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AZN

AstraZeneca

$40.97

0.33 (0.81%)

13:28
11/11/18
11/11
13:28
11/11/18
13:28

AstraZeneca announced positive results from DECLARE-TIMI 58 outcomes rial

AstraZeneca announced positive full results from the DECLARE-TIMI 58 cardiovascular outcomes trial for FARXIGA. The data were presented as a late-breaking abstract at the American Heart Association Scientific Sessions 2018 in Chicago, IL, and simultaneously published in the New England Journal of Medicine. Results from DECLARE-TIMI 58, the largest SGLT-2 inhibitor CVOT conducted to date, including more than 17,000 patients across 33 countries, showed that FARXIGA significantly reduced the risk of hospitalization for heart failure or CV death composite vs. placebo by 17%, one of the two primary efficacy endpoints. The reduction in hHF or CV death was consistent across the entire patient population, which included those with CV risk factors and those with established CV disease. FARXIGA is not indicated to reduce the risk of CV events or hHF. Additionally, there were fewer major adverse cardiovascular events observed with FARXIGA for the other primary efficacy endpoint, however this did not reach statistical significance. DECLARE-TIMI 58 also confirmed the well-established safety profile for FARXIGA, which met the primary safety endpoint of non-inferiority versus placebo, demonstrating no increase in the composite of MACE, defined as CV death, heart attack, or stroke. Further, on other relevant safety measures, the trial showed no imbalance with FARXIGA versus placebo in amputations, fractures, bladder cancer or Fournier's gangrene. The respective incidences of diabetic ketoacidosis and genital infections were rare. Although secondary endpoints were only nominally significant, the renal composite endpoint showed that FARXIGA reduced the rate of new or worsening nephropathy by 24% vs. placebo across the broad patient population studied, and there were fewer all-cause mortality events with FARXIGA vs. placebo. FARXIGA is not indicated to reduce the risk of HF, other CV outcomes, nephropathy or all-cause mortality.

  • 15

    Nov

AZN AstraZeneca
$40.97

0.33 (0.81%)

10/22/18
CANT
10/22/18
NO CHANGE
Target $68
CANT
Overweight
Tesaro price target raised to $68 from $57 at Cantor Fitzgerald
Cantor Fitzgerald analyst Alethia Young raised her price target for Tesaro (TSRO) to $68 saying AstraZeneca's (AZN) presented the Solo1 study using olaparib as a first-line treatment for BRCA ovarian cancer patients is positive for Tesaro's first-line study Prima study, with data expected in the second half of 2019. AstraZeneca's data clearly support broad use in first-line "at least" for BRCA ovarian cancer patients, which is positive for the PARP inhibitor class, Young tells investors in a research note. The analyst increased PARP inhibitor penetration in the BRCA patient at peak to 75% from 65% and reiterates an Overweight rating on Tesaro.
10/23/18
WOLF
10/23/18
INITIATION
WOLF
Outperform
AstraZeneca reinitiated with an Outperform at Wolfe Research
Wolfe Research analyst Time Anderson reinitiated AstraZeneca with an Outperform.
10/24/18
CANT
10/24/18
NO CHANGE
Target $68
CANT
Overweight
Cantor Fitzgerald sees nothing fundamental for Tesaro weakness
Cantor Fitzgerald analyst Alethia Young reiterates an Overweight rating and $68 price target on Tesaro's (TSRO) shares as she sees nothing fundamental on recent weakness. While she acknowledges that the stock is down around 28% since ESMO, the analyst pointed out that the AstraZeneca's (AZN) SOLO1 data is a positive read for the niraparib PRIMA study that will read out in 2H 2019. Further, Young believes that key catalysts for Tesaro remain SITC - GARNET and AMBER data, pivotal data in endometrial for its PD-1 licensed from AnaptysBio (ANAB), and PRIMA data in first line ovarian in 2H 2019.
10/25/18
WELS
10/25/18
NO CHANGE
WELS
Wells Fargo says Trump speech today won't be end of drug pricing proposals
Wells Fargo analyst David Maris notes that Politico and other media outlets are reporting that President Donald Trump will propose several new initiatives to address high drug prices when he speaks later today at the U.S. Department of Health and Human Services. Maris thinks Trump's focus will be on how other countries are "freeloading" on U.S. innovation with lower negotiated pricing, stating that news reports make it appear that the administration is targeting the industry for action, rather than other countries to raise their spending. While Maris acknowledges the timing of the speech being near the mid-term elections, he believes these proposals are simply the follow-though of earlier promises. He also expects this is not the end of proposals to address the issue of U.S. drug pricing. Publicly traded large-cap drugmakers include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY).

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BA

Boeing

$374.04

-0.98 (-0.26%)

21:05
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SPY

SPDR S&P 500 ETF Trust

$292.86

2.56 (0.88%)

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S&P 500

$0.00

(0.00%)

20:54
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SPDR S&P 500 ETF Trust

$292.86

2.56 (0.88%)

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S&P 500

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DHT

DHT Holdings

$5.17

0.075 (1.47%)

20:46
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20:46
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DHT Holdings rating change at Evercore ISI »

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PLL

Piedmont Lithium

$12.98

-0.24 (-1.82%)

20:45
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Piedmont Lithium announces Mineral Resource estimate of 2.8MT at Central »

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T

AT&T

$32.11

0.03 (0.09%)

, BA

Boeing

$374.04

-0.98 (-0.26%)

20:25
04/23/19
04/23
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20:25
Earnings
Notable companies reporting before tomorrow's open »

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T

AT&T

$32.11

0.03 (0.09%)

BA

Boeing

$374.04

-0.98 (-0.26%)

TMO

Thermo Fisher

$263.74

4.68 (1.81%)

CAT

Caterpillar

$142.08

-0.28 (-0.20%)

ANTM

Anthem

$250.75

6.71 (2.75%)

NSC

Norfolk Southern

$201.68

0.15 (0.07%)

GD

General Dynamics

$182.33

5.27 (2.98%)

NOC

Northrop Grumman

$292.59

9.73 (3.44%)

BSX

Boston Scientific

$35.88

0.95 (2.72%)

BIIB

Biogen

$229.89

1.15 (0.50%)

SIRI

Sirius XM

$6.14

0.03 (0.49%)

SWK

Stanley Black & Decker

$147.37

1.89 (1.30%)

DPZ

Domino's Pizza

$270.25

4.19 (1.57%)

KNX

Knight-Swift

$35.01

0.295 (0.85%)

OC

Owens Corning

$55.60

1.24 (2.28%)

GNTX

Gentex

$22.09

0.23 (1.05%)

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T

AT&T

$32.11

0.03 (0.09%)

20:09
04/23/19
04/23
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20:09
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AT&T's WarnerMedia to sell 30 Hudson Yards for ~$2.2B »

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BSX

Boston Scientific

$35.88

0.95 (2.72%)

20:07
04/23/19
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20:07
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20:07
Recommendations
Boston Scientific analyst commentary at Piper Jaffray »

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FFHL

Fuwei Films

$2.66

0.05 (1.92%)

19:16
04/23/19
04/23
19:16
04/23/19
19:16
Hot Stocks
Fuwei Films delays reporting Q4 results »

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NWE

NorthWestern

$68.06

0.46 (0.68%)

19:12
04/23/19
04/23
19:12
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19:12
Earnings
NorthWestern reports Q1 adjusted EPS $1.23, consensus $1.18 »

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MNOV

MediciNova

$10.68

0.77 (7.77%)

19:03
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19:03
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MediciNova gets Notice of Allowance from U.S. PTC for MN-166 in glioblastoma »

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MANH

Manhattan Associates

$61.13

0.96 (1.60%)

, CSL

Carlisle

$128.57

1.94 (1.53%)

18:58
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18:58
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Fly Intel: After Hours Movers »

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MANH

Manhattan Associates

$61.13

0.96 (1.60%)

CSL

Carlisle

$128.57

1.94 (1.53%)

TER

Teradyne

$44.60

-0.26 (-0.58%)

EBAY

eBay

$36.66

0.51 (1.41%)

SNAP

Snap

$11.99

0.46 (3.99%)

SIX

Six Flags

$52.39

0.8 (1.55%)

NAVI

Navient

$12.45

0.38 (3.15%)

BSX

Boston Scientific

$35.88

0.95 (2.72%)

ABBV

AbbVie

$78.65

0.55 (0.70%)

IRBT

iRobot

$130.42

1.71 (1.33%)

SPN

Superior Energy

$4.97

-0.02 (-0.40%)

RHI

Robert Half

$68.83

1.46 (2.17%)

TSS

TSYS

$102.25

1.46 (1.45%)

SYK

Stryker

$186.95

4.905 (2.69%)

EW

Edwards Lifesciences

$180.89

2.64 (1.48%)

TXN

Texas Instruments

$116.37

1.43 (1.24%)

AMTD

TD Ameritrade

$54.28

0.61 (1.14%)

BURL

Burlington Stores

$161.96

1.76 (1.10%)

CP

Canadian Pacific

$219.33

0.215 (0.10%)

LRN

K12

$36.23

0.805 (2.27%)

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GE

General Electric

$9.34

0.02 (0.21%)

18:55
04/23/19
04/23
18:55
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18:55
Hot Stocks
DOJ says ex-GE engineer, Chinese man charged with theft of GE trade secrets »

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HAS

Hasbro

$100.34

12.32 (14.00%)

18:23
04/23/19
04/23
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18:23
Hot Stocks
Hasbro CEO: We expect to return to profitable growth this year »

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ABBV

AbbVie

$78.65

0.55 (0.70%)

18:21
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AbbVie says FDA approves SKYRIZI »

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TSS

TSYS

$102.25

1.46 (1.45%)

18:19
04/23/19
04/23
18:19
04/23/19
18:19
Earnings
TSYS backs FY19 EPS view $4.75-$4.90, consensus $4.86 »

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HCC

Warrior Met Coal

$31.78

1.21 (3.96%)

18:16
04/23/19
04/23
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18:16
Hot Stocks
Warrior Met Coal declares $4.41 special cash dividend »

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LBTYA

Liberty Global

$27.28

-0.01 (-0.04%)

18:15
04/23/19
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18:15
Hot Stocks
Liberty Global names Lutz Shuler as Virgin Media CEO »

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  • 07

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VMI

Valmont

$131.14

-1.17 (-0.88%)

18:09
04/23/19
04/23
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18:09
General news
Valmont reaffirms FY19 revenue view up 7%-8% »

Reaffism FY19 capital…

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VMI

Valmont

$131.14

-1.17 (-0.88%)

18:08
04/23/19
04/23
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18:08
Earnings
Valmont narrows FY19 EPS view to $8.30-$8.90 from $8.10-$8.90 »

Consensus is for FY19 EPS…

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VMI

Valmont

$131.14

-1.17 (-0.88%)

18:07
04/23/19
04/23
18:07
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18:07
Earnings
Valmont reports Q1 EPS $1.84 ex-items, consensus $1.74 »

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HNHPF

Hon Hai Precision

$0.00

(0.00%)

18:06
04/23/19
04/23
18:06
04/23/19
18:06
Periodicals
Foxconn, Wisconsin renegotiating LCD plant contract, CNBC reports »

Wisconsin Governor Tony…

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BSX

Boston Scientific

$35.88

0.95 (2.72%)

17:47
04/23/19
04/23
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04/23/19
17:47
Hot Stocks
Breaking Hot Stocks news story on Boston Scientific »

Boston Scientific up over…

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TPL

Texas Pacific Land Trust

$896.00

0.19 (0.02%)

17:45
04/23/19
04/23
17:45
04/23/19
17:45
Hot Stocks
Texas Pacific Land Trust says trustee nominee Eric Oliver should be disqualified »

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GLD

SPDR Gold Shares

$120.11

-0.26 (-0.22%)

17:41
04/23/19
04/23
17:41
04/23/19
17:41
Hot Stocks
SPDR Gold Shares holdings fall to 749.63MT from 751.68MT »

This is the lowest level…

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SNAP

Snap

$11.99

0.46 (3.99%)

17:39
04/23/19
04/23
17:39
04/23/19
17:39
Hot Stocks
Snap CEO says 'definitely excited about what we're seeing' with new Android app »

Says there is "a lot…

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