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MRK

Merck

$72.34

0.12 (0.17%)

12:26
10/21/18
10/21
12:26
10/21/18
12:26

Merck's Keytruda shows complete response rate of nearly 40% in high-risk NMIBC

Merck announced the first presentation of results from an interim analysis of KEYNOTE-057, a Phase 2 trial evaluating Keytruda, Merck's anti-PD-1 therapy, for previously treated patients with high-risk non-muscle invasive bladder cancer with carcinoma in situ or CIS plus papillary disease. An interim analysis of the study's primary endpoint showed a complete response rate of 38.8 % at three months with Keytruda in patients whose disease was unresponsive to Bacillus Calmette-Guerin therapy, the current standard of care for this disease, and who were ineligible for or who refused to undergo radical cystectomy. The study's primary endpoints are CR rate and disease-free survival rate. The secondary endpoints include safety and duration of response. At the time of analysis, 72.5% of responding patients had an ongoing response and 25% experienced recurrent disease after CR. One patient who did not develop recurrent disease discontinued study treatment and started alternative therapy. No patients in Cohort A developed muscle invasive or metastatic urothelial carcinoma. Of the patients who achieved a CR at three months, 80% had a CR lasting for six months or longer, based on the Kaplan-Meier method. The median duration of response was not yet reached. The median follow-up was 14.0 months. The safety of Keytruda in KEYNOTE-057 was consistent with what has been seen in previous trials among patients treated with Keytruda monotherapy. Treatment-related adverse events occurred in 63.1% of patients. The most common TRAEs with an incidence of 5% or more were pruritus, fatigue, diarrhea, hypothyroidism and maculopapular rash. Grade 3-5 TRAEs occurred in 13 patients, and there was one treatment-related death, per investigator assessment.

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MRK Merck
$72.34

0.12 (0.17%)

10/16/18
WELS
10/16/18
NO CHANGE
WELS
Drug price in ads not impactful, may cause confusion, says Wells Fargo
Wells Fargo analyst David Maris acknowledges that the U.S. Department of Health and Human Services' proposal to include drug prices in advertisements has a "noble goal" of making drugs more affordable and keeping patients well informed. However, given how different list prices are relative to out of pocket costs, "one must ask if this is increasing transparency or likely going to lead to more confusion," he contends. The analyst also believes that the unintended consequence could be worse care, while noting that the drug price information will likely fall into the category of the side effect information in drug ads currently, tuned out by many and will have no material impact. While he supports the idea of increased transparency, Maris wonders whether the potential benefit is not outweighed by the potential negative for the most vulnerable. Publicly traded companies in the space include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).
10/16/18
SBSH
10/16/18
NO CHANGE
Target $79
SBSH
Buy
Merck price target raised to $79 from $70 at Citi
Citi analyst Andrew Baum raised his price target for Merck (MRK) to $79 and reiterates a Buy rating on the shares. Following upward revisions to his Lynparza expectations, the analyst raised his earnings forecasts for Merck by 1%-9% over the 2021 to 2025 timeframe. The analyst anticipates that positive Lynparza first-line ovarian cancer trial will make Lynparza standard of care in wild type first-line ovarian cancer patients and leaving it well positioned to take market share in immuno-oncology based combinations post 2021. Baum also raised his price target for AstraZeneca (AZN), Merck's partner on Lynparza, to GBP 70 from GBP 62. He also has a Buy rating on those shares.
10/16/18
BTIG
10/16/18
INITIATION
Target $82
BTIG
Buy
Esperion initiated with a Buy at BTIG
BTIG analyst Thomas Shrader initiated Esperion (ESPR) with a Buy rating and a price target of $82, saying that with its development of bempedoic acid, or BA, to reduce cholesterol, the next key question is about the drug's safety. The analyst notes that while the data from Study 1 in May were disappointing, Study 2 readout in the next few weeks should have more answers. Shrader adds that the introduction of "non-stain" into the cholesterol market has already worked for Merck's (MRK) Zetia, and if BA is perceived well on its safety profile, it is "highly supportive" of its investment story.
10/11/18
FBCO
10/11/18
NO CHANGE
Target $81
FBCO
Outperform
Merck price target raised to $81 from $71 at Credit Suisse
Credit Suisse analyst Vamil Divan raised his price target for Merck to $81 from $71, while reiterating an Outperform rating on the shares. While the shares have had a significant move this year, the analyst sees room for additional upside as the company continues to roll out Keytruda, most notably in the 1st line non-small cell lung setting. However, Divan also acknowledges longer-term investors remain concerned about how the company will navigate the Januvia patent expiration in mid-2022.

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AAPL

Apple

$193.42

2 (1.04%)

, PCG

PG&E

$24.39

6.62 (37.25%)

19:29
11/18/18
11/18
19:29
11/18/18
19:29
Hot Stocks
Fly Intel: Top five weekend stock stories »

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AAPL

Apple

$193.42

2 (1.04%)

PCG

PG&E

$24.39

6.62 (37.25%)

CBS

CBS

$57.49

0.23 (0.40%)

VIA

Viacom

$37.05

0.96 (2.66%)

VIAB

Viacom

$33.00

1.13 (3.55%)

AMZN

Amazon.com

$1,593.59

-26.41 (-1.63%)

KSS

Kohl's

$72.48

-0.7 (-0.96%)

TGT

Target

$79.67

-1.09 (-1.35%)

HD

Home Depot

$177.11

-0.25 (-0.14%)

TIF

Tiffany

$106.48

0.52 (0.49%)

BBY

Best Buy

$66.41

-1.34 (-1.98%)

TJX

TJX

$51.47

-0.98 (-1.87%)

JCP

J.C. Penney

$1.29

-0.08 (-5.84%)

LB

L Brands

$35.28

-0.41 (-1.15%)

T

AT&T

$30.30

0.18 (0.60%)

BP

BP

$40.85

-0.3 (-0.73%)

CVX

Chevron

$119.14

2.18 (1.86%)

XOM

Exxon Mobil

$78.99

0.81 (1.04%)

RDS.A

Royal Dutch Shell

$62.02

0.34 (0.55%)

RDS.B

Royal Dutch Shell

$63.97

0.19 (0.30%)

APC

Anadarko

$56.39

0.9 (1.62%)

EOG

EOG Resources

$105.21

3.57 (3.51%)

OXY

Occidental Petroleum

$73.32

0.71 (0.98%)

COG

Cabot Oil & Gas

$25.73

0.09 (0.35%)

EQT

EQT Corporation

$16.62

-0.55 (-3.20%)

HAL

Halliburton

$32.46

0.02 (0.06%)

SLB

Schlumberger

$48.24

0.17 (0.35%)

AMGN

Amgen

$194.23

1.83 (0.95%)

THS

TreeHouse

$51.92

0.72 (1.41%)

03/08/13
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    Jan

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    Jan

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    Mar

ZAYO

Zayo Group

$23.70

1.495 (6.73%)

, BX

Blackstone

$32.48

-0.02 (-0.06%)

18:50
11/18/18
11/18
18:50
11/18/18
18:50
Periodicals
Zayo said to get interest from Blackstone-Stonepeak Group, Bloomberg reports »

Zayo (ZAYO) has attracted…

ZAYO

Zayo Group

$23.70

1.495 (6.73%)

BX

Blackstone

$32.48

-0.02 (-0.06%)

KKR

KKR

$21.83

-0.46 (-2.06%)

03/08/13
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03/08/13
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  • 29

    Nov

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    Dec

PCG

PG&E

$24.39

6.62 (37.25%)

18:08
11/18/18
11/18
18:08
11/18/18
18:08
Periodicals
PG&E reports another outage on morning when California started, Reuters says »

PG&E, facing investor…

03/08/13
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KL

Kirkland Lake Gold

$18.97

0.28 (1.50%)

18:04
11/18/18
11/18
18:04
11/18/18
18:04
Hot Stocks
Kirkland Lake Gold appoints David Soares as CFO, Eric Kallio as senior VP »

Kirkland Lake Gold…

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EXPD

Expeditors

$73.67

0.14 (0.19%)

17:19
11/18/18
11/18
17:19
11/18/18
17:19
Conference/Events
Expeditors management to meet with Wolfe Research »

Meeting to be held in…

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  • 19

    Nov

CBS

CBS

$57.49

0.23 (0.40%)

, VIAB

Viacom

$33.00

1.13 (3.55%)

16:54
11/18/18
11/18
16:54
11/18/18
16:54
Periodicals
CBS, Viacom merger could be a few months away, NY Post reports »

After CBS (CBS) CEO Les…

CBS

CBS

$57.49

0.23 (0.40%)

VIAB

Viacom

$33.00

1.13 (3.55%)

VIA

Viacom

$37.05

0.96 (2.66%)

03/08/13
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03/06/13
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03/06/13
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  • 19

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AIMT

Aimmune

$29.61

0.05 (0.17%)

16:51
11/18/18
11/18
16:51
11/18/18
16:51
Hot Stocks
PALISADE trial of Aimmune's AR101 published in New England Journal of Medicine »

Aimmune Therapeutics…

03/08/13
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  • 27

    Nov

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    Dec

T

AT&T

$30.30

0.18 (0.60%)

, CMCSA

Comcast

$38.60

0.11 (0.29%)

16:31
11/18/18
11/18
16:31
11/18/18
16:31
Hot Stocks
Box Office Battle: 'Fantastic Beasts 2' wins weekend with $62M »

AT&T (T) subsidiary…

T

AT&T

$30.30

0.18 (0.60%)

CMCSA

Comcast

$38.60

0.11 (0.29%)

CMCSK

Comcast

$0.00

(0.00%)

SNE

Sony

$50.80

-0.81 (-1.57%)

FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

FOXA

21st Century Fox

$48.18

-0.11 (-0.23%)

LGF.A

Lionsgate

$20.88

0.365 (1.78%)

DIS

Disney

$116.20

-0.9 (-0.77%)

VIAB

Viacom

$33.00

1.13 (3.55%)

VIA

Viacom

$37.05

0.96 (2.66%)

03/08/13
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03/06/13
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03/06/13
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  • 03

    Dec

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    Dec

VLKAY

Volkswagen

$0.00

(0.00%)

, GOOG

Alphabet

$1,062.01

-2.73 (-0.26%)

15:45
11/18/18
11/18
15:45
11/18/18
15:45
Periodicals
Volkswagen CEO says Waymo has 1/2-year head start, Reuters reports »

Volkwagen (VLKAY) is up…

VLKAY

Volkswagen

$0.00

(0.00%)

GOOG

Alphabet

$1,062.01

-2.73 (-0.26%)

GOOGL

Alphabet Class A

$1,069.13

-2.09 (-0.20%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 28

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T

AT&T

$30.30

0.18 (0.60%)

, FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

15:21
11/18/18
11/18
15:21
11/18/18
15:21
Hot Stocks
AT&T, Fox Networks renew multi-year deal across distribution platforms »

AT&T (T) and Fox…

T

AT&T

$30.30

0.18 (0.60%)

FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

FOXA

21st Century Fox

$48.18

-0.11 (-0.23%)

03/08/13
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03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
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  • 03

    Dec

  • 04

    Dec

AAPL

Apple

$193.42

2 (1.04%)

13:35
11/18/18
11/18
13:35
11/18/18
13:35
Periodicals
Apple CEO views new regulations as 'inevitable,' Axios reports »

Apple CEO Tim Cook says…

03/08/13
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03/06/13
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NSRGY

Nestle

$0.00

(0.00%)

, RIO

Rio Tinto

$50.94

0.89 (1.78%)

13:05
11/18/18
11/18
13:05
11/18/18
13:05
Periodicals
Nespresso, Rio Tinto joining forces to make coffee pods greener, Reuters says »

Nespresso, part of food…

NSRGY

Nestle

$0.00

(0.00%)

RIO

Rio Tinto

$50.94

0.89 (1.78%)

03/08/13
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SNOA

Sonoma Pharmaceuticals

$1.11

-0.095 (-7.92%)

12:54
11/18/18
11/18
12:54
11/18/18
12:54
Hot Stocks
Sonoma Pharmaceuticals announces pricing of public offering of units »

Sonoma Pharmaceuticals…

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  • 29

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NVS

Novartis

$87.74

0.52 (0.60%)

, DBVT

DBV Technologies

$16.70

0.31 (1.89%)

04:55
11/18/18
11/18
04:55
11/18/18
04:55
Conference/Events
American College of Allergy, Asthma & Immunology to hold a meeting »

2018 ACAAI Meeting will…

NVS

Novartis

$87.74

0.52 (0.60%)

DBVT

DBV Technologies

$16.70

0.31 (1.89%)

REGN

Regeneron

$345.10

3.56 (1.04%)

SHPG

Shire

$175.59

-3.39 (-1.89%)

TEVA

Teva

$22.25

-0.37 (-1.64%)

SNY

Sanofi

$45.11

0.56 (1.26%)

GSK

GlaxoSmithKline

$40.35

-0.06 (-0.15%)

AZN

AstraZeneca

$40.67

-0.685 (-1.66%)

CHD

Church & Dwight

$65.42

-0.39 (-0.59%)

BSX

Boston Scientific

$37.22

0.75 (2.06%)

03/08/13
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03/06/13
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PDVW

pdvWireless

$39.84

0.06 (0.15%)

16:30
11/17/18
11/17
16:30
11/17/18
16:30
Conference/Events
pdvWireless management to meet with Morgan Stanley »

Meeting to be held in…

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03/06/13
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03/06/13
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CBS

CBS

$57.49

0.23 (0.40%)

16:28
11/17/18
11/17
16:28
11/17/18
16:28
Conference/Events
CBS management to meet with Morgan Stanley »

Meeting to be held in…

03/08/13
Wedge Partners
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03/06/13
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  • 19

    Nov

THS

TreeHouse

$51.92

0.72 (1.41%)

, CAG

Conagra Brands

$33.09

0.66 (2.04%)

12:54
11/17/18
11/17
12:54
11/17/18
12:54
Periodicals
Treehouse Foods stock may have room to gain, Barron's says »

Treehouse Foods (THS)…

THS

TreeHouse

$51.92

0.72 (1.41%)

CAG

Conagra Brands

$33.09

0.66 (2.04%)

03/08/13
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03/06/13
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AMGN

Amgen

$194.23

1.83 (0.95%)

12:51
11/17/18
11/17
12:51
11/17/18
12:51
Periodicals
Amgen may be 'a remedy' for tougher times, Barron's says »

Amgen may be a stock that…

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    Dec

AAPL

Apple

$193.42

2 (1.04%)

, LITE

Lumentum

$41.50

0.46 (1.12%)

12:47
11/17/18
11/17
12:47
11/17/18
12:47
Periodicals
Apple stock could continue to slide, Barron's says »

Apple's (AAPL) stock…

AAPL

Apple

$193.42

2 (1.04%)

LITE

Lumentum

$41.50

0.46 (1.12%)

QRVO

Qorvo

$66.32

1.18 (1.81%)

03/08/13
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03/06/13
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03/06/13
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APC

Anadarko

$56.39

0.9 (1.62%)

, RDS.B

Royal Dutch Shell

$63.97

0.19 (0.30%)

12:41
11/17/18
11/17
12:41
11/17/18
12:41
Periodicals
Investors may find bargains among oil, natural gas stocks, Barron's says »

Investors have been…

APC

Anadarko

$56.39

0.9 (1.62%)

RDS.B

Royal Dutch Shell

$63.97

0.19 (0.30%)

RDS.A

Royal Dutch Shell

$62.02

0.34 (0.55%)

XOM

Exxon Mobil

$78.99

0.81 (1.04%)

CVX

Chevron

$119.14

2.18 (1.86%)

BP

BP

$40.85

-0.3 (-0.73%)

EOG

EOG Resources

$105.21

3.57 (3.51%)

OXY

Occidental Petroleum

$73.32

0.71 (0.98%)

COG

Cabot Oil & Gas

$25.73

0.09 (0.35%)

EQT

EQT Corporation

$16.62

-0.55 (-3.20%)

HAL

Halliburton

$32.46

0.02 (0.06%)

SLB

Schlumberger

$48.24

0.17 (0.35%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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  • 26

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LB

L Brands

$35.28

-0.41 (-1.15%)

, JCP

J.C. Penney

$1.29

-0.08 (-5.84%)

12:34
11/17/18
11/17
12:34
11/17/18
12:34
Periodicals
Kohl's, Target set to thrive this holiday season, Barron's says »

Store chains have been…

LB

L Brands

$35.28

-0.41 (-1.15%)

JCP

J.C. Penney

$1.29

-0.08 (-5.84%)

TJX

TJX

$51.47

-0.98 (-1.87%)

BBY

Best Buy

$66.41

-1.34 (-1.98%)

TIF

Tiffany

$106.48

0.52 (0.49%)

HD

Home Depot

$177.11

-0.25 (-0.14%)

TGT

Target

$79.67

-1.09 (-1.35%)

KSS

Kohl's

$72.48

-0.7 (-0.96%)

AMZN

Amazon.com

$1,593.59

-26.41 (-1.63%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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  • 03

    Mar

T

AT&T

$30.30

0.18 (0.60%)

, FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

09:18
11/17/18
11/17
09:18
11/17/18
09:18
OnTheFly
Week in review: How Trump's policies moved stocks »

Catch up on the top…

T

AT&T

$30.30

0.18 (0.60%)

FOX

21st Century Fox

$47.73

-0.1 (-0.21%)

FOXA

21st Century Fox

$48.18

-0.11 (-0.23%)

AMZN

Amazon.com

$1,593.59

-26.41 (-1.63%)

CMCSA

Comcast

$38.60

0.11 (0.29%)

CMCSK

Comcast

$0.00

(0.00%)

DDAIF

Daimler AG

$0.00

(0.00%)

FCAU

Fiat Chrysler

$16.46

-0.12 (-0.72%)

F

Ford

$9.05

-0.26 (-2.79%)

GM

General Motors

$35.76

0.21 (0.59%)

HMC

Honda

$28.21

0.01 (0.04%)

NSANY

Nissan

$0.00

(0.00%)

TM

Toyota

$116.87

-0.02 (-0.02%)

VLKAY

Volkswagen

$0.00

(0.00%)

NYT

New York Times

$26.30

-0.2 (-0.75%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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NVS

Novartis

$87.74

0.52 (0.60%)

, DBVT

DBV Technologies

$16.70

0.31 (1.89%)

04:55
11/17/18
11/17
04:55
11/17/18
04:55
Conference/Events
American College of Allergy, Asthma & Immunology to hold a meeting »

2018 ACAAI Meeting will…

NVS

Novartis

$87.74

0.52 (0.60%)

DBVT

DBV Technologies

$16.70

0.31 (1.89%)

REGN

Regeneron

$345.10

3.56 (1.04%)

SHPG

Shire

$175.59

-3.39 (-1.89%)

TEVA

Teva

$22.25

-0.37 (-1.64%)

SNY

Sanofi

$45.11

0.56 (1.26%)

GSK

GlaxoSmithKline

$40.35

-0.06 (-0.15%)

AZN

AstraZeneca

$40.67

-0.685 (-1.66%)

CHD

Church & Dwight

$65.42

-0.39 (-0.59%)

BSX

Boston Scientific

$37.22

0.75 (2.06%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
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MSI

Motorola Solutions

$129.97

0.72 (0.56%)

18:48
11/16/18
11/16
18:48
11/16/18
18:48
Hot Stocks
Motorola Solutions: ITC confirms Hytera products infringe Motorola patents »

Motorola Solutions…

03/08/13
Wedge Partners
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Credit Suisse
03/06/13
Citigroup
03/06/13
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PCG

PG&E

$24.39

6.62 (37.25%)

18:23
11/16/18
11/16
18:23
11/16/18
18:23
Periodicals
CPUC isn't ruling out board shuffle, breakup for PG&E, Bloomberg says »

The California Public…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
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