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INO

Inovio

$3.73

-0.21 (-5.33%)

09:07
04/18/19
04/18
09:07
04/18/19
09:07

Inovio's dBITE shows tumor-killing activity in peer-reviewed publication

Inovio's novel DNA-encoded Bi-specific T Cell Engagers, or dBiTEs, generated potent anti-tumor activities and cleared established tumors in preclinical studies according to results published in peer-reviewed journal JCI Insight article by Inovio and its collaborators at The Wistar Institute. For this study, Inovio developed a novel dBiTE for the treatment of ovarian and breast cancers. A single dose of Inovio's HER2 dBiTE resulted in high levels of corresponding BiTE in mice for up to four months, exceeding what is typically displayed with the currently approved BiTE's short half-life of only a few hours. The HER2 dBiTE treatment effectively killed HER2-expressing tumor cells resulting in a near-complete tumor clearance. Inovio's CEO Joseph Kim said, "(...) Our dBiTE technology could be utilized to overcome the greatest shortcomings of traditional BiTEs, particularly its incredibly short half-life. Based on these promising preclinical results, we plan to rapidly advance our first dBiTE candidate into clinical testing, as well as develop more cancer tumor-targeting dBiTEs as partnering candidates." Inovio's dBiTE is a new application of Inovio's dMAb platform.

  • 08

    May

INO Inovio
$3.73

-0.21 (-5.33%)

03/25/19
CANT
03/25/19
INITIATION
CANT
Overweight
Inovio initiated with an Overweight at Cantor Fitzgerald
03/26/19
CANT
03/26/19
INITIATION
Target $12
CANT
Overweight
Inovio initiated with an Overweight at Cantor Fitzgerald
Cantor Fitzgerald analyst Charles Duncan last night initiated coverage of Inovio Pharmaceuticals with an Overweight rating and $12 price target. With the "large and growing" need for non-invasive therapies to treat human papillomavirus-related cervical dysplasia that can also help clear HPV infection, the ongoing Phase 3 Reveal-1/-2 studies are the major value driver for the stock in the next 12-18 months, Duncan tells investors in a research note.
03/26/19
03/26/19
INITIATION

Fly Intel: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Dunkin' Brands (DNKN) initiated with a Perform at Oppenheimer. 2. Dow (DOW) initiated with an Outperform at Bernstein. 3. Nvidia (NVDA) initiated with an Overweight at Piper Jaffray. 4. Pan American Silver (PAAS) initiated with a Sector Perform at National Bank. 5. Inovio (INO) initiated with an Overweight at Cantor Fitzgerald. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
04/02/19
PIPR
04/02/19
NO CHANGE
PIPR
Overweight
Inovio d-BiTEs news a 'significant pleasant surprise,' says Piper Jaffray
Piper Jaffray analyst Christopher Raymond said Inovio (INO) presented what he considers interesting, "albeit preclinical," data on DNA-encoded bispecific T-cell engagers, or "d-BiTEs," that could offer the advantages of Amgen's (AMGN) BiTE technology while "also offering what we see as an elegantly simple approach to addressing the inherent half-life challenges of current BiTE technology." Raymond said he did not expect that the company would be working on DNA-encoded bispecifics and called the announcement "a significant pleasant surprise" from the American Association for Cancer Research Annual Meeting. Raymond keeps an Overweight rating on Inovio shares.

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MNK

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APTO

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EPZM

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