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VCNX

Vaccinex

$7.00

0.09 (1.30%)

08:37
10/02/18
10/02
08:37
10/02/18
08:37

Vaccinex presents data on anti-semaphorin 4D monoclonal antibody technology

Vaccinex announced it presented both a poster and a podium session regarding its anti-semaphorin 4D monoclonal antibody technology, which serves as the basis of its investigational drug pepinemab. The data were presented at the International Cancer Immunotherapy Conference, or CIC. The data outlined results from several preclinical studies of the anti-SEMA4D MAb as both a single agent and in combination with various immunotherapy agents. The data demonstrated the blockade of semaphorin 4D allowed dendritic and cytotoxic T cells to migrate into the tumor, while reversing myeloid-derived immunosuppression. Further, the anti-SEMA4D MAb enhanced the activity of co-administered immunotherapy in mouse melanoma, head and neck, and colon carcinoma models. Specifically, the company's MAb plus anti-CTLA-4 resulted in 100 percent survival and 90 percent tumor rejection in head and neck cancer models. In addition, anti-SEMA4D combined with HDAC inhibitor entinostat resulted in maximal tumor growth delay and 90% complete response in Colon26 tumor models. The design of ongoing pepinemab combination immunotherapy clinical trials was also presented.

VCNX Vaccinex
$7.00

0.09 (1.30%)

09/04/18
BTIG
09/04/18
INITIATION
Target $20
BTIG
Buy
Vaccinex initiated with a Buy at BTIG
BTIG analyst Thomas Shrader initiated Vaccinex with a Buy rating and a price target of $20, citing the prospects of its VX15 development as "an anti-Semaphorin 4D monoclonal antibody with broad abilities to modulate the function of immune cells." The analyst cites the drug's potential ability to inhibit the inflammation that does much of the damage in patients with Huntington's disease, along with the evidence of benefits in cancer patients as "VX15 demonstrated an ability to turn cold tumors hot by reducing the effects of immunosuppressive cells from the tumor microenvironment". Shrader believes that a "deep-pocket partner" will be needed for Vaccinex programs, but sees the possibility of "non-dilutive funding down the road".
09/04/18
OPCO
09/04/18
INITIATION
Target $22
OPCO
Outperform
Vaccinex initiated with an Outperform at Oppenheimer
Oppenheimer analyst Leland Gershell started Vaccinex with an Outperform rating and $22 price target. Although key clinical readouts lie one to two years away, the analyst believes the shares will reward the patient investor.
09/04/18
09/04/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Roku (ROKU) initiated with a Buy at Guggenheim. 2. Zayo Group (ZAYO) initiated with a Buy at Jefferies. 3. Amalgamated Bank (AMAL) initiated with an Overweight at JPMorgan, a Buy at Sandler O'Neill, a Market Perform at Keefe Bruyette, and a Neutral at Piper Jaffray. 4. Vaccinex (VCNX) initiated with an Outperform at Oppenheimer and a Buy at BTIG. 5. Skyline (SKY) initiated with a Hold at SunTrust. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

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SIBN

SI-BONE

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SI-BONE 7.2M share IPO priced at $15.00 »

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AMX

America Movil, also tag AMOV

$15.77

0.38 (2.47%)

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America Movil, also tag AMX

$15.03

(0.00%)

20:44
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20:44
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America Movil reports Q3 net income MXN18.96B vs. MXN2.52B last year »

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America Movil, also tag AMOV

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America Movil, also tag AMX

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ABT

Abbott

$70.94

2.22 (3.23%)

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U.S. Bancorp

$50.97

0.44 (0.87%)

20:25
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Earnings
Notable companies reporting before tomorrow's open »

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ABT

Abbott

$70.94

2.22 (3.23%)

USB

U.S. Bancorp

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0.44 (0.87%)

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ADTN

Adtran

$18.15

1.08 (6.33%)

20:24
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Earnings
Adtran reports Q3 adjusted EPS 21c, consensus 4c »

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WAFD

Washington Federal

$29.75

0.45 (1.54%)

20:02
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20:02
Earnings
Washington Federal reports Q4 EPS 62c, consensus 62c »

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UNH

UnitedHealth

$272.24

12.44 (4.79%)

19:30
10/16/18
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19:30
Recommendations
UnitedHealth analyst commentary at Piper Jaffray »

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  • 16

    Oct

CDAY

Ceridian

$38.44

1.38 (3.72%)

19:25
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Conference/Events
Ceridian to hold a conference »

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  • 16

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HMC

Honda

$27.70

0.65 (2.40%)

19:07
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19:07
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19:07
Periodicals
Honda Aircraft sees higher light jet deliveries next year, Reuters says »

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  • 24

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VALE

Vale

$15.50

0.045 (0.29%)

18:59
10/16/18
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18:59
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18:59
Periodicals
Vale plans to use cash flow cautiously going forward, Reuters says »

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VICR

Vicor Corporation

$38.35

1.42 (3.85%)

, NFLX

Netflix

$346.40

13.29 (3.99%)

18:55
10/16/18
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18:55
Hot Stocks
Fly Intel: After Hours Movers »

UP AFTER EARNINGS: Vicor…

VICR

Vicor Corporation

$38.35

1.42 (3.85%)

NFLX

Netflix

$346.40

13.29 (3.99%)

LRCX

Lam Research

$145.33

2.72 (1.91%)

AMAT

Applied Materials

$34.76

1.33 (3.98%)

UAL

United Continental

$83.51

2.17 (2.67%)

FULT

Fulton Financial

$16.39

0.29 (1.80%)

CSX

CSX

$72.15

1.29 (1.82%)

CREE

Cree

$37.56

2.53 (7.22%)

ROKU

Roku

$63.67

1.97 (3.19%)

IBM

IBM

$145.02

3.9 (2.76%)

UFPI

Universal Forest

$34.08

1.27 (3.87%)

SONC

Sonic

$43.27

-0.03 (-0.07%)

EIGR

Eiger BioPharmaceuticals

$10.88

0.63 (6.15%)

SBH

Sally Beauty

$18.91

0.42 (2.27%)

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NFLX

Netflix

$346.40

13.29 (3.99%)

18:38
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Hot Stocks
Netflix says it has a 'long, long runway' in India »

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CBL

CBL & Associates

$3.52

0.085 (2.48%)

, SHLD

Sears

$0.40

0.09 (29.03%)

18:33
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Hot Stocks
CBL Properties updates on redevelopment plan for Sears stores »

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CBL

CBL & Associates

$3.52

0.085 (2.48%)

SHLD

Sears

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0.09 (29.03%)

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  • 30

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VZ

Verizon

$53.68

0.08 (0.15%)

18:26
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Verizon says Bay, Gulf counties customers to be credited 3 months of service »

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  • 12

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BMO

Bank of Montreal

$80.19

0.93 (1.17%)

18:09
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Periodicals
Bank of Montreal names Wolford investment banking vice chair, Reuters says »

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SFTBF

SoftBank

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18:02
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Periodicals
SoftBank COO says 'anxiously' looking at Saudi Arabia situation, Reuters says »

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  • 16

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IBM

IBM

$145.02

3.9 (2.76%)

18:01
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Hot Stocks
IBM sees growth in cloud overall »

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CELC

Celcuity

$26.90

0.4 (1.51%)

, PBYI

Puma Biotechnology

$42.22

1.17 (2.85%)

17:57
10/16/18
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17:57
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17:57
Hot Stocks
Celcuity, Puma Biotechnology and West Cancer Center to conduct Phase 2 trial »

Celcuity (CELC) announced…

CELC

Celcuity

$26.90

0.4 (1.51%)

PBYI

Puma Biotechnology

$42.22

1.17 (2.85%)

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  • 19

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DVN

Devon Energy

$37.08

0.98 (2.71%)

17:51
10/16/18
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17:51
Recommendations
Devon Energy analyst commentary at MUFG »

Devon Energy price target…

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VIA

Viacom

$36.07

1.11 (3.18%)

, VIAB

Viacom

$32.83

1.05 (3.30%)

17:51
10/16/18
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17:51
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17:51
Periodicals
Viacom launches Nickelodeon Chinese Animation Development Project, Variety says »

According to Variety,…

VIA

Viacom

$36.07

1.11 (3.18%)

VIAB

Viacom

$32.83

1.05 (3.30%)

IQ

iQIYI

$25.91

-0.19 (-0.73%)

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  • 16

    Oct

BHP

BHP Billiton

$48.48

0.38 (0.79%)

17:38
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Hot Stocks
BHP Billiton reports Q1 iron ore output 61.4M tons, up 10% from last year »

FY19 guidance for iron…

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UBER

Uber

$0.00

(0.00%)

17:37
10/16/18
10/16
17:37
10/16/18
17:37
Periodicals
Uber increases junk-bond offering to $2B, Bloomberg says »

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IBM

IBM

$145.02

3.9 (2.76%)

17:32
10/16/18
10/16
17:32
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17:32
Hot Stocks
IBM says growth was led by hybrid cloud, analytics and AI, digital and security »

Says remains on track…

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