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PTI

Proteostasis

$7.39

0.22 (3.07%)

19:30
10/23/18
10/23
19:30
10/23/18
19:30

Proteostasis 11M share Secondary priced at $6.75

The deal size was increased to 11M shares from 9M shares. Leerink, Piper Jaffray and Cantor Fitzgerald are acting as joint book running managers for the offering.

  • 24

    Oct

PTI Proteostasis
$7.39

0.22 (3.07%)

10/18/18
RBCM
10/18/18
UPGRADE
RBCM
Outperform
Proteostasis upgraded to Outperform from Sector Perform at RBC Capital
10/18/18
RBCM
10/18/18
UPGRADE
Target $9
RBCM
Outperform
Proteostasis upgraded to Outperform at RBC Capital on positive CF data
As reported earlier, RBC Capital analyst Brian Abrahams upgraded Proteostasis (PTI) to Outperform from Sector Perform and also raised his price target to $9 from $4 following an "impressive" set of data from its phase 2 cystic fibrosis doublet trial. The analyst notes that while it is too soon to determine if it will pose a "competitive threat to developmental CFTR modulators marketed by Vertex Pharma (VRTX), the trial showed "clean, consistent, dose-dependent lung function improvements".
10/18/18
10/18/18
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Nike (NKE) upgraded to Outperform from Perform at Oppenheimer with analyst Brian Nagel saying Nike represents an "already dominant, legacy global brand that is now aggressively embracing the power of digital to enhance most facets of its business." 2. United Continental (UAL) upgraded to Outperform from Neutral at Macquarie and to Overweight from Equal Weight at Stephens. 3. Generac (GNRC) upgraded to Neutral from Sell at Goldman Sachs with analyst Jerry Revich saying the company's organic growth outlook is improving amid rising power disturbances. 4. Proteostasis (PTI) upgraded to Outperform from Sector Perform at RBC Capital with analyst Brian Abrahams citing an "impressive" set of data from its phase 2 cystic fibrosis doublet trial. 5. Safe Bulkers (SB) upgraded to Outperform from In Line at Evercore ISI with analyst Jonathan Chappell saying the disconnect between dry bulk equity prices and spot rates continues to widen due to global trade/macro fears. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
10/18/18
MSCO
10/18/18
NO CHANGE
MSCO
Overweight
Vertex weakness on competitor data an overreaction, says Morgan Stanley
Morgan Stanley analyst Matthew Harrison attributes weakness in shares of Vertex (VRTX) to the fact that potential competitor Proteostasis (PTI) released initial Phase 1 data showing that its doublet achieved a roughly 6% increase in FEV1 in the highest dose, compared with about 5% for the VX-661 doublet in Phase 1/2. However, he would caution over-interpretation of the results, noting that Proteostasis' data includes only about five patients per arm; the high mean FEV1 increase may be the result of a "super-responder"; and doublet data "isn't meaningful given triplets with 10-15% FEV1 improvement will be the new standard of care." The analyst, who sees Vertex's sizeable lead and robust data limiting any competitive risks, keeps an Overweight rating on Vertex shares, which are down about 4% in morning trading.

TODAY'S FREE FLY STORIES

WMT

Walmart

$99.59

1.32 (1.34%)

14:10
03/18/19
03/18
14:10
03/18/19
14:10
Options
Walmart calls lead puts 3:1 and implied volatility is at 52-week lows »

Walmart calls lead puts…

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14:10
03/18/19
03/18
14:10
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14:10
General news
Oil Action: WTI crude »

Oil Action: WTI crude…

RCII

Rent-A-Center

$21.29

-0.0697 (-0.33%)

14:07
03/18/19
03/18
14:07
03/18/19
14:07
Hot Stocks
LMR Partners reports 7.02% passive stake in Rent-A-Center »

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  • 16

    Apr

SKX

Skechers

$32.80

0.22 (0.68%)

14:05
03/18/19
03/18
14:05
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14:05
Options
Skechers call volume above normal and directionally bullish »

Bullish option flow…

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14:05
03/18/19
03/18
14:05
03/18/19
14:05
General news
Fed funds futures are little changed, though deferred contracts are fractionally lower »

Fed funds futures are…

SNE

Sony

$46.06

-0.195 (-0.42%)

, EA

Electronic Arts

$98.17

-0.82 (-0.83%)

14:03
03/18/19
03/18
14:03
03/18/19
14:03
Hot Stocks
Sony Playstation, EA announce first season of Apex Legends starts March 19 »

Sony (SNE) Playstation…

SNE

Sony

$46.06

-0.195 (-0.42%)

EA

Electronic Arts

$98.17

-0.82 (-0.83%)

03/08/13
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GEVO

Gevo

$2.40

0.11 (4.80%)

14:03
03/18/19
03/18
14:03
03/18/19
14:03
Hot Stocks
Gevo calls out mention of company by Richard Branson »

Gevo's official…

03/08/13
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  • 27

    Mar

FLIR

Flir Systems

$49.83

-0.31 (-0.62%)

13:53
03/18/19
03/18
13:53
03/18/19
13:53
Downgrade
Flir Systems rating change  »

Flir Systems downgraded…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 19

    Apr

RIO

Rio Tinto

$57.03

1.04 (1.86%)

13:49
03/18/19
03/18
13:49
03/18/19
13:49
Periodicals
SEC can pursue Rio Tinto fraud cause, judge says, Reuters reports »

U.S. District Judge…

03/08/13
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03/08/13
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CREE

Cree

$56.77

-0.14 (-0.25%)

13:45
03/18/19
03/18
13:45
03/18/19
13:45
Options
Cree call volume above normal and directionally bullish »

Bullish option flow…

03/08/13
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  • 01

    May

ON

ON Semiconductor

$21.95

-0.23 (-1.04%)

13:39
03/18/19
03/18
13:39
03/18/19
13:39
Hot Stocks
ON Semiconductor has introduced two new silicon carbide, SiC Mosfet devices »

ON Semiconductor has…

03/08/13
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03/06/13
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03/06/13
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GOOG

Alphabet

$1,180.85

-4.41 (-0.37%)

, GOOGL

Alphabet Class A

$1,184.84

-6.94 (-0.58%)

13:38
03/18/19
03/18
13:38
03/18/19
13:38
Periodicals
Google denies working with Chinese military, NBCNews reports »

Google denied…

GOOG

Alphabet

$1,180.85

-4.41 (-0.37%)

GOOGL

Alphabet Class A

$1,184.84

-6.94 (-0.58%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
Citigroup
03/06/13
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  • 18

    Mar

  • 27

    Mar

  • 04

    Apr

  • 27

    Oct

13:35
03/18/19
03/18
13:35
03/18/19
13:35
General news
U.S. corporate bond update: a couple of issuers are jumping in »

U.S. corporate bond…

CCI

Crown Castle

$124.05

-1.03 (-0.82%)

13:35
03/18/19
03/18
13:35
03/18/19
13:35
Options
Crown Castle put volume heavy and directionally bearish »

Bearish flow noted in…

03/08/13
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03/06/13
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13:35
03/18/19
03/18
13:35
03/18/19
13:35
General news
Treasury Option Action: call spread liquidation »

Treasury Option Action:…

FB

Facebook

$159.31

-6.68 (-4.02%)

13:33
03/18/19
03/18
13:33
03/18/19
13:33
Periodicals
Blumenthal wants Facebook probe after live stream of mosque attack, NY Post says »

Senator Richard…

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 27

    Mar

  • 04

    Apr

DJX

Dow Jones Industrial Average

$0.00

(0.00%)

, SPX

S&P 500

$0.00

(0.00%)

13:30
03/18/19
03/18
13:30
03/18/19
13:30
Periodicals
U.K. speaker says parliament won't vote again on Brexit deal, WSJ reports »

John Bercow, speaker of…

DJX

Dow Jones Industrial Average

$0.00

(0.00%)

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$281.92

0.61 (0.22%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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GNL

Global Net Lease

$18.38

-0.1 (-0.54%)

13:29
03/18/19
03/18
13:29
03/18/19
13:29
Conference/Events
Global Net Lease management to meet with JMP Securities »

Meeting to be held in…

03/08/13
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  • 25

    Mar

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    Apr

NVRO

Nevro

$44.31

0.56 (1.28%)

13:27
03/18/19
03/18
13:27
03/18/19
13:27
Conference/Events
Nevro management to meet with JMP Securities »

Meeting to be held in…

03/08/13
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  • 20

    Mar

  • 21

    Mar

NVRO

Nevro

$44.15

0.4 (0.91%)

13:27
03/18/19
03/18
13:27
03/18/19
13:27
Conference/Events
Nevro management to meet with SVB Leerink »

Meeting to be held in New…

03/08/13
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  • 20

    Mar

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    Mar

APYX

Apyx Medical

$7.93

0.005 (0.06%)

13:25
03/18/19
03/18
13:25
03/18/19
13:25
Conference/Events
Apyx Medical management to meet with JMP Securities »

Meeting to be held in…

03/08/13
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  • 21

    Mar

T

AT&T

$30.77

0.09 (0.29%)

13:24
03/18/19
03/18
13:24
03/18/19
13:24
Periodicals
Kevin Tsujihara ousted as Warner Bros. CEO, CNBC reports »

Kevin Tsujihara has been…

03/08/13
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03/08/13
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  • 20

    Mar

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    Mar

  • 24

    Apr

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    Apr

  • 20

    May

CXP

Columbia Property

$21.99

-0.13 (-0.59%)

13:21
03/18/19
03/18
13:21
03/18/19
13:21
Conference/Events
Columbia Property management to meet with JMP Securities »

Meeting to be held in the…

03/08/13
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  • 20

    Mar

BSX

Boston Scientific

$37.77

-2.38 (-5.93%)

13:20
03/18/19
03/18
13:20
03/18/19
13:20
Options
Quarter million dollar block of calls sold to open in Boston Scientific »

Quarter million dollar…

03/08/13
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  • 18

    May

  • 28

    May

MIK

Michaels

$11.72

0.04 (0.34%)

, DSW

DSW

$25.05

-0.34 (-1.34%)

13:19
03/18/19
03/18
13:19
03/18/19
13:19
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

MIK

Michaels

$11.72

0.04 (0.34%)

DSW

DSW

$25.05

-0.34 (-1.34%)

HDS

HD Supply

$42.88

-0.12 (-0.28%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 19

    Mar

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