/2 study presentation for pegzilarginase in Arginase 1 Deficiency at the American College of Medical Genetics and Genomics meeting. Messer points to "significant improvements in multiple parameters" for 2 patients after they completed just 8 weeks of dosing, which should "substantially de-risk" the ARG1-D program going forward. The analyst expects a multi-dose readout in Q3 and a pivotal study design to be completed by the end of this year while forecasting a commercial launch in late 2020. Messer also keeps his Buy rating on Aeglea BioTherapeutics.
04/24/18
EVER
04/24/18
INITIATION
Target $37
EVER
Outperform
Aeglea BioTherapeutics initiated with an Outperform at Evercore ISI
Evercore ISI analyst Joshua Schimmer started Aeglea BioTherapeutics with an Outperform rating and $37 price target, calling it "one of the most compelling investment opportunities in all of small-cap biotech" after the company's pegzilarginase demonstrated early proof of concept with an acceptable safety profile.
04/24/18
04/24/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. First Data (FDC) initiated with a Buy at Mizuho. 2. Allergan (AGN) resumed with a Buy at Citi. 3. Alder Biopharmaceuticals (ALDR) initiated with a Neutral at Goldman Sachs. 4. ConvergeOne (CVON) initiated with an Outperform at Cowen. 5. Aeglea BioTherapeutics (AGLE) initiated with an Outperform at Evercore ISI. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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