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BCRX

BioCryst

$7.92

0.22 (2.86%)

05:48
04/22/19
04/22
05:48
04/22/19
05:48

Piper sees 'significant' potential in HAE for BioCryst after expert call

Piper Jaffray analyst Tyler Van Buren reiterates an Overweight rating on BioCryst Pharmaceuticals with a $15 price target after hosting a call with an expert in hereditary angioedema. A focus of the discussion was on BioCryst's oral capsule and liquid formulations of BCX7353, a plasma kallikrein inhibitor, Van Buren tells investors in a research note. The expert was "quite optimistic" on the Phase III APeX-2 trial reading out later this quarter, and believes that roughly half of all HAE patients would be candidates if a ~50% reduction in attacks is observed with good tolerability, adds the analyst. This suggests "significant" peak sales potential based on a market that is currently $2B-plus and heading towards $3B, says Van Buren. Since CSL and Shire (SHPG) have essentially had a duopoly for years, the expert also believes payors will be very receptive to a less expensive oral option, according to the analyst.

BCRX BioCryst
$7.92

0.22 (2.86%)

03/04/19
PIPR
03/04/19
NO CHANGE
Target $15
PIPR
Overweight
Piper Jaffray expects positive results from BioCryst's Phase III APeX-2 trial
Piper Jaffray analyst Tyler Van Buren "fully" expects positive results from BioCryst's Phase III APeX-2 trial next quarter and notes that the increased enrollment and improved powering is an encouraging development. Additionally, the analyst says that recent full presentation of the Phase II ZENITH-1 results for the 7353 oral liquid program continue to give him a high level of confidence in the future outcome of the Phase III trial. In addition to these two late stage programs, the company's pipeline is expanding rapidly with IV antiviral galidesivir, BCX9250 for FOP, and BCX9930 for complement-mediated diseases all entering the clinic this year, he adds. Van Buren reiterates an Overweight rating and $15 price target on the shares as he continues to have a high level of confidence in the $500M-plus potential of each the 7353 oral capsule and oral liquid assets and believes that the early-stage pipeline could generate significant additional value.
03/06/19
PIPR
03/06/19
NO CHANGE
PIPR
Departure of Gottlieb brings some biopharma uncertainty, says Piper Jaffray
Piper Jaffray remains "largely bullish" on the biopharma sector but acknowledges a "new and unexpected" source of uncertainty now with the announced departure of FDA commissioner Scott Gottlieb, analysts led by Christopher Raymond tell investors in a research note. With a track record of favoring innovation and pushing for increased regulatory efficiency while also advocating for more competition, Dr. Gottlieb was about as "market friendly, patient focused and industry friendly as one could have hoped," Piper writes. The firm adds that while it has no reason to believe the next commissioner "will be quite as radical and potentially damaging to the industry," it does think investors would do well to watch the selection process very closely.
03/12/19
PIPR
03/12/19
NO CHANGE
PIPR
Biopharma stocks should be up sharply on Sharpless selection, says Piper Jaffray
Piper Jaffray analyst Christopher Raymond said he expects biopharma stocks to be up sharply on news that former National Cancer Institute director Ned Sharpless will be named acting FDA commissioner. The biotech sector "experienced a swoon of sorts" since Scott Gottlieb announced his departure, but with the announcement of Gottlieb's favored choice as successor Raymond believes the FDA will remain "on its current industry-friendly and efficiency driven trajectory," the analyst tells investors.
04/02/19
LEHM
04/02/19
NO CHANGE
Target $8
LEHM
Equal Weight
BioCryst price target raised to $8 from $6 at Barclays
Barclays analyst Gena Wang raised her price target for BioCryst Pharmaceuticals to $8 from $6 following a deep dive ahead of the BCX7353 APeX-2 Phase 3 readout in Q2 for the prevention of hereditary angioedema attacks. The analyst believes APeX-2 is "well powered to allow for statistical significance" with only greater than 25-30% attack reduction. However, she continues to see some risk in the trial outcome and a high bar for future commercial uptake. Wang keeps an Equal Weight rating on BioCryst.

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