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VCNX

Vaccinex

$7.00

0.09 (1.30%)

08:37
10/02/18
10/02
08:37
10/02/18
08:37

Vaccinex presents data on anti-semaphorin 4D monoclonal antibody technology

Vaccinex announced it presented both a poster and a podium session regarding its anti-semaphorin 4D monoclonal antibody technology, which serves as the basis of its investigational drug pepinemab. The data were presented at the International Cancer Immunotherapy Conference, or CIC. The data outlined results from several preclinical studies of the anti-SEMA4D MAb as both a single agent and in combination with various immunotherapy agents. The data demonstrated the blockade of semaphorin 4D allowed dendritic and cytotoxic T cells to migrate into the tumor, while reversing myeloid-derived immunosuppression. Further, the anti-SEMA4D MAb enhanced the activity of co-administered immunotherapy in mouse melanoma, head and neck, and colon carcinoma models. Specifically, the company's MAb plus anti-CTLA-4 resulted in 100 percent survival and 90 percent tumor rejection in head and neck cancer models. In addition, anti-SEMA4D combined with HDAC inhibitor entinostat resulted in maximal tumor growth delay and 90% complete response in Colon26 tumor models. The design of ongoing pepinemab combination immunotherapy clinical trials was also presented.

VCNX Vaccinex
$7.00

0.09 (1.30%)

09/04/18
BTIG
09/04/18
INITIATION
Target $20
BTIG
Buy
Vaccinex initiated with a Buy at BTIG
BTIG analyst Thomas Shrader initiated Vaccinex with a Buy rating and a price target of $20, citing the prospects of its VX15 development as "an anti-Semaphorin 4D monoclonal antibody with broad abilities to modulate the function of immune cells." The analyst cites the drug's potential ability to inhibit the inflammation that does much of the damage in patients with Huntington's disease, along with the evidence of benefits in cancer patients as "VX15 demonstrated an ability to turn cold tumors hot by reducing the effects of immunosuppressive cells from the tumor microenvironment". Shrader believes that a "deep-pocket partner" will be needed for Vaccinex programs, but sees the possibility of "non-dilutive funding down the road".
09/04/18
OPCO
09/04/18
INITIATION
Target $22
OPCO
Outperform
Vaccinex initiated with an Outperform at Oppenheimer
Oppenheimer analyst Leland Gershell started Vaccinex with an Outperform rating and $22 price target. Although key clinical readouts lie one to two years away, the analyst believes the shares will reward the patient investor.
09/04/18
09/04/18
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Roku (ROKU) initiated with a Buy at Guggenheim. 2. Zayo Group (ZAYO) initiated with a Buy at Jefferies. 3. Amalgamated Bank (AMAL) initiated with an Overweight at JPMorgan, a Buy at Sandler O'Neill, a Market Perform at Keefe Bruyette, and a Neutral at Piper Jaffray. 4. Vaccinex (VCNX) initiated with an Outperform at Oppenheimer and a Buy at BTIG. 5. Skyline (SKY) initiated with a Hold at SunTrust. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

WOLWF

Woolworths Group

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Lendlease Group

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EFSC

Enterprise Financial

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FB

Facebook

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FB

Facebook

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ENB

Enbridge

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0.425 (1.19%)

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LIN

Linde plc

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HENKY

Henkel

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CAG

Conagra Brands

$21.58

0.34 (1.60%)

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13:15
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General news
IMF trimmed global growth amid "no-deal" Brexit and trade war concerns »

IMF trimmed global growth…

UQM

UQM Technologies

$1.10

0.05 (4.76%)

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SNY

Sanofi

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-0.54 (-1.28%)

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RTN

Raytheon

$165.11

2.285 (1.40%)

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IBCP

Independent Bank

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-0.11 (-0.48%)

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FX Update: The dollar majors have been directionally challenged »

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EDIT

Editas Medicine

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GOOG

Alphabet

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6.96 (0.64%)

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Alphabet Class A

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GOOG

Alphabet

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LAD

Lithia Motors

$87.13

1.57 (1.84%)

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CYDY

CytoDyn

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ABT

Abbott

$71.43

0.9 (1.28%)

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SFUN

Fang Holdings

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TS

Tenaris

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0.64 (2.70%)

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PAAS

Pan American Silver

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-0.31 (-2.14%)

09:42
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CRWS

Crown Crafts

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AL

Air Lease

$37.50

0.6 (1.63%)

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Boeing

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