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MRNS

Marinus Pharmaceuticals

$5.15

-0.03 (-0.58%)

, SAGE

Sage Therapeutics

$102.08

-0.55 (-0.54%)

11:57
12/10/18
12/10
11:57
12/10/18
11:57

JMP boosts Marinus target to $29, sees 'clear' competitor to Sage Therapeutics

JMP Securities analyst Jason Butler raised his price target for Marinus Pharmaceuticals (MRNS) to $29 from $22 after the company announced positive results for both IV and oral formulations of ganaxolone in postpartum depression. The stock in midday trading is up 1c to $5.18. The results make comparisons to Sage Therapeutics' (SAGE) brexanolone and SAGE-217 relevant, Butler tells investors in a research note. Further, the analyst sees "potentially differentiating attributes" for ganaxolone. Specifically, at 60 hours, the optimal dose cohort for the IV formulation showed a 16.9 point reduction from baseline in HAM-D, and by comparison, in its Phase 3 trial, brexanolone showed a 17.7 point to 19.9 point reduction, explains the analyst. Butler increased his probability of approval for ganaxolone in PPD to 70% from 55%. He believes this morning's results show that Marinus represents a "clear and relevant competitor" to Sage. The analyst reiterates an Outperform rating on Marinus Pharmaceuticals.

MRNS

Marinus Pharmaceuticals

$5.15

-0.03 (-0.58%)

SAGE

Sage Therapeutics

$102.08

-0.55 (-0.54%)

  • 19

    Dec

  • 19

    Mar

MRNS Marinus Pharmaceuticals
$5.15

-0.03 (-0.58%)

12/10/18
JMPS
12/10/18
NO CHANGE
Target $29
JMPS
Outperform
Marinus Pharmaceuticals price target raised to $29 from $22 at JMP Securities
JMP Securities analyst Jason Butler raised his price target on Marinus Pharmaceuticals to $29 after the company announced it is advancing both ganaxolone studies into the next phase of development to evaluate IV and oral dose regimens.
07/19/18
MZHO
07/19/18
NO CHANGE
Target $13
MZHO
Buy
Marinus can rally 100% on postpartum depression data, says Mizuho
Mizuho analyst Difei Yang believes Marinus Pharmaceuticals' Q3 top-line data from part 1 of the Phase 2 Magnolia study of ganaxolone IV in women with postpartum depression will be an "important catalyst" for the shares. The analyst sees upside potential of 100%-plus, assuming "convincing data including a clear dose response." She believes the downside is limited given the history of the compound and potential in other indications. Yang reiterates a Buy rating on Marinus with a $13 price target.
07/02/18
CANT
07/02/18
INITIATION
Target $19
CANT
Overweight
Marinus Pharmaceuticals initiated with an Overweight at Cantor Fitzgerald
Cantor Fitzgerald analyst Elemer Piros started Marinus Pharmaceuticals with an Overweight rating and $19 price target. The analyst views the stock's risk/reward as compelling into upcoming data catalysts for ganaxolone, a positive allosteric modulator of GABAA receptor.
06/06/18
LTCO
06/06/18
INITIATION
Target $20
LTCO
Buy
Marinus Pharmaceuticals initiated with a Buy at Ladenburg
Ladenburg Thalmann analyst Michael Higgins started Marinus Pharmaceuticals with a Buy rating and $20 price target.
SAGE Sage Therapeutics
$102.08

-0.55 (-0.54%)

11/13/18
LEER
11/13/18
INITIATION
Target $80
LEER
Underperform
Sage Therapeutics initiated with an Underperform at Leerink
Leerink analyst Marc Goodman started Sage Therapeutics with an Underperform and $80 price target as he initiates Neuroscience space with a Positive View. The analyst believes the Neuroscience sector is experiencing a "renaissance" as multiple new agents and mechanisms are coming up the pipeline across major therapeutic areas, the number of clinical studies is growing nicely, and the FDA is friendly to innovation in this space, companies are getting smarter about speed-to-market strategies and selecting niche sub-populations to focus on for initial product approvals, payer pushback on usage is much lower than in other categories, and physicians are enthusiastic about new agents. Regarding Sage Therapeutics, while Goodman sees lead asset Zulresso being approved by year end and enabling Sage to establish a commercial organization in the U.S. and EU, he expects a very slow ramp and believes this will be a niche product.
11/12/18
LEER
11/12/18
INITIATION
Target $80
LEER
Underperform
Sage Therapeutics initiated with an Underperform at Leerink
Leerink Partners analyst Marc Goodman started Sage Therapeutics with an Underperform rating and $80 price target.
11/06/18
BMOC
11/06/18
NO CHANGE
Target $203
BMOC
Outperform
BMO Capital optimistic about Sage Therapeutics upcoming data readouts
BMO Capital analyst Gary Nachman kept his Outperform rating and $203 price target on Sage Therapeutics after its Q3 results, saying the company's "much higher SG&A" spending is "supporting preparations for an expected launch of Zulresso" for postpartum depression in March of 2019. The analyst anticipates approval for Zulresso by the December PDUFA following a "very favorable AdComm last week". Nachman is also positive on Sage Therapeutics' development of trials for SAGE-217 in major depressive disorders, which he claims may be "an even bigger opportunity if successful".
11/06/18
11/06/18
NO CHANGE

Sage Therapeutics pricing for Zulresso at a premium to Piper Jaffray estimate
Piper Jaffray analyst Danielle Brill, who maintained an Overweight rating and $206 price target on Sage Therapeutics shares, noted that the announced plans to price Zulresso at $25,000-$35,000 per course -- should it be approved on its December 19 PDUFA date -- which is at a premium to Piper's estimated net pricing of $15,000. Brill also noted that the drug's sales force has been hired, which includes ~130 reps, and ~50 patient support/access personnel, and she is awaiting final commercial details following PDUFA announcement.

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GOLD

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