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WVE

Wave Life Sciences

$24.77

-9.28 (-27.25%)

10:49
04/16/19
04/16
10:49
04/16/19
10:49

Safety data from Wave Life's Exon-51 SAD DMD trial seems reasonably clean, says Mizuho

Mizuho analyst Salim Syed notes that Wave Life Sciences disclosed safety data from its Phase 1 Exon-51 SAD DMD trial, and based on this Phase 1 trial and preclinical work, the company has selected two doses to move forward into its Phase 2/3 trial, 3mg/kg and 4.5mg/kg. The analyst believes the safety data seems "reasonably clean," and that the Street should be not be getting hung up on the reported adverse events. Syed reiterates a Buy rating and $65 price target on the shares.

  • 16

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WVE Wave Life Sciences
$24.77

-9.28 (-27.25%)

11/27/18
LEER
11/27/18
INITIATION
Target $61
LEER
Outperform
Wave Life Sciences initiated with an Outperform at Leerink
Leerink analyst Mani Foroohar initiated Wave Life Sciences with an Outperform rating and a price target of $61.
11/27/18
LEER
11/27/18
INITIATION
LEER
Leerink initiates select Genetic Medicine names on increasing regulatory clarity
Leerink analyst Mani Foroohar initiated select Genetic Medicine stocks, stating that the field is "is rich with companies developing drugs" to treat rare diseases and that he is increasingly more bullish on "innovation velocity and increasing regulatory clarity in the sector. Based on his "balanced view of pricing dynamics", the analyst issues an Outperform rating on Wave Life Sciences (WVE), Rocket Pharmaceuticals (RCKT), Intellia Therapeutics (NTLA), Eidos Therapeutics (EIDX), Dicerna (DRNA) and Bluebird Bio (BLUE). The analyst likes Wave Life Sciences as a pure play on Oligotherapeutics and its stereopure chemistry platform as a differentiated approach to oligo drug design. Foroohar is positive on Rocket Pharma's lead assets in gene therapies for Fanconi Anemia and Leukocyte Adhesion Deficiency-I "which will likely be the company's first potential approved product." The analyst is positive on Intellia Therapeutics' "robust balance sheet to support development, trading at a material discount to closest comps peers". For Eidos, the analyst cites the prospects of its drug candidate for TTR amyloidosis currently in a placebo-controlled Phase 2 study that may offer a competitive profile relative to Pfizer's (PFE) tafamidis. For Dicerna, Foroohar notes that its DCR-PHXC "is an RNAi therapeutic that targets lactate dehydrogenase A for the treatment of all subtypes of Primary Hyperoxaluria vs. competitor Alnylam's (ALNY) lumasiran, which only treats PH Type 1. For Bluebird Bio, the analyst is positive on its position as a "leader in ex vivo gene therapy, with four programs with visibility towards near-term regulatory approval". Foroohar initiates Avrobio (AVRO), Alnylam (ALNY), and Ionis Pharmaceuticals (IONS) with Market Perform rating based on competitive launches for their products along with "mixed" early signs of their results. The analyst also rates Regenxbio (RGNX) at underperform, saying that its "current valuation more than accounts for robust royalty streams from sales in spinal muscular atrophy" and other partnered assets.
12/06/18
12/06/18
NO CHANGE

Mizuho defending Wave Life Sciences after stock decline
Mizuho analyst Salim Syed maintained a Buy rating and $65 price target on Wave Life Sciences, and defended the stock after its double digit decline. Syed said some of the decline was related to the broader market decline, as the tape is generally red, but some is Wave Life specific, as a lack of details in the company's recent press release has disappointed some investors. The analyst said he spoke to management and believes the decline is unwarranted, as management alleviated concerns regarding the drug trial.
04/16/19
LEER
04/16/19
NO CHANGE
LEER
Outperform
Wave Life Sciences suvodirsen data with little read-through for efficacy, says SVB Leerink
SVB Leerink analyst Mani Foroohar says that Wave Life Sciences' first-in-human safety data from the Phase I trial of suvodirsen in exon 51 skipping-amenable Duchenne Muscular Dystrophy shows that it was generally sage and well-tolerated up to the 5mg/kg dose, and notes the company has selected the 3.0mg/kg and 4.5mg/kg doses to pivotal trials. While the stock is trading down and investors seem to see negative read-throughs for the potential efficacy of suvodirsen at 5mg/kg, given that drisapersen was dosed at 6mg/kg in clinical trials, the analyst believes that due to differences in chemistry between the compounds, comparison of doses between drugs is not appropriate proxy of potential efficacy. Foroohar maintains his 30% probability of success on the suvodirsen program and reiterates an Outperform rating on the shares.

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MTSI

Macom

$15.86

-0.33 (-2.04%)

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GRTS

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$12.32

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MTSI

Macom

$15.86

-0.33 (-2.04%)

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CBS

CBS

$51.34

-0.01 (-0.02%)

, VIAB

Viacom

$29.69

0.42 (1.43%)

20:39
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Viacom

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INTC

Intel

$58.72

-0.06 (-0.10%)

20:34
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Intel lays off dozens in autonomous vehicle division, The Information reports »

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CMCSA

Comcast

$41.87

-0.11 (-0.26%)

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Comcast

$0.00

(0.00%)

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Comcast

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-0.11 (-0.26%)

CMCSK

Comcast

$0.00

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MMM

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ABBV

AbbVie

$78.71

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MO

Altria Group

$54.70

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UPS

UPS

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BMY

Bristol-Myers

$44.63

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RTN

Raytheon

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-2.08 (-1.11%)

ITW

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BAX

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VLO

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LUV

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HSY

Hershey

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ROK

Rockwell Automation

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HES

Hess Corp.

$65.79

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FCX

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IP

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DHI

D.R. Horton

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TSCO

Tractor Supply

$104.09

0.88 (0.85%)

MAS

Masco

$39.98

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IVZ

Invesco

$21.53

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CLF

Cleveland-Cliffs

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0.025 (0.26%)

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PBR

Petrobras

$15.34

-0.45 (-2.85%)

20:15
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Periodicals
Breaking Periodicals news story on Petrobras »

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BTI

British American Tobacco

$39.33

-0.45 (-1.13%)

19:28
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Periodicals
BAT faces legal action over giving workers free cigarettes, Bloomberg says »

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POR

Portland General Electric

$51.20

0.61 (1.21%)

19:22
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WPG

Washington Prime

$4.55

-0.08 (-1.73%)

19:14
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Washington Prime reports Q1 FFO 31c, consensus 29c »

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AVH

Avianca

$3.91

-0.09 (-2.25%)

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SAM

Boston Beer

$276.71

-1.24 (-0.45%)

, AXTI

AXT Inc.

$4.74

0.09 (1.94%)

19:03
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Fly Intel: After Hours Movers »

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AXTI

AXT Inc.

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BCOV

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FB

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NOW

ServiceNow

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MSFT

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LRCX

Lam Research

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TILE

Interface

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CHDN

Churchill Downs

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KN

Knowles

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CMG

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TSLA

Tesla

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XLNX

Xilinx

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PTC

PTC

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1.12 (1.11%)

NTGR

Netgear

$35.03

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SAVE

Spirit Airlines

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O'Reilly Automotive

$396.80

1.14 (0.29%)

MMLP

Martin Midstream Partners

$9.84

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PBFX

PBF Logistics

$21.36

-0.37 (-1.70%)

, PBF

PBF Energy

$33.09

-0.805 (-2.38%)

19:02
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Earnings
PBF Logistics reports preliminary Q1 revenue $78.3M-$79.3M, consensus $78.17M »

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PBFX

PBF Logistics

$21.36

-0.37 (-1.70%)

PBF

PBF Energy

$33.09

-0.805 (-2.38%)

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PBFX

PBF Logistics

$21.36

-0.37 (-1.70%)

, PBF

PBF Energy

$33.09

-0.805 (-2.38%)

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PBF Logistics acquires remaining 50% interest in Torrance Valley Pipeline Compan »

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PBFX

PBF Logistics

$21.36

-0.37 (-1.70%)

PBF

PBF Energy

$33.09

-0.805 (-2.38%)

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NOW

ServiceNow

$242.41

-1.085 (-0.45%)

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PBFX

PBF Logistics

$21.36

-0.37 (-1.70%)

18:57
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NFBK

Northfield Bancorp

$14.70

0.09 (0.62%)

18:56
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NFBK

Northfield Bancorp

$14.70

0.09 (0.62%)

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Earnings
Northfield Bancorp reports Q1 EPS 19c, consensus 19c »

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ZUO

Zuora

$20.03

0.04 (0.20%)

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TSLA

Tesla

$258.70

-5.15 (-1.95%)

, MXWL

Maxwell

$4.28

-0.095 (-2.17%)

18:31
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Tesla says 50% of deliveries occurred in last 10 days of quarter »

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Tesla

$258.70

-5.15 (-1.95%)

MXWL

Maxwell

$4.28

-0.095 (-2.17%)

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OMAB

OMA Airports

$48.34

-0.25 (-0.51%)

18:18
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18:18
Earnings
OMA Airports reports Q1 EPS 67c, two estimates 73c »

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HMC

Honda

$27.70

-0.8 (-2.81%)

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Honda to recall roughly 94,000 cars in U.S. over faulty timing belts »

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NTDOY

Nintendo

$0.00

(0.00%)

18:05
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Nintendo says 'Super Mario Maker 2' coming to Switch June 28 »

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  • 08

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ARGO

Argo Group

$74.46

0.515 (0.70%)

18:04
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Argo Group says Voce making 'false and misleading' statements about company »

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  • 11

    Jun

SJW

SJW Corp.

$61.56

0.3 (0.49%)

18:03
04/24/19
04/24
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18:03
Earnings
SJW Corp. reports Q1 EPS 21c with items, consensus 14c »

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