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OMED

OncoMed

$2.47

-0.17 (-6.44%)

12:37
10/21/18
10/21
12:37
10/21/18
12:37

OncoMed announces interim phase 1b results for Navicixizumab, Paclitaxel combo

OncoMed Pharmaceuticals announced interim results from its ongoing Phase 1b trial investigating navicixizumab, OncoMed's anti-DLL4/VEGF bispecific antibody, in combination with paclitaxel in patients with platinum-resistant ovarian cancer. The patients had received a median of four prior therapies, all of whom had received prior paclitaxel and 69% had received prior bevacizumab. 22 of the 26 patients treated with the novel regimen experienced clinical benefit. Notably 11 of the 26 patients achieved a partial response and the median progression-free survival was 5.4 months. Historical response rates for patients with heavily pretreated platinum-resistant ovarian cancer treated with chemotherapy are typically 15% or less. The ongoing Phase 1b multicenter, open-label, dose-escalation and expansion trial is designed to assess the safety, preliminary efficacy, immunogenicity, pharmacokinetics and biomarker effects of navicixizumab plus paclitaxel. The trial has been expanded to enroll up to 60 patients with platinum-resistant ovarian cancer who have previously received bevacizumab and/or have failed at least two prior therapies.

OMED OncoMed
$2.47

-0.17 (-6.44%)

09/20/18
HCWC
09/20/18
NO CHANGE
Target $2
HCWC
Neutral
OncoMed price target lowered to $2 after Celgene pass at H.C. Wainwright
H.C. Wainwright analyst Edward White lowered his price target on OncoMed (OMED) shares to $2 from $3 after partner Celgene (CELG) passed on its option to license navicixizumab. Worldwide development, commercialization and rights to navicixizumab now remain under OncoMed's control while Celgene retains options to license OncoMed's anti-TIGIT monoclonal antibody, etigilimab, and anti-RSPO3, rosmantuzumab, noted White. The analyst, who notes there is potential the company could partner the asset, keeps a Neutral rating on OncoMed shares.

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SKT

Tanger Factory

$15.90

0.13 (0.82%)

14:35
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Tanger Factory put volume heavy and directionally bearish »

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USAT

USA Technologies

$7.43

-0.22 (-2.88%)

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USAT

USA Technologies

$7.43

-0.22 (-2.88%)

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USA Technologies says unlikely to meet Nasdaq deadline for filing compliance »

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USAT

USA Technologies

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FISV

Fiserv

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Fiserv call volume above normal and directionally bullish »

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TD

Toronto-Dominion

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0.4 (0.69%)

, DB

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TD accepted Epstein accounts after Deutsche cut ties, Bloomberg says »

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IVV

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-0.845 (-0.28%)

, SPY

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SPY

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HYG

iShares iBoxx $ High Yield Corporate Bond

$87.41

0.05 (0.06%)

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ITE

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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

14:17
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NASDAQ market internals summary »

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$NYE

NYSE Market Internals

$0.00

(0.00%)

14:16
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NYSE market internals summary »

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PDD

Pinduoduo

$33.65

-0.98 (-2.83%)

14:15
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Pinduoduo put volume heavy and directionally bearish »

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FIT

Fitbit

$4.00

0.3347 (9.13%)

14:11
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Periodicals
Fitbit deciding whether to explore sale, Reuters says »

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FIT

Fitbit

$3.69

0.025 (0.68%)

14:07
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Fitbit rises after report of hiring bank to consider sale »

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FIT

Fitbit

$3.73

0.06 (1.64%)

14:03
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Periodicals
Breaking Periodicals news story on Fitbit »

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W

Wayfair

$122.80

-5.865 (-4.56%)

13:55
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Wayfair put volume heavy and directionally bearish »

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DELL

Dell Technologies

$52.26

-0.8 (-1.51%)

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Dell Technologies to hold a business news update meeting »

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FTR

Frontier Communications

$1.00

-0.0006 (-0.06%)

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U.S. equity markets »

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BTU

Peabody Energy

$15.47

-1.56 (-9.16%)

, ARCH

Arch Coal

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SPY

SPDR S&P 500 ETF Trust

$298.09

-1.586381 (-0.53%)

, SPX

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$0.00

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Chinese delgation cancels farm trip to Montana, Reuters reports »

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SPY

SPDR S&P 500 ETF Trust

$298.09

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SPX

S&P 500

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DJX

Dow Jones Industrial Average

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NDX

Nasdaq 100 Index

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RACE

Ferrari

$151.80

-1.95 (-1.27%)

13:30
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Trader trims risk by legging out of iron condor in Ferrari »

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MGM

MGM Resorts

$29.05

-0.01 (-0.03%)

13:25
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MGM Resorts call volume above normal and directionally bullish »

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SPY

SPDR S&P 500 ETF Trust

$300.00

0.323619 (0.11%)

, SPX

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$0.00

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SPY

SPDR S&P 500 ETF Trust

$300.00

0.323619 (0.11%)

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WMT

Walmart

$117.62

0.58 (0.50%)

, MO

Altria Group

$41.19

1.08 (2.69%)

13:21
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Periodicals
Walmart to stop sale of e-cigarettes in stores, Yahoo Finance reports »

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WMT

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$117.62

0.58 (0.50%)

MO

Altria Group

$41.19

1.08 (2.69%)

BTI

British American Tobacco

$36.57

0.07 (0.19%)

IMBBY

Imperial Brands

$0.00

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PM

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1.07 (1.49%)

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MGM

MGM Resorts

$29.04

-0.02 (-0.07%)

13:21
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Periodicals
Breaking Periodicals news story on MGM Resorts »

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