Breaking News Instant updates and real-time market news.

MKGAY

Merck KGaA

$0.00

(0.00%)

10:05
12/10/18
12/10
10:05
12/10/18
10:05

Merck KGaA announces FDA orphan drug designation for M7824

Merck KGaA announced that the US Food and Drug Administration has granted orphan drug designation to M7824, the first regulatory designation for the bifunctional immunotherapy, for the treatment of biliary tract cancer. The FDA orphan drug designation follows the recent presentation of the first clinical data for M7824 in BTC at the European Society of Medical Oncology congress in October. M7824 is an investigational bifunctional immunotherapy designed to combine co-localized blocking of the transforming growth factor-beta and anti-PD-L1 immune escape mechanisms. The first clinical data for M7824 in BTC, presented at the ESMO congress in October, demonstrated clinical activity in Asian patients who had progressed after platinum-based first-line treatment. The ORR among the total of 30 patients was 20%, as assessed by IRC, and responses were observed across PD-L1 levels with a duration of response ranging from 8.3 months to 13.9+ months. Grade 3 or higher TRAEs were experienced by 10 patients and the most common Grade 3 TRAEs were rash and lipase increase. M7824 is an investigational bifunctional immunotherapy that combines a TGF-beta trap with the anti-PD-L1 mechanism in one fusion protein. Designed to combine co-localized blocking of the two immunosuppressive pathways, M7824 is thought to control tumor growth by potentially restoring and enhancing anti-tumor responses. M7824 is an important part of a novel combination approach that seeks to harness the power of the immune system and address the tremendously complex nature of difficult-to-treat tumors. To-date, more than 670 patients with various types of solid tumors have been treated across the program with M7824. In addition to BTC, M7824 is being studied in solid tumor indications, including non-small cell lung, HPV associated tumors and gastrointestinal cancers, such as gastric cancer, esophageal squamous cell carcinoma and esophageal adenocarcinoma.

TODAY'S FREE FLY STORIES

PAYS

Paysign

$11.27

-0.56 (-4.73%)

20:32
11/14/19
11/14
20:32
11/14/19
20:32
Initiation
Paysign initiated at DA Davidson »

Paysign initiated with a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 19

    Nov

  • 25

    Nov

  • 26

    Nov

LPTX

Leap Therapeutics

$0.57

-0.5922 (-50.83%)

20:25
11/14/19
11/14
20:25
11/14/19
20:25
Downgrade
Leap Therapeutics rating change at Raymond James »

Leap Therapeutics…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

FTNT

Fortinet

$100.07

0.38 (0.38%)

20:25
11/14/19
11/14
20:25
11/14/19
20:25
Upgrade
Fortinet rating change at Credit Suisse »

Fortinet upgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

  • 18

    Nov

  • 19

    Nov

  • 05

    Dec

  • 06

    Dec

  • 09

    Dec

  • 12

    Dec

JD

JD.com

$33.57

0.21 (0.63%)

, WVE

Wave Life Sciences

$27.90

-0.07 (-0.25%)

20:25
11/14/19
11/14
20:25
11/14/19
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

JD

JD.com

$33.57

0.21 (0.63%)

WVE

Wave Life Sciences

$27.90

-0.07 (-0.25%)

RYTM

Rhythm Pharmaceuticals

$21.52

0.38 (1.80%)

JCP

J.C. Penney

$1.10

0.01 (0.92%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

  • 15

    Nov

  • 09

    Dec

SBS

Sabesp

$12.21

-0.02 (-0.16%)

20:22
11/14/19
11/14
20:22
11/14/19
20:22
Earnings
Sabesp reports Q3 adjusted EBITDA up 109.8% at BRL3.01B »

Reports Q3 adjusted…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 18

    Nov

LINX

Linx S.A.

$7.11

-0.8 (-10.11%)

19:16
11/14/19
11/14
19:16
11/14/19
19:16
Recommendations
Linx S.A. analyst commentary at Jefferies »

Linx S.A. price target…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

CNP

CenterPoint Energy

$26.68

-1.42 (-5.05%)

19:12
11/14/19
11/14
19:12
11/14/19
19:12
Downgrade
CenterPoint Energy rating change at Credit Suisse »

CenterPoint Energy…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SPX

S&P 500

$0.00

(0.00%)

, SPY

SPDR S&P 500 ETF Trust

$309.54

0.46 (0.15%)

19:09
11/14/19
11/14
19:09
11/14/19
19:09
Periodicals
Kudlow says U.S. near trade agreement with China, Reuters says »

White House economic…

SPX

S&P 500

$0.00

(0.00%)

SPY

SPDR S&P 500 ETF Trust

$309.54

0.46 (0.15%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

BMRN

BioMarin

$75.55

-0.54 (-0.71%)

18:41
11/14/19
11/14
18:41
11/14/19
18:41
Hot Stocks
BioMarin CEO: Our products have a very long life cycle »

In an interview on…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 07

    Dec

OXY

Occidental Petroleum

$37.76

-0.36 (-0.94%)

18:38
11/14/19
11/14
18:38
11/14/19
18:38
Periodicals
Judge rejects Icahn's suit seeking Occidental acquisition records, Reuters says »

A Delaware court judge…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

FTCH

Farfetch

$7.49

-0.54 (-6.72%)

, DGII

Digi International

$15.10

0.33 (2.23%)

18:35
11/14/19
11/14
18:35
11/14/19
18:35
Hot Stocks
Fly Intel: After Hours Movers »

UP AFTER EARNINGS:…

FTCH

Farfetch

$7.49

-0.54 (-6.72%)

DGII

Digi International

$15.10

0.33 (2.23%)

AMAT

Applied Materials

$56.89

-0.24 (-0.42%)

KLIC

Kulicke & Soffa

$25.18

-0.22 (-0.87%)

HP

Helmerich & Payne

$39.30

0.04 (0.10%)

WPM

Wheaton Precious Metals

$26.47

-0.12 (-0.45%)

RDNT

RadNet

$15.92

0.09 (0.57%)

RH

RH

$175.19

1.98 (1.14%)

ACB

Aurora Cannabis

$3.29

-0.25 (-7.06%)

OSMT

Osmotica Pharmaceuticals

$4.00

-0.03 (-0.74%)

GLOB

Globant

$108.99

3.975 (3.79%)

DLB

Dolby

$65.56

-0.14 (-0.21%)

NVDA

Nvidia

$209.88

1.33 (0.64%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 14

    Nov

  • 15

    Nov

  • 15

    Nov

  • 15

    Nov

  • 20

    Nov

  • 03

    Dec

  • 04

    Dec

  • 05

    Dec

  • 09

    Dec

  • 09

    Dec

  • 12

    Dec

  • 13

    Dec

  • 06

    Jan

VIA

Viacom

$25.31

0.175 (0.70%)

, VIAB

Viacom

$22.48

0.44 (2.00%)

18:24
11/14/19
11/14
18:24
11/14/19
18:24
Hot Stocks
Viacom CEO: The road ahead for the company is very exciting »

In an interview on…

VIA

Viacom

$25.31

0.175 (0.70%)

VIAB

Viacom

$22.48

0.44 (2.00%)

CBS

CBS

$37.62

0.78 (2.12%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 14

    Nov

  • 09

    Dec

NVDA

Nvidia

$209.88

1.33 (0.64%)

18:22
11/14/19
11/14
18:22
11/14/19
18:22
Hot Stocks
Breaking Hot Stocks news story on Nvidia »

Nvidia CFO says continue…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 20

    Nov

  • 06

    Jan

NVDA

Nvidia

$209.88

1.33 (0.64%)

18:04
11/14/19
11/14
18:04
11/14/19
18:04
Hot Stocks
Nvidia CEO says Q4 will be much stronger driven by AI and inference »

Says computational…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 20

    Nov

  • 06

    Jan

BABA

Alibaba

$182.69

0.21 (0.12%)

17:50
11/14/19
11/14
17:50
11/14/19
17:50
Syndicate
Alibaba launches Hong Kong IPO »

Alibaba Group Holding…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 19

    Nov

17:49
11/14/19
11/14
17:49
11/14/19
17:49
Conference/Events
William Blair SaaS analyst to hold a luncheon meeting »

SaaS Analyst Pfau holds a…

HP

Helmerich & Payne

$39.30

0.04 (0.10%)

17:49
11/14/19
11/14
17:49
11/14/19
17:49
Earnings
Helmerich & Payne sees FY20 CapEx approximately $275M-$300M »

57-62% expected for…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

PPG

PPG

$129.82

-0.5 (-0.38%)

, PG

Procter & Gamble

$120.49

-0.15 (-0.12%)

17:49
11/14/19
11/14
17:49
11/14/19
17:49
Hot Stocks
Trian Fund exits PPG, cuts Wendy's in Q3 »

Nelson Peltz' Trian…

PPG

PPG

$129.82

-0.5 (-0.38%)

PG

Procter & Gamble

$120.49

-0.15 (-0.12%)

MDLZ

Mondelez

$52.90

0.2 (0.38%)

LM

Legg Mason

$38.60

-0.22 (-0.57%)

GE

General Electric

$11.30

-0.01 (-0.09%)

WEN

Wendy's

$20.90

-0.01 (-0.05%)

BK

BNY Mellon

$48.42

0.07 (0.14%)

SYY

Sysco

$81.51

0.27 (0.33%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 15

    Nov

  • 19

    Nov

  • 19

    Nov

  • 02

    Dec

  • 11

    Dec

  • 16

    Jan

  • 29

    Jan

HP

Helmerich & Payne

$39.30

0.04 (0.10%)

17:48
11/14/19
11/14
17:48
11/14/19
17:48
Earnings
Helmerich & Payne reports Q4 cont ops EPS 38c, consensus 23c »

Reports Q4 revenue…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Nov

17:47
11/14/19
11/14
17:47
11/14/19
17:47
Conference/Events
DA Davidson software analysts to hold a dinner meeting »

Analysts host a Security…

MDCO

The Medicines Co.

$50.89

-1.905 (-3.61%)

17:46
11/14/19
11/14
17:46
11/14/19
17:46
Conference/Events
Roth Capital pharmaceuticals analysts to hold a luncheon »

Analysts host Dr. John…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 16

    Nov

NVDA

Nvidia

$209.88

1.33 (0.64%)

17:44
11/14/19
11/14
17:44
11/14/19
17:44
Hot Stocks
Nvidia CFO says Q3 decline in automotive revenue driven by one-time item »

Says AI cockbit business…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 20

    Nov

  • 06

    Jan

CPE

Callon Petroleum

$4.20

-0.265 (-5.94%)

, PSDO

Presidio

$16.56

-0.02 (-0.12%)

17:44
11/14/19
11/14
17:44
11/14/19
17:44
Hot Stocks
Paulson adds Callon Petroleum, lowers stake in Lyft in Q3 »

John Paulson's…

CPE

Callon Petroleum

$4.20

-0.265 (-5.94%)

PSDO

Presidio

$16.56

-0.02 (-0.12%)

OSG

Overseas Shipholding

$1.84

0.045 (2.51%)

STC

Stewart

$43.10

0.11 (0.26%)

AGN

Allergan

$182.47

0.91 (0.50%)

HZNP

Horizon Pharma

$29.82

-0.48 (-1.58%)

ONCE

Spark Therapeutics

$110.78

-0.65 (-0.58%)

MYL

Mylan

$17.26

-0.01 (-0.06%)

S

Sprint

$5.86

-0.21 (-3.46%)

LYFT

Lyft

$41.90

-1.39 (-3.21%)

TMUS

T-Mobile

$76.87

-1.15 (-1.47%)

PCG

PG&E

$6.70

-0.19 (-2.76%)

WCG

WellCare

$301.86

-2.56 (-0.84%)

TSU

Tim Participacoes

$15.53

0.44 (2.92%)

GLD

SPDR Gold Shares

$138.57

0.59 (0.43%)

BHC

Bausch Health

$27.77

0.38 (1.39%)

CELG

Celgene

$110.03

-0.42 (-0.38%)

DISCK

Discovery Inc.

$28.04

0.12 (0.43%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 14

    Nov

  • 18

    Nov

  • 19

    Nov

  • 19

    Nov

  • 04

    Dec

  • 07

    Dec

  • 09

    Dec

  • 07

    Jan

  • 25

    Mar

  • 04

    Apr

17:41
11/14/19
11/14
17:41
11/14/19
17:41
Conference/Events
BTIG energy analysts to hold a luncheon »

Energy Analysts host…

17:40
11/14/19
11/14
17:40
11/14/19
17:40
Conference/Events
Wolfe Research tech strategist to hold analyst/industry webcast »

Tech Strategist…

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.