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AZN

AstraZeneca

$41.08

-0.82 (-1.96%)

06:53
04/04/19
04/04
06:53
04/04/19
06:53

AstraZeneca reports publication of Fasenra Phase 2 trial results in NEJM

A Phase 2 trial has demonstrated that Fasenra can achieve near-complete depletion of eosinophils and improve clinical outcomes in hypereosinophilic syndrome, AstraZeneca announced. The results are published in the New England Journal of Medicine. In the randomized phase of the 20-patient trial, the primary efficacy endpoint was the percentage of patients who reduced their absolute blood eosinophil counts by 50% or more at week 12. This was achieved by 90% of patients treated with Fasenra compared with 30% of patients treated with placebo, a statistically significant difference. In the open-label phase of the trial, 74% of patients maintained a reduction in eosinophil counts and had clinical improvements in their symptoms through week 48. Of these patients, 64% were able to taper background HES medications. In patients from whom tissue biopsies were obtained, there was near-complete depletion of eosinophils following treatment with Fasenra.

  • 07

    May

AZN AstraZeneca
$41.08

-0.82 (-1.96%)

04/01/19
COWN
04/01/19
UPGRADE
Target $48
COWN
Outperform
Cowen upgrades AstraZeneca to Outperform after cancer partnership pullback
As previously reported, Cowen analyst Steve Scala upgraded AstraZeneca to Outperform from Market Perform, stating that the 5% stock decline on news of the company's partnership with Daiichi Sankyo for trastuzumab deruxtecan, which he calls a "promising" breast cancer drug, offers a compelling entry point. Key opinion leading doctors he speaks with anticipate use of trastuzumab deruxtecan in many patients with metastatic HER2+ disease, while low HER2+ "shows promise but requires more data," said Scala. Meanwhile, Imfinzi, Tagrisso and Lynparza all have "big potential" and Roxadustat "offers upside," the analyst tells investors. He raised his price target on AstraZeneca shares to $48 from $42.
04/01/19
04/01/19
UPGRADE

Fly Intel: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. UPS (UPS) upgraded to Buy from Hold at Berenberg with analyst Joel Spungin saying he is increasingly confident that UPS will deliver margin improvement in both its International business and the U.S. this year, following an in-depth review of European parcel markets. 2. AstraZeneca (AZN) upgraded to Outperform from Market Perform at Cowen with analyst Steve Scala saying the 5% stock decline on news of the company's partnership with Daiichi Sankyo for trastuzumab deruxtecan, which he calls a "promising" breast cancer drug, offers a compelling entry point. 3. Energizer (ENR) upgraded to Conviction Buy from Neutral at Goldman Sachs with analyst Jason English saying he sees a credible path to top-tier EBIT, EBITDA and EPS growth over the next three years "fueled almost entirely" by debt-reduction and synergies from its recently completed deals for the Global Battery & Lighting business and Global Auto Care business of Spectrum Brands (SPB). 4. Anadarko (APC) resumed with a Buy from Neutral at Citi with analyst Robert Morris citing the stock's underperformance over the past three months and the company's recent success in the Delaware Basin for the upgrade. 5. F5 Networks (FFIV) upgraded to Buy from Neutral at Nomura Instinet with analyst Jeffrey Kvaal saying "long an out-of-favor name," F5 shares are now ~25% below their 2018 peak following the acquisition of Nginx. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
04/02/19
UBSW
04/02/19
DOWNGRADE
UBSW
Sell
AstraZeneca downgraded to Sell from Neutral at UBS
UBS analyst Michael Leuchten downgraded AstraZeneca to Sell from Neutral and lowered his price target for the shares to GBP 54 from GBP 59. Last week's oncology deal with Japan's Daiichi Sankyo suggests limited cash generation in the near term and is a sign of slow margin recovery, Leuchten tells investors in a research note. He believes AstraZeneca can't generate enough cash flow to support its current enterprise value.
04/02/19
04/02/19
DOWNGRADE

Fly Intel: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. AstraZeneca (AZN) downgraded to Sell from Neutral at UBS with analyst Michael Leuchten saying last week's oncology deal with Japan's Daiichi Sankyo suggests limited cash generation in the near term and is a sign of slow margin recovery. 2. Alcoa (AA) downgraded to Neutral from Outperform at Credit Suisse with analyst Curt Woodworth saying China is set to accelerate supply growth over the next several years as capacity swaps convert to new smelters and provincial focus pivots to growth model. 3. Pacific Biosciences (PACB) downgraded to Equal Weight from Overweight at Stephens with analyst Drew Jones saying the shares are within 10% of the looming purchase price by Illumina (ILMN). 4. Wingstop (WING) downgraded to Neutral from Buy at Guggenheim with analyst Matthew DiFrisco saying he sees increased risk to moderating new store growth and the current valuation multiple. 5. DowDuPont (DWDP) downgraded to Neutral from Buy at Citi and BofA/Merrill. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

PDD

Pinduoduo

$23.61

-0.82 (-3.36%)

12:45
04/24/19
04/24
12:45
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12:45
Options
Pinduoduo call volume above normal and directionally bullish »

Bullish option flow…

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12:45
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12:45
General news
Treasury 5-year auction preview: analysts're optimistic on the auction »

Treasury 5-year auction…

NOC

Northrop Grumman

$281.56

-11.03 (-3.77%)

12:37
04/24/19
04/24
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Northrop Grumman sees restricted portfolio growing faster than restricted in '19 »

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CBU

Community Bank System

$65.00

0.15 (0.23%)

12:36
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04/24
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12:36
Hot Stocks
Community Bank says holder, regulatory approvals received for Kinderhook merger »

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    May

FDX

FedEx

$196.18

1.05 (0.54%)

, UPS

UPS

$114.25

0.65 (0.57%)

12:32
04/24/19
04/24
12:32
04/24/19
12:32
Earnings
Fly Intel: What to watch in UPS earnings report »

UPS (UPS) is scheduled to…

FDX

FedEx

$196.18

1.05 (0.54%)

UPS

UPS

$114.25

0.65 (0.57%)

03/08/13
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QQQ

Invesco QQQ Trust

$190.13

-0.18 (-0.09%)

12:30
04/24/19
04/24
12:30
04/24/19
12:30
Options
Notable call spread in Invesco QQQ as shares ease off record highs »

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NOC

Northrop Grumman

$282.44

-10.15 (-3.47%)

12:27
04/24/19
04/24
12:27
04/24/19
12:27
Hot Stocks
Northrop Grumman sees return to growth for TS segment later this year »

Says will continue to see…

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    May

AMZN

Amazon.com

$1,915.34

-8.74 (-0.45%)

12:26
04/24/19
04/24
12:26
04/24/19
12:26
Periodicals
Amazon team auditing Alexa can access customer addresses, Bloomberg reports »

The Amazon.com team…

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12:25
04/24/19
04/24
12:25
04/24/19
12:25
Conference/Events
Morgan Stanley power/utilities analyst to hold an analyst/industry conference ca »

Power & Utilities,…

NLSN

Nielsen

$25.60

0.03 (0.12%)

, ETM

Entercom

$6.43

0.095 (1.50%)

12:22
04/24/19
04/24
12:22
04/24/19
12:22
Hot Stocks
Entercom, Nielsen announce data-driven strategic agreement »

Entercom (ETM) and…

NLSN

Nielsen

$25.60

0.03 (0.12%)

ETM

Entercom

$6.43

0.095 (1.50%)

03/08/13
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NOC

Northrop Grumman

$280.86

-11.73 (-4.01%)

12:20
04/24/19
04/24
12:20
04/24/19
12:20
Hot Stocks
Northrop Grumman still sees 'strong' cash flow in 2019 »

Says Space portfolio is…

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COP

ConocoPhillips

$65.49

-0.96 (-1.44%)

12:20
04/24/19
04/24
12:20
04/24/19
12:20
Options
Call buyer in Conoco ahead of earnings next week »

Call buyer in Conoco…

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ZM

Zoom Video

$65.93

-3.12 (-4.52%)

, MSFT

Microsoft

$124.90

-0.6 (-0.48%)

12:19
04/24/19
04/24
12:19
04/24/19
12:19
On The Fly
Fly Intel: What to watch in Microsoft earnings report »

Microsoft (MSFT) is…

ZM

Zoom Video

$65.93

-3.12 (-4.52%)

MSFT

Microsoft

$124.90

-0.6 (-0.48%)

03/08/13
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$NSD

NASDAQ Market Internals

$0.00

(0.00%)

12:17
04/24/19
04/24
12:17
04/24/19
12:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

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$NYE

NYSE Market Internals

$0.00

(0.00%)

12:16
04/24/19
04/24
12:16
04/24/19
12:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

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LPL

LG Display

$8.35

-1.14 (-12.02%)

12:10
04/24/19
04/24
12:10
04/24/19
12:10
Downgrade
LG Display rating change at HSBC »

LG Display downgraded to…

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OXY

Occidental Petroleum

$60.91

-1.44 (-2.31%)

, APC

Anadarko

$71.89

7.77 (12.12%)

12:09
04/24/19
04/24
12:09
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12:09
On The Fly
Fly Intel: Wall Street's top stories at midday »

The major averages are…

OXY

Occidental Petroleum

$60.91

-1.44 (-2.31%)

APC

Anadarko

$71.89

7.77 (12.12%)

CVX

Chevron

$118.80

-3.2 (-2.62%)

BA

Boeing

$378.71

4.67 (1.25%)

T

AT&T

$30.75

-1.36 (-4.24%)

CAT

Caterpillar

$138.18

-3.9 (-2.74%)

CBS

CBS

$51.44

0.09 (0.18%)

VIA

Viacom

$36.81

0.53 (1.46%)

VIAB

Viacom

$29.88

0.61 (2.08%)

SAP

SAP

$127.96

13.12 (11.42%)

SLAB

Silicon Labs

$105.83

12.195 (13.02%)

EBAY

eBay

$38.25

1.59 (4.34%)

RES

RPC, Inc.

$11.10

-1.8 (-13.95%)

IRBT

iRobot

$103.20

-27.22 (-20.87%)

SNAP

Snap

$11.36

-0.63 (-5.25%)

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TDOC

Teladoc

$54.67

0.32 (0.59%)

, HUM

Humana

$249.01

0.71 (0.29%)

12:09
04/24/19
04/24
12:09
04/24/19
12:09
Recommendations
Teladoc, Humana analyst commentary at Baird »

Humana virtual primary…

TDOC

Teladoc

$54.67

0.32 (0.59%)

HUM

Humana

$249.01

0.71 (0.29%)

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MPC

Marathon Petroleum

$60.06

-0.94 (-1.54%)

12:05
04/24/19
04/24
12:05
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12:05
Options
Marathon Petroleum call volume above normal and directionally bullish »

Bullish option flow…

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UMC

UMC

$1.94

0.015 (0.78%)

12:04
04/24/19
04/24
12:04
04/24/19
12:04
Upgrade
UMC rating change at JPMorgan »

UMC upgraded to Neutral…

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  • 24

    Apr

LRN

K12

$31.56

-4.665 (-12.88%)

12:01
04/24/19
04/24
12:01
04/24/19
12:01
Hot Stocks
K12 falls -12.4% »

K12 is down -12.4%, or…

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SPN

Superior Energy

$4.28

-0.685 (-13.80%)

12:01
04/24/19
04/24
12:01
04/24/19
12:01
Hot Stocks
Superior Energy falls -13.9% »

Superior Energy is down…

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  • 24

    Apr

RES

RPC, Inc.

$11.04

-1.86 (-14.42%)

12:01
04/24/19
04/24
12:01
04/24/19
12:01
Hot Stocks
RPC, Inc. falls -14.2% »

RPC, Inc. is down -14.2%,…

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SAP

SAP

$128.22

13.38 (11.65%)

12:01
04/24/19
04/24
12:01
04/24/19
12:01
Hot Stocks
SAP rises 11.7% »

SAP is up 11.7%, or…

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  • 24

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APC

Anadarko

$71.92

7.8 (12.16%)

12:00
04/24/19
04/24
12:00
04/24/19
12:00
Hot Stocks
Anadarko rises 12.4% »

Anadarko is up 12.4%, or…

03/08/13
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03/06/13
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03/06/13
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